Review
Pathology
Lan Jiang, Ge Sun, Lina Zou, Yue Guan, Yongzheng Hang, Yanan Liu, Zhiren Zhou, Xueqing Zhang, Xiaojing Huang, Hongzhi Pan, Shengzhong Rong, Hongkun Ma
Summary: This study used meta-analysis to evaluate the relationship between noncoding RNAs and the prognosis of bladder cancer. It found that high expression of circ-ZFR, lnc-TUG1, miR-222, and miR-21 were correlated with poor overall survival in bladder cancer. High expression of miR-155 and miR-143 predicted poor progression-free survival, while low expression of lnc-GAS5 predicted poor overall survival, and low expression of miR-214 predicted poor recurrence-free survival.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Medicine, Research & Experimental
Ju-Yeon Kim, Eun Jung Jung, Jae-Myung Kim, Youngsim Son, Han Shine Lee, Seung-Jin Kwag, Ji-Ho Park, Jin-Kyu Cho, Han-Gil Kim, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong, Young-Tae Ju
Summary: miR-221 and miR-222 play a significant role in the progression and invasion of breast cancer cells by regulating the target gene ANXA3. The expression levels of miR-221/222 are associated with aggressive characteristics of breast cancer, and downregulation of ANXA3 through increased expression of miR-221/222 reduces breast cancer progression and increases the effectiveness of chemotherapy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Oncology
Ferran Moratalla-Navarro, Anna Diez-Villanueva, Ainhoa Garcia-Serrano, Adria Closa, David Cordero, Xavier Sole, Elisabet Guino, Rebeca Sanz-Pamplona, Xavier Sanjuan, Cristina Santos, Sebastiano Biondo, Ramon Salazar, Victor Moreno
Summary: In this study, a microRNA signature was identified to recognize patients at high recurrence risk in stage II colorectal cancer. The validity of these findings has been confirmed in an independent group of stage II microsatellite stable colon adenocarcinoma patients. Most of the microRNAs present in the signature have prognostic relevance in various other cancer types. Some of these microRNAs are involved in pivotal pathways of cancer progression.
Article
Oncology
Jedrzej Borowczak, Krzysztof Szczerbowski, Mateusz Maniewski, Marek Zdrenka, Piotr Slupski, Paulina Antosik, Sylwia Kolodziejska, Marta Sekielska-Domanowska, Mariusz Dubiel, Magdalena Bodnar, Lukasz Szylberg
Summary: This article investigates the prognostic role of cyclin-dependent kinase 9 expression in urothelial carcinoma. The results show that high CDK9 expression is associated with a better prognosis, tumor grade, stage, and invasiveness, contradicting previous findings. CDK9 may play a crucial role in the early stages of urothelial carcinoma.
Article
Biochemistry & Molecular Biology
Liangliang Ren, Minxiao Jiang, Dingwei Xue, Huan Wang, Zeyi Lu, Lifeng Ding, Haiyun Xie, Ruyue Wang, Wenqin Luo, Li Xu, Mingchao Wang, Shicheng Yu, Sheng Cheng, Liqun Xia, Haifeng Yu, Peng Huang, Naijin Xu, Gonghui Li
Summary: The study reveals that nitroxoline suppresses metastasis in bladder cancer via the EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Pathology
Wen Bi, Jingjing Li, Mengqiu Xiong, Bei Pan, Zhongqiu Zhang, Lubanga Nasifu, Bangshun He, Ping Wang
Summary: MicroRNA-27a (miR-27a) is abnormally expressed in cancer patients and can serve as a potential diagnostic and prognostic biomarker. It is a valuable diagnostic biomarker in serum/plasma and can predict poor prognosis in cancer patients. However, its diagnostic value is slightly reduced in tumor tissue samples.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Endocrinology & Metabolism
Chen-Kai Chou, Shun-Yu Chi, Yi-Yung Hung, Yi-Chien Yang, Hung-Chun Fu, Jia-He Wang, Chueh-Chen Chen, Hong-Yo Kang
Summary: The study revealed that dysregulated expression of miR-146b and androgen receptor (AR) played critical roles in the tumorigenesis of papillary thyroid carcinoma (PTC). It was confirmed that miR-146b expression was significantly inversely correlated with AR expression. Further experiments showed that AR might bind to the androgen receptor element on the promoter region of miR-146b, leading to repression of miR-146b expression and reduction of PTC tumor aggressiveness. PTC patients with low AR/high miR-146b expression were associated with advanced tumor characteristics.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biotechnology & Applied Microbiology
Zongwei Lv, Junhui Hou, Yuan Wang, Xia Wang, Yibing Wang, Kefeng Wang
Summary: This study conducted a bibliometric analysis in the field of bladder cancer immunotherapy to explore the research trends, hotspots, and frontiers. The findings revealed that researchers from the United States published the most papers and had extensive collaboration with other countries. The University of Texas MD Anderson CANC CTR was the top institution in terms of published articles and collaborative research. The J UROLOGY was the most active and frequently co-cited journal. The study categorized bladder cancer immunotherapy research into three main categories: basic research, clinical trials, and prognosis. The future direction of research may focus on tumor microenvironment, immune checkpoint inhibitors, and their combination with other drugs.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Medicine, General & Internal
Dengke Fu, Yang Chen, Dongkui Xu
Summary: The study found that circulating miR-449a levels were significantly decreased in CRC patients compared to healthy controls, and low miR-449a levels were significantly associated with CEA and CA19-9 levels as well as a lower 5-year overall survival rate. Low circulating miR-449a levels were also identified as an independent risk factor for CRC.
Article
Genetics & Heredity
Jingwei Ma, Meng Zhu, Xiaofeng Ye, Bo Wu, Tao Wang, Muyuan Ma, Tao Li, Ning Zhang
Summary: This study analyzed PSAT1-targeted miRNAs as a prognostic predictor for gastric cancer. The study found that PSAT1 expression was related to the clinical manifestations and prognosis of gastric cancer. Six microRNAs associated with gastric cancer were identified, and a model for predicting bone metastasis in gastric cancer was constructed.
FRONTIERS IN GENETICS
(2022)
Article
Urology & Nephrology
Wei Shen Tan, Roberto Contieri, Nicolo Maria Buffi, Giovanni Lughezzani, Valentina Grajales, Mark Soloway, Paolo Casale, Rodolfo Hurle, Ashish M. Kamat
Summary: The purpose of this study was to determine whether the International Bladder Cancer Group IR-NMIBC scoring system can predict the need for delayed transurethral resection of bladder tumor in low-grade nonmuscle-invasive bladder cancer patients managed by active surveillance. The study found that the scoring system can predict the risk of subsequent transurethral resection of bladder tumor in patients on active surveillance.
JOURNAL OF UROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Li Zuo, Xiaoli Li, Hailong Zhu, Anqi Li, Yonggang Wang
Summary: Detection of miR-181a in circulating tumor cells (CTCs) of ovarian cancer patients may allow for early diagnosis and prognostic evaluation. MiR-181a could be involved in the development and progression of ovarian cancer as an oncogene. The expression of miR-181a in CTCs captured by EpCAM liposome magnetic beads (Ep-LMBs) correlates with clinical characteristics of ovarian cancer.
Article
Endocrinology & Metabolism
Satoshi Yamaguchi, Dongxiao Zhang, Akihiro Katayama, Naoko Kurooka, Ryosuke Sugawara, Haya Hamed Hassan Albuayjan, Atsuko Nakatsuka, Jun Eguchi, Jun Wada
Summary: MiR-221-3p and miR-222-3p are upregulated in obesity, and overexpression of miR-222-3p may enhance adipogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Gloria Ravegnini, Cesar Serrano, Riccardo Ricci, Qianqian Zhang, Irene Terrenato, Agnese Graziosi, Giorgia Valori, Stefania Landolfi, Patrizia Hrelia, Sabrina Angelini
Summary: This study found that miRNA expression in metastatic gastrointestinal stromal tumors has similar characteristics in primary sites and metastases, with the primary origin appearing to be the main determinant of the metastatic miRNA profile.
Article
Oncology
Antonio De Leo, Dario de Biase, Jacopo Lenzi, Giovanna Barbero, Daniela Turchetti, Marco Grillini, Gloria Ravegnini, Sabrina Angelini, Claudio Zamagni, Sara Coluccelli, Giulia Dondi, Pierandrea De Iaco, Anna Myriam Perrone, Giovanni Tallini, Donatella Santini, Claudio Ceccarelli
Summary: The study investigates the impact of ARID1A and CTNNB1/beta-catenin alterations in 125 molecularly classified endometrial carcinomas, showing that ARID1A mutation in NSMP cases is associated with worse outcomes while tumors with ARID1A wild-type and beta-catenin alteration have indolent clinicopathologic features. This study highlights how identifying these alterations in endometrial cancer can help characterize tumor aggressiveness and metastatic potential.
Review
Medicine, General & Internal
Matthew J. Page, Joanne E. McKenzie, Patrick M. Bossuyt, Isabelle Boutron, Tammy C. Hoffmann, Cynthia D. Mulrow, Larissa Shamseer, Jennifer M. Tetzlaff, Elie A. Akl, Sue E. Brennan, Roger Chou, Julie Glanville, Jeremy M. Grimshaw, Asbjorn Hrobjartsson, Manoj M. Lalu, Tianjing Li, Elizabeth W. Loder, Evan Mayo-Wilson, Steve McDonald, Luke A. McGuinness, Lesley A. Stewart, James Thomas, Andrea C. Tricco, Vivian A. Welch, Penny Whiting, David Moher
Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Matthew J. Page, Joanne E. McKenzie, Patrick M. Bossuyt, Isabelle Boutron, Tammy C. Hoffmann, Cynthia D. Mulrow, Larissa Shamseer, Jennifer M. Tetzlaff, Elie A. Akl, Sue E. Brennan, Roger Chou, Julie Glanville, Jeremy M. Grimshaw, Asbjorn Hrobjartsson, Manoj M. Lalu, Tianjing Li, Elizabeth W. Loder, Evan Mayo-Wilson, Steve McDonald, Luke A. McGuinness, Lesley A. Stewart, James Thomas, Andrea C. Tricco, Vivian A. Welch, Penny Whiting, David Moher
Summary: The article introduces PRISMA 2020, an updated reporting guideline for systematic reviews and meta-analyses.
Review
Oncology
Anna Myriam Perrone, Gloria Ravegnini, Stefano Miglietta, Lisa Argnani, Martina Ferioli, Eugenia De Crescenzo, Marco Tesei, Marco Di Stanislao, Giulia Girolimetti, Giuseppe Gasparre, Anna Maria Porcelli, Francesca De Terlizzi, Claudio Zamagni, Alessio Giuseppe Morganti, Pierandrea De Iaco
Summary: Electrochemotherapy (ECT) is an emerging treatment for solid tumors that involves maximizing the action of specific cytotoxic drugs through the tumor-directed delivery of non-ablative electrical pulses. Despite mainly being recommended for palliative care, ECT has the potential to improve patient outcomes by preventing or delaying tumor progression. Additionally, the efficacy of different drugs in ECT, such as cisplatin and bleomycin, should be compared through systematic literature reviews to explore the possibilities of overcoming chemoresistance and improving local control.
Article
Oncology
Anna Myriam Perrone, Martina Ferioli, Lisa Argnani, Francesca De Terlizzi, Cecilia Pirovano, Piero Covarelli, Giulia Dondi, Marco Tesei, Eugenia De Crescenzo, Gloria Ravegnini, Andrea Galuppi, Alessio G. Morganti, Pierandrea De Iaco
Summary: A multicenter prospective observational study found that palliative electrochemotherapy (ECT) can improve quality of life in patients with vulvar cancer (VC), with better results in patients with good clinical response, smaller lesions, and lesions located in the anterior part.
Article
Cell Biology
Irene Soffritti, Maria D'Accolti, Gloria Ravegnini, Maria-Cristina Arcangeletti, Clara Maccari, Flora De Conto, Adriana Calderaro, Elisabetta Caselli
Summary: Viral infections, particularly by HCMV and HHV-6, may play a role in the onset and progression of systemic sclerosis by modulating miRNA expression and causing cell fibrosis, potentially serving as biomarkers for SSc diagnosis, assessment of disease progression, and antifibrotic therapies.
Review
Oncology
Gloria Ravegnini, Francesca Gorini, Eugenia De Crescenzo, Antonio De Leo, Dario De Biase, Marco Di Stanislao, Patrizia Hrelia, Sabrina Angelini, Pierandrea De Iaco, Anna Myriam Perrone
Summary: Endometrial cancer is the most common gynecological cancer with challenging diagnostic and prognostic features. miRNAs play an important role in EC but there is currently lack of consensus in studies. Future research needs to explore more diagnostic and prognostic biomarkers and address the challenges in the current classification schemes.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Maria A. Pantaleo, Milena Urbini, Angela Schipani, Margherita Nannini, Valentina Indio, Antonio De Leo, Bruno Vincenzi, Antonella Brunello, Giovanni Grignani, Mariaelena Casagrande, Elena Fumagalli, Elena Conca, Maristella Saponara, Elisa Gruppioni, Annalisa Altimari, Dario De Biase, Giovanni Tallini, Gloria Ravegnini, Daniela Turchetti, Marco Seri, Andrea Ardizzoni, Paola Secchiero, Annalisa Astolfi
Summary: Germline SDHA variants are highly prevalent in SDHA-deficient GIST, and the disease may occur in older adults as well. Genetic testing and surveillance should be conducted for SDHA mutation carriers and their relatives.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Camelia Alexandra Coada, Giulia Dondi, Gloria Ravegnini, Antonio De Leo, Donatella Santini, Eugenia De Crescenzo, Marco Tesei, Alessandro Bovicelli, Susanna Giunchi, Ada Dormi, Marco Di Stanislao, Alessio G. Morganti, Dario De Biase, Pierandrea De Iaco, Anna Myriam Perrone
Summary: Endometrial cancer is the most common gynecological malignancy. Risk stratification should be based on the integration of histologic, clinical, and molecular parameters.
Review
Health Care Sciences & Services
Gloria Ravegnini, Martina Ferioli, Alessio Giuseppe Morganti, Lidia Strigari, Maria Abbondanza Pantaleo, Margherita Nannini, Antonio De Leo, Eugenia De Crescenzo, Manuela Coe, Alessandra De Palma, Pierandrea De Iaco, Stefania Rizzo, Anna Myriam Perrone
Summary: The contribution of radiomics and AI in the radiological preoperative assessment of patients with uterine sarcomas (USs) is still insufficiently supported by evidence. While promising, the quality of studies should be a top priority in the utilization of these new technologies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gloria Ravegnini, Margherita Nannini, Valentina Indio, Cesar Serrano, Francesca Gorini, Annalisa Astolfi, Aldo Di Vito, Fabiana Morroni, Maria Abbondanza Pantaleo, Patrizia Hrelia, Sabrina Angelini
Summary: GISTs with PDGFRA D842V mutation show differential miRNA expression compared to non-D842V mutated GISTs. Differentially expressed miRNAs mainly target genes involved in the immune response pathways. Additionally, the miRNA-mRNA network reveals the indolent behavior of D842V mutated GISTs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Martina Ruscelli, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Giulia Querzoli, Marco Grillini, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Alessia Costantino, Riccardo Ciudino, Matteo Errani, Alessia Papapietro, Sara Coluccelli, Daniela Turchetti, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Emanuela D'Angelo, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Dario de Biase, Antonio De Leo
Summary: This study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice of endometrial carcinoma (EC). It found that molecular classes and risk groups were correlated with disease-free survival. The study supports the prognostic importance of EC molecular classification and the essential role of histopathologic assessment in patients' management.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Camelia Alexandra Coada, Miriam Santoro, Vladislav Zybin, Marco Di Stanislao, Giulia Paolani, Cecilia Modolon, Stella Di Costanzo, Lucia Genovesi, Marco Tesei, Antonio De Leo, Gloria Ravegnini, Dario De Biase, Alessio Giuseppe Morganti, Luigi Lovato, Pierandrea De Iaco, Lidia Strigari, Anna Myriam Perrone
Summary: This study investigated the potential of radiomic features extracted from pre-surgical CT scans to predict disease-free survival (DFS) in endometrial cancer (EC) patients. Machine learning models achieved high sensitivities and specificities in both training and test sets, showing promise for predicting EC recurrence.
Review
Oncology
Federica Medici, Stefania Rizzo, Milly Buwenge, Alessandra Arcelli, Martina Ferioli, Gabriella Macchia, Francesco Deodato, Savino Cilla, Pierandrea De Iaco, Anna Myriam Perrone, Silvia Strolin, Lidia Strigari, Gloria Ravegnini, Alberto Bazzocchi, Alessio G. Morganti
Summary: Sarcopenia is a syndrome characterized by age-related loss of skeletal muscle mass and function, worsens radiation-induced toxicity and prognosis, and has a negative impact on the quality of life. Myosteatosis, a pathological infiltration of muscle tissue by adipose tissue, is correlated with prognosis in cancer patients. Sarcopenic obesity, characterized by large fat mass, is independently associated with higher mortality and worse complications compared to sarcopenia alone. Assessment of sarcopenia is commonly done using CT images. Several studies have shown the negative impact of sarcopenia on overall survival in patients undergoing radiation therapy for various tumors. Further research is needed to find ways to prevent and manage sarcopenia during and after radiation therapy in both adult and pediatric patients.