4.6 Article

Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C

期刊

WORLD JOURNAL OF GASTROENTEROLOGY
卷 20, 期 5, 页码 1289-1297

出版社

BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v20.i5.1289

关键词

Acoustic radiation force impulse; Body mass index; Chronic hepatitis C; Computer-assisted morphometric image analysis; Fibrosis stage; Hyaluronic acid; Liver stiffness measurement; Transient elastography; Velocity of shear wave

资金

  1. MEXT
  2. Strategic Research Foundation at Private Universities of the Japanese Government
  3. Ministry of Health, Labor, and Welfare of the Japanese Government
  4. Grants-in-Aid for Scientific Research [24590711] Funding Source: KAKEN

向作者/读者索取更多资源

AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse (ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computer-assisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage (beta = 0.1865, P < 0.0001) and hyaluronic acid levels (beta = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index (BMI)(beta = -0.0334, P = 0.0001) in F0 or F1, with gamma-glutamyltranspeptidase levels (beta = 0.0048, P = 0.0012) in F2, and with fibrosis stage (beta = 0.2921, P = 0.0044) and hyaluronic acid levels (beta = 0.0012, P = 0.0025) in F3 or F4. The ARFI cutoff value was 1.28 m/s for F >= 2, 1.44 m/s for F >= 3, and 1.73 m/s for F4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, gamma-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

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