Article
Medicine, General & Internal
Changqing Cao, Jinghua Wang, Yuning Li, Yumei Li, Liyan Ma, Mohamed E. A. Abdelrahim, Yi Zhu
Summary: OM-85 consumption is significantly associated with a lower frequency, total duration, incidence, number of antibiotic courses, and antibiotic use in respiratory tract infections. However, it is not significantly related to adverse events or wheezing attacks frequency. This indicates that OM-85 could be a valuable tool to improve immunity against recurrent respiratory tract infections, especially in critical situations like the COVID-19 pandemic.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Lei Fang, Liang Zhou, Michael Tamm, Michael Roth
Summary: OM-85 may reduce the risk of SARS-CoV-2 infection by modifying host cell membrane proteins and specific glycosaminoglycans.
Review
Endocrinology & Metabolism
Fabio Cardinale, Michele Fiore, Giorgio Piacentini, Alfonso Varricchio
Summary: This manuscript provides an overview of the clinical evidence on the efficacy and safety of bacterial lysates, particularly OM-85, in preventing recurrent respiratory infections in children. The study shows that OM-85 significantly reduces the number and duration of respiratory tract infections, antibiotic courses, and wheezing respiratory illnesses in young children. It is also effective and well-tolerated when used concurrently with inactivated influenza vaccine.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Respiratory System
Joon Young Choi, Yong Bum Park, Tai Joon An, Kwang Ha Yoo, Chin Kook Rhee
Summary: This study evaluated the clinical efficacy of Broncho-Vaxom (BV) in reducing the risk of exacerbations in chronic obstructive pulmonary disease (COPD) patients. The results showed that the use of BV was associated with fewer moderate and moderate-to-severe exacerbations, and also delayed the occurrence of moderate COPD exacerbations.
BMC PULMONARY MEDICINE
(2023)
Article
Immunology
Susanna Esposito, Stefania Ballarini, Alberto Argentiero, Luca Ruggiero, Giovanni A. Rossi, Nicola Principi
Summary: This study describes the microbiota profiles in pre-school children with recurrent respiratory tract infections (rRTIs) and investigates the potential influencing factors. The study also evaluates the changes in microbiota associated with the treatment of OM-85 oral bacterial lysate. The findings suggest that there are differences in microbiota composition in gut and nasopharynx samples, and some changes occur during the treatment process.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Susanna Esposito, Michele Cassano, Renato Cutrera, Francesco Menzella, Alfonso Varricchio, Marzio Uberti
Summary: Prevention is unanimously recognized as the most important intervention to reduce the disease burden of recurrent respiratory infections in adults and children. The use of immunomodulation to enhance the effectiveness of vaccines, with OM-85 being a valuable tool in optimizing the management of such infections, is gaining increasing favor among clinicians. The combined use of OM-85 and influenza vaccine is seen as an effective and safe approach to improve current prevention strategies and reduce the burden of recurrent respiratory infections.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Respiratory System
Jefferson Antonio Buendia, Diana Guerrero Patino, Erika Fernanda Lindarte
Summary: This study evaluated the cost-utility of OM-85 BV in reducing recurrent respiratory tract infections in children using a decision tree model. The results showed that OM-85 BV is a cost-effective strategy for reducing the incidence of recurrent respiratory tract infections in children.
BMC PULMONARY MEDICINE
(2022)
Article
Immunology
Daphne Peeters, Pieter Verhulst, Anja A. P. H. Vaessen-Verberne, Xandra W. van den Tweel, Jeroen G. Noordzij, Gertjan J. A. Driessen
Summary: The study found that 64% of children presenting with recurrent respiratory tract infections in general pediatric practice had no detectable underlying pathology. Common diagnoses included asthma/preschool wheezing and adenoid hypertrophy, with none of the children having severe primary immunodeficiency or pulmonary illnesses such as cystic fibrosis. These findings can help guide pediatricians in diagnosing children with respiratory tract infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Pediatrics
Imran Khan Laghari, Tahira Nawaz, Sultan Mustafa, Abid Ali Jamali, Sanober Fatima
Summary: Respiratory tract infections, especially pneumonia, are one of the most common infections in the pediatric population worldwide. Probiotics, which are live microorganisms that provide health benefits to the host when administered in adequate amounts, are thought to modulate the immune system and potentially prevent respiratory tract infections. This study aimed to investigate the effectiveness of probiotics in reducing the severity and frequency of recurrent respiratory tract infections.
Article
Pharmacology & Pharmacy
Pietro Gareri, Caterina Trevisan, Angela Marie Abbatecola, Alba Malara, Raffaele Antonelli Incalzi
Summary: This study suggests that the bacterial lysates product OM-85 may have potential efficacy in preventing acute respiratory tract infections in older individuals.
REVIEWS ON RECENT CLINICAL TRIALS
(2023)
Review
Endocrinology & Metabolism
G. L. Marseglia, M. Benazzo, P. Biasci, F. Blasi, C. Cricelli, M. Doria, S. Leonardi, D. G. Peroni, F. Scaglione, G. Ciprandi
Summary: Respiratory infections are a significant burden, and immune response defects may lead to their recurrence; OM-85 bacterial lysate is considered a valuable option in managing recurrent respiratory infections, enhancing immune response to prevent infections, reduce COPD exacerbations, and shorten disease duration.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Immunology
Krist Helen Antunes, Gisele Cassao, Leonardo Duarte Santos, Sofia Giacomet Borges, Juliana Poppe, Joao Budelon Goncalves, Eduarda da Silva Nunes, Guilherme Fernando Recacho, Vitoria Barbosa Sousa, Gabriela Souza Da Silva, Daniel Mansur, Renato T. Stein, Christian Pasquali, Ana Paula Duarte De Souza
Summary: This study demonstrates that airway administration of OM-85 in mice can prevent RSV-induced disease and reduce lung inflammation. The protective effects are dose and time-dependent, with complete protection achieved using four doses of 1mg OM-85 via intranasal delivery. OM-85 improves antiviral response and maintains immune balance to achieve protection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Kenichiro Takahashi, Tsuguto Fujimoto, Nozomu Hanaoka, Mariko Tamura, Yoko Suzuki, Shigetaka Sugihara
Summary: This study aims to investigate the usefulness of clinical manifestations in deciding the use of adenovirus IC kits for children with upper respiratory infections (URI). The study found that when patients lack the clinical manifestations of fever, rhinorrhea, and tonsillar exudate, the results of adenovirus IC kits are often negative.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Pediatrics
Stefania Ballarini, Ledit Ardusso, Jose Antonio Ortega Martell, Oliviero Sacco, Wojciech Feleszko, Giovanni A. Rossi
Summary: Respiratory tract infections (RTI) are a common childhood illness caused by viruses. Current preventive measures and treatments have limited effectiveness in managing associated wheezing illness and asthma. However, early-life exposure to microbes has been shown to enhance the immune response and reduce the risk of infectious and allergic disorders. Bacterial lysates (BLs) acting on gut microbiota have shown promise in preventing recurrent RTIs and wheezing. OM-85, a product studied extensively in vitro, animal, and human cell studies, has shown potential immune training-based activities against respiratory viruses.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Lu Zhang, Xuqiong Wang, Dong Wang, Yinling Guo, Xinying Zhou, Haiyan Yu
Summary: This study demonstrated that adjuvant YPFG therapy can improve clinical response rate and increase serum immunoglobulin levels while decreasing TNF-alpha level in children with recurrent respiratory tract infections.
FRONTIERS IN PEDIATRICS
(2022)