期刊
WORLD JOURNAL OF PEDIATRICS
卷 9, 期 4, 页码 293-299出版社
ZHEJIANG UNIV PRESS
DOI: 10.1007/s12519-013-0438-9
关键词
non-alcoholic fatty liver disease; obesity; type 2 diabetes mellitus
类别
资金
- American Heart Association (AHA) [13SDG14640038]
- Yale Center for Clinical Investigation (YCCI)
- Pediatric Endocrine Society (PES)
- CTSA from the National Center for Advancing Translational Science (NCATS), a component of the National Institutes of Health (NIH) [UL1 RR024139]
- NIH roadmap for Medical Research
Background: The increased prevalence of childhood obesity in the last few years has been accompanied by the increase in prevalence of type 2 diabetes in pediatrics. In this paper, we will review the risk factors and the pathogenic determinants leading to type 2 diabetes in youth. Data sources: We searched on PubMed with the key words: obesity, type 2 diabetes, children, adolescents, youth, non-alcoholic fatty liver disease, genes and selected those publications written in English that we judged to be relevant to the topic of the review. Results: Based on the data present in the literature, we reviewed the following three topics: 1) the role of ectopic fat deposition, in particular of fatty liver, in the pathogenesis of pediatric type 2 diabetes; 2) the progression to type 2 diabetes in pediatrics and how it differs from adults, and 3) current theraputic options. Conclusion: Type 2 diabetes in youth is a complex disease, creating new challenges in treatment and prevention.
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