Article
Gastroenterology & Hepatology
Philippe Mathurin
Summary: For severe alcoholic hepatitis patients not responding to medical therapy, postponing the decision to list for transplantation is harmful as there are no other therapeutic alternatives available. Early transplantation, with a strict selection process, has gained increasing support from experts globally, but there is still significant heterogeneity in its application across countries and even within the same country.
JOURNAL OF HEPATOLOGY
(2021)
Article
Microbiology
Nathan L. Meyers, Tal Ashuach, Danielle E. Lyons, Mir M. Khalid, Camille R. Simoneau, Ann L. Erickson, Mehdi Bouhaddou, Thong T. Nguyen, G. Renuka Kumar, Taha Y. Taha, Vaishaali Natarajan, Jody L. Baron, Norma Neff, Fabio Zanini, Tokameh Mahmoudi, Stephen R. Quake, Nevan J. Krogan, Stewart Cooper, Todd C. Mcdevitt, Nir Yosef, Melanie Ott
Summary: HCV infection can cause liver disease and increase the risk of cancer, but the underlying mechanisms are not well understood. This study identifies liver stem cells as novel targets for HCV infection and suggests that erroneous differentiation of these cells may contribute to impaired liver regeneration and cancer development.
Review
Virology
Aleksei Suslov, Markus H. Heim, Stefan Wieland
Summary: Infectious diseases cause significant human suffering and socioeconomic burden worldwide. Understanding the interactions between human pathogens and hosts is crucial for developing effective treatment strategies. However, there is a lack of model systems that accurately replicate these interactions. The tropism of hepatitis B (HBV) and C (HCV) viruses for the human liver poses challenges in studying their interactions during the natural progression of these infections. This review summarizes the efforts to advance our knowledge of virus-host interactions in chronic HCV and HBV infection through the analysis of surplus liver biopsy tissue donated by patients.
Review
Gastroenterology & Hepatology
Bhupinder Kaur, Russell Rosenblatt, Vinay Sundaram
Summary: Severe alcoholic hepatitis (sAH) is defined by certain criteria and is associated with immunocompromised state and increased risk of infections. This review discusses the common infections and risk factors in sAH patients, as well as the diagnostic, therapeutic, and prophylactic strategies currently used.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Lucija Virovic-Jukic, Dominik Ljubas, Sanja Stojsavljevic-Shapeski, Neven Ljubicic, Tajana Filipec Kanizaj, Ivana Mikolasevic, Ivica Grgurevic
Summary: Severe alcoholic hepatitis has limited treatment options and poor outcomes with current supportive medical care and corticosteroids. While new treatment options like granulocyte colony-stimulating factor and stem cell transplantation are being explored, evidence for their efficacy remains scarce and further research is needed. Insights into the pathogenesis of AH and liver regeneration processes are crucial for the development of new treatment options, but high-quality studies and reliable experimental models are lacking.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Hsiao-Sang Chu, Olivia J. Killeen, Yi-Ting Hsieh, Tung-Hung Su, H. Kaz Soong, Chung-Liang Shih, Fung-Rong Hu
Summary: This study aims to investigate the rationality of the allocation guidelines in a hepatitis B endemic area that uses corneas from hepatitis B donors. The results showed that allocating corneas from HBsAg(+) or anti-HBc(+) donors to HBsAg(+) or hepatitis B surface antibody recipients maximizes cornea usage from hepatitis B donors without compromising transplant safety.
Review
Gastroenterology & Hepatology
Philipp Kasper, Sonja Lang, Hans-Michael Steffen, Muenevver Demir
Summary: Alcohol-associated liver disease is a leading cause of liver-related mortality and a common reason for liver transplantation worldwide. The COVID-19 pandemic has resulted in increased rates of alcohol-associated hepatitis, highlighting the seriousness of this health problem. However, managing alcoholic hepatitis and its complications remains challenging in clinical practice.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Yang Wang, Jiaxi Li, Shanshan Wang, Yuheng Pang, Pengxiang Liu, Bangxiang Xie, Shuangshuang Dou, Tongwang Yang, Xiaoni Liu, Ying Shi, Dexi Chen
Summary: Hepatitis B virus (HBV) infection is a serious public health problem and studies on the pathogenesis of chronic hepatitis B (CHB) combined with nonalcoholic fatty liver disease (NAFLD) are needed. This study explored the correlation between HBV-related autophagy and the progression of NAFLD. The results showed that HBV promoted the occurrence of NAFLD and lipid droplet accumulation in hepatocytes. Furthermore, HBV-related autophagy was found to inhibit the decomposition of lipid droplets, leading to their accumulation in hepatocytes and promoting the progression of NAFLD.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Genetics & Heredity
Meritxell Llorens-Revull, Josep Gregori, Cristina Dopazo, Francisco Rodriguez-Frias, Damir Garcia-Cehic, Maria Eugenia Soria, Qian Chen, Ariadna Rando, Celia Perales, Juan Ignacio Esteban, Josep Quer, Itxarone Bilbao
Summary: Cirrhosis caused by chronic HCV infection is a common indication for liver transplantation, requiring prompt treatment with direct-acting antivirals (DAAs). Post-LT HCV reinfection patterns vary, and quasispecies complexity is not predictive of liver damage progression. Higher VL values post-LT, particularly at day 15, may predict fast liver fibrosis progression, independent of fibrosis stage.
Article
Gastroenterology & Hepatology
Naohiko Kinoshita, Toshihide Shima, Kei Terasaki, Hirohisa Oya, Takayuki Katayama, Junko Matsumoto, Yasuhide Mitsumoto, Masayuki Mizuno, Chiemi Mizuno, Rina Hirohashi, Kyoko Sakai, Takeshi Okanoue
Summary: This study compared the platelet counts between NAFLD and CLD-C patients and found that NAFLD patients had significantly higher platelet counts and smaller spleen volume in the liver fibrosis stage, indicating milder hypersplenism and higher platelet production in NAFLD than CLD-C.
HEPATOLOGY RESEARCH
(2022)
Review
Medicine, General & Internal
Muhammad Nauman Zahid
Summary: There is concern about using organs from HCV-positive donors for transplantation. However, direct-acting antiviral drugs have been proven to effectively treat Hepatitis C in transplant patients. This review will examine the impact of DAA treatments on transplants of different organs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Giacomo Germani, Debora Angrisani, Giovanni Addolorato, Manuela Merli, Chiara Mazzarelli, Claudia Tarli, Barbara Lattanzi, Adelaide Panariello, Paola Prandoni, Lucia Craxi, Giovanni Forza, Alessandra Feltrin, Andrea Ronzan, Paolo Feltracco, Antonio Grieco, Salvatore Agnes, Antonio Gasbarrini, Massimo Rossi, Luciano De Carlis, D'Amico Francesco, Umberto Cillo, Luca S. Belli, Patrizia Burra
Summary: This study assessed the outcomes of early liver transplantation (eLT) in patients with severe alcoholic hepatitis (sAH) and found that eLT significantly improved survival in non-responders to medical therapy, when a strict selection process was applied.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Jose Carlos Rodrigues Nascimento, Lianna C. Pereira, Juliana Magalhaes C. Rego, Ronaldo P. Dias, Paulo Goberlanio B. Silva, Silvio Alencar C. Sobrinho, Gustavo R. Coelho, Ivelise Regina C. Brasil, Edmilson F. Oliveira-Filho, James S. Owen, Pierluigi Toniutto, Reinaldo B. Oria
Summary: This study aimed to determine the impact of APOE alleles on outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation. The results suggest that the E4 allele may protect against progression of liver fibrosis and degree of inflammation in these patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Bianca Cerbu, Mirela Loredana Grigoras, Felix Bratosin, Iulia Bogdan, Cosmin Citu, Adrian Vasile Bota, Madalina Timircan, Melania Lavinia Bratu, Mihaela Codrina Levai, Iosif Marincu
Summary: This study investigates the impact of the COVID-19 virus on patients with cirrhosis and identifies laboratory serum tests that can predict the risk of acute-on-chronic liver failure (ACLF) and admission to the intensive care unit (ICU).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Brian P. Lee, Gene Y. Im, John P. Rice, Ann Lazar, Ethan Weinberg, Hyosun Han, Haripriya Maddur, R. Mark Ghobrial, George Therapondos, Christine Hsu, Oren K. Fix, Sheila Eswaran, Kirti Shetty, Jag Chhatwal, Ozden O. Dalgic, Neha Jakhete, Constance Mobley, David W. Victor, Neil Mehta, Lisanne Dinges, Mary Rinella, Thomas D. Schiano, Michael R. Lucey, Norah Terrault
Summary: Early liver transplantation for alcoholic hepatitis can save lives, but concerns about continued alcohol use exist. This study identified distinct patterns of alcohol use post-transplantation and found that early alcohol use was associated with higher risk of mortality at 3 and 5 years. Pre-transplant characteristics were associated with post-transplant alcohol use patterns, which can inform candidate selection and addiction care after transplantation.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ashwani K. Singal, Paul Kwo, Allison Kwong, Suthat Liangpunsakul, Alexandre Louvet, Pranoti Mandrekar, Craig McClain, Jessica Mellinger, Gyongyi Szabo, Norah Terrault, Mark Thursz, Gerald S. Winder, W. Ray Kim, Vijay H. Shah
Summary: ALD is becoming a major cause of liver-related mortality and transplantation globally. Research methodologies focused on diagnosing, treating, and predicting ALD and AH were discussed at the scientific sessions.
Article
Gastroenterology & Hepatology
Yousaf B. Hadi, Raja S. Khan, Dhairya A. Lakhani, Ali Y. Khan, Rida U. Jannat, Adnan Aman Khan, Syeda Fatima Naqvi, George Obeng, Justin T. Kupec, Ashwani K. Singal
Summary: This study aimed to investigate the effect of shorter antibiotic duration on patient outcomes in patients with cirrhosis and upper gastrointestinal bleeding. A retrospective study of 980 cirrhosis patients found that a short course of antibiotics (around 3 days) for prophylaxis is safe and sufficient in the absence of active infection.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Pradeep Yarra, Winston Dunn, Zobair Younossi, Yong-Fang Kuo, Ashwani K. Singal
Summary: This study found that previous RYGB in patients with AC is associated with increased likelihood of concomitant AH, hepatic encephalopathy, and infection, but similar in-hospital mortality.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Ashwani K. Singal, Yong-Fang Kuo, K. Rajender Reddy, Ramon Bataller, Paul Kwo
Summary: The study found that in 2019, there were 27,180 hospitalisations caused by Hepatorenal syndrome (HRS), requiring an estimated $4.2 billion USD in healthcare expenditures. Despite a decrease in in-hospital mortality over time, HRS remains a significant cause of death in patients hospitalized with cirrhosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Letter
Gastroenterology & Hepatology
Mohamed A. Elfeki, Ashwani K. Singal
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Nipun Verma, Ashwani K. Singal
Summary: This article is linked to the papers by Singal et al. To read these papers, visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Ashwani K. K. Singal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Anand V. Kulkarni, Ashwani K. Singal
DIGESTIVE AND LIVER DISEASE
(2023)
Editorial Material
Gastroenterology & Hepatology
Chencheng Xie, Ashwani K. Singal
HEPATOLOGY INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Malia Holbeck, Hannah Statz DeVries, Ashwani K. Singal
Summary: Alcohol-associated liver disease (ALD) is a common liver disease and a reason for liver transplantation (LT). Patients with ALD often have alcohol use disorder (AUD) and psychiatric comorbidities. Early identification of ALD and treatment of AUD can prevent progression to advanced stages of the disease. However, there are barriers to screening and treatment for AUD in ALD patients. This review discusses the multidisciplinary care model for managing the dual pathology of ALD and AUD, with a focus on the roles of hepatologists, psychiatrists, addiction counselors, and social workers.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ashwani K. Singal, Yong-Fang Kuo
Summary: This study compared the waitlist and post-transplant outcomes of liver transplantation alone (LTA) and simultaneous liver kidney (SLK) listings. It found that SLK patients had lower mortality on the waitlist and higher survival rates after transplantation. Therefore, the kidney function of patients should be taken into consideration when choosing the transplantation method.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Ayooluwatomiwa Deborah Adekunle, Adeyinka Adejumo, Ashwani K. K. Singal
Summary: Alcohol-associated liver disease (ALD) is a complex and rapidly increasing disease without approved therapeutic targets. Challenges in study designs and clinical trials need to be overcome to drive drug development in this field. ALD management should focus on achieving and maintaining alcohol abstinence, while early liver transplantation protocols and noninvasive biomarkers require improvement. Integrated multidisciplinary care models are urgently needed to improve long-term outcomes for ALD patients with alcohol use disorder and liver disease.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Ashwani K. Singal, Lorenzo Leggio, Andrea DiMartini
Summary: Alcohol-associated liver disease (ALD) is a leading cause for liver transplantation (LT) globally, particularly during the COVID-19 pandemic and among young individuals. Alcohol use disorder (AUD) is prevalent in the majority of ALD patients, and early liver transplantation (eLT) has emerged as a potential treatment for selected patients with alcohol-associated hepatitis. However, the challenge lies in addressing AUD treatment, which requires an integrated multidisciplinary care approach.
LIVER TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Zobair M. Younossi, Yusuf Yilmaz, Mohamed El-Kassas, Ajay Duseja, Saeed Hamid, Gamal Esmat, Nahum Mendez-Sanchez, Wah Kheong Chan, Ashwani K. Singal, Brian Lam, Sean Felix, Elena Younossi, Manisha Verma, Jillian K. Price, Fatema Nader, Issah Younossi, Andrei Racila, Maria Stepanova
Summary: Patients with chronic liver disease may experience a significant burden from COVID-19 infection and the pandemic. A survey found that 11.3% of patients reported an impact on their liver disease, with 73% experiencing delays in follow-up care. Furthermore, 81% of patients with a history of COVID-19 and 69% without a history experienced worsening in at least one area.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Andrea F. DiMartini, Lorenzo Leggio, Ashwani K. Singal
Summary: Despite its recognition as a public health issue, the diagnosis and treatment of alcohol use disorder, especially in cases of alcohol-associated liver disease, are often overlooked. Integrated care models involving hepatologists and addiction specialists are considered to be the optimal approach for managing patients with dual pathology. However, the implementation of these models is challenging due to various barriers at the patient, clinician, and system levels.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
