Article
Gastroenterology & Hepatology
Soon Kyu Lee, Jeong Won Jang, Heechul Nam, Pil Soo Sung, Hee Yeon Kim, Jung Hyun Kwon, Sung Won Lee, Do Seon Song, Chang Wook Kim, Myeong Jun Song, Ho Joong Choi, Young Kyoung You, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
Summary: Sorafenib shows better outcomes in patients with liver transplantation (LT) compared to those without LT, likely due to smaller intrahepatic HCC and preserved hepatic function in LT recipients. Multiple subgroup analyses and propensity-score matching confirm the superior efficacy of sorafenib in the LT setting.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Oncology
Jina Kim, Hwa Kyung Byun, Tae Hyung Kim, Sun Il Kim, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Jinsil Seong
Summary: This study investigated the efficacy of liver-directed concurrent chemoradiotherapy (LD-CCRT) compared to sorafenib in hepatocellular carcinoma patients with portal vein tumor thrombosis (PVTT). The results showed that LD-CCRT led to significantly improved survival compared to sorafenib, and patients who underwent surgical treatment after LD-CCRT had even longer overall survival.
Article
Multidisciplinary Sciences
Liming Zheng, Xi Gu, Guojun Zheng, Xin Li, Meifang He, Longgen Liu, Xike Zhou
Summary: The study constructed a predictive model using various analysis methods to successfully identify high-risk patients for early HCC recurrence, and predict patients' response to adjuvant sorafenib treatment. The model can optimize risk stratification for early HCC recurrence and evaluate patient response to adjuvant sorafenib after liver resection.
Article
Gastroenterology & Hepatology
Jens Ricke, Regina Schinner, Max Seidensticker, Antonio Gasbarrini, Otto M. van Delden, Holger Amthauer, Bora Peynircioglu, Irene Bargellini, Roberto Iezzi, Enrico N. De Toni, Peter Malfertheiner, Maciej Pech, Bruno Sangro
Summary: The study revealed that selective internal radiation therapy (SIRT) has a negative impact on liver function in patients with hepatocellular carcinoma, which may affect patient outcomes. Patients should be carefully selected before undergoing SIRT and treatment techniques should be optimized to maximize protection of non-target liver parenchyma.
JOURNAL OF HEPATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bohyun Kim, Soon Sun Kim, Sung Won Cho, Jae Youn Cheong, Jimi Huh, Jai Keun Kim, Jei Hee Lee, Hye Ri Ahn, Hyo Jung Cho
Summary: Liver stiffness quantified using magnetic resonance elastography is a potential biomarker for predicting poor overall survival and significant liver injury in advanced hepatocellular carcinoma patients treated with sorafenib.
EUROPEAN RADIOLOGY
(2021)
Review
Oncology
Shenglan Huang, Dan Li, LingLing Zhuang, Liying Sun, Jianbing Wu
Summary: This meta-analysis explored the efficacy and safety of sorafenib in hepatocellular carcinoma patients after radical surgery, revealing that sorafenib can improve overall survival, recurrence-free survival, and reduce recurrence rates without intolerable side effects. More evidence is needed for a definitive conclusion.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Jialiang Luo, Lei Li, Zhengyumeng Zhu, Bo Chang, Fan Deng, Di Wang, Xiao Lu, Daming Zuo, Qingyun Chen, Jia Zhou
Summary: This study demonstrated that the combination of fucoidan and sorafenib could overcome sorafenib resistance in hepatocellular carcinoma cells by interacting with cell membrane EGFR and suppressing EGFR redistribution and downstream signaling. The simultaneous treatment of fucoidan and sorafenib might serve as a potential therapeutic strategy against sorafenib-resistant HCC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Surgery
Maria Conticchio, Antonella Delvecchio, Valentina Ferraro, Matteo Stasi, Annachiara Casella, Nicola Chetta, Emma De Marinis, Andrea Madaro, Margherita Raele, Rosalinda Filippo, Michele Ammendola, Michele Tedeschi, Nicola deAngelis, Riccardo Memeo
Summary: Spontaneous rupture of hepatocellular carcinoma (HCC) is a rare complication, and its management requires considering the clinical conditions of the patient and the best curative treatment. We reported a case of an emergency robotic liver resection for a ruptured HCC in an elderly patient. Minimally invasive liver resection is currently recognized as a safe and feasible approach for the treatment of HCC in elderly patients.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Oncology
Zhancheng Qiu, Weili Qi, Youwei Wu, Lingling Li, Chuan Li
Summary: This study examines the impact of public insurance status on the survival outcomes of HCC patients after liver resection in China. The results show that underinsured HCC patients have worse survival outcomes after liver resection. This may be due to the limited access to care for underinsured patients, but further exploration is needed for conclusive evidence.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ningbin Luo, Xiangyang Huang, Yinan Ji, Guanqiao Jin, Yunying Qin, Bangde Xiang, Danke Su, Weizhong Tang
Summary: This study found that the functional liver imaging score (FLIS) based on preoperative gadoxetic acid-enhanced MRI can predict posthepatectomy liver failure (PHLF) in hepatocellular carcinoma (HCC) patients. FLIS has a higher predictive power than the MELD score, ALBI score, and ICG-R15 clearance.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Won Ick Chang, Byoung Hyuck Kim, Yoon Jun Kim, Jung-Hwan Yoon, Yong Jin Jung, Eui Kyu Chie
Summary: This study aimed to investigate the clinical benefits of locoregional radiation therapy (RT) before, after, and concurrent with sorafenib therapy for Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) patients. The results showed that locoregional RT was associated with significantly longer survival in BCLC stage C HCC patients who were treated with sorafenib, especially in patients treated with sorafenib for 12 weeks or more. Incorporating locoregional RT could improve the dismal prognosis for these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Qinqin Liu, Nan You, Jing Li, Ke Wu, Xuehui Peng, Zheng Wang, Liang Wang, Yinan Zhu, Lu Zheng
Summary: The study found that the combination of camrelizumab and sorafenib significantly improved the overall response rate and progression-free survival of patients with advanced HCC, but had no significant impact on overall survival. The combination therapy group exhibited more adverse events in terms of efficacy, but most of these adverse events were easily controlled after treatment. Further prospective randomized trials are needed to confirm the potential clinical benefits of this combination therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Geriatrics & Gerontology
Jinhuan Yang, Kaiwen Chen, Chongming Zheng, Kaiyu Chen, Jian Lin, Qishan Meng, Ziyan Chen, Liming Deng, Haitao Yu, Tuo Deng, Zhiyuan Bo, Qikuan He, Yi Wang, Gang Chen
Summary: This study found that sarcopenia is associated with adverse outcomes after liver resection for HCC, with higher rates of major complications, blood transfusion, hospitalization expenses, and longer hospital stay. Evaluating sarcopenia upon admission can help classify high-risk patients and reduce the risk of major complications.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Oncology
Kuan-Chun Hsueh, Cheng-Chun Lee, Pi-Teh Huang, Chih-Yu Liang, Shun-Fa Yang
Summary: Multiple studies have found that liver resection (LR) can improve survival outcomes in intermediate- and advanced-stage hepatocellular carcinoma (HCC) patients. However, there is limited knowledge regarding the benefits of LR for recurrent HCC patients who have undergone systemic treatment. This study aimed to evaluate the impact of LR on advanced-stage HCC patients who received sorafenib as a systemic treatment.
Article
Oncology
Shogo Tanaka, Shoji Kubo, Takeaki Ishizawa
Summary: Laparoscopic liver resection (LLR) is widely accepted in the surgical treatment of hepatocellular carcinoma (HCC) due to its advantages such as earlier recovery and fewer complications compared to open liver resection (OLR). LLR is technically feasible for selected patients with HCC even in challenging situations. Robot-assisted liver resection (RALR) has also gained popularity and is expected to become the main approach for minimally invasive surgery in the future.
Article
Surgery
L. Lievain, A. Aktouf, I. Auquit-Auckbur, D. Coquerel-Beghin, M. Scotte, P. -Y. Milliez
ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
(2015)
Letter
Surgery
Lilian Schwarz, Pierre Michel, Michel Scotte
Article
Geriatrics & Gerontology
David Fuks, Pierre Duhaut, Francois Mauvais, Marc Pocard, Vincent Haccart, Jean-Christophe Paquet, Bertrand Millat, Simon Msika, Igor Sielezneff, Michel Scotte, Denis Chatelain, Jean Marc Regimbeau
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2015)
Article
Gastroenterology & Hepatology
Jean Marc Regimbeau, David Fuks, Patrick Pessaux, Philippe Bachellier, Denis Chatelain, Momar Diouf, Artigas Raventos, Georges Mantion, Jean-Francois Gigot, Laurence Chiche, Gerard Pascal, Daniel Azoulay, Alexis Laurent, Christian Letoublon, Emmanuel Boleslawski, Michel Rivoire, Jean-Yves Mabrut, Mustapha Adham, Yves-Patrice Le Treut, Jean-Robert Delpero, Francis Navarro, Ahmet Ayav, Karim Boudjema, Gennaro Nuzzo, Michel Scotte, Olivier Farges
Article
Surgery
Lilian Schwarz, Michael Bubenheim, Isabelle Gardin, Emmanuel Huet, Ghassan Riachi, Erick Clavier, Odile Goria, Pierre Vera, Michel Scotte
WORLD JOURNAL OF SURGERY
(2016)
Article
Surgery
Olivier Farges, Nathalie Goutte, Safi Dokmak, Noelle Bendersky, Bruno Falissard
Article
Medicine, General & Internal
Jean Marc Regimbeau, David Fuks, Karine Pautrat, Francois Mauvais, Vincent Haccart, Simon Msika, Muriel Mathonnet, Michel Scotte, Jean Christophe Paquet, Corinne Vons, Igor Sielezneff, Bertrand Millat, Laurence Chiche, Herve Dupont, Pierre Duhaut, Cyril Cosse, Momar Diouf, Marc Pocard
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2014)
Article
Surgery
Cyril Cosse, Jean Marc Regimbeau, David Fuks, Francois Mauvais, Michel Scotte
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2013)
Article
Anatomy & Morphology
L. Schwarz, E. Huet, T. Yzet, D. Fuks, J. M. Regimbeau, M. Scotte
SURGICAL AND RADIOLOGIC ANATOMY
(2014)
Article
Surgery
D. Fuks, J. -M. Regimbeau, P. Pessaux, P. Bachellier, A. Raventos, G. Mantion, J. -F. Gigot, L. Chiche, G. Pascal, D. Azoulay, A. Laurent, C. Letoublon, E. Boleslawski, M. Rivoire, J. -Y. Mabrut, M. Adham, Y. -P. Le Treut, J. -R. Delpero, F. Navarro, A. Ayav, K. Boudjema, G. Nuzzo, M. Scotte, O. Farges
JOURNAL OF VISCERAL SURGERY
(2013)
Article
Endocrinology & Metabolism
Guillaume Philouze, Eglantine Voitellier, Laurence Lacaze, Emmanuel Huet, Antoine Gancel, Gaetan Prevost, Michael Bubenheim, Michel Scotte
JOURNAL OF OBESITY
(2017)
Review
Gastroenterology & Hepatology
Laurence Lacaze, Michel Scotte
WORLD JOURNAL OF HEPATOLOGY
(2015)
Article
Urology & Nephrology
G. Philouze, M. Scotte
PROGRES EN UROLOGIE
(2013)
Article
Endocrinology & Metabolism
Sylvie Pham, Antoine Gancel, Michel Scotte, Estelle Houivet, Emmanuel Huet, Herve Lefebvre, Jean-Marc Kuhn, Gaetan Prevost
JOURNAL OF OBESITY
(2014)
