Article
Oncology
Byungyoon Yun, Sang Hoon Ahn, Juyeon Oh, Jin-Ha Yoon, Beom Kyung Kim
Summary: The study examined the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and the recurrence of hepatocellular carcinoma (HCC) in patients who underwent surgical resection. The results showed that MAFLD was significantly associated with an increased risk of HCC recurrence and all-cause mortality. The study highlights the importance of developing preventive strategies through the management of metabolic health.
Article
Virology
Song-Huy Nguyen-Dinh, Wei-Feng Li, Yueh-Wei Liu, Chih-Chi Wang, Yen-Hao Chen, Jing-Houng Wang, Chao-Hung Hung
Summary: Epidemiological data suggest that there are etiological variations of hepatocellular carcinoma (HCC) in different geographic areas, which may be associated with different outcomes. This study compared the viral etiology, clinicopathological characteristics, and surgical outcomes between Taiwanese and Vietnamese patients with HCC. The results showed that although the viral etiology and clinicopathological characteristics differed, the postoperative overall survival was comparable between patients in Taiwan and Vietnam.
Article
Oncology
Shilei Bai, Pinghua Yang, Yanping Wei, Jie Wang, Caixia Lu, Yong Xia, Anfeng Si, Baohua Zhang, Feng Shen, Yexiong Tan, Kui Wang
Summary: This study aimed to establish prediction models for postoperative survival in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) with microvascular invasion (MVI). Nomograms for disease recurrence and overall survival (OS) were developed using preoperative serological indicators, tumor clinicopathologic features, surgical margin, and postoperative adjuvant TACE. The nomograms showed good predictive performance and accurately stratified patients into different risk groups.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fei Wu, Haitao Sun, Changwu Zhou, Peng Huang, Yuyao Xiao, Chun Yang, Mengsu Zeng
Summary: This study evaluated whether radiological similarity and clinicopathological factors determine the prognosis in bifocal hepatocellular carcinoma (bHCC) stratified by the Milan criteria. The study found that the radiological similarity of bHCC lesions is associated with long-term prognosis, in addition to other factors.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Qiuyan Mo, Yingchun Liu, Zihan Zhou, Runwei Li, Wenfeng Gong, Bangde Xiang, Weizhong Tang, Hongping Yu
Summary: The De Ritis ratio is an independent predictor for overall survival in HBV-related HCC patients undergoing hepatectomy, allowing for prognostic stratification and personalized treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaomi Li, Jingyan Wang, Xiaoyan Ding, Yawen Xu, Minghua Yu, Hongxiao Wu, Na Deng, Wei Li, Jinglong Chen
Summary: The clinical efficacy of lenvatinib was compared between hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and hepatitis C virus (HCV)-related HCC. The study found that patients with HBV-HCC had higher objective response rate and disease control rate compared to HCV-HCC, but there were no significant differences in progression-free survival and overall survival between the two groups. Multivariate regression analysis identified HBV infection and antiviral time > 5 years as independent favorable factors for progression-free survival. Overall, lenvatinib seemed to be more effective in HBV-related HCC compared to HCV-related HCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Marco Y. W. Zaki, Ahmed M. Fathi, Samara Samir, Nardeen Eldafashi, Kerolis Y. William, Maiiada Hassan Nazmy, Moustafa Fathy, Upkar S. Gill, Shishir Shetty
Summary: HBV and HCV infections are the most common risk factors for hepatocellular carcinoma (HCC), and their distribution affects the global prevalence of this type of liver cancer. Hepatitis infections elicit immune responses within the liver microenvironment, and persistent viral infection leads to chronic liver inflammation and carcinogenesis.
Article
Cell Biology
Xi Chen, Minfeng Zhang, Nan Li, Rui Pu, Ting Wu, Yibo Ding, Peng Cai, Hongwei Zhang, Jun Zhao, Jianhua Yin, Guangwen Cao
Summary: The study identified HBV preS variants G40C and C147T as serological biomarkers for HCC prognosis, with a prognostic model consisting of serological alpha-fetoprotein and G40C achieving the best performance in predicting postoperative prognosis.
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Article
Immunology
Gaopeng Li, Zhuangqiang Wang, Dong Chen, Jun Yin, Zhiyuan Mo, Bianyin Sun, Tao Yang, Xinning Zhang, Zhensheng Zhai, Yaoxuan Li, Pinggui Chen, Yunyan Dai, Zhiming Wang, Jun Ma
Summary: This study aimed to explore a TPX2-related ceRNA regulatory network in HBV-infected HCC and the potential impact on HCC prognosis. The TRHDE-AS1/miR-23b/PKIA ceRNA network was found to be associated with HCC prognosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Min-Kyu Kang, Gyeonghwa Kim, Jung Gil Park, Se Young Jang, Hye Won Lee, Won Young Tak, Young Oh Kweon, Soo Young Park, Yu Rim Lee, Keun Hur
Summary: This study investigated the clinical significance and prognostic utility of hsa_circ_0004018 and hsa_circ_0003570 in patients with hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). The findings suggest that both circRNAs are downregulated in HCC tissues and high expression levels are inversely associated with overall and progression-free survival in HBV-HCC patients. The combination of hsa_circ_0003570 and hsa_circ_0004018 may serve as a potential prognostic biomarker for HBV-HCC.
Review
Gastroenterology & Hepatology
Ming-He Zhang, Yu-Feng Yuan, Li-Juan Liu, Yu-Xin Wei, Wan-Yue Yin, Lan-Zhuo-Yin Zheng, Ying-Ying Tang, Zhao Lv, Fan Zhu
Summary: Hepatitis B virus (HBV) infection is a significant risk factor for hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) have potential as biomarkers for early detection and therapy of HBV-associated HCC. This review summarizes the current progress on the role of miRNAs in the diagnosis and treatment of HBV-HCC, discussing the mechanism by which HBV regulates miRNAs and the exact effect of miRNAs on HCC promotion. In the near future, miRNA-based diagnostic, prognostic, and therapeutic applications will be integrated into clinical practice.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yao-Chung Liu, Chien-Wei Su, Po-Shen Ko, Rheun-Chuan Lee, Chia-Jen Liu, Yi-Hsiang Huang, Jyh-Pyng Gau, Jin-Hwang Liu
Summary: The study explored the use of valproic acid and hydralazine in conjunction with chemotherapy for advanced hepatocellular carcinoma. The results demonstrated that this sequential chemotherapy was effective and had manageable toxicities.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Chih-Chieh Ko, Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Cheng-Yuan Hsia, Yi-Hsiang Huang, Chien-Wei Su, Hao-Jan Lei, Rheun-Chuan Lee, Ming-Chih Hou, Teh-Ia Huo
Summary: This study investigated the clinical characteristics, outcome, and prognostic role of ALBI grade in dual HBV/HCV-related HCC. The study found that dual viral infection does not accelerate the development of HCC in HBV carriers, and patient survival is similar between dual HBV/HCV-related HCC and single HBV- or HCV-related HCC group. The ALBI grade is a robust prognostic model in dual virus-related HCC to discriminate patient long-term survival.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Jia- Liao, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: This study developed a new prognostic model, the TBS-ALBI system, based on tumor burden score (TBS) and albumin-bilirubin (ALBI) grade, to predict the prognosis of hepatocellular carcinoma (HCC). The TBS-ALBI system showed significant survival differences in different patient groups, and had the lowest corrected Akaike information criterion (AICc) and the highest homogeneity compared to other staging models. The system was consistently stable across different viral etiologies, cancer stages, and treatment strategies.
Article
Cell Biology
Yung-Sheng Chang, Chien-Wei Su, San-Chi Chen, Yen-Ying Chen, Yuh-Jin Liang, Jaw-Ching Wu
Summary: Research has shown that upregulation of USP22 and ABCC1 expression during sorafenib treatment contributes to resistance in hepatocellular carcinoma cells. USP22 has potential as a therapeutic target for overcoming sorafenib resistance.
Article
Medicine, General & Internal
Cheng-Yen Liao, Chun-Yang Lee, Cheng-Yi Wei, Yee Chao, Yi-Hsiang Huang, Ming-Chih Hou, Yu-Hui Su, Jaw-Ching Wu, Chien-Wei Su
Summary: The incidence of hepatocellular carcinoma (HCC) is higher in men than women, but the impact of sex disparities on HCC outcomes remains unclear. This retrospective study compared the clinical manifestations and prognoses of male and female HCC patients. Male patients were younger at diagnosis and had better liver function, but had greater tumor burdens. Fewer male patients underwent curative therapies. The 5-year overall survival rates were slightly higher in female patients. Female sex was associated with lower mortality in younger patients but not in older patients with HCC.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Chun-Yang Lee, Gar-Yang Chau, Cheng-Yi Wei, Yee Chao, Yi-Hsiang Huang, Teh-Ia Huo, Ming-Chih Hou, Yu-Hui Su, Jaw-Ching Wu, Chien-Wei Su
Summary: The study found that surgical resection leads to better prognoses than non-surgical treatments for hepatocellular carcinoma patients with tumor rupture at diagnosis. Additionally, a sequential combination of transarterial chemoembolization (TACE) and surgical resection had similar clinical outcomes to surgical resection alone.
SCIENTIFIC REPORTS
(2022)
Article
Nursing
Yueh-Ling Liao, Tsae-Jyy Wang, Chien-Wei Su, Shu-Yuan Liang, Chieh-Yu Liu, Jun-Yu Fan
Summary: The study found that decision support intervention had a positive effect on improving treatment knowledge and reducing decisional conflict in patients with hepatocellular cancer (HCC). However, it did not significantly impact decision self-efficacy and decision satisfaction.
CLINICAL NURSING RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
I-Cheng Lee, Keng-Hsin Lan, Chien-Wei Su, Chung-Pin Li, Yee Chao, Han-Chieh Lin, Ming-Chih Hou, Yi-Hsiang Huang
Summary: This study compared the efficacy and renal safety of ETV, TDF, and TAF in HBV-infected cancer patients undergoing chemotherapy. The results showed that TAF had good renal safety and comparable efficacy with ETV and TDF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
I-Cheng Lee, Pei-Chang Lee, Yee Chao, Chen-Ta Chi, Chi-Jung Wu, Yi-Ping Hung, Chien-Wei Su, Ming-Chih Hou, Yi-Hsiang Huang
Summary: This study evaluated the application and impact of antiviral therapy for patients with HBV-related HCC receiving TKI therapy, and found that the use of NUC therapy can improve overall survival, while patients without NUC therapy had a higher HBV reactivation rate.
Article
Oncology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Jia- Liao, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: Tumor burden score (TBS), estimated by the diameter and number of tumor nodules, is a feasible prognostic marker for HCC patients within the Milan criteria. Among patients with low TBS, radiofrequency ablation (RFA) should be considered the priority treatment modality.
Article
Medicine, General & Internal
Chia-Chu Fu, Cheng-Yi Wei, Chi-Jen Chu, Pei-Chang Lee, Teh-Ia Huo, Yi-Hsiang Huang, Yee Chao, Ming-Chih Hou, Jaw-Ching Wu, Chien-Wei Su
Summary: This study retrospectively enrolled 2198 patients with HCC and normal serum AFP levels. The results showed that liver functional reserve, anti-viral therapy, tumor size, vascular invasion, and treatment modalities were prognostic factors for HCC patients with normal serum AFP levels, while serum AFP levels themselves were not associated with prognosis.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Editorial Material
Gastroenterology & Hepatology
Wei-Yu Kao, Chien-Wei Su
LIVER INTERNATIONAL
(2022)
Article
Oncology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Jia- Liao, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: Liver functional reserve is critical in managing hepatocellular carcinoma (HCC) patients. This study compared four albumin-based liver reserve models (ALBI/EZ-ALBI/PALBI/PAL) versus MELD in HCC patients undergoing transarterial chemoembolization (TACE) and found that all four albumin-based models were better prognostic tools than MELD scores. Among them, PALBI score was the best model for evaluating liver reserve.
Article
Gastroenterology & Hepatology
Yu-Hsuan Tseng, Chuen-Huei Liu, Chun-Yang Lee, Nai-Chi Chiu, Chien-Wei Su
Summary: This article presents a rare but potentially life-threatening complication of acute pancreatitis - splenic artery pseudoaneurysm. The patient had mild symptoms on admission but experienced severe complications during hospitalization. Despite treatment with embolization and splenectomy, the patient eventually died from severe sepsis.
ADVANCES IN DIGESTIVE MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Chia-Chu Fu, Hao-Jan Lei, Lei-Chi Wang, Cheng-Yi Wei, Chien-Wei Su, Ming-Chih Hou, Yi-Hsiang Huang, Pei-Chang Lee
Summary: This case highlights the clinical significance of unusual extrahepatic metastases of HCC, especially for patients at an advanced stage of the tumor.
ADVANCES IN DIGESTIVE MEDICINE
(2022)