Article
Medicine, General & Internal
Camelia Gianina Foncea, Ioan Sporea, Raluca Lupusoru, Tudor Voicu Moga, Felix Bende, Roxana Sirli, Alina Popescu
Summary: The study showed that the Lille score at Day 4 (LM4) is as useful as the Lille score at Day 7 (LM7) in predicting patients' response to corticosteroids and 28-day mortality. Additionally, using LM4 can help avoid prolonged corticosteroid therapy and its complications, providing potential benefits for patients with severe alcoholic hepatitis and liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Fangfang Duan, Chen Liu, Hang Zhai, Min Quan, Jun Cheng, Song Yang
Summary: This study evaluated the prognostic performance of the MELD score in Chinese patients with alcohol-related liver disease (ARLD). The results showed that the MELD 3.0 score was not superior to the original MELD or the MELD-Na in predicting the mortality of ARLD patients.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Kevin Lamm, Maggie McCarter, Mark W. Russo
Summary: This study concluded that in the study population, the use of steroids was not futile in patients with a DF score greater than 54.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jiazhen Zheng, Ziyi Li, Hengyi Xu
Summary: Alcoholic hepatitis is a rapidly progressing and severe stage of alcoholic liver disease, and alterations in the intestinal microbiota play a pivotal role in its pathogenesis. Understanding the dynamics of the gut microbiota can contribute to the development of new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Xiaojuan Chao, Shaogui Wang, Xiaowen Ma, Chen Zhang, Hui Qian, Sha Neisha Williams, Zhaoli Sun, Zheyun Peng, Wanqing Liu, Feng Li, Namratha Sheshadri, Wei-Xing Zong, Hong-Min Ni, Wen-Xing Ding
Summary: In alcohol-associated liver disease, liver-specific knockout of TSC1 gene leads to continuous activation of mTORC1, promoting liver cell repopulation, ductular reaction, inflammation, fibrosis, and liver injury.
Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Review
Gastroenterology & Hepatology
Emilie K. Mitten, Gyorgy Baffy
Summary: Mechanobiology is an interdisciplinary research field that focuses on the impact of physical forces on cell and tissue function. Mechanotransduction is the process by which cells sense and respond to physical forces, and it plays a significant role in the behavior of liver cells. Disruption of mechanical homeostasis in non-alcoholic fatty liver disease may contribute to disease progression and the development of complications.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Naoto Fujiwara, Eric Trepo, Indu Raman, Quan-Zhen Li, Delphine Degre, Thierry Gustot, Christophe Moreno, Yujin Hoshida
Summary: The study identified a 6-plasma-protein panel as a surrogate for the 123-gene signature in severe alcoholic hepatitis patients. The composite score ps-MELD, combining plasma signature with MELD score, showed a strong association with short-term survival, outperforming existing clinical scores.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Toshifumi Tada, Takashi Kumada, Atsushi Hiraoka, Kazuya Kariyama, Joji Tani, Masashi Hirooka, Koichi Takaguchi, Masanori Atsukawa, Shinya Fukunishi, Ei Itobayashi, Kunihiko Tsuji, Kazuto Tajiri, Hironori Ochi, Toru Ishikawa, Satoshi Yasuda, Chikara Ogawa, Hidenori Toyoda, Takeshi Hatanaka, Takashi Nishimura, Satoru Kakizaki, Kazuhito Kawata, Noritomo Shimada, Fujimasa Tada, Kazuhiro Nouso, Akemi Tsutsui, Hideko Ohama, Asahiro Morishita, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Hisashi Kosaka, Michitaka Imai, Atsushi Naganuma, Shinichiro Nakamura, Yohei Koizumi, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa
Summary: The aim of this study was to investigate whether the neo-GPS could predict prognosis in HCC patients treated with Atez/Bev. The results showed that the neo-GPS was independently associated with overall survival and performed better than the traditional GPS in predicting prognosis.
Review
Cell Biology
Ying Zhou, Ruoman Wu, Xinqi Wang, Xiaofeng Bao, Chunfeng Lu
Summary: This review summarizes the recent progress on the roles and mechanisms of necroptosis in alcoholic liver disease (ALD) and discusses the potential association between necroptosis and the primary pathological hallmarks of ALD, including oxidative stress, hepatic steatosis, and inflammation. The review emphasizes the crosstalk between necroptosis and other pathogenesis of ALD and provides a theoretical basis for targeting necroptosis as a novel treatment for ALD.
CELL PROLIFERATION
(2022)
Review
Biochemistry & Molecular Biology
Tieshan Teng, Shuai Qiu, Yiming Zhao, Siyuan Zhao, Dequan Sun, Lingzhu Hou, Yihang Li, Ke Zhou, Xixi Yu, Changyong Yang, Yanzhang Li
Summary: Non-alcoholic fatty liver disease (NAFLD) is strongly correlated with obesity, insulin resistance, metabolic syndrome, and genetic components. The disease progression includes non-alcoholic fatty liver, non-alcoholic steatohepatitis, and liver cirrhosis, with different clinical phenotypes. There is currently no FDA-approved medication specifically for treating NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Seol Hee Park, Young-Sun Lee, Jaemin Sim, Seonkyung Seo, Wonhyo Seo
Summary: Excessive alcohol consumption contributes significantly to liver diseases, and the liver is the primary organ for alcohol metabolism. The importance of non-oxidative alcohol metabolites in cellular damage has also been discovered. Furthermore, the impact of extrahepatic alcohol effects is crucial for the progression of alcoholic liver disease.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Letter
Gastroenterology & Hepatology
Benjamin Buchard, Luc Sevigne, Claude Darcha, Leon Muti, Juliette Joubert, Armand Abergel
Summary: The article is linked to the paper by Forrest et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Engineering, Chemical
Alfredo Caturano, Carlo Acierno, Riccardo Nevola, Pia Clara Pafundi, Raffaele Galiero, Luca Rinaldi, Teresa Salvatore, Luigi Elio Adinolfi, Ferdinando Carlo Sasso
Summary: Non-alcoholic Fatty Liver Disease (NAFLD) is characterized by fat accumulation in hepatocytes without alcohol consumption, with insulin resistance (IR) playing a key role in its development. A recent expert consensus has suggested using the term Metabolic-Associated Fatty Liver Disease (MAFLD) instead. This disease is associated with an increase in free fatty acid levels and pro-inflammatory cytokines, ultimately leading to insulin resistance and increasing cardiovascular risk.
Article
Gastroenterology & Hepatology
Rong Fan, Guanlin Li, Ning Yu, Xiujuan Chang, Tamoore Arshad, Wen-Yue Liu, Yan Chen, Grace Lai-Hung Wong, Yiyue Jiang, Xieer Liang, Yongpeng Chen, Xiao-Zhi Jin, Zheng Dong, Howard Ho-Wai Leung, Xiao-Dong Wang, Zhen Zeng, Terry Cheuk-Fung Yip, Qing Xie, Deming Tan, Shaoli You, Dong Ji, Jun Zhao, Arun J. Sanyal, Jian Sun, Ming-Hu Zheng, Vincent Wai-Sun Wong, Yongping Yang, Jinlin Hou
Summary: This study evaluated the performance of the aMAP score in diagnosing fibrosis in patients with chronic hepatitis B (CHB). The results showed that the aMAP score had higher accuracy in diagnosing cirrhosis and advanced fibrosis compared to other markers. The combination of aMAP and LSM further improved the accuracy in detecting cirrhosis and advanced fibrosis. The aMAP-LSM model had satisfactory performance in diagnosing fibrosis stage for treated CHB patients, especially those with a significant decrease in LSM after treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)