期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 20, 期 33, 页码 11618-11629出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i33.11618
关键词
Hepatitis B virus; Interferon; Toll-like receptor; Interferon stimulated genes; Innate immune response
资金
- National Natural Science Foundation of China [31200135, 31200699]
- German Research Foundation [TRR60, GK1045/2, GK1949]
Hepatitis B virus (HBV) infection is one of the major causes of liver diseases, affecting more than 350 million people worldwide. The interferon (IFN)-mediated innate immune responses could restrict HBV replication at the different steps of viral life cycle. Indeed, IFN-alpha has been successfully used for treatment of patients with chronic hepatitis B. However, the role of the innate immune response in HBV replication and the mechanism of the anti-HBV effect of IFN-alpha are not completely explored. In this review, we summarized the currently available knowledge about the IFN-mediated anti-HBV effect in the HBV life cycle and the possible effectors downstream the IFN signaling pathway. The antiviral effect of Toll-like receptors (TLRs) in HBV replication is briefly discussed. The strategies exploited by HBV to evade the IFN- and TLR-mediated antiviral actions are summarized. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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