Article
Environmental Sciences
Fei Zhou, Leiming Wang, Han Ge, Diancai Zhang, Weizhi Wang
Summary: This study revealed that CD109 plays a crucial role in 5-FU resistance in gastric cancer cells by activating the JNK/MAPK signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Retraction
Cell Biology
Dong-Mei Wu, Shan Wang, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu, Gui-Quan Chen, Yuan-Lin Zheng
Summary: The study was retracted due to significant flaws and inconsistencies between the results presented and the experimental methods described, leading to the invalidity of the conclusions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingjing Liu, Qi Zhang, Jiyu Wang, Changli Wang, Tian Lan, Tianyi Wang, Bing Wang
Summary: Knockdown of BAP31 in colorectal cancer cells enhances chemosensitivity to 5-FU and reduces stemness, potentially through the inhibition of the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jiazhen Wu, Yuxuan Gan, Huijuan Luo, Nan Xu, Liping Chen, Mengyao Li, Fengkun Guan, Ziren Su, Zhixiu Lin, Jianhui Xie, Yuhong Liu
Summary: The study found that beta-patchoulene can significantly improve symptoms of intestinal mucositis, mainly by improving water transport and mucus barrier to alleviate diarrhea.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Article
Biotechnology & Applied Microbiology
Gahyeon Ryu, Gi Bae Kim, Taeho Yu, Sang Yup Lee
Summary: The establishment of a bio-based circular economy is crucial for addressing the climate crisis and promoting sustainable development. Designing metabolic pathways for microbial cell factories is essential, and computer-supported tools and deep learning techniques can aid in pathway prediction and enzyme discovery. Leveraging these computational tools and strategies, particularly the capabilities of deep learning, has the potential to accelerate the advent of a bio-based circular economy.
METABOLIC ENGINEERING
(2023)
Article
Integrative & Complementary Medicine
Sun Lei-Tao, Zhang Le-Yin, Shan Fei-Yu, Shen Min-He, Ruan Shan-Ming
Summary: This study found that Jiedu Sangen decoction (JSD) may reverse 5-fluorouracil (5-FU) resistance by suppressing the PI3K/AKT/HIF-1 alpha signaling pathway, inhibiting glycolysis and inducing apoptosis, thereby enhancing anti-tumor activity.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Ivan Ponce, Nelson Garrido, Nicolas Tobar, Francisco Melo, Patricio C. Smith, Jorge Martinez
Summary: The research revealed that increased tissue stiffness stimulates lactate production and glucose uptake by mammary fibroblasts, which is correlated with the expression of specific proteins. Additionally, mammary stromal cells cultured on stiff matrices generated factors that stimulated epithelial breast migration.
Article
Biotechnology & Applied Microbiology
Zhengyi Ruan, Lili Lu, Li Zhang, Min Dong
Summary: miR-181c regulates MEST, affecting ovarian cancer cells' resistance to DDP via the Wnt/beta-catenin signaling pathway.
CANCER GENE THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Fahima Danesh Pouya, Maria Gazouli, Yousef Rasmi, Dimitra Ioanna Lampropoulou, Mohadeseh Nemati
Summary: Colorectal cancer is a common cancer, and drug resistance is a major cause of chemotherapy failure and disease recurrence. Many studies have identified mechanisms that contribute to chemoresistance in colorectal cancer, and microRNAs may serve as potential therapeutic targets or biomarkers for predicting drug response.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma, Lingyu Zhao
Summary: This study demonstrates that MeCP2 confers 5-FU resistance in gastric cancer cells by upregulating the NOX4/PKM2 pathway. Knockdown of MeCP2 enhances the sensitivity of cells to 5-FU, and silencing NOX4 can rescue the inductive effect of MeCP2 overexpression on 5-FU sensitivity. In vivo experiments also show that MeCP2 knockdown enhances 5-FU sensitivity in tumors.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Xiao-Xue Qiao, Hui-Bo Shi, Li Xiao
Summary: miR-653 acts as a tumor suppressor in CRC progression, and serum exosomal hsa-circ-0004771 may serve as a predictive biomarker for 5-FU resistance in CRC patients, potentially through the miR-653/ZEB2 axis.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Xingui Wu, Ruyuan Yu, Meisongzhu Yang, Yameng Hu, Miaoling Tang, Shuxia Zhang, Ainiwaerjiang Abudourousuli, Xincheng Li, Ziwen Li, Xinyi Liao, Yingru Xu, Man Li, Suwen Chen, Wanying Qian, Rongni Feng, Jun Li, Fenjie Li
Summary: The study reveals that metabolic pathways are disordered in pancreatic cancer and identifies key gene modules associated with the progression of pancreatic cancer. Furthermore, the study confirms the correlation between pancreatic cancer stages, M2 macrophages, and glutathione peroxidase 2 (GPX2).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marwa M. M. Refaie, Sayed Shehata, Asmaa M. A. Bayoumi, Nashwa Fathy Gamal El-Tahawy, Walaa Yehia Abdelzaher
Summary: The study demonstrated that FEN reversed 5FU-induced cardiotoxicity through various mechanisms, including upregulation of PPAR alpha, inhibition of the IL-6/STAT signaling pathway, and possessing anti-inflammatory, antiapoptotic, and antioxidant properties.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Medicine, Research & Experimental
Yue Zhang, Mengxian Sun, Dongwei Wang, Yaju Hu, Ruonan Wang, Hongtao Diao, Xiaoqi Shao, Yun Li, Xu Li, Mingyang Leng, Lexun Wang, Meiling Yan, Xianglu Rong, Jiao Guo
Summary: This study demonstrated that FTZ can alleviate cardiac hypertrophy in both animal and cell models. The mechanism underlying this protective effect is through the regulation of the miR-214-SIRT3 axis. These findings suggest that FTZ may be a potential therapeutic target for cardiac hypertrophy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Surgery
Menghua Dai, Qiaofei Liu, Cheng Xing, Xiaodong Tian, Feng Cao, Wenbo Tang, Shaocheng Lv, Yongsu Ma, Dongxin Zhang, Jorg Kleeff, Yinmo Yang, Rong Liu, Qiang He, Fei Li, Guangming Li, Junchao Guo, Quan Liao, Yupei Zhao
Summary: The study found that early drain removal did not significantly decrease the incidence of grade 2-4 complications for patients undergoing pancreaticoduodenectomy with low or intermediate risk. There were no significant differences between the two groups in terms of comprehensive complication index, B/C grade pancreatic fistula incidence, total medical expenses, and postoperative in-hospital stay.
Editorial Material
Oncology
Wenjing Zhao, Yupei Zhao
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Wenjing Zhao, Shanglong Liu, Lin Cong, Yupei Zhao
Summary: The study identified that the enhanced solid component/MN and an MPD diameter of 10 mm or greater are the most important predictors for predicting HGD/malignancy in BD-IPMN. These features should be considered as indications for surgery.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
Guangyu Chen, Junyu Long, Ruizhe Zhu, Gang Yang, Jiangdong Qiu, Fangyu Zhao, Yuezhe Liu, Jinxin Tao, Taiping Zhang, Yupei Zhao
Summary: This study developed and validated a prognostic signature for pancreatic cancer patients using RNA-seq and DNA methylation expression data, identifying nine DNA methylation-driven genes associated with overall survival. A predictive signature was established and patients were stratified based on risk scores, showing significantly favorable survival outcomes in the low-risk group. Furthermore, a nomogram incorporating clinical variables was developed for predicting individualized prognosis of PC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiqun Xing, Haiyan Ding, Bo Hou, Zhixin Hao, Ya Hu, Wenjia Zhu, Sayuan Liang, Feng Feng, Fang Li, Yupei Zhao, Li Huo
Summary: This study compared the performance of F-18-FDG PET/MRI and PET/CT in the clinical evaluation of pancreatic neoplasms. The results showed that both PET/MRI and PET/CT had comparable overall performance in identifying pancreatic neoplasms. However, PET/MRI showed better performance for patients with suspected pancreatic neoplasms but no visible FDG uptake on PET/CT.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Review
Microbiology
Yuan Fang, Gang Yang, Jinshou Yang, Jie Ren, Lei You, Yupei Zhao
Summary: Pancreatic ductal adenocarcinoma is associated with the human microbiota, which can serve as a biomarker for early diagnosis and risk assessment, as well as a target for intervention to improve treatment efficacy.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Tengfei Meng, Hongjin Shi, Feng Ao, Peng Wang, Longyao Wang, Lan Wang, Yujun Zhu, Yunxiang Lu, Yupei Zhao
Summary: With the increasing utilization of clean energy, the development and utilization of hydrogen energy has become a research topic of great significance. In this study, a nitrogen-doped biomass carbon (1NC@3)-based composite cobalt selenide (CS) heterojunction was prepared using kelp as the raw material. The electrochemical performance of the CS/1NC@3 catalyst in oxygen evolution reaction (OER) was evaluated and showed promising results, with a low overpotential and enhanced charge transport speed.
Article
Chemistry, Inorganic & Nuclear
Cheng-Peng Zhang, Yu-Jun Zhu, Danfeng Wang, Junfeng Qian, Yu-Pei Zhao, Cheng Lian, Zhi-Hui Zhang, Ming-Yang He, Sheng-Chun Chen, Qun Chen
Summary: By investigating the ligand effect of coordination polymers (CPs), it was found that secondary ligands can regulate the stability and catalytic performance of CPs, playing an important role in oxidative cross-coupling reactions.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Li-Xin Chi, Ntampaka D. Clarisse, Song Yang, Wen-Li Bao, Mi Xiao, Yu-Pei Zhao, Jing-Tang Wang, Qun Chen, Zhi-Hui Zhang
Summary: The utilization of solar energy to decompose water and produce hydrogen is an important strategy to solve ecological and energy crises. CdS-modified Metal-Organic Frameworks (MOFs) composites Zn(L-For)-MOF/CdS with high photocatalytic performance for hydrogen production were successfully prepared. The Zn(L-For)-MOF/CdS (4:1) material exhibited excellent hydrogen evolution performance with a high hydrogen yield of 267.6 mu mol/h.
JOURNAL OF SOLID STATE CHEMISTRY
(2023)
Article
Chemistry, Organic
Feng Jiang, Tengfei Meng, Ying Zhou, Zhenying Xiong, Yupei Zhao, Wengang Guo
Summary: We report an enantio- and diastereodivergent synthesis of enantioenriched fluorenes with broad substrate scope and high enantioselectivity (up to 99% ee) under low catalyst loading (0.1 mol %). The success of this method lies in the pseudo-diastereodivergent desymmetrization of stereoisomers of meso-epoxides enabled by the same organocatalyst. Furthermore, some of the chiral fluorenes obtained exhibit high fluorescence quantum yields (up to 76.6%), as evidenced by photophysical properties studies.
Article
Chemistry, Multidisciplinary
Xin Yue, Ying Zhou, Yan Zhang, Tengfei Meng, Yupei Zhao, Wengang Guo
Summary: In this study, we have developed a sequential visible-light-promoted Wolff rearrangement of 1-diazonaphthalen-2(1H)-ones, followed by capturing the in situ generated ketene intermediates with various alcohols, resulting in diverse 1H-indene-3-carboxylates in moderate to good yields under mild reaction conditions. The broad substrate scope, high functional group tolerance, and robust conditions make the resulting derivative a versatile platform for the synthesis of numerous bioactive molecules.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Rexiati Ruze, Jianlu Song, Xinpeng Yin, Yuan Chen, Ruiyuan Xu, Chengcheng Wang, Yupei Zhao
Summary: Research on obesity- and diabetes mellitus (DM)-related carcinogenesis has grown rapidly due to the increasing prevalence of obesity and DM, which have been recognized as important risk factors for cancer. The complex process of obesity and DM promoting pancreatic carcinogenesis involves their local impact on the pancreas and systemic changes that favor cancer initiation. Mechanisms include the excessive accumulation of nutrients and metabolites, impairments in gastrointestinal and sex hormone levels, microbiome dysfunction, and the establishment of an immunosuppressive tumor microenvironment. This review analyzes the immunometabolic mechanisms of obesity- and DM-related pancreatic carcinogenesis and discusses how metabolic disorders affect anticancer immunity and promote cancer initiation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Oncology
Shaobo Chen, Xianming Hou, Surong Hua, Ziwen Liu, Binglu Li, Xiaoyi Li, Lin Cong, Quan Liao, Jugao Fang, Lizhen Hou, Shanghua Jing, Zhen Zhao, Jianwu Qin, Songtao Zhang, Zhendong Li, Dongning Huang, Ning Zhang, Yongfu Zhao, Jun Liu, Shujun Wang, Ge Chen, Yupei Zhao
Summary: The study developed a novel tracer called MHI, which can help surgeons identify and preserve parathyroid glands and detect more lymph nodes during thyroid surgery, proving to be a safe and effective technique.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Jonathan Sullivan, Yupei Zhao, Simon Chadwick, Michael Gow
Summary: Football in China is expanding rapidly, but little is known about Chinese football fans and their behaviors. This study conducted an online survey and found similarities between Chinese football fans and fans elsewhere in the world, but also identified differences resulting from the characteristics of China's domestic football infrastructure. Additionally, it was found that football fans in China tend to support more than one club and consume football in non-traditional ways.
JOURNAL OF GLOBAL SPORT MANAGEMENT
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Yue Meng-Lewis, Donna Wong, Yupei Zhao, Gavin Lewis
Summary: This study investigates the career development process of 35 esports athletes from 16 professional esports clubs in China, showing that traditional career theories may not effectively capture the complex and dynamic nature of esports careers. The authors suggest that Chaos Theory in Careers (CTC) could offer better explanations for the characteristics of esports careers.
SPORT MANAGEMENT REVIEW
(2022)
