Article
Biochemistry & Molecular Biology
Shreya Kumar, Grace E. Mulia, Marxa L. Figueiredo
Summary: Combination therapy of chemotherapy and immunotherapy shows potential as a novel therapeutic strategy for treating bone-metastatic prostate cancer, with reduced chemotherapy-associated toxicity, enhanced sensitivity to immunotherapy, and improved bone quality.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Anita Ferraretto, Giovanni Lombardi
Summary: Bone metastases are a major issue in the progression of breast cancer, posing a significant treatment challenge. Interleukin-11 plays a key role in bone metastasis and could be a candidate for anti-metastatic therapy. Further research is needed to understand the contribution of different cytokines in breast cancer progression and develop effective therapeutic strategies.
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Alessandro Fulgenzi, Anita Ferraretto
Summary: Bone metastasis is a severe complication of common cancers like breast and prostate cancer, reducing survival rates and quality of life. Following a Mediterranean diet can prevent cancer and improve patient health, potentially impacting the spread of cancer to the bones.
Article
Endocrinology & Metabolism
Muhammad Sajid Hamid Akash, Momina Shahid, Shaleem Suhail, Kanwal Rehman, Ahmed Nadeem, Tahir Maqbool Mir
Summary: This study found a significant association between AGT T174M (rs4762) genetic polymorphism and hypertension in diabetic patients within the Pakistani population. The C/T genotype of AGT T174M (rs4762) was found to be significantly higher in both hypertensive and hypertensive diabetic patients compared to the control group, and it was identified as a risk factor for developing hypertension in these populations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Desiree M. Straign, Claire L. Ihle, Meredith D. Provera, Philip Owens
Summary: Prostate cancer bone metastases are common and often lead to painful skeletal events, with the BMP and TGF beta signaling pathways showing distinct effects in lytic or blastic bone lesions. Inhibiting BMP with DMH1 treatment restricts colonization of cancer cells in bone and preserves bone health. This suggests that profiling bone lesions in metastatic prostate cancer can help identify therapeutic targets to improve treatment outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Xian-Ling Cao, Xuan-You Zhou, Nai-Xin Xu, Song-Chang Chen, Chen-Ming Xu
Summary: This study conducted a systematic review and meta-analysis to investigate the relationship between IL-4 and IL-10 gene polymorphisms and preterm birth (PTB). The findings suggest that the over-dominant gene model AA + GG vs. AG of IL-10-1082A/G (rs1800896) polymorphism may be associated with genetic susceptibility to PTB and may have a protective function against PTB risk. However, no clear association was found between IL-4-590C/T (rs2243250), IL-10-592A/C (rs1800872), and IL-10-819T/C (rs1800871) polymorphisms and PTB. Further research is needed to confirm these findings due to the limitations of the included studies and the risk of publication bias.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ju-Chuan Hu, Shian-Shiang Wang, Ying-Erh Chou, Kun-Yuan Chiu, Jian-Ri Li, Chuan-Shu Chen, Sheng-Chun Hung, Cheng-Kuang Yang, Yen-Chuan Ou, Chen-Li Cheng, Chia-Yen Lin, Shun-Fa Yang
Summary: Evidence suggests that certain SNPs of MALAT1 are significantly associated with the susceptibility to advanced Gleason grade and nodal metastasis in prostate cancer, indicating an enhanced oncogenic potential in the presence of these SNPs.
Review
Oncology
Anne Natalie Prigol, Michele Patricia Rode, Fernanda da Luz Efe, Najla Adel Saleh, Tania Beatriz Creczynski-Pasa
Summary: Bone metastatic prostate cancer is associated with high mortality risks, and miRNA expression changes are closely related to the development, diagnosis, and treatment of this condition. Recent studies focus on the roles of miRNAs in bone metastasis, including their impact on metastasis-related processes and abnormal bone remodeling. Moreover, miRNAs can be harnessed for developing treatment tools and serve as noninvasive biomarkers for detecting prostate cancer metastasis. Overall, miRNA expression profiles and miRNA-based tools have significant importance in improving the quality of life and longevity of patients.
Article
Oncology
Mireia Olivan, Marta Garcia, Leticia Suarez, Marc Guiu, Laura Gros, Olga Mendez, Marina Rigau, Jaume Reventos, Miguel F. Segura, Ines de Torres, Jacques Planas, Xavier de la Cruz, Roger R. Gomis, Juan Morote, Ruth Rodriguez-Barrueco, Anna Santamaria
Summary: Around 70% of advanced-stage prostate cancer (PCa) patients will experience bone metastasis, severely affecting patients' quality of life and typically progressing to lethal PCa. Understanding the molecular heterogeneity of PCa cell populations and the signaling pathways associated with bone tropism is crucial. This study provides a genomic signature involved in PCa bone growth, contributing to a better understanding of the mechanisms responsible for this process.
Article
Immunology
Matheus Braga, Fernanda Formaggi Lara-Armi, Janisleya Silva Ferreira Neves, Marco Antonio Rocha-Loures, Mariana de Souza Terron-Monich, Larissa Danielle Bahls-Pinto, Quirino Alves de Lima Neto, Joana Maira Valentini Zacarias, Ana Maria Sell, Jeane Eliete Laguila Visentainer
Summary: The IL10 -1082 A>G (rs1800896) genotype is associated with AS, with AS patients having higher levels of IL-10 in serum, and the IL17F rs763780 polymorphism can affect the levels of IL-17F in the serum.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Catherine S. Johnson, Leah M. Cook
Summary: One of the challenges in improving survival of prostate cancer is designing new therapies to target bone metastases. Although regulation of the bone environment has been well characterized, current bone-targeted therapies have limited impact on patient survival, highlighting the complexity of the tumor-bone environment. Chemokine signaling is an important factor in promoting prostate cancer progression in the bone. Understanding and targeting this signaling pathway may provide promising options for treating bone metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Cinzia Baldessari, Stefania Pipitone, Eleonora Molinaro, Krisida Cerma, Martina Fanelli, Cecilia Nasso, Marco Oltrecolli, Marta Pirola, Elisa D'Agostino, Giuseppe Pugliese, Sara Cerri, Maria Giuseppa Vitale, Bruno Madeo, Massimo Dominici, Roberto Sabbatini
Summary: Bone metastases and bone health are important considerations in the management of prostate cancer patients. This review discusses the biology and clinical implications of bone metastases, as well as current therapeutic strategies. The importance of evaluating bone health and considering specific treatments is emphasized to address the risks associated with both poor bone health and bone metastasis.
Review
Biochemistry & Molecular Biology
Tingting Lv, Zijie Li, Dehua Wang, Xiaojin Guo, Xiaokuan Zhang, Jing Cao, Zhiyu Wang
Summary: This review summarizes the role of exosomes in PCa bone metastasis, including their influence on bone quality and structure, modulation of bone marrow microenvironment, and potential clinical applications in treatment strategies.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Andy Goebel, Stefania Dell'Endice, Nikolai Jaschke, Sophie Paehlig, Amna Shahid, Lorenz C. Hofbauer, Tilman D. Rachner
Summary: Inflammation plays a critical role in bone metastasis by supporting the survival, migration, invasion, and growth of tumor cells, serving as a key factor in the tumorigenesis and progression of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Mengmeng Long, Xuemeng Liu, Xu Huang, Min Lu, Xiaomei Wu, Lingyan Weng, Qiuping Chen, Xueting Wang, Li Zhu, Zhongping Chen
Summary: A bone-targeted and hypoxia-responsive polymeric micelle system was developed for effective treatment of bone metastatic prostate cancer, demonstrating significant inhibition of tumor growth in metastatic bone, promotion of osteoblast activity, relief of bone pain, and prolonged survival time.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Sanjay Varikuti, Bhawana Singh, Greta Volpedo, Dinesh K. Ahirwar, Bijay K. Jha, Noushin Saljoughian, Agostinho G. Viana, Chaitenya Verma, Omar Hamza, Gregory Halsey, Erin A. Holcomb, Ritvik J. Maryala, Steve Oghumu, Ramesh K. Ganju, Abhay R. Satoskar
BRITISH JOURNAL OF CANCER
(2020)
Article
Oncology
Shiva Kant, Pravin Kesarwani, Anthony R. Guastella, Praveen Kumar, Stewart F. Graham, Katie L. Buelow, Ichiro Nakano, Prakash Chinnaiyan
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Cell Biology
Shiva Kant, Pravin Kesarwani, Antony Prabhu, Stewart F. Graham, Katie L. Buelow, Ichiro Nakano, Prakash Chinnaiyan
CELL DEATH & DISEASE
(2020)
Review
Biotechnology & Applied Microbiology
Shadma Yaqoob, Areena H. Siddiqui, R. Harsvardhan, J. Ahmad, V. K. Srivastava, M. K. Verma, P. Verma, A. N. Singh
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Henu Kumar Verma, Neha Merchant, Manish Kumar Verma, Cansu Ilke Kuru, Anand Narayan Singh, Fulden Ulucan, Poonam Verma, Antaripa Bhattacharya, L. V. K. S. Bhaskar
BIOMEDICAL JOURNAL
(2020)
Review
Biochemistry & Molecular Biology
Manish Charan, Ajeet K. Verma, Shahid Hussain, Swati Misri, Sanjay Mishra, Sarmila Majumder, Bhuvaneswari Ramaswamy, Dinesh Ahirwar, Ramesh K. Ganju
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Manish Charan, Subhadip Das, Sanjay Mishra, Nabanita Chatterjee, Sanjay Varikuti, Kirti Kaul, Swati Misri, Dinesh K. Ahirwar, Abhay R. Satoskar, Ramesh K. Ganju
CELL DEATH & DISEASE
(2020)
Review
Immunology
Shahid Hussain, Bo Peng, Mathew Cherian, Jonathan W. Song, Dinesh K. Ahirwar, Ramesh K. Ganju
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
Tasha Wilkie, Ajeet K. Verma, Helong Zhao, Manish Charan, Dinesh K. Ahirwar, Sashi Kant, Vijay Pancholi, Sanjay Mishra, Ramesh K. Ganju
Summary: Recent studies suggest that human breast tissue may contain a bacterial microbiota, with a unique microbiota mainly enriched with Gram-negative bacteria in breast tumors. A signaling axis involving LPS/S100A7/TLR4/RAGE in breast cancer cells may exacerbate breast tumor burden.
MOLECULAR ONCOLOGY
(2022)
Review
Cell Biology
Sanjay Mishra, Manish Charan, Ajeet Kumar Verma, Bhuvaneswari Ramaswamy, Dinesh Kumar Ahirwar, Ramesh K. Ganju
Summary: Ethnic differences in mTOR and ERK-1/2 signaling pathways may be associated with the development and progression of different human malignancies. While socioeconomic disparities contribute to the differences in cancer incidence rates among different ethnic groups, genetic and molecular variations also play a significant role in racial disparities in the development of malignancies. Further studies are needed to explore the significance of racial disparity in abnormal mTOR and ERK-1/2 kinase signaling pathways for potentially developing tailored anti-cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Dinesh K. Ahirwar, Manish Charan, Sanjay Mishra, Ajeet K. Verma, Konstantin Shilo, Bhuvaneswari Ramaswamy, Ramesh K. Ganju
Summary: Slit2 inhibits metastasis in breast cancer by activating the phagocytic activity of M1-like TAMs against tumor cells and diminishing fibrosis. Slit2 expression along with CD163(+) TAMs could be used as an improved prognostic biomarker in patients with breast cancer.
Article
Oncology
Sanjay Mishra, Manish Charan, Rajni Kant Shukla, Pranay Agarwal, Swati Misri, Ajeet K. Verma, Dinesh K. Ahirwar, Jalal Siddiqui, Kirti Kaul, Neety Sahu, Kunj Vyas, Ayush Arpit Garg, Anum Khan, Wayne O. Miles, Jonathan W. Song, Nidhi Bhutani, Ramesh K. Ganju
Summary: S100A7 and cPLA2 are highly expressed in breast cancer patients and are associated with decreased overall survival. Further studies revealed that S100A7/RAGE signaling promotes the expression of cPLA2 and its oncogenic effects. Inhibiting cPLA2 can reduce S100A7-mediated tumor growth and metastasis, as well as increase immune cell infiltration.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Kirti Kaul, Martin Benej, Sanjay Mishra, Dinesh K. Ahirwar, Marshleen Yadav, Kristin I. Stanford, Naduparambil K. Jacob, Nicholas C. Denko, Ramesh K. Ganju
Summary: The study reveals that Slit2 modulates immune metabolism to increase BMDM polarization towards an anti-tumor phenotype, presenting a potential novel therapeutic strategy to enhance the anti-tumor immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Swati Misri, Kirti Kaul, Sanjay Mishra, Manish Charan, Ajeet Kumar Verma, Martin P. Barr, Dinesh K. Ahirwar, Ramesh K. Ganju
Summary: This study demonstrates that cannabidiol (CBD) inhibits the growth and metastasis of drug-resistant non-small cell lung cancer cells (NSCLC) and induces apoptosis of cisplatin-resistant cells. It acts through the TRPV2 receptor and modulates oxidative stress pathways. CBD could be a promising therapeutic strategy for cisplatin-resistant NSCLC.
Article
Medicine, Research & Experimental
Muayad F. Almahariq, Thomas J. Quinn, Pravin Kesarwani, Shiva Kant, C. Ryan Miller, Prakash Chinnaiyan
Summary: Inhibition of CSF-IR improved the response to radiotherapy in treating GBM by reducing M2 polarization, with the combination of radiotherapy and BLZ-945 leading to the longest survival in mouse models. Ultimately, targeting TAMs through CSF-IR inhibition may enhance the antitumor immune response induced by radiotherapy.