Review
Radiology, Nuclear Medicine & Medical Imaging
Maria Silvia De Feo, Viviana Frantellizzi, Luciano De Sio, Alessio Farcomeni, Giuseppe De Vincentis, Roberto Pani
Summary: The purpose of this systematic review was to collect and analyze published studies on intraoperative gamma detection of positron-emitting tracers for radioguided surgery (RGS) applications. A systematic literature search was conducted in multiple databases to identify relevant studies published until October 2022. The results showed that RGS procedures using positron emitters, primarily fluorine-18-fluoro-2-deoxyglucose ([F-18]FDG), have been beneficial in improving surgeons' ability to achieve complete tumor resection. However, further technical advancements are needed to overcome the challenges associated with detecting annihilation photons resulting from positron-electron collisions.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Article
Urology & Nephrology
Paolo Dell'Oglio, Philippa Meershoek, Tobias Maurer, Esther M. K. Wit, Pim J. van Leeuwen, Henk G. van der Poel, Fijs W. B. van Leeuwen, Matthias N. van Oosterom
Summary: The DROP-IN probe offers improved SN detection rates in robotic surgery compared to traditional gamma probe and fluorescence imaging, demonstrating good safety profile. The combination of DROP-IN probe with fluorescence imaging allows for more efficient identification of sentinel lymph nodes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilse G. T. Baeten, Jacob P. Hoogendam, Arthur J. A. T. Braat, Ronald P. Zweemer, Cornelis G. Gerestein
Summary: This study evaluated the safety and feasibility of using a tethered drop-in gamma-probe for sentinel lymph node (SLN) detection in patients with early-stage cervical cancer. The results showed that the drop-in gamma-probe had a bilateral SLN detection rate of 80% and an overall detection rate of 100%. The use of the drop-in gamma-probe enhanced the maneuverability and surgical autonomy during robot-assisted SLN detection.
Review
Radiology, Nuclear Medicine & Medical Imaging
Lorenzo Muraglia, Francesco Mattana, Giulia Zuccotti, Francesco Collamati, Stefano Luzzago, Laura Lavinia Travaini, Gennaro Musi, Francesco Ceci
Summary: PSMA-PET has higher diagnostic accuracy compared to conventional imaging for staging high-risk prostate cancer (PCa), and PSMA-RGS shows promising results in improving surgery accuracy to remove nodal metastasis. Gamma probes have been more extensively explored, while the clinical use of beta probes is still in feasibility studies. Additionally, Cerenkov luminescence imaging, micro-image guidance, and augmented reality/virtual reality approaches in surgery are generating future perspectives for PSMA-guided surgery in PCa.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samaneh Azargoshasb, Krijn H. M. Houwing, Paul R. Roos, Sven van Leeuwen, Michael Boonekamp, Elio Mazzone, Kevin Bauwens, Paolo Dell'Oglio, Fijs W. B. van Leeuwen, Matthias N. van Oosterom
Summary: This study introduces a new surgical method based on fluorescence video tracking, which integrates the Drop-In gamma-probe with navigated robotic surgery. Experimental validation of the feasibility of this method further advances the symbiosis between nuclear medicine and robotic surgery.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Vollmer, Nuria Sanchez-Izquierdo, Daniel Martinez, David Sanchez-Lorente, Sebastian Casanueva-Eliceiry, Marc Boada, Angela Guirao, Inmaculada Romero-Zayas, Sergi Vidal-Sicart, Pilar Paredes
Summary: The study evaluated the intraoperative use of a PGC for margin assessment of pulmonary nodules, showing a high negative predictive value and a short intraoperative time required for its use, making the PGC a useful tool for providing supplementary information to histopathologic results. Further studies are needed for external validation from different surgical teams.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Environmental Sciences
Owusu Fordjour Aidoo, Jonathan Osei-Owusu, Shaphan Yong Chia, Aboagye Kwarteng Dofuor, Akua Konadu Antwi-Agyakwa, Harry Okyere, Michael Gyan, George Edusei, Kodwo Dadzie Ninsin, Rahmat Quaigrane Duker, Shahida Anusha Siddiqui, Christian Borgemeister
Summary: Pesticide residues pose a significant threat to public health and the environment. However, the use of ozone as a residue-free method for degrading pesticide traces has shown great effectiveness and affordability. Ozone treatment has been proven effective in removing pesticide residues from soil, water, and food, making it a recommended strategy for reducing pesticide residues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Hui Wang, Xiaoting Zhang, Ping Li, Fang Huang, Tiancong Xiu, Hongtong Wang, Wei Zhang, Wen Zhang, Bo Tang
Summary: Atherosclerosis, a disease driven by lipoproteins, lacks effective therapy for reversal. Therefore, there is an urgent need for a noninvasive and reliable early detection approach to prevent plaque formation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Computer Science, Artificial Intelligence
Jia Wen Seow, Mei Kuan Lim, Raphael C. W. Phan, Joseph K. Liu
Summary: When used maliciously, deepfake technology can have detrimental implications on politics and society. Due to a lack of specific laws addressing deepfakes, detection plays a vital role. This paper provides a comprehensive overview of deepfake generation and detection, as well as discusses trends for future research.
Review
Microbiology
Hemant Joshi, Divya Kandari, Subhrangsu Sundar Maitra, Rakesh Bhatnagar
Summary: Tuberculosis (TB) infection is a major cause of death globally, and early detection of the pathogen is crucial for successful diagnosis. Recent advancements in TB biomarkers, specifically secretory proteins from Mycobacterium tuberculosis, have been explored for early diagnosis and treatment. This review discusses the latest developments in piezoelectric, magnetic, optical, and electrochemical biosensors, highlighting their strengths and limitations. Additionally, the review explores the construction of biosensors using integrated technologies, such as analytical chemistry, molecular biology, and nanotechnology.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Article
Computer Science, Theory & Methods
Zhaoxin Fan, Yazhi Zhu, Yulin He, Qi Sun, Hongyan Liu, Jun He
Summary: This study presents a comprehensive review of the latest developments in object pose detection and tracking using deep learning. It focuses on methods that use monocular RGB/RGBD data as input and covers three major tasks. Detailed information about metrics, datasets, and methods for both detection and tracking is provided, along with comparative results of state-of-the-art methods on publicly available datasets, as well as insightful observations and inspiring future research directions.
ACM COMPUTING SURVEYS
(2023)
Review
Food Science & Technology
Xin Dong, Vijaya Raghavan
Summary: Seafood is a nutritious food that plays a significant role in human health, but seafood allergy has become a global health issue. This review provides an overview of recent advances in processing techniques and allergen-detection methods for seafood products, aiming to provide key information for further research.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sergi Vidal-Sicart, Renato A. Valdes A. Valdes Olmos
Summary: Molecular imaging technologies, such as radioguided surgery, are increasingly used in cancer diagnosis, monitoring, and treatment guidance. Traditional applications of radioguided surgery involve handheld probes or portable devices to selectively remove tissues marked with a radiotracer. However, there are limitations and potentials that require improvement of these conventional devices.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Review
Optics
Alfredo Borgia, Raffaele Raimondi, Tania Sorrentino, Francesco Santoru, Matilde Buzzi, Vittorio Borgia, Vincenzo Scorcia, Giuseppe Giannaccare
Summary: This study aimed to summarize the results of ocular biometry using SS-OCT and analyze the agreement, repeatability, and reproducibility of different devices. The findings demonstrate that optical biometers based on SS-OCT technology produce highly repeatable and reproducible results, indicating their potential to lead in ocular biometry.
Article
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Summary: The study shows that robot-assisted minimally invasive surgery combined with PSMA-radioguidance is effective in resecting PSMA-avid lesions, offering potential benefits for the treatment of patients with prostate cancer.
Review
Biotechnology & Applied Microbiology
Corinne A. Calo, David M. O'Malley
Summary: ADCs offer promising targeted therapy in recurrent ovarian cancer with excellent response rates, especially when used in combination therapy. While mirvetuximab soravtansine is the only ADC evaluated in a phase 3 trial, numerous other ADCs and trials are emerging in the field. Continued development of target antigens and ADCs are likely to play a key role in treating recurrent, platinum-resistant disease.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2021)
Article
Oncology
Heather Hampel, Rachel Pearlman, Albert de la Chapelle, Colin C. Pritchard, Weiqiang Zhao, Dan Jones, Ahmet Yilmaz, Wei Chen, Wendy L. Frankel, Adrian A. Suarez, Casey Cosgrove, Floor Backes, Larry Copeland, Jeffrey Fowler, David O'Malley, Ritu Salani, Joseph P. McElroy, Peter P. Stanich, Paul Goodfellow, David E. Cohn
Summary: The study revealed that double somatic MMR gene PV are as common as Lynch syndrome among endometrial cancer patients. Paired tumor and germline testing for patients with non-methylated dMMR tumor may be the most efficient approach for Lynch syndrome screening.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Surgery
Mahmoud Abdelwahab, Courtney D. Lynch, Patrick Schneider, Stephen Thung, Maged M. Costantine, David O'Malley, Mark B. Landon, Tim M. Pawlik, Kartik K. Venkatesh
Summary: Pregnant patients do not have a higher risk of major 30-day postoperative complications compared with non-pregnant patients following non-obstetric surgery, except in colorectal and hernia surgeries where pregnant patients may face higher risks.
AMERICAN JOURNAL OF SURGERY
(2022)
Review
Oncology
Angeles Alvarez Secord, David M. O'Malley, Anil K. Sood, Shannon N. Westin, Joyce F. Liu
Summary: PARP inhibitors and antiangiogenics have shown activity in women with advanced ovarian cancer, and combination therapy can enhance their efficacy. The combination of PARP inhibitors and antiangiogenics demonstrates good safety and efficacy in women with newly diagnosed and recurrent ovarian cancer. Further clarification is needed to determine which patients are suitable for monotherapy or combination therapy in the future.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Floor J. Backes, Lai Wei, Min Chen, Kasey Hill, Kyle Dzwigalski, Ming Poi, Mitch Phelps, Ritu Salani, Larry J. Copeland, Jeffrey M. Fowler, David E. Cohn, Kristin Bixel, Casey Cosgrove, John Hays, David O'Malley
Summary: This study aimed to estimate the maximally tolerated dose and toxicities of lenvatinib and paclitaxel in patients with recurrent endometrial and platinum resistant epithelial ovarian cancer, and observed encouraging activity in both types of cancer, indicating the need for further development.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Andrew R. Clamp, Domenica Lorusso, Amit M. Oza, Carol Aghajanian, Ana Oaknin, Andrew Dean, Nicoletta Colombo, Johanne Weberpals, Giovanni Scambia, Alexandra Leary, Robert W. Holloway, Margarita Amenedo Gancedo, Peter C. Fong, Jeffrey C. Goh, David M. O'Malley, Deborah K. Armstrong, Susana Banerjee, Jesus Garcia-Donas, Elizabeth M. Swisher, Terri Cameron, Sandra Goble, Robert L. Coleman, Jonathan A. Ledermann
Summary: In patients with recurrent ovarian cancer, maintenance treatment with rucaparib significantly improved progression-free survival regardless of progression-free interval following penultimate platinum, number of prior chemotherapies, and previous use of bevacizumab.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Obstetrics & Gynecology
Monique McKiever, Courtney D. Lynch, Olubukola O. Nafiu, Christian Mpody, David M. O'Malley, Mark B. Landon, Maged M. Costantine, Timothy M. Pawlik, Kartik K. Venkatesh
Summary: In the United States, pregnant non-Hispanic Black women undergoing nonobstetric surgery were found to have a higher risk of major postoperative complications compared to White women.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Vicky Makker, Matthew H. Taylor, Ana Oaknin, Antonio Casado Herraez, Robert Orlowski, Lea Dutta, Min Ren, Melissa Zale, David M. O'Malley
Summary: The combination of lenvatinib plus pembrolizumab in the treatment of advanced endometrial carcinoma following prior systemic therapy showed efficacy, with manageable safety profile and common adverse reactions occurring within the first 10 weeks of treatment. Most adverse reactions were managed through study drug dose modifications and concomitant medications.
Article
Medicine, Research & Experimental
Rebecca C. Arend, David M. O'Malley, Susana Banerjee, Kimmie McLaurin, Richard Davidson, Grainne H. Long
Summary: This study aimed to characterize the utilization of PARP inhibitors in women with ovarian cancer in the real-world setting. Differences were observed among licensed PARPi in terms of adverse event risk, dose modifications, treatment persistence, healthcare resource utilization, and costs.
ADVANCES IN THERAPY
(2022)
Article
Oncology
David M. O'Malley, Giovanni Mendonca Bariani, Philippe A. Cassier, Aurelien Marabelle, Aaron R. Hansen, Ana De Jesus Acosta, Wilson H. Miller, Tamar Safra, Antoine Italiano, Linda Mileshkin, Lei Xu, Fan Jin, Kevin Norwood, Michele Maio
Summary: Pembrolizumab demonstrated durable antitumor activity and encouraging survival outcomes in previously treated patients with MSI-H/dMMR endometrial cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
David M. O'Malley, Maryna Neffa, Bradley J. Monk, Tamar Melkadze, Marilyn Huang, Anna Kryzhanivska, Iurie Bulat, Tarek M. Meniawy, Andrea Bagameri, Edward W. Wang, Bernard Doger de Speville Uribe, Roberto Hegg, Waldo Ortuzar Feliu, Marek Ancukiewicz, Iwona Lugowska
Summary: This phase II trial evaluated the efficacy of dual treatment with balstilimab and zalifrelimab in patients with recurrent and/or metastatic cervical cancer. The results showed promising and durable clinical activity, with favorable tolerability, in these patients.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Larry J. Copeland, Mark F. Brady, Robert A. Burger, William H. Rodgers, Helen Q. Huang, David Cella, David M. O'Malley, Daron G. Street, Krishnansu S. Tewari, David P. Bender, Robert T. Morris, William J. Lowery, David S. Miller, Summer B. Dewdney, Nick M. Spirtos, Shashikant B. Lele, Saketh Guntupalli, Frederick R. Ueland, Gretchen E. Glaser, Robert S. Mannel, Philip J. DiSaia
Summary: The study found that maintenance therapy with paclitaxel and paclitaxel poliglumex did not improve overall survival in patients with newly diagnosed ovarian/tubal/peritoneal cancer, but may slightly increase progression-free survival. Gastrointestinal and neurologic toxicities were more common in the taxane treatment arms.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Bradley J. Monk, Christine Parkinson, Myong Cheol Lim, David M. O'Malley, Ana Oaknin, Michelle K. Wilson, Robert L. Coleman, Domenica Lorusso, Paul Bessette, Sharad Ghamande, Athina Christopoulou, Diane Provencher, Emily Prendergast, Fuat Demirkiran, Olga Mikheeva, Oladapo Yeku, Anita Chudecka-Glaz, Michael Schenker, Ramey D. Littell, Tamar Safra, Hung-Hsueh Chou, Mark A. Morgan, Vit Drochytek, Joyce N. Barlin, Toon Van Gorp, Fred Ueland, Gabriel Lindahl, Charles Anderson, Dearbhaile C. Collins, Kathleen Moore, Frederik Marme, Shannon N. Westin, Iain A. McNeish, Danny Shih, Kevin K. Lin, Sandra Goble, Stephanie Hume, Keiichi Fujiwara, Rebecca S. Kristeleit
Summary: This study evaluates the efficacy of rucaparib as a first-line maintenance treatment in ovarian cancer patients, showing significant benefits of rucaparib compared to placebo in patients with and without HRD.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Letter
Oncology
Bradley J. Monk, Keiichi Fujiwara, David M. O'Malley, Robert L. Coleman, Iain A. McNeish, Kevin K. Lin, Stephanie Hume, Rebecca S. Kristeleit
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
David M. O'Malley, Thomas C. Krivak, Nashwa Kabil, Jiefen Munley, Kathleen N. Moore
Summary: PARP inhibitors have revolutionized the treatment of ovarian cancer. This review provides a comprehensive overview of the data on olaparib, niraparib, and rucaparib in ovarian cancer patients, with a focus on their use as maintenance therapy in the US. Biomarker testing is crucial to identify patients who will benefit from PARP inhibitor maintenance therapy. Clinical trial data support the use of PARP inhibitors as second-line or later maintenance therapy in platinum-sensitive relapsed ovarian cancer patients. Real-world data and trials exploring novel combination strategies are expected to provide further insights into the optimal management of ovarian cancer with PARP inhibitors.
