Article
Multidisciplinary Sciences
Ola E. E. Abdel-Sattar, Rasha Mosa Allam, Ahmed M. M. Al-Abd, Bharathi Avula, Kumar Katragunta, Ikhlas A. A. Khan, Ahmed M. M. El-Desoky, Shanaz O. O. Mohamed, Ali El-Halawany, Essam Abdel-Sattar, Meselhy R. R. Meselhy
Summary: The genus Phyllanthus has potential in the treatment of various diseases, and its extracts showed cytotoxicity against breast cancer cells. The methylene chloride fraction exhibited the strongest cytotoxic activity among all tested fractions.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Inorganic & Nuclear
Elisa Parcero Hernandes, Raquel Dosciatti Bini, Karina Midori Endo, Verci Alves de Oliveira Junior, Igor Vivian de Almeida, Gustavo Sanguino Dias, Ivair Aparecido dos Santos, Paula Nunes de Oliveira, Veronica Elisa Pimenta Vicentini, Luiz Fernando Cotica
Summary: This study investigates the biocompatibility of magnetic nanoparticles as a drug carrier system, showing that NP-Fe3O4/SiO2 and NP-Fe3O4 have high cell viability against breast adenocarcinoma cells (MCF-7) and can potentially be used for treating breast cancer.
Article
Polymer Science
Ionut-Cristian Radu, Catalin Zaharia, Ariana Hudita, Eugenia Tanasa, Octav Ginghina, Minodora Marin, Bianca Galateanu, Marieta Costache
Summary: In this study, Bombyx mori silk sericin nanocarriers loaded with doxorubicin were prepared using nanoprecipitation, showing potential in breast cancer therapy. Morphological, size, and chemical characterization revealed the formation of sericin nanoparticles in the 25-40 nm range, with specific interactions impacting drug delivery and release behavior. Biological investigation demonstrated high activity of the nanocarriers in inducing significant DNA damage in breast cancer cells.
Article
Polymer Science
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi
Summary: This study investigated the enhancement of cytotoxicity of alpha-mangostin (AMG) in breast cancer cells through the modification of chitosan molecular weight. Chitosan-based nanoparticles were developed, and their physicochemical characteristics and cytotoxicity were evaluated. The results showed that the prepared nanoparticles significantly enhanced the cytotoxicity of breast cancer cells compared to the non-nano particle formulation.
Article
Multidisciplinary Sciences
Weihua Gong, Panpan Fang, Maodong Leng, Ying Shi
Summary: This study aimed to explore the role of GSDME methylation in the sensitivity of chemotherapy for breast cancer. The results showed that decitabine could increase the expression of GSDME and induce cell apoptosis, improving the chemosensitivity of breast cancer cells to paclitaxel. Therefore, decitabine/GSDME/pyroptosis-based treatment strategies may provide a new approach to overcome the resistance of breast cancer to paclitaxel chemotherapy.
Article
Biochemistry & Molecular Biology
Blassan P. George, Naresh K. Rajendran, Nicolette N. Houreld, Heidi Abrahamse
Summary: This study synthesized zinc oxide nanoparticles using Rubus fairholmianus root extract and found that it can induce apoptosis in breast cancer cells through the mitochondria-mediated apoptotic pathway.
Article
Biochemistry & Molecular Biology
Imrich Geci, Peter Bober, Eva Filova, Evzen Amler, Jan Sabo
Summary: Breast cancer is the most common cancer in women worldwide and its aggressive nature is attributed to weakened intercellular adhesion regulated by GTPases. In this study, we investigated the role of ARHGAP1 in the inactivation of Rho GTPases after doxorubicin treatment. Proteomic analysis revealed that ARHGAP1 inactivated RAC1, CDC42, and RHOA GTPases, leading to epithelial-mesenchymal transitions through the TGF-beta signaling pathway. These findings shed light on the molecular mechanism behind reduced cell adhesion and increased metastasis risk in drug-resistant breast cancer cells treated with doxorubicin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Aljohra M. Al-Otaibi, Asma S. Al-Gebaly, Rafa Almeer, Gadah Albasher, Wedad S. Al-Qahtani, Ahmed E. Abdel Moneim
Summary: The utilization of green-synthesized selenium nanoparticles (SeNPs-apigenin) as a treatment for breast cancer shows potential in reducing cell viability and inducing apoptosis. It directly targets specific genes and regulates the release of cytochrome C, resulting in permanent DNA damage and cell death.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Applied
Elumalai Kowsalya, Kithiyon MosaChristas, Chinna Rani Inbaraj Jaquline, Pannerselvam Balashanmugam, Thiyagarajan Devasena
Summary: Green synthesis of functionalized gold nanoparticles using leaf aqueous extracts from 10 different plants was successful, with Pterygota alata showing enhanced antioxidant activity and potent anticancer efficacy against MCF-7 breast cancer cells. The phytosynthesized AuNPs may be a promising anti-cancer strategy for breast cancer without toxicity to normal cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hyunju Choi, Hee-Do Kim, Yeon-Woo Choi, Hakseong Lim, Kyung-Woon Kim, Kyoung-Sook Kim, Young-Choon Lee, Cheorl-Ho Kim
Summary: This study isolated the GM3-interacting protein NOLC1 using the T7 phage display method, further elucidating the functional roles of GM3 and providing evidence for the association between GM3 and NOLC1.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Sherif Ashraf Fahmy, Soad Nasr, Asmaa Ramzy, Abdelhameed S. Dawood, Anwar Abdelnaser, Hassan Mohamed El-Said Azzazy
Summary: Loading ascorbic acid (AA) and geranium oil (GO) into niosomal nanovesicles can improve their physicochemical properties and enhance their cytotoxic effects on breast cancer cells. The AA-GO niosomal vesicles showed higher inhibitory effects on cancer cell growth and induced apoptosis compared to free AA or GO, suggesting their potential as a treatment strategy for breast cancer.
Article
Polymer Science
Nabil A. Alhakamy, Usama A. Fahmy, Shaimaa M. Badr Eldin, Osama A. A. Ahmed, Hibah M. Aldawsari, Solomon Z. Okbazghi, Mohamed A. Alfaleh, Wesam H. Abdulaal, Abdulmohsin J. Alamoudi, Fatma M. Mady
Summary: This study demonstrates that incorporating quercetin, scorpion venom peptides, and Phospholipon(R) 90H into a nano-based delivery platform improves the cellular uptake and antiproliferative efficacy of quercetin, showing potential as a therapeutic approach for the treatment of breast cancer.
Article
Chemistry, Medicinal
Mahmoud M. Habibullah, Syam Mohan, Nabeel Kashan Syed, Hafiz A. Makeen, Qazi Mohammad Sajid Jamal, Hani Alothaid, Farkad Bantun, Alaa Alhazmi, Ali Hakamy, Yahia A. Kaabi, Ghalia Samlan, Mohtashim Lohani, Neelaveni Thangavel, Mohamed Ahmed Al-Kasim
Summary: In this study, the anticancer efficacy of Chitosan nanoparticles loaded with human growth hormone hGH fragment 176-191 peptide plus the clinical chemotherapeutic doxorubicin was evaluated. Molecular docking simulations and viability assays were used to determine the impact of hGH fragment 176-191 peptide on the binding affinities and efficacy of doxorubicin against breast cancer cells. The synthesized dual-loaded Chitosan nanoparticles showed greater anti-proliferative activity than doxorubicin-loaded Chitosan, suggesting that this dual-loading strategy may enhance the potency of doxorubicin and reduce non-target tissue exposure.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Shaghayegh Saharkhiz, Atefeh Zarepour, Negar Nasri, Marco Cordani, Ali Zarrabi
Summary: This study introduces and evaluates a smart pH-responsive niosomal formulation capable of delivering Doxorubicin (DOX) and Curcumin (CUR) individually or in combination, demonstrating effective anticancer efficacy.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ahmed S. Doghish, Gharieb S. El-Sayyad, Al-Aliaa M. Sallam, Waleed F. Khalil, Waleed M. A. El Rouby
Summary: The synthesized GO-based nanocomposites showed significant anticancer activity, especially against the MCF-7 breast cancer cell line, with GO-EDTA exhibiting the strongest cytotoxic effect. Through various analytical techniques and cytotoxicity assays, the anticancer effects of the nanocomposites were confirmed.
Article
Nanoscience & Nanotechnology
Chiranjib Nayek, M-Ali AL-Akhras, Venkatesha Narayanaswamy, Abbas Khaleel, Imaddin A. Al-Omari, Andrivo Rusydi, Ihab M. Obaidatl
Article
Biotechnology & Applied Microbiology
Tareq M. Osaili, Borhan A. Albiss, Anas A. Al-Nabulsi, Rawan F. Alromi, Amin Olaimat, Murad Al-Holy, Ioannis Savvaidis, Richard Holley
JOURNAL OF FOOD SAFETY
(2019)
Article
Nanoscience & Nanotechnology
Venkatesha Narayanaswamy, Ihab M. Obaidat, Sachin Latiyan, Shilpee Jain, Chiranjib Nayek, Sumana Goankar, M-Ali AL-Akhras, Imaddin A. Al-Omari
Article
Environmental Sciences
Zaid Q. Ababneh, Anas M. Ababneh, Majd S. Bani Hani, Riad S. Ababneh, Khaled M. Aljarrah
Article
Construction & Building Technology
Hussain H. Alzoubi, Borhan A. Albiss, Shatha S. Abu Sini
CONSTRUCTION AND BUILDING MATERIALS
(2020)
Article
Oncology
Khaled Aljarrah, M-Ali Al-Akhras, Duaa J. Al-Khalili, Zaid Ababneh
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Noora Ba Sunbul, Ibrahim Oraiqat, Benjamin Rosen, Cameron Miller, Christopher Meert, Martha M. Matuszak, Shaun Clarke, Sara Pozzi, Jean M. Moran, Issam El Naqa
Summary: The study developed and implemented an efficient and accurate commissioning procedure for small-field static beam animal irradiation studies using radiochromic gel dosimetry on an MV research linear accelerator. Various dosimetry tools were used to perform relative dosimetry measurements, resulting in confirmation of absolute dosimetry within 1.4% and agreement of the relative output factor measurements with a maximum difference of 4.3%. Radiochromic gel dosimeters were found to be efficient for full relative dosimetry commissioning in high-energy small-field animal irradiation studies.
Article
Polymer Science
Muna A. Abu-Dalo, Saja A. Al-Rosan, Borhan A. Albiss
Summary: This study investigated the photocatalytic degradation of methylene blue using polymeric membranes impregnated with ZnO nanostructures under UV-light and sunlight irradiation. The results showed that the cellulose acetate membranes impregnated with ZnO nanoparticles exhibited more rapid degradation of methylene blue under sunlight compared to UV-light.
Article
Polymer Science
Muna A. Abu-Dalo, Maysa A. Al-Atoom, Mohannad T. Aljarrah, Borhan A. Albiss
Summary: In this study, polymer membranes impregnated with carbon nanotubes were developed and evaluated for removing phenolic compounds from olive mill wastewater. It was found that the addition of carbon nanotubes improved the hydrophilicity and water flux of the membranes, and the amount of carbon nanotubes significantly affected the morphology and water flux of the membranes.
Article
Chemistry, Multidisciplinary
Ahmad M. M. Alsaad, Qais M. M. Al-Bataineh, Issam A. A. Qattan, Ihsan A. A. Aljarrah, Areen A. A. Bani-Salameh, Ahmad A. A. Ahmad, Borhan A. A. Albiss, Ahmad Telfah, Renat F. F. Sabirianov
Summary: We fabricated and characterized ferroelectric films of the organic molecular diisopropylammonium chloride using various methods. Our findings suggest that these films could be a promising alternative to lead-based perovskites for various applications such as piezoelectric devices and optoelectronics.
Article
Environmental Sciences
Zaid Q. Ababneh, Moayed Almusallam, Ibrahim Alfajri, Anas M. Ababneh, Khaled M. Aljarrah, Mark A. Tries, Nawaf Al Anazi
Summary: The study investigated organ and effective dose for adult patients in the most common type of X-ray examinations, showing wide variation in organ doses. The obtained values for effective dose were relatively lower than those reported in existing literature.
RADIATION PROTECTION DOSIMETRY
(2021)
Article
Biology
Nawaf Alanazi, Shahad Alabdullatif, Maryam Albahrani, Malak Aljamaan, Fatimah Alsayegh, Aysha Bhalli, Khaled Aljarrah, Zafar Iqbal
Summary: This study investigated the impact of sickle cell disease in children at King Abdulaziz Hospital in Al-Ahsa in the Eastern province of Saudi Arabia. The results showed that approximately one-third of the patients had mild disease, and hydroxyurea was found to reduce disease severity by lowering corrected reticulocyte and WBC counts. More research is needed to understand the exact mechanisms of mild SCD and the role of hydroxyurea in disease management.
ADVANCEMENTS IN LIFE SCIENCES
(2021)
Article
Engineering, Environmental
Muna Abu-Dalo, Azza Jaradat, Borhan A. Albiss, Nathir A. F. Al-Rawashdeh
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2019)
Proceedings Paper
Nanoscience & Nanotechnology
Tariq AlZoubi, Borhan Albiss, M-Ali Al-Akhras, Hamzeh Qutaish, Enad Alabed, Sheik Nazrul
7TH INTERNATIONAL CONFERENCE ON NANO AND MATERIALS SCIENCE (ICNMS 2019)
(2019)