☆ 4.6 Article

Genetic polymorphism in pathogenesis of irritable bowel syndrome

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

期刊

WORLD JOURNAL OF GASTROENTEROLOGY

卷 20, 期 47, 页码 17693-17698

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BAISHIDENG PUBLISHING GROUP INC

DOI: 10.3748/wjg.v20.i47.17693

关键词

Irritable bowel syndrome; Genetic polymorphism; Cytokines; Serotonin; Psychiatric distress; Endocannabinoids

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Gastroenterology & Hepatology

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摘要

Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3 mo according to ROME III: relief by defecation, onset associated with a change in stool frequency or onset with change in appearance or form of stool. Recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms, as well as the therapeutic responses in treating IBS patients. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

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Olagunju, Babayemi Oluwaseun Olakunde, Mojisola Morenike Oluwasanu, Emad Omar, Ahmed Omar Bali, Sokking Ong, Obinna E. Onwujekwe, Doris Ortega-Altamirano, Nikita Otstavnov, Stanislav S. Otstavnov, Bilcha Oumer, Mayowa O. Owolabi, P. A. Mahesh, Alicia Padron-Monedero, Jagadish Rao Padubidri, Keyvan Pakshir, Adrian Pana, Anamika Pandey, Shahina Pardhan, Fatemeh Pashazadeh Kan, Maja Pasovic, Jenil R. Patel, Siddhartha Pati, Sanjay M. Pattanshetty, Uttam Paudel, Renato B. Pereira, Mario F. P. Peres, Arokiasamy Perianayagam, Maarten J. Postma, Hadi Pourjafar, Akram Pourshams, Akila Prashant, Thejodhar Pulakunta, Mirza Muhammad Fahd Fahd Qadir, Mohammad Rabiee, Navid Rabiee, Amir Radfar, Raghu Anekal Radhakrishnan, Ata Rafiee, Alireza Rafiei, Sima Rafiei, Fakher Rahim, Shadi Rahimzadeh, Mosiur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Aashish Rajesh, Vajiheh Ramezani-Doroh, Kamal Ranabhat, Priyanga Ranasinghe, Chythra R. Rao, Sowmya J. Rao, Sina Rashedi, Mohammad-Mahdi Rashidi, Goura Kishor Rath, David Laith Rawaf, Salman Rawaf, Lal Rawal, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Misganu Teshoma Regasa, Andre M. N. Renzaho, Maryam Rezaei, Nima Rezaei, Mohsen Rezaeian, Aziz Rezapour, Sahba Rezazadeh-Khadem, Abanoub Riad, Ligia Estefania Rios Lopez, Jefferson Antonio Buendia Rodriguez, Luca Ronfani, Gholamreza Roshandel, Godfrey M. Rwegerera, Maha Mohamed Saber-Ayad, Siamak Sabour, Basema Saddik, Erfan Sadeghi, Saeid Sadeghian, Umar Saeed, Amirhossein Sahebkar, K. M. Saif-Ur-Rahman, S. Mohammad Sajadi, Sarvenaz Salahi, Sana Salehi, Marwa Rashad Salem, Hamideh Salimzadeh, Abdallah M. Samy, Juan Sanabria, Francesco Sanmarchi, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Susan M. Sawyer, Mete Saylan, Ione Jayce Ceola Schneider, Abdul-Aziz Seidu, Mario Sekerija, Endalew Gemechu Sendo, Sadaf G. Sepanlou, Allen Seylani, Kenbon Seyoum, Feng Sha, Omid Shafaat, Masood Ali Shaikh, Erfan Shamsoddin, Mohammed Shannawaz, Rajesh Sharma, Sara Sheikhbahaei, Adithi Shetty, B. Suresh Kumar Shetty, Pavanchand H. Shetty, Jae Il Shin, Reza Shirkoohi, K. M. Shivakumar, Parnian Shobeiri, Soraya Siabani, Migbar Mekonnen Sibhat, Sudeep K. Siddappa Malleshappa, Negussie Boti Sidemo, Diego Augusto Santos Silva, Guilherme Silva Julian, Achintya Dinesh Singh, Jasvinder A. Singh, Jitendra Kumar Singh, Surjit Singh, Abiy H. Sinke, Yitagesu Sintayehu, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Lee Smith, Ahmad Sofi-Mahmudi, Mohammad Sadegh Soltani-Zangbar, Suhang Song, Emma Elizabeth Spurlock, Paschalis Steiropoulos, Kurt Straif, Ranjeeta Subedi, Mu'awiyyah Babale Sufiyan, Rizwan Suliankatchi Abdulkader, Saima Sultana, Viktoria Szerencses, Miklos Szocska, Seidamir Pasha Tabaeian, Rafael Tabaras-Seisdedos, Mohammadreza Tabary, Takahiro Tabuchi, Hooman Tadbiri, Majid Taheri, Amir Taherkhani, Ken Takahashi, Mircea Tampa, Ker-Kan Tan, Vivian Y. Tat, Ahmad Tavakoli, Abdelghani Tbakhi, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Fisaha Haile Tesfay, Bekele Tesfaye, Jarnail Singh Thakur, Rekha Thapar, Aravind Thavamani, Arulmani Thiyagarajan, Nihal Thomas, Ruoyan Tobe-Gai, Munkhsaikhan Togtmol, Seyed Abolfazl Tohidast, Hamid Reza Tohidinik, Musliu Adetola Tolani, Daniel Nigusse Tollosa, Mathilde Touvier, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Mai Thi Ngoc Tran, Jaya Prasad Tripathy, Biruk Shalmeno Tusa, Gebresilasea Gendisha Ukke, Irfan Ullah, Saif Ullah, Krishna Kishore Umapathi, Bhaskaran Unnikrishnan, Era Upadhyay, Tolassa Wakayo Ushula, Marco Vacante, Sahel Valadan Tahbaz, Shoban Babu Varthya, Massimiliano Veroux, Paul J. Villeneuve, Francesco S. Violante, Vasily Vlassov, Giang Thu Vu, Yasir Waheed, Ning Wang, Paul Ward, Adisu Birhanu Weldesenbet, Yi Feng Wen, Ronny Westerman, Andrea Sylvia Winkler, Befikadu Legesse Wubishet, Suowen Xu, Seyed Hossein Yahyazadeh Jabbari, Lin Yang, Sanni Yaya, Vahid Yazdi-Feyzabadi, Taklo Simeneh Yazie, Sisay Shewasinad Yehualashet, Alex Yeshaneh, Yigizie Yeshaw, Birhanu Wubale Yirdaw, Naohiro Yonemoto, Mustafa Z. Younis, Zabihollah Yousefi, Chuanhua Yu, Ismaeel Yunusa, Vesna Zadnik, Mazyar Zahir, Telma Zahirian Moghadam, Mohammad Zamani, Maryam Zamanian, Hamed Zandian, Fariba Zare, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Jianrong Zhang, Zhi-Jiang Zhang, Arash Ziapour, Mohammad Zoladl, Christopher J. L. Murray, Christina Fitzmaurice, Archie Bleyer, Nickhill Bhakta, Teferi Gebru Gebremeskel

Summary: This study provides comprehensive data on the burden of cancer among adolescents and young adults globally. The results show that in 2019, there were 1.19 million incident cancer cases and 396,000 cancer deaths among individuals aged 15-39 years worldwide. Cancer was the fourth leading cause of death and tenth leading cause of disability-adjusted life-years (DALYs) in this age group.

LANCET ONCOLOGY (2022)

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Review Emergency Medicine

WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections

Massimo Sartelli, Federico Coccolini, Yoram Kluger, Ervis Agastra, Fikri M. Abu-Zidan, Ashraf El Sayed Abbas, Luca Ansaloni, Abdulrashid Kayode Adesunkanmi, Goran Augustin, Miklosh Bala, Oussama Baraket, Walter L. Biffl, Marco Ceresoli, Elisabetta Cerutti, Osvaldo Chiara, Enrico Cicuttin, Massimo Chiarugi, Raul Coimbra, Daniela Corsi, Francesco Cortese, Yunfeng Cui, Dimitris Damaskos, Nicola de'Angelis, Samir Delibegovic, Zaza Demetrashvili, Belinda De Simone, Stijn W. de Jonge, Stefano Di Bella, Salomone Di Saverio, Therese M. Duane, Paola Fugazzola, Joseph M. Galante, Wagih Ghnnam, George Gkiokas, Carlos Augusto Gomes, Ewen A. Griffiths, Timothy C. Hardcastle, Andreas Hecker, Torsten Herzog, Aleksandar Karamarkovic, Vladimir Khokha, Peter K. Kim, Jae Il Kim, Andrew W. Kirkpatrick, Victor Kong, Renol M. Koshy, Kenji Inaba, Arda Isik, Rao Ivatury, Francesco M. Labricciosa, Yeong Yeh Lee, Ari Leppaniemi, Andrey Litvin, Davide Luppi, Ronald V. Maier, Athanasios Marinis, Sanjay Marwah, Cristian Mesina, Ernest E. Moore, Frederick A. Moore, Ionut Negoi, Iyiade Olaoye, Carlos A. Ordonez, Mouaqit Ouadii, Andrew B. Peitzman, Gennaro Perrone, Tadeja Pintar, Giuseppe Pipitone, Mauro Podda, Kemal Rasa, Julival Ribeiro, Gabriel Rodrigues, Ines Rubio-Perez, Ibrahima Sall, Norio Sato, Robert G. Sawyer, Vishal G. Shelat, Michael Sugrue, Antonio Tarasconi, Matti Tolonen, Bruno Viaggi, Andrea Celotti, Claudio Casella, Leonardo Pagani, Sameer Dhingra, Gian Luca Baiocchi, Fausto Catena

Summary: Skin and soft-tissue infections (SSTIs) range from simple superficial infections to severe necrotizing infections. International multi-society collaboration aims to promote global standards of care in SSTIs by providing reasonable approaches to management. An extensive review of English literature led to the sharing of evidence by an international task force.

WORLD JOURNAL OF EMERGENCY SURGERY (2022)

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Article Medicine, General & Internal

Long-Term Outcomes and Prognostic Factors of Superficial Esophageal Cancer in Patients Aged ≥ 65 Years

Jin Won Chang, Da Hyun Jung, Cheal Wung Huh, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee

Summary: This study evaluated the clinical outcomes and prognostic factors of elderly patients undergoing endoscopic submucosal dissection or surgical resection for superficial esophageal cancer. The results identified cancer history of other organs, American Society of Anesthesiologists performance status, and presence of lymphovascular involvement as independent risk factors for poor overall survival. These risk factors could be useful in predicting the long-term prognosis of elderly patients with superficial esophageal cancer.

FRONTIERS IN MEDICINE (2022)

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Editorial Material Public, Environmental & Occupational Health

Editorial: Malnutrition: A Cause or a Consequence of Poverty?

Zheng Feei Ma, Chee Woon Wang, Yeong Yeh Lee

FRONTIERS IN PUBLIC HEALTH (2022)

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Review Gastroenterology & Hepatology

Asia-Pacific guidelines for managing functional dyspepsia overlapping with other gastrointestinal symptoms

Kok-Ann Gwee, Yeong Yeh Lee, Hidekazu Suzuki, Uday Chand Ghoshal, Gerald Holtmann, Tao Bai, Giovanni Barbara, Min-hu Chen, Andrew Seng Boon Chua, Peter R. Gibson, Xiaohua Hou, Jinsong Liu, Atsushi Nakajima, Nitesh Pratap, Sanjeev Sachdeva, Kewin Tien Ho Siah, Alex Yu Sen Soh, Kentaro Sugano, Jan Tack, Victoria Ping Yi Tan, Xudong Tang, Marjorie Walker, Deng-Chyang Wu, Ying-Lian Xiao, Khairil Khuzaini Zulkifli, Clarissa Toh

Summary: Contemporary systems categorize patients into sub-classes based on symptoms to enable targeted treatment, but overlapping symptom categories negatively impact outcomes, lacking guidance on management. An APAGE working group developed clinical practice guidelines for management of patients with functional dyspepsia (FD) who have overlaps with other functional gastrointestinal disorders. They identified putative pathophysiology and provided a management algorithm for primary and secondary care clinicians.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2023)

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Article Multidisciplinary Sciences

Development and validation of audio-based guided imagery and progressive muscle relaxation tools for functional bloating

Vincent Tee, Garry Kuan, Yee Cheng Kueh, Nurzulaikha Abdullah, Kamal Sabran, Nashrulhaq Tagiling, Nur-Fazimah Sahran, Tengku Ahmad Iskandar Tengku Alang, Yeong Yeh Lee

Summary: This study developed and validated audio-based guided imagery (GI) and progressive muscle relaxation (PMR) techniques for managing bloating. The tools were validated using psychometric and physiological approaches, showing effectiveness in relieving bloating symptoms.

PLOS ONE (2022)

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Review Biochemistry & Molecular Biology

A review on mechanobiology of cell adhesion networks in different stages of sporadic colorectal cancer to explain its tumorigenesis

Siti Hawa Ngalim, Norwahida Yusoff, Rayzel Renitha Johnson, Siti Razila Abdul Razak, Xinyue Chen, Jamie K. Hobbs, Yeong Yeh Lee

Summary: Sporadic colorectal cancer (CRC) is strongly linked to external factors such as poor diet and lifestyle, and various microbial and native cells in the colon contribute to its development. Cell adhesion networks play a crucial role in tumorigenesis and the progression of sporadic CRC stages.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2022)

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Article Multidisciplinary Sciences

Efficacy and safety of pre-gastroscopy commercial carbohydrate-rich whey protein beverage vs. plain water: a randomised controlled trial

Bee Chen Lua, Mohd Nizam Md Hashim, Mung Seong Wong, Yeong Yeh Lee, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Wan Zainira Wan Zain, Syed Hassan Syed Abd Aziz, Maya Mazuwin Yahya, Michael Pak-Kai Wong

Summary: The clinical benefits and safety of carbohydrate loading before gastroscopy are still unclear. This study found that a commercial carbohydrate-rich whey protein beverage resulted in higher gastric residual volume compared to plain water, but also improved well-being in terms of anxiety, hunger, and thirst. Both interventions were found to be safe.

SCIENTIFIC REPORTS (2022)

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Article Gastroenterology & Hepatology

Post COVID-19 irritable bowel syndrome

Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara

Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.

GUT (2023)

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Article Gastroenterology & Hepatology

A prospective comparison of UK and Malaysian patients with irritable bowel syndrome in secondary care

Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford

Summary: By comparing IBS patients from the UK and Malaysia, it was found that UK patients were more likely to consume alcohol, had more frequent symptoms such as pain, bloating, and meal-related issues, higher symptom scores, greater limitation of activities, and a higher likelihood of reporting abnormal anxiety. UK patients also had higher levels of perceived stress, gastrointestinal symptom-specific anxiety, and somatoform symptom-reporting.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2023)

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Review Gastroenterology & Hepatology

A Malaysian consensus report on the diagnosis and treatment of Helicobacter pylori infection

Khean-Lee Goh, Yeong Yeh Lee, Alex Hwong-Ruey Leow, Raja Affendi Raja Ali, Shiaw Hooi Ho, Sanjiv Mahadeva, Rosaida Hj Mohd Said, Raman Muthukaruppan Chettiar, Hoi Poh Tee

Summary: There are misconceptions in Malaysian clinical practice regarding the appropriate diagnostic method and treatment strategies for Helicobacter pylori infection. To address this, an expert panel of nine key opinion leaders in gastroenterology developed a set of consensus statements relevant to the Malaysian healthcare practice. The panel achieved consensus in three areas of H. pylori infection management: indications for testing, diagnosis, and treatment. They proposed 19 consensus statements, which can serve as a guide for physicians across various healthcare settings in Malaysia.

JGH OPEN (2023)

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Editorial Material Gastroenterology & Hepatology

Editorial: Recognising the regional variations in profile of irritable bowel syndrome-better late than never! Authors' reply

Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2023)

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Article Public, Environmental & Occupational Health

Dietary patterns associated with colorectal cancer risk in the Malaysian population: a case-control study with exploratory factor and regression analysis

Ainaa Almardhiyah Abd Rashid, Lydiatul Shima Ashari, Nor Hamizah Shafiee, Raja Affendi Raja Ali, Lee Yeong Yeh, Mohd Razif Shahril, Hamid Jan Jan Mohamed

Summary: A study in Malaysia found that the processed diet pattern, characterized by a high intake of confectionaries and fast foods, was associated with an increased risk of colorectal cancer. Further research is needed to understand the impact of different dietary patterns on the gut microbiota associated with colorectal cancer, in order to develop prevention measures through lifestyle changes.

BMC PUBLIC HEALTH (2023)

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Article Gastroenterology & Hepatology

Real-world practice of Helicobacter pylori management: A survey among physicians in Southeast Asia

Duc Trong Quach, Ratha-korn Vilaichone, Mai Ngoc Luu, Yeong Yeh Lee, Ang Tiing Leong, Muhammad Miftahussurur, Than Than Aye, Dewi Norwani Basir, Ky Vutha, Sengdao Vannarath, Jose D. Sollano, Varocha Mahachai

Summary: This study evaluates the real-world practice of H. pylori management in Southeast Asia and finds that multidrug-resistant strains are emerging in the region. It reveals that inappropriate regimens containing antibiotics with high resistance rates are not uncommon, especially among non-gastroenterologist physicians. Furthermore, there are significant issues with the conventional first-line treatment in countries with high clarithromycin resistance.

HELICOBACTER (2023)

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Review Biotechnology & Applied Microbiology

Efficacy and safety of nab-paclitaxel in metastatic gastric cancer: a meta-analysis

Suhana Ahmad, Lidawani Lambuk, Naveed Ahmed, Ali Mussa, Vincent Tee, Ros Akmal Mohd Idris, Nur Fazimah Sahran, Yean Yean Chan, Rosline Hassan, Yeong Yeh Lee, Rohimah Mohamud

Summary: Nab-paclitaxel demonstrates good efficacy and safety in the treatment of metastatic gastric cancer, providing better disease response and longer survival.

NANOMEDICINE (2023)

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