Article
Oncology
Yuan-Tzu Lan, Shih-Ching Chang, Pei-Ching Lin, Chun-Chi Lin, Hung-Hsin Lin, Shen-Chieh Huang, Chien-Hsing Lin, Wen-Yi Liang, Wei-Shone Chen, Jeng-Kai Jiang, Jen-Kou Lin, Shung-Haur Yang
Summary: The prognosis and molecular differences between mucinous adenocarcinoma (MAC) and non-mucinous adenocarcinoma (NMAC) in colorectal cancer (CRC) are controversial. Genetic alterations are distinct between MAC and NMAC, with tumor location having an impact on genetic alterations and patient prognosis in MAC and NMAC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
An Huang, Yong Yang, Jing-Yi Shi, Yu-Kun Li, Jing-Xuan Xu, Yu Cheng, Jin Gu
Summary: Mucinous adenocarcinoma (MAC) is a unique subtype of colorectal cancer characterized by distinct clinical and molecular features compared to non-MAC (NMAC). MAC is more frequently located in the proximal colon and associated with a poorer prognosis.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Rui-Qi Zou, Hai-Jie Hu, Fei Liu, Tian-Run Lv, Jun-Ke Wang, Parbatraj Regmi, Fu-Yu Li
Summary: Clinicopathological features and surgical outcomes differ significantly between gallbladder mucinous adenocarcinoma (GBMAC) and conventional gallbladder adenocarcinoma (GBAC). GBMAC exhibits more aggressive biological behaviors and poorer survival outcomes even after curative surgery, with the presence of signet-ring cell component indicating worse prognosis.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Ming Li, Yan-Xia Mei, Ji-Hang Wen, Yu-Rong Jiao, Qiang-Rong Pan, Xiang-Xing Kong, Jun Li
Summary: Hepatoid adenocarcinoma (HAC) is a rare malignant tumor that resembles hepatocellular carcinoma. It is often associated with elevated levels of alpha-fetoprotein (AFP) and can occur in various organs. The biological aggression, poor prognosis, and clinicopathological characteristics of HAC differ significantly from typical adenocarcinomas, but the underlying mechanisms are still unclear.
Article
Oncology
Chien-Hung Gow, Min-Shu Hsieh, Yi-Nan Liu, Yi-Hsuan Lee, Jin-Yuan Shih
Summary: Pulmonary invasive mucinous adenocarcinoma (IMA) has unique histological patterns. This study compared clinical characteristics, pathological features, and survival outcomes of IMA patients with non-IMA-type ADC patients. A new two-tier grading system might be useful in predicting recurrence-free survival for stage I-IIIA IMAs.
Article
Oncology
Jianxia Li, Liu Yang, Fan Bai, Yue Cai, Jianwei Zhang, Zehua Wu, Yang Fu, Yanhong Deng
Summary: Colorectal cancer with mucinous component has distinct clinicopathological characteristics and controversial prognosis. Molecular features of adenocarcinoma with mucinous component and mucinous adenocarcinoma are similar but different from those of conventional adenocarcinoma, and they are not independent prognostic factors for colorectal cancer.
Article
Cell Biology
Rongbin Ge, Jing Zhang, Min Lu, Yuchuan Shi, Shi Yan, Zixuan Xue, Zongwei Wang, Antonio Lopez-Beltran, Liang Cheng
Summary: Primary mucinous adenocarcinoma of the urethra is an extremely rare entity. This study characterized the clinicopathological, immunohistochemical and molecular features of 35 cases, providing crucial insights into its diagnosis, management and potential targeted treatments. The study identified a greater sensitivity to CDX2, SATB2 and CDH17 in these tumors for the first time, and identified characteristics such as an MSI-low profile, non-V600E BRAF mutations and an absence of ALK rearrangements.
Article
Oncology
Ian S. Reynolds, Paul M. Cromwell, Eanna J. Ryan, Erinn McGrath, Rory Kennelly, Ronan Ryan, Niall Swan, Kieran Sheahan, Des C. Winter, Emir Hoti
Summary: This study compared the clinicopathological outcomes of patients with mucinous colorectal cancer liver metastases (CRCLM) undergoing liver resection to a matched group of patients with adenocarcinoma not otherwise specified (NOS), and evaluated the accuracy of preoperative magnetic resonance imaging (MRI) in detecting the presence of mucin in liver metastases. The results showed that patients with mucinous CRCLM had similar outcomes to patients with adenocarcinoma NOS, and histological subtype should not be considered when deciding on resectability of CRCLM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zehua Wu, Yi Cheng, Huaiming Wang, Dian Liu, Xiaoxing Qi, Chao Wang, Yuanzhe Zhang, Yuting Zhang, Runkai Cai, Hong Huo, Jianwei Zhang, Yue Cai, Weiwei Li, Huabin Hu, Yanhong Deng
Summary: In recent years, HER2-low colorectal cancer tumors have been found to be similar to HER2-zero tumors and different from HER2-high tumors. Routine examination of HER2 immunohistochemistry (IHC) is needed in early-stage colorectal cancer. HER2-high expression is an independent prognostic factor of disease-free survival. This is a multi-center retrospective study that included patients with colorectal cancer who had radical surgical resection and determined HER2 status through IHC.
Article
Medicine, General & Internal
Jung-Soo Pyo, Nae Yu Kim, Kyueng-Whan Min, Dong-Wook Kang
Summary: The present study aimed to evaluate the correlations between peritumoral tumor budding (PTB) and clinicopathological characteristics of colorectal cancer (CRC) based on histological components. The study found that high PTB was significantly correlated with left-sided tumors, lymphatic invasion, lymph node metastasis, distant metastasis, and high pTNM stage in CRC. However, no significant correlations were found between PTB and other clinicopathological characteristics. The prognostic implications of PTB also varied depending on the histological components.
Article
Cell Biology
Wei-Chin Chang, Yu Zhi Zhang, Janina L. Wolf, Sergei M. Hermelijn, J. Marco Schnater, Jan H. von derThusen, Alexandra Rice, Sylvie Lantuejoul, Benedicte Mastroianni, Carol Farver, Fiona Black, Sanjay Popat, Andrew G. Nicholson
Summary: This study focused on describing a series of mucinous adenocarcinomas arising from CPAMs, with the majority being early-stage diseases mostly associated with KRAS mutations. Surgery with lobectomy seems to be effective in curing most cases, although recurrence can occur decades later.
Article
Pathology
Satsuki Kishikawa, Takuo Hayashi, Tsuyoshi Saito, Kazuya Takamochi, Shinji Kohsaka, Kei Sano, Noriko Sasahara, Keita Sasa, Taisei Kurihara, Kieko Hara, Yoshiyuki Suehara, Fumiyuki Takahashi, Kenji Suzuki, Takashi Yao
Summary: This study evaluated the clinicopathological, immunohistochemical, and molecular characteristics of 70 cases of invasive mucinous adenocarcinoma (IMA) of the lung, revealing a significant association between diffuse expression of MUC6 and KRAS-wild-type tumors, smaller tumor size, and female patients. Patients with tumors exhibiting diffuse MUC6 expression had significantly favorable outcomes, suggesting a distinct clinicopathological subset characterized by wild-type KRAS and possibly less aggressive clinical course.
Article
Oncology
Yu-Wen Zhou, Yi-Xiu Long, Ye Chen, Ji-Yan Liu, Dan Pu, Jia-Yan Huang, Feng Bi, Qiu Li, Hong-Feng Gou, Meng Qiu
Summary: The study compared the efficacy of first-line bevacizumab plus chemotherapy and cetuximab plus chemotherapy in metastatic colorectal cancer patients with mucinous adenocarcinoma or mucinous component. The results showed that bevacizumab-based chemotherapy was associated with significantly better overall survival in patients with mucinous adenocarcinoma or mucinous component, regardless of tumor sites.
Article
Gastroenterology & Hepatology
Fanny E. R. Vuik, Stella A. Nieuwenburg, Iris D. Nagtegaal, Ernst J. Kuipers, Manon C. W. Spaander
Summary: The study found that younger patients were more likely to have signet-ring cells and poorly differentiated tumors, as well as a higher risk of lymph node metastases. Over time, there was an increase in the proportion of colorectal cancers diagnosed in women, especially in the younger age group.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pathology
Irene Chen, Xiaoqin Liu, Sierra Kovar-Peltz, Stephanie J. Conrad, Hannah H. Chen, Xiaoyan Liao
Summary: This study retrospectively analyzed 87 cases of appendiceal adenocarcinoma (APCA), goblet cell adenocarcinoma (GCA), and low/high-grade appendiceal mucinous neoplasms (LAMN/HAMN). The study found that these entities have overlapping clinical presentation and histomorphology, leading to diagnostic challenges. The study also identified previously unrecognized crypt atypia in GCA.