Review
Cell Biology
Jacek Baj, Alicja Forma, Monika Sitarz, Piero Portincasa, Gabriella Garruti, Danuta Krasowska, Ryszard Maciejewski
Summary: Gastric cancer is a prevalent malignancy worldwide and ranks as the fourth leading cause of cancer-related deaths. The pathogenesis of gastric cancer involves the interaction between genetic and environmental factors, with Helicobacter pylori infection playing a major role. Understanding the mechanisms of H. pylori pathogenicity is crucial for developing eradication strategies to prevent carcinogenesis.
Article
Gastroenterology & Hepatology
Sungil Jang, Lori M. Hansen, Hanfu Su, Jay Solnick, Jeong-Heon Cha
Summary: This study found that the number of cagA copies in Helicobacter pylori is higher in mice with less intense immune response and lower in mice with more intense immune response. Additionally, cagY recombination is also associated with H. pylori virulence.
Review
Biochemistry & Molecular Biology
Roghayeh Mohammadzadeh, Shaho Menbari, Abbas Pishdadian, Hadi Farsiani
Summary: Helicobacter pylori, a worldwide spread bacterium, co-evolves with humans and is responsible for intra-gastric and extra-gastric diseases. Through the production of virulence factors and immune evasion strategies, H. pylori becomes a prominent pathogenic bacterium. Understanding these factors can help predict infection severity and aid in the development of an effective vaccine.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2023)
Review
Microbiology
Lu Han, Xu Shu, Jian Wang
Summary: This review summarizes the oxidative stress response triggered by Helicobacter pylori (HP) in the gastric mucosa and the subsequent signaling pathways. The findings are expected to help in the formulation of new targeted drugs for preventing the occurrence of early gastric cancer and its progression to middle and advanced cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Bui Hoang Phuc, Vo Phuoc Tuan, Ho Dang Quy Dung, Tran Thanh Binh, Pham Huu Tung, Tran Dinh Tri, Ngo Phuong Minh Thuan, Vu Van Khien, Tran Thi Huyen Trang, Junko Akada, Takeshi Matsumoto, Yoshio Yamaoka
Summary: The acquisition of tfs3/4 ICE was common in H. pylori strains in patients with gastroduodenal disease in Vietnam, and the complete cluster of tfs3 ICE was a reliable marker for the severity of disease in the H. pylori infected population.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Aura M. Rodriguez, Daniel A. Urrea, Carlos F. Prada
Summary: Helicobacter pylori is a pathogenic bacteria that causes diseases in the human stomach, with high genetic diversity among strains observed in different geographic lineages. Analysis of virulence factor genetic variability in H. pylori strains can provide key information in understanding their pathogenic behavior.
Article
Gastroenterology & Hepatology
Ahmed Morad Asaad, Gasser El-Azab, Eman Abdelsameea, Osama Elbahr, Ahmed Kamal, Mohamed Abdel-Samiee, Ahmed Abdelfattah, Heba Abdallah, Doha Maher, Ahmed El-Refaie, Samar Ebrahim Ghanem, Shamshul Ansari, Samah Mohammed Awad
Summary: This study investigates H. pylori infection and resistance patterns in Egyptian patients, as well as the impact of H. pylori virulence genetic determinants on the success of 14-day triple therapy. The results show a low eradication rate with the triple therapy and high resistance to clarithromycin, amoxicillin, and metronidazole. Successful eradication is significantly associated with vacA s1-positive strains, while failed eradication is significantly associated with clarithromycin and amoxicillin-resistant strains.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Pediatrics
Cristian Dan Marginean, Cristina Oana Marginean, Lorena Elena Melit
Summary: It is well known that H. pylori infection can result in both gastrointestinal and extraintestinal manifestations. Early eradication of H. pylori may prevent the development of extraintestinal conditions. However, there are conflicting studies on the role of H. pylori in these conditions, highlighting the need for further research. Early diagnosis and treatment of H. pylori infection in childhood may be crucial in preventing associated inflammation and extraintestinal conditions.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Fernanda Gonzalez, Paula Diaz, Alejandra Sandoval-Borquez, Daniela Herrera, Andrew F. G. Quest
Summary: Extracellular vesicles are important in host-pathogen interactions, playing a role in modulating inflammatory responses and promoting disease development. Both EVs from cells infected with H. pylori and H. pylori-OMVs are involved in the development of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rosanna Capparelli, Domenico Iannelli
Summary: Genetic diversity plays a significant role in protection against Helicobacter pylori infection, and different Hp strains require different research approaches. Selecting genes from the same family and extending the analysis to metabolism enhance the reliability and effectiveness of the study. MyD88, TIRAP, and IL1RL1 have been shown to play a protective role against Hp infection in this combined approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Moyan Liu, Max Nieuwdorp, Willem M. de Vos, Elena Rampanelli
Summary: This review highlights the importance of tryptophan-derived metabolites in host physiology and summarizes their role in maintaining intestinal homeostasis and regulating immune and metabolic responses. Furthermore, it discusses the effects of microbial tryptophan catabolites on intestinal and extraintestinal disorders and their mechanisms of action.
Review
Immunology
Li Wang, Zheng-Min Cao, Li-Li Zhang, Xin-can Dai, Zhen-ju Liu, Yi-xian Zeng, Xin-Ye Li, Qing-Juan Wu, Wen-liang Lv
Summary: Through nearly 40 years of research, it has been found that Helicobacter pylori is associated with the natural history of many upper gastrointestinal diseases and may be associated with other types of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Prateek Sharma, Shravani M. Phatak, Prisha Warikoo, Akshita Mathur, Shweta Mahant, Kunal Das, Rajashree Das
Summary: Gastroduodenal diseases, especially those caused by Helicobacter pylori, have been prevalent for a long time. However, recent studies have started unraveling the role of other gut microbiota in these diseases and the complex relationship between H. pylori and gastrointestinal microbiota.
Article
Multidisciplinary Sciences
Rumiko Suzuki, Naruya Saitou, Osamu Matsuari, Seiji Shiota, Takashi Matsumoto, Junko Akada, Nagisa Kinjo, Fukunori Kinjo, Kuniko Teruya, Makiko Shimoji, Akino Shiroma, Mototsugu Kato, Kazuhito Satou, Takashi Hirano, Masahiro Asaka, Kirill Kryukov, Yoshan Moodley, Yoshio Yamaoka
Summary: Helicobacter pylori, a virulence bacterium, can be used as a marker for tracing human migration. This study identified indigenous H. pylori strains hspOkinawa and hpRyukyu in Okinawa, Japan and revealed their origin and divergence patterns.