Review
Gastroenterology & Hepatology
Ana Elisa Valencise Quaglio, Thais Gagno Grillo, Ellen Cristina Souza De Oliveira, Luiz Claudio Di Stasi, Ligia Yukie Sassaki
Summary: Dysbiosis in the gut microbiota is closely associated with various gastrointestinal disorders such as IBS, IBD, and CRC, potentially leading to mucosal barrier disruption, chronic inflammation, and cancer progression. Specific harmful bacteria, like E. coli and ETBF, are linked to an increased risk of developing CRC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Benedetto Neri, Maria Lia Scribano, Alessandro Armuzzi, Fabiana Castiglione, Renata D'Inca, Ambrogio Orlando, Stefano Festa, Gabriele Riegler, Walter Fries, Gianmichele Meucci, Patrizia Alvisi, Filippo Mocciaro, Claudio Papi, Michelangela Mossa, Giorgia Sena, Luisa Guidi, Anna Testa, Sara Renna, Iris Frankovic, Anna Viola, Marta Patturelli, Carlo Chiaramonte, Livia Biancone
Summary: The sequence chronic inflammation-dysplasia-cancer is involved in the development of several gastrointestinal cancers. The characteristics of IBD, including CRC-related symptoms at onset, play a role in the long-term outcome of CRC in IBD patients. CRC has a higher incidence in UC and CD patients. Surveillance programs should focus on high-risk subgroups of patients.
Review
Biochemistry & Molecular Biology
Lifang Liang, Rongxiao Lin, Ying Xie, Huaqing Lin, Fangyuan Shao, Wen Rui, Hongyuan Chen
Summary: This review briefly summarizes the expression of CypA, CypB, and CypD in IBD and CRC, their relationship with the development of these two intestinal diseases, as well as the possible pathogenesis, providing a modest reference for future clinical research and treatments.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Liliana Lykowska-Szuber, Anna Maria Rychter, Magdalena Dudek, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Zawada, Piotr Eder, Maciej Lesiak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Studies have shown an increased risk of cardiovascular disease in patients with IBD, potentially due to inflammation-induced endothelial dysfunction and development of CVD, as well as gut microbiota dysbiosis. Dietary patterns have also been identified to influence the relationship between IBD and CVD.
Article
Gastroenterology & Hepatology
Kristiina Rajamaki, Aurora Taira, Riku Katainen, Niko Valimaki, Anna Kuosmanen, Roosa-Maria Plaketti, Toni T. Seppala, Maarit Ahtiainen, Erkki-Ville Wirta, Emilia Vartiainen, Paivi Sulo, Janne Ravantti, Suvi Lehtipuro, Kirsi J. Granberg, Matti Nykter, Tomas Tanskanen, Ari Ristimaki, Selja Koskensalo, Laura Renkonen-Sinisalo, Anna Lepisto, Jan Bohm, Jussi Taipale, Jukka-Pekka Mecklin, Mervi Aavikko, Kimmo Palin, Lauri A. Aaltonen
Summary: By comprehensively characterizing IBD-associated tumorigenesis using multiple high-throughput approaches, distinct mechanisms of WNT pathway dysregulation were identified in IBD-CRC, which skew the tumors towards a mesenchymal subtype. Additionally, epigenetic modifications and noncoding mutations in specific genes were found in IBD-CRC, highlighting further differences compared to sCRC.
Review
Microbiology
Muhammad Afzaal, Farhan Saeed, Yasir Abbas Shah, Muzzamal Hussain, Roshina Rabail, Claudia Terezia Socol, Abdo Hassoun, Mirian Pateiro, Jose M. Lorenzo, Alexandru Vasile Rusu, Rana Muhammad Aadil
Summary: The human gut contains a complex microbial community, which forms a connecting axis with other organs and plays a vital role in host-microbe interactions. Dysbiosis of the gut microbiota is linked to various human diseases. Understanding the role of gut microbiota in health and disease is crucial for maintaining health and treating diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Sunil Kumar, Awanish Kumar
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal system that is increasing globally. The alteration in intestinal microbiota is associated with IBD, but the role of microbes in IBD is still controversial.
MICROBIAL PATHOGENESIS
(2022)
Review
Endocrinology & Metabolism
Yuxuan Xia, Li Zhang, Dickson Kofi Wiredu Ocansey, Qiang Tu, Fei Mao, Xiumei Sheng
Summary: Inflammatory bowel disease (IBD) and colorectal cancer (CRC) share a common factor in their development, glycolysis, which affects various aspects of gastrointestinal tissues. In IBD, glycolysis impacts the intestinal microbiota, mucosal barrier function, and the immune system, while in CRC, it is linked to multiple signaling pathways and transcription factors. A comprehensive study of glycolysis is crucial for a better understanding of the pathogenesis and therapeutic targets of both IBD and CRC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patricia Teixeira Santana, Siane Lopes Bittencourt Rosas, Beatriz Elias Ribeiro, Ygor Marinho, Heitor S. P. de Souza
Summary: Microbe-host communication is crucial for maintaining vital functions of a healthy host. Disruption of this communication is associated with various diseases, including Crohn's disease and ulcerative colitis. Identifying microorganisms that affect disease susceptibility and phenotypes in humans is still challenging. Recent insights into the role of diet and environmental factors on the gut microbiome have direct implications for the immune response and the development of IBD. The complexity of IBD pathogenesis suggests the need for an integrative approach to identify specific therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Sheng Liu, Wenjing Zhao, Ping Lan, Xiangyu Mou
Summary: Inflammatory bowel disease (IBD) is a global disease with accelerating incidence worldwide, and dysbiosis of gut microbiota has been consistently associated with IBD. Some alterations in microbiome may have protective or causative effects on IBD. Therapeutic approaches targeting microbiome are a promising strategy for alleviating and curing IBD.
Review
Oncology
Elisa Marabotto, Stefano Kayali, Silvia Buccilli, Francesca Levo, Giorgia Bodini, Edoardo G. Giannini, Vincenzo Savarino, Edoardo Vincenzo Savarino
Summary: This review summarizes the current epidemiology, risk factors, and prevention strategies for colorectal cancer (CRC) in patients with inflammatory bowel diseases (IBDs). It focuses on the importance of chemoprevention and endoscopic surveillance as proposed by international scientific societies. Unresolved research and clinical problems related to this topic are also highlighted to improve diagnostic strategies and management.
Article
Cell Biology
Bartolo Tamburini, Marco Pio La Manna, Lidia La Barbera, Leila Mohammadnezhad, Giusto Davide Badami, Mojtaba Shekarkar Azgomi, Francesco Dieli, Nadia Caccamo
Summary: Inflammatory bowel disease (IBD) is a pressing global health problem with increasing incidence worldwide. While the exact etiology is still unclear, a complex interaction of factors, including immune system defects, microbial dysbiosis, genetic predisposition, and environmental factors, contribute to the development of inflammation. This review aims to analyze the intricate balance between these elements in maintaining intestinal homeostasis and preventing or minimizing the adverse effects of IBD on health.
Review
Infectious Diseases
Ziyu Jiang, Lingchang Li, Jianan Chen, Guoli Wei, Yi Ji, Xi Chen, Jingbing Liu, Jiege Huo
Summary: The relationship between gut microbiota and cancer is multifaceted, involving the impact of microbes on the host gut and tumor sites, carcinogenic microbes like Helicobacter pylori, and the influence of diet on cancer risk. Dietary supplementation with prebiotics and probiotics can decrease cancer incidence, while inflammatory diets may increase the risk of cancer.
INFECTION GENETICS AND EVOLUTION
(2021)
Letter
Gastroenterology & Hepatology
Bridgette Andrew, Annie Zhou, Steven Trinh, Ashish Srinivasan, Abhinav Vasudevan
Summary: This article is linked to the papers by Oh et al. and provides the related links.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Immunology
Maria Kulecka, Natalia Zeber-Lubecka, Aneta Balabas, Pawel Czarnowski, Katarzyna Baginska, Maria Glowienka, Anna Kluska, Magdalena Piatkowska, Michalina Dabrowska, Edyta Waker, Michal Mikula, Jerzy Ostrowski
Summary: In this study, the researchers compared the metagenomic and metabolomic profiles of Clostridioides difficile diarrheal cancer and inflammatory bowel disease patients. They found that C. difficile infection exacerbates intestinal dysbiosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Giuseppe A. Scardina, Massimiliano Messina, Dario Melilli, Enzo Cumbo, Francesco Carini, Giovanni Tomasello, Pietro Messina
MEDICAL SCIENCE MONITOR
(2019)
Article
Biochemistry & Molecular Biology
Celeste Caruso Bavisotto, Calogero Cipolla, Giuseppa Graceffa, Rosario Barone, Fabio Bucchieri, Donatella Bulone, Daniela Cabibi, Claudia Campanella, Antonella Marino Gammazza, Alessandro Pitruzzella, Rossana Porcasi, Pier Luigi San Biagio, Giovanni Tomasello, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello, Francesca Rappa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Engineering, Biomedical
Giusi Alberti, Margherita Mazzola, Carola Gagliardo, Alessandro Pitruzzella, Alberto Fucarini, Marco Giammanco, Giovanni Tomasello, Francesco Carini
Summary: The human gut microbiome plays a crucial role in maintaining the optimal balance for normal metabolic and immune function. Extracellular vesicles (EVs) are involved in cell-cell communication and may have important implications in conditions like inflammatory bowel disease (IBD) and colorectal cancer (CRC).
BIOMEDICAL PAPERS-OLOMOUC
(2021)
Review
Cell Biology
Malak Fouani, Charbel A. Basset, Abdo R. Jurjus, Lavinia Giovanna Leone, Giovanni Tomasello, Angelo Leone
Summary: Salivary glands play a crucial role in oral health and are closely linked to the progression of diabetes, which can lead to changes in salivary protein deregulation and impact oral health.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Review
Biology
Marco Giammanco, Margherita Mazzola, Manfredi Marco Giammanco, Giovanni Tomasello, Francesco Carini
Summary: Omega-3 PUFAs have beneficial effects on intestinal microbiota, and may help prevent intestinal diseases such as colorectal cancer.
JOURNAL OF BIOLOGICAL RESEARCH-BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE
(2021)
Review
Biology
Giorgia Intili, Letizia Paladino, Francesca Rappa, Giusi Alberti, Alice Plicato, Federica Calabro, Alberto Fucarino, Francesco Cappello, Fabio Bucchieri, Giovanni Tomasello, Francesco Carini, Alessandro Pitruzzella
Summary: This paper analyzes the correlations between gut microbiota (GM) and various neurodegenerative processes, focusing on the effects of GM dysbiosis on the human nervous system. Alterations in the communication between the microbiota and nervous cell populations can lead to pathological conditions. The review describes the connection between intestinal microbiome alterations (dysbiosis) and the onset of neurodegenerative diseases, exploring mechanisms such as the gut-brain axis, mitochondrial pathways, adaptive humoral immunity, and microvesicular pathways. These pathways represent potential therapeutic targets against neuroinflammation and neurodegeneration.
Review
Biology
Marco Giammanco, Herbert R. Marini, Socrate Pallio, Manfredi Marco Giammanco, Giovanni Tomasello, Francesco Carini, Fabio Venturella, Gaetano Leto, Maurizio La Guardia
JOURNAL OF BIOLOGICAL RESEARCH-BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE
(2020)
Review
Biology
Giovanni Tomasello, Marco Giammanco, Margherita Mazzola, Provvidenza Damiani, William Ra, Paola Giammanco, Francesca Rappa, Alessandro Pitruzzella, Dario Saguto, Benedetto Di Trapani, Giovanni Taverna, Mike Carini, Antonio Ciulla, Francesco Carini
JOURNAL OF BIOLOGICAL RESEARCH-BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE
(2020)
Letter
Surgery
Benedetto Di Trapani, Carola M. Gagliardo, Carlo Bargiggia, Simone Tomasini, Bernardo Molinelli, Mario Feo, Antonio Ciulla, Francesco Carini, Giovanni Tomasello
MINERVA CHIRURGICA
(2020)
Article
Oncology
Calogero Porrello, Roberto Gullo, Carola Maria Gagliardo, Antonino Vaglica, Martina Palazzolo, Filippo Giangregorio, Dario Iadicola, Andrea Catanzaro, Gregorio Scerrino, Felice Lo Faso, Francesco Carini, Giovanni Tomasello
Article
Surgery
C. Porrello, D. Iadicola, E. M. Grutta, M. Palazzolo, A. Vaglica, C. Gagliardo, F. Giangregorio, E. Gulotta, F. Lo Faso, R. Gullo, F. Carini, G. Tomasello, G. Cocorullo
GIORNALE DI CHIRURGIA
(2019)
Article
Surgery
C. Porrello, R. Gullo, C. M. Gagliardo, A. Vaglica, M. Palazzolo, F. Giangregorio, D. Iadicola, E. Gulotta, V Mannino, F. Lo Faso, G. Tomasello, F. Carini, G. Cocorullo
GIORNALE DI CHIRURGIA
(2019)
Article
Surgery
C. Porrello, G. Scerrino, A. Vaglica, M. Palazzolo, C. M. Gagliardo, F. Giangregorio, D. Iadicola, G. Tomasello, F. Lo Faso, K. Kawamukai, N. Lacava, Fabrizio Carini, G. Cocorullo, R. Gullo
GIORNALE DI CHIRURGIA
(2019)
Article
Surgery
C. Porrello, R. Gullo, C. M. Gagliardo, A. Vaglica, M. Palazzolo, F. Giangregorio, D. Iadicola, G. Profita, F. Lo Faso, G. Tomasello, Fabrizio Carini, G. Cocorullo
GIORNALE DI CHIRURGIA
(2019)
Article
Medicine, General & Internal
Vincenzo Davide Palumbo, Benedetto Di Trapani, Antonio Bruno, Mario Feo, Bernardo Molinelli, Simone Tomasini, Attilio Ignazio Lo Monte, Marianna Messina, Giovanni Tomasello
JOURNAL OF MEDICAL CASE REPORTS
(2019)