Article
Oncology
Phillip M. Kemp Bohan, Shu-Ching Chang, Gary L. Grunkemeier, Holly V. Spitzer, Elizabeth L. Carpenter, Alexandra M. Adams, Timothy J. Vreeland, Daniel W. Nelson
Summary: The study found that treatment at high-volume centers (HVC) and academic centers (AC) was associated with improved overall survival (OS) for patients with pancreatic adenocarcinoma (PAC). However, considering mediating variables reduced the magnitude of this benefit. Further research is needed to identify patients who would benefit most from selective referral to HVC or AC.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Phillip M. Kemp Bohan, Shu-Ching Chang, Gary L. Grunkemeier, Holly V. Spitzer, Elizabeth L. Carpenter, Alexandra M. Adams, Timothy J. Vreeland, Daniel W. Nelson
Summary: This study examined the effects of hospital volume, facility type, and travel distance on overall survival in patients undergoing surgery for pancreatic adenocarcinoma. The results showed that treatment at high-volume centers or academic centers was associated with a lower risk of death, while travel distance did not impact overall survival. Mediating variables explained a portion of the survival benefit.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Citadel J. Cabasag, Melina Arnold, Mark Rutherford, Aude Bardot, Jacques Ferlay, Eileen Morgan, Alana Little, Prithwish De, Elijah Dixon, Ryan R. Woods, Nathalie Saint-Jacques, Sue Evans, Gerda Engholm, Mark Elwood, Neil Merrett, David Ransom, Dianne L. O'Connell, Freddie Bray, Isabelle Soerjomataram
Summary: This study compares the net survival rates of pancreatic cancer across seven high-income countries at different ages and stages. The results show that the survival rates are generally low in these countries, with most patients being diagnosed at an advanced stage. The study highlights the importance of early diagnosis and treatment in improving pancreatic cancer prognosis.
BRITISH JOURNAL OF CANCER
(2022)
Article
Surgery
Jana S. Hopstaken, Pauline A. J. Vissers, Rutger Quispel, Judith de Vos-Geelen, Lodewijk A. A. Brosens, Ignace H. J. T. de Hingh, Lydia G. Van der Geest, Marc G. Besselink, Kees J. H. M. van Laarhoven, Martijn W. J. Stommel
Summary: This study assessed the impact of network treatment on time to chemotherapy, completion of adjuvant chemotherapy, and survival in pancreatic cancer patients. The results showed that network treatment did not affect the timing of chemotherapy, completion of adjuvant chemotherapy, and overall survival. There were significant variations observed between different pancreatic cancer networks in terms of time to chemotherapy and completion of adjuvant chemotherapy.
Article
Oncology
Karen M. Mulligan, Kate Glennon, Fionan Donohoe, Yvonne O'Brien, Brian C. Mc Donnell, Helena C. Bartels, Carolien Vermeulen, Tom Walsh, Conor Shields, Orla McCormack, John Conneely, William D. Boyd, Ruaidhri Mc Vey, Jurgen Mulsow, Donal J. Brennan
Summary: The implementation of a multidisciplinary team approach in surgery, combined with meticulous preoperative optimization, led to significantly improved rates of complete resection, especially in women undergoing primary cytoreductive surgery.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Surgery
Omar J. Shah, Manmohan Singh
Summary: Pancreatic cancer surgery has made advances in recent years with the incorporation of vascular reconstruction and new surgical techniques to improve the resectability of tumors.
UPDATES IN SURGERY
(2023)
Review
Surgery
Bathiya Ratnayake, Sayali A. Pendharkar, Saxon Connor, Jonathan Koea, Diana Sarfati, Elizabeth Dennett, Sanjay Pandanaboyana, John A. Windsor
Summary: Contemporary literature confirms a strong relationship between patient volume and clinical outcomes for pancreatic cancer resection, with high-volume centers showing lower mortality, morbidity, failure-to-rescue, and positive resection margin rates.
Article
Surgery
Gilbert Z. Murimwa, Jennie Meier, Mithin Nehrubabu, Herbert J. Zeh, Adam C. Yopp, Patricio M. Polanco
Summary: This study investigates the impact of social determinants of health and travel burden on the survival rate of patients with pancreatic cancer. The results show that surgical treatment and longer distance from accredited cancer centers are associated with better survival rates, while higher area deprivation index leads to worse outcomes. The study also suggests that lower area deprivation index can improve survival rates with increasing travel burden.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Kristen E. Rhodin, Vignesh Raman, Austin Eckhoff, Annie Liu, John Creasy, Daniel P. Nussbaum, Dan G. Blazer
Summary: The study found that fragmented care for stage II/III gastric cancer patients is associated with poorer outcomes, including reduced preferred perioperative treatment and decreased survival rates. Factors associated with coordinated care include residence in metropolitan areas and treatment at academic and high-volume centers.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Sidra N. Bonner, Andrew M. Ibrahim, Nick Kunnath, Justin B. Dimick, Hari Nathan
Summary: Receiving complex cancer surgery at high-quality hospitals was associated with reduced disparities between individuals living in the most and least deprived neighborhoods. Increasing accessibility to high-quality hospitals may improve surgical outcomes and mitigate social disparities.
Review
Immunology
Zhe Zhao, Weike Zhang, Longbin Pang, Liangjie Zeng, Surui Liu, Jie Liu
Summary: This study aims to determine the incidence and risk of pancreatic adverse events associated with immune checkpoint inhibitors (ICIs) therapy for solid tumors. The use of ICIs was associated with an increased risk of pancreatic immune-related adverse events, and PD-1 inhibitors and dual ICI therapy had a higher risk compared to PD-L1 inhibitors and single ICI therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Heikki Huhta, Minna Nortunen, Sanna Merilainen, Olli Helminen, Joonas H. Kauppila
Summary: Higher annual hospital volume of pancreatic surgery is associated with improved short- and long-term survival for pancreatic ductal adenocarcinoma.
Article
Multidisciplinary Sciences
Venkataraghavan Ramamoorthy, Kelvin Chan, Sandeep Appunni, Zhenwei Zhang, Md Ashfaq Ahmed, Peter McGranaghan, Anshul Saxena, Muni Rubens
Summary: Major adverse cardiovascular and cerebrovascular events (MACCE) are a significant cause of morbidity and mortality during the perioperative period. This study aimed to identify national trends in perioperative MACCE and its components, as well as the types of cancer surgeries associated with high rates of perioperative MACCE. A retrospective analysis of the National Inpatient Sample, from 2005 to 2014, was conducted, including hospitalizations for major surgeries of various cancers. The results showed a significant decrease in perioperative MACCE for acute myocardial infarction and death, while stroke did not significantly change. Logistic regression analysis identified esophageal, pancreatic, lung, liver, and colorectal cancers as having significantly higher odds of perioperative MACCE. These findings can contribute to risk stratification and better decision-making for high-risk surgeries.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Michael Dougan, Adrienne M. Luoma, Stephanie K. Dougan, Kai W. Wucherpfennig
Summary: Immunotherapies have had a significant impact on cancer treatment over the past decade, but inflammatory toxicities remain a major concern for certain therapies. Understanding the balance between pro- and anti-inflammatory pathways is crucial for limiting inflammatory toxicities while preserving anti-tumor efficacy.
Article
Cardiac & Cardiovascular Systems
Kristen E. Rhodin, Vignesh Raman, Christopher W. Jensen, Lillian Kang, Daniel P. Nussbaum, Betty C. Tong, Dan G. Blazer III, Thomas A. D'Amico
Summary: This study aimed to determine the impact of multi-institutional care on survival in patients with clinical stage II or III esophageal cancer. The results showed that there was no significant difference in survival between patients who received multi-institutional care and those who received care at a single institution. Therefore, for complex cancer care, patients may consider receiving part of their care closer to home, but traveling to surgical centers of excellence should be encouraged.
ANNALS OF THORACIC SURGERY
(2023)