Article
Gastroenterology & Hepatology
Sanchit Sharma, Samagra Agarwal, Deepak Madhu, Randeep Rana, Anany Gupta, Srikanth Gopi, Deepak Gunjan, Anoop Saraya
Summary: This study compared the long-term outcomes of patients with cirrhosis with gastric variceal bleeding and esophageal variceal bleeding. It found that rebleeding was more predominant in patients with gastric variceal bleeding, while ascites was the most significant event in patients with esophageal variceal bleeding.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Cardiac & Cardiovascular Systems
Niuniu Li, Qiang Wu, Juan Meng, Cheng Feng, Siwei Jiang, Meixia Chen, Wenhui Xu, Fei Wang, Yifan Zhang, Juncai Liu, Cheng Xu, Gaolin Liu, Hong Gao
Summary: This article discusses a case of targeted therapy for pulmonary arterial hypertension in portopulmonary hypertension. The use of macitentan in a patient with CLF, PoPH, and HPS resulted in improved symptoms and no hepatic safety concerns. This suggests that administering macitentan may be a safe and effective treatment option for patients diagnosed with PoPH (with CLF and HPS).
Review
Gastroenterology & Hepatology
Yong Lv, Daiming Fan, Guohong Han
Summary: Liver diseases, especially viral hepatitis, have a major impact in China and globally. Portal hypertension is the most severe complication of chronic liver diseases, and TIPS is an effective treatment for these complications. This review focuses on the history, current application, and management of TIPS complications in China.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Raffaele Bruno, Calogero Camma, Paolo Caraceni, Gennaro D'Amico, Ignazio Grattagliano, Vincenzo La Mura, Oliviero Riggio, Filippo Schepis, Marco Senzolo, Paolo Angeli, Roberto de Franchis
Summary: This article discusses the importance of portal hypertension and ascites in the natural history of liver cirrhosis and the need for updated guidance on clinical management. The committee conducted a systematic review of the literature to determine relevant evidence and identified key questions for the guidelines based on the PICO format.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Alexander Queck, Louise Schwierz, Wenyi Gu, Philip G. Ferstl, Christian Jansen, Frank E. Uschner, Michael Praktiknjo, Johannes Chang, Maximilian J. Brol, Filippo Schepis, Manuela Merli, Christian P. Strassburg, Jennifer Lehmann, Carsten Meyer, Jonel Trebicka
Summary: This study investigated the efficacy of transjugular intrahepatic portosystemic shunt insertion (TIPS) in patients with refractory or recurrent ascites. The results showed that the extent of portal hepatic pressure gradient (PPG) reduction after TIPS was associated with short-term ascites control and long-term survival.
Review
Medicine, General & Internal
Maxime Fauter, Geoffrey Rossi, Ayoub Drissi-Bakhkhat, Marianne Latournerie, Mathieu Gerfaud-Valentin, Isabelle Durieu, Yvan Jamilloux, Francois Bailly, Matthieu Mahevas, Pascal Seve
Summary: This study retrospectively analyzed the clinical characteristics, treatment methods, and outcomes of patients with hepatic sarcoidosis and symptomatic portal hypertension. The results showed that symptomatic portal hypertension is a severe complication of hepatic sarcoidosis with poor response to specific treatments. Early management and detection of hepatic comorbidities are crucial.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Hiroshi Yoshida, Tetsuya Shimizu, Masato Yoshioka, Nobuhiko Taniai
Summary: Portal hypertension is most commonly caused by chronic liver disease, leading to increased portal pressure and changes in portal system hemodynamics. In chronic liver disease, increased intrahepatic vascular resistance requires sufficient portal hypertension to maintain portal flow into the liver. Splanchnic and systemic arterial vasodilatations increase blood flow into the portal venous system, resulting in portal hypertension and collateral formation.
HEPATOLOGY RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Bogdan Dumitru Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Luis Ibanez, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nouria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Helene Larrue, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Remy Schwarzer, Christian Jansen, Marie-Angele Robic, Irene Conejo, Javier Martinez Gonzalez, Maria Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Georgina Casanovas, Jaume Bosch, Juan-Carlos Garcia-Pagan, Dominique Thabut
Summary: pTIPS is more effective in improving survival compared to endoscopic treatment for high-risk patients with cirrhosis and variceal bleeding. HE at admission does not affect the efficacy of pTIPS.
Article
Gastroenterology & Hepatology
Elliot B. Tapper, Zhe Zhao, G. Scott Winder, Neehar D. Parikh
Summary: Deprescribing benzodiazepines in patients with cirrhosis may reduce the risk of falls and fractures but does not improve survival or liver health.
Review
Radiology, Nuclear Medicine & Medical Imaging
Hitoshi Maruyama, Shuichiro Shiina
Summary: Portal hypertension is a key pathophysiology of chronic liver diseases, with the development of collaterals affecting portal venous circulation and liver blood flow balance. The development of collaterals is related to liver function reserve and clinical presentations such as esophageal varices and gastric varices.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Medicine, General & Internal
Ying-Hao Chang, Xiao-Lei Zhou, Dan Jing, Zhen Ni, Shan-Hong Tang
Summary: IPSVS is a rare hepatic disease with varying clinical manifestations, causing complications such as hepatic encephalopathy in severe cases. Management options should be carefully considered for patients with severe portal hypertension due to the risk of hemorrhage. In this case, the patient only received symptomatic treatment and did not experience recurrence of hepatic encephalopathy during a 1-year follow-up.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Gastroenterology & Hepatology
Ki Tae Yoon, Hongqun Liu, Samuel S. Lee
Summary: NSBB therapy in cirrhotic patients is effective in preventing bleeding, but may have detrimental effects in decompensated cirrhosis. While some studies suggest harmful effects of NSBBs, overall, using beta-blockers in cirrhosis seems to outweigh the risks and provide more benefits.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ayako Sato, Sho Watanabe, Mari Iseki, Yurina Yamada, Ryohei Kobayashi, Makoto Furuya, Katsuhiro Arai, Eri Ohshina, Yoshihiro Tashiro, Takahito Nozaka, Mana Matsuoka, Masato Yauchi, Katsumasa Kobayashi, Taichi Matsumoto, Yohei Furumoto, Toru Asano, Seishin Azuma
Summary: This study aimed to clarify the benefit of anticoagulation on mortality, liver function, and the incidence of liver cirrhosis-related complications in cirrhotic PVT patients. The results showed that anticoagulation significantly improved overall survival and reduced the size of thrombus. Furthermore, it decreased the incidence of complications such as ascites and encephalopathy. Therefore, anticoagulation is an effective and safe treatment for patients with PVT.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Caroline L. L. Matchett, Puru Rattan, Joseph P. P. McConnell, Leslie J. J. Donato, Douglas A. A. Simonetto, Patrick S. S. Kamath
Summary: The triglyceride (TG) threshold for diagnosis of chylous ascites in patients with portal hypertension remains uncertain. This retrospective analysis of lipoprotein electrophoresis on 286 ascites samples found that an ascitic TG level of >= 81 mg/dL has a sensitivity of 95.4% and specificity of 94.6% for the diagnosis of chylous ascites by the presence of significant chylomicron population.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Veeral Ajmera, Beom Kyung Kim, Kun Yang, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Natalie E. Quach, Xin Tu, Xinlian Zhang, Mazen Noureddin, Alina M. Allen, Rohit Loomba
Summary: Liver stiffness assessed by magnetic resonance elastography (MRE) is associated with liver-related events, and the combination of MRE and Fibrosis-4 has excellent negative predictive value for hepatic decompensation.
