Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Oncology
Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng, Longyu Jin
Summary: PTBP3 is overexpressed in LUSC tissues and its high expression is significantly correlated with poor prognosis. PTBP3 knockdown results in decreased cell proliferation rate. Bioinformatics analysis reveals that PTBP3 is involved in cell cycle regulation in LUSC.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yiru Kong, Jing Li, Xiaohua Liang, Xinli Zhou
Summary: This study aims to investigate the role of MIB2 in lung cancer development. MIB2 expression was found to be upregulated in lung cancer tissue compared to normal tissue, both in public databases and clinical samples. Knockdown of MIB2 inhibited proliferation, metastasis, and invasion of lung cancer cell lines, as well as downregulated cell cycle control pathway proteins.
Article
Environmental Sciences
Mingjun Sun, Jingwen Tan, Mengjie Wang, Weihua Wen, Yuefeng He
Summary: The study found that arsenic increased the expression of AS3MT in vivo and in vitro, directly acting on cells and affecting the progression of non-small cell lung cancer by regulating cell cycle genes.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Pathology
Lizhong Zeng, Yang Chen, Jingyan Yuan, Xin Lyu, Lei Zhang, Xueli Yan, Ke Mi, Na Li, Fangze Xing, Shuanying Yang
Summary: LMO7DN's low expression in LUAD may serve as a predictor for good prognosis and inhibits cell proliferation by affecting the cell cycle. This study highlights the significant role of LMO7DN in LUAD.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Multidisciplinary Sciences
Kui Xiao, Shenggang Liu, Yijia Xiao, Yang Wang, Zhiruo Zhu, Yaohui Wang, De Tong, Jiehan Jiang
Summary: This study identified a miRNA, hsa-mir-30a, that is differentially expressed in NSCLC and mainly affects the disease by regulating the cell cycle and drug metabolism.
Article
Cell Biology
Ruijun Liu, Ruili Liu, Zhiyi Guo, Jianghao Ren, Jia Huang, Qingquan Luo, Qiang Tan
Summary: This study demonstrates the significance of KNTC1 in non-small-cell lung cancer by participating in the regulation of cell proliferation, migration, and invasion through the segregation of sister chromatids. The findings also suggest a positive association between KNTC1 depletion and PSMB8 expression. These findings indicate that KNTC1 may serve as a novel therapeutic target for non-small-cell lung cancer.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jing Shen, Guiling Liu, Hongyan Qi, Xueping Xiang, Jimin Shao
Summary: The study found that JMJD5 can cooperate with HUWE1 to degrade EGFR, thereby inhibiting the growth of NSCLC and enhancing the sensitivity of TKI. Additionally, JMJD5 can be transported into recipient cells via extracellular vesicles, thus inhibiting NSCLC growth.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Joo Yeon Jeong, Haangik Park, Hong Yoo, Eun-Jin Kim, Borami Jeon, Jong Deog Lee, Dawon Kang, Changjoon Justin Lee, Sun Ha Paek, Eun Joo Roh, Gwan-Su Yi, Sang Soo Kang
Summary: Despite advances in diagnostic and therapeutic technologies, lung cancer remains a major cause of cancer-related deaths worldwide. This study explores the effects of antipsychotic drugs on non-small cell lung cancer (NSCLC). The results suggest that certain antipsychotics, including trifluoperazine (TFP) and its synthetic analogs, can inhibit the proliferation and migration of lung cancer cells, and promote apoptosis. Additionally, a synthetic TFP analog shows even stronger anticancer effects than TFP. This study provides insights into the potential of antipsychotics as a preventive and therapeutic approach for NSCLC.
Article
Reproductive Biology
Haiting Yu, Dan Zou, Na Ni, Suxian Zhang, Qin Zhang, Lihua Yang
Summary: In this study, it was found that overexpression of NCAPG is negatively associated with survival rate of ovarian cancer patients. Silencing NCAPG can inhibit OC cell proliferation and invasion, and induce apoptosis. Furthermore, downregulation of NCAPG can also suppress OC cell proliferation and invasion by activating the p38 MAPK signaling pathway.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Review
Biochemistry & Molecular Biology
Maria Magdalena Barreca, Chiara Zichittella, Riccardo Alessandro, Alice Conigliaro
Summary: Hypoxia, a key characteristic of the tumor microenvironment, is crucial for cancer progression and therapeutic response. The hypoxia-inducible factors (HIFs) play a master regulatory role in modulating hypoxic gene expression and signaling pathways, ultimately changing the cell phenotype to be more aggressive. Non-coding RNAs (ncRNAs) have been identified as important molecular mediators in hypoxic responses, regulating gene expression at various levels and contributing to tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Xue Zhang, Jianzhu Zhao, Qing Li, Di Qin, Wenwei Li, Xinyu Wang, Mengfei Bi, Qingwei Li, Tiesong Li
Summary: The lamprey PHB2 gene inhibits the proliferation of NSCLC cells by down-regulating the expression and phosphorylation levels of cell cycle-associated proteins, with the most significant effect observed in Calu-1 cells.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Oncology
Kang Sup Kim, Sang Hoon Kim, Hyuk Jin Cho, Hong Jin Sur, Yong Sun Choi
Summary: In this study, we introduced and shared our experience of using holmium laser-assisted method for partial cystectomy in bladder cancer patients. The results showed that the technique is effective, safe, and provides precise tumor removal with minimal ureteral orifice involvement.
Review
Chemistry, Physical
Se Kwon Kim, Geoffrey S. D. Beach, Kyung-Jin Lee, Teruo Ono, Theo Rasing, Hyunsoo Yang
Summary: Ferrimagnets, composed of multiple antiferromagnetically coupled magnetic elements, offer advantages of both ferromagnets and antiferromagnets, including easy control of magnetization by external field, faster dynamics than ferromagnets, and potential for high-density devices. This Review provides a summary of recent progress in ferrimagnetic spintronics, focusing on functionalities such as spin transport, spin texture dynamics, and all-optical switching.
Review
Pharmacology & Pharmacy
Azita Navvabi, Ahmad Homaei, Brett I. I. Pletschke, Nazila Navvabi, Se-Kwon Kim
Summary: Marine microorganisms are valuable resources for novel biological compounds and can survive under extreme conditions. Cellulases derived from marine sources have high demand in various industries and biotechnological applications. The biodiversity in the ocean provides a rich source of complex polysaccharides that can be degraded by marine microorganisms. Evaluating the ability of marine cellulase producers can lead to potential biotechnological applications.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Physics, Condensed Matter
Se Kwon Kim, Oleg Tchernyshyov
Summary: This paper provides a pedagogical introduction to the mechanics of ferromagnetic solitons. It starts with the dynamics of a single spin and develops all the tools needed for describing the dynamics of solitons in a ferromagnet.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2023)
Article
Urology & Nephrology
Eun Jae Kim, Jae Chul Lee, Don Hee Lyu, Useok Choi, Jin Bong Choi, Kang Sup Kim, Bong Hee Park, Sooyoun Kim, Seung-Ju Lee, Chang Hee Han, Sangrak Bae
Summary: The purpose of this study was to investigate the trend of genital warts over the past 10 years in Korea. The results showed a significant increase in the number of patients receiving treatment, particularly among males. Surgical treatment was the main approach, with males predominantly undergoing surgery and females mainly receiving drug treatment.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Materials Science, Multidisciplinary
Geun-Hee Lee, Junsung Kim, Kab-Jin Kim, Se Kwon Kim
Summary: This study investigated the scattering properties of antiferromagnetic spin waves at an interface with varying exchange coefficient. The study focused on the polarization of spin waves. The analytical solutions for the scattering problems of spin waves in the presence of magnetic anisotropy and external magnetic field were obtained. The results showed distinct scattering behaviors of right-handed and left-handed spin waves in the presence of an external field that breaks the degeneracy between the two modes. Additionally, it was demonstrated that right-handed and left-handed spin waves with identical incident wave functions can be spatially separated after being reflected from the interface.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Multidisciplinary Sciences
Gyeongji Kang, Young-Joo Kim, Sung-Jin Lee, Se Kwon Kim, Dae-Young Lee, Kahye Song
Summary: In this study, a weaving-inspired grasping mechanism is proposed to increase payload capacity in soft grippers. A flexible continuum structure with multiple closed-loop strips and a kirigami-inspired approach enables the reversible creation of a woven configuration. The woven structure provides exceptional loading capacity, while the softness of the gripper material ensures safe and adaptive interactions with objects.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Lijun Li, Ju-Yeong Jeong, Yanggeun Joo, Heemyoung Hong, Se Kwon Kim, Heejun Yang
Summary: In this research, unique phase-slip centers were designed in artificially-stacked junction areas, and energy dissipation was observed. Two types of energy dissipation modes were newly identified in the artificially-stacked NbSe2 when subjected to an in-plane magnetic field.
Article
Materials Science, Multidisciplinary
Seungho Lee, Kouki Nakata, Oleg Tchernyshyov, Se Kwon Kim
Summary: We theoretically investigate the interaction between magnons and a skyrmion-textured domain wall in a two-dimensional antiferromagnet and elucidate the resultant properties of magnon transport. Based on the obtained scattering properties of magnons and the domain wall, we show that the thermal transport decreases as the domain wall's chirality increases. Our results suggest that the thermal transport of an antiferromagnet is tunable by modulating the skyrmion charge density of the domain wall, which might be useful for realizing electrically tunable spin caloritronic devices.
Article
Materials Science, Multidisciplinary
Wooyon Kim, Se Kwon Kim
Summary: In this work, we theoretically investigate the interaction between spin waves and a domain wall in a one-dimensional easy-cone ferromagnet. We find that the gapless spin waves on top of a domain wall exhibit finite reflection, in contrast to the perfect transmission of gapful spin waves in easy-axis magnets. Based on these scattering properties, we study the thermal-magnon-driven dynamics of a domain wall and show that transmitted magnons exert a magnonic torque on the domain wall, leading to its linear motion with respect to the applied thermal bias. The peculiar gapless nature of spin waves in easy-cone magnets enables the thermally driven domain-wall motion even at low temperatures, providing a platform for studying the interaction of gapless spin waves and nonlinear excitations.
Article
Materials Science, Multidisciplinary
Jongpil Yun, Se Kwon Kim
Summary: The existing proposals for superfluidlike spin transport have been limited to easy-plane magnets, but in this work, we show that superfluidlike spin transport can also be realized based on easy-axis magnets. We find that by applying a spin torque, a nonequilibrium easy-cone state can be engendered in easy-axis magnets, breaking the U(1) spin-rotational symmetry and enabling superfluidlike spin transport. Using micromagnetic simulations, we confirm the theoretical prediction and demonstrate the potential of dynamic states of magnets for studying spin-transport phenomena.
Article
Materials Science, Multidisciplinary
Seunghun Lee, Gyungchoon Go, Se Kwon Kim
Summary: This paper proposes a method to manipulate magnonic topological phases by electronic boundary operations of spin chirality injection, which solves the limitation of bulk non-electronic manipulation. The chirality-induced topological phase transition can be detected experimentally through the shoulder in the thermal Hall conductivity profile.
Article
Materials Science, Multidisciplinary
Gyungchoon Go, Seunghun Lee, Se Kwon Kim
Summary: In easy-cone ferromagnets and easy-cone antiferromagnets, the spin-wave nonreciprocity can occur without intrinsic bulk chirality. By injecting a nonlocal spin current from normal metals to easy-cone magnets, a nonequilibrium chiral spin texture is generated, resulting in spin waves exhibiting nonreciprocity proportional to the injected spin current. This provides a field-free means to manipulate the spin-wave nonreciprocity and can lead to a significant thermal rectification effect at low temperatures.
Article
Andrology
Kang Sup Kim, Yong Sun Choi, Woong Jin Bae, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Chang Hee Han, Sae Woong Kim
Summary: The study demonstrated that MESWT is an effective treatment modality for patients with CP/CPPS, improving pain and quality of life significantly compared to the placebo group. No adverse events were reported in both groups during the study period.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Andrology
Kang Sup Kim, Yong Sun Choi, Woong Jin Bae, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sun Tae Ahn, Du Geon Moon, Sae Woong Kim
Summary: The study compared and assessed the effectiveness and safety of low-intensity extracorporeal shockwave therapy (Li-ESWT) versus placebo treatment in CPPS IIIb patients. Results indicated that Li-ESWT improved the NIH-CPSI score, pain, and quality of life in CPPS IIIb patients, suggesting it could be an effective alternative treatment modality for CPPS IIIb. No patients experienced side effects related to ESWT during therapeutic period or follow-up duration.
WORLD JOURNAL OF MENS HEALTH
(2022)
