Article
Medicine, General & Internal
Haruka Fujinami, Akira Teramoto, Saeko Takahashi, Takayuki Ando, Shinya Kajiura, Ichiro Yasuda
Summary: This study demonstrates that the use of the S-O clip during colorectal endoscopic submucosal dissection (ESD) can effectively reduce the surgery duration, increase the dissection speed and en bloc resection rate, and decrease the complication rate, especially in the right colon.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Pierre Lafeuille, Timothee Wallenhorst, Alexandru Lupu, Jeremie Jacques, Thomas Lambin, Marine Camus, Clara Yzet, Thierry Ponchon, Florian Rostain, Jerome Rivory, Fabien Subtil, Mathieu Pioche
Summary: The novel FESDC strategy appears to be a safe and feasible option for the permanent endoscopic closure of gastrointestinal fistulas, with a moderate success rate in the long term, even for patients with previous failed endoscopic therapy. Further studies are needed to determine the role of this technique in the management of chronic gastrointestinal fistulas.
Review
Medicine, General & Internal
Yu Kamitani, Kouichi Nonaka, Yoshitsugu Misumi, Hajime Isomoto
Summary: Recent improvements in endoscopists' skills and technological advances have made endoscopic submucosal dissection (ESD) a standard treatment in general hospitals. To enhance safety and efficiency, therapeutic procedures and training methods are continuously developed. This article reviews these methods and describes the ESD training system in a Japanese university hospital.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kaho Nakatani, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Naoya Tada, Kazuhiro Koduka, Takanori Matsui, Taiga Chiyo, Nobuya Kobayashi, Tatsuo Yachida, Joji Tani, Asahiro Morishita, Hajime Isomoto, Tsutomu Masaki
Summary: The study investigated the efficacy and safety of the B-OTSC method for preventing delayed adverse events in patients undergoing duodenal ESD. The results showed a 100% closure rate and no delayed adverse events, indicating that B-OTSC is a safe and effective method for closure after duodenal ESD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Hideyuki Takashiro, Hirofumi Saito, Katsunobu Tawada, Yuhei Oyama, Shinichi Tazawa, Masatoshi Usui, Hiromasa Nomoto, Kazuhiko Kita
Summary: The study retrospectively compared the efficacy and safety of the early clip-with-line (ECL) method with the conventional method for colorectal endoscopic submucosal dissection (ESD). It was found that the ECL group had significantly shorter procedure time and no perforation events occurred. There were no significant differences in clinical characteristics between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Yuichiro Ozeki, Kingo Hirasawa, Ryosuke Ikeda, Sho Onodera, Atsushi Sawada, Masafumi Nishio, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Masataka Taguri, Shin Maeda
Summary: WP-ESD can effectively and safely treat fibrotic colorectal neoplasms with shorter procedure time compared to conventional C-ESD.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Surgery
Yuki Kamigaichi, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Akira Furudoi, Seiji Onogawa, Hideharu Okanobu, Takeshi Mizumoto, Tomohiro Miwata, Shiro Okamoto, Kenichi Yoshimura, Kazuaki Chayama
Summary: Severe submucosal fibrosis and poor scope operability are common risk factors for interruption, piecemeal resection, and perforation in standardized colorectal ESD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Mitsushige Sugimoto, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Masaki Murata, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Mitsuhiro Fujishiro, Atsushi Masamune, Takashi Kawai
Summary: This study reveals a high incidence of delayed bleeding after ESD in Japanese patients older than 80 years, especially in those receiving hemodialysis and taking warfarin. Special care is required in the management of ESD to prevent delayed bleeding in patients older than 80 years.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Jiayu Qiu, Jun Xu, Yanxia Zhang, Foqiang Liao, Zhenhua Zhu, Xu Shu, Youxiang Chen, Xiaolin Pan
Summary: The study aimed to investigate the applications of OTSC in the treatment of upper non-variceal gastrointestinal bleeding (UNVGIB), perforations, and fistulas in China. The results showed that OTSC had a high technical and clinical success rate in the treatment of these diseases, especially for Dieulafoy's lesion or patients under antithrombotic therapy for UNVGIB.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Kurato Miyazaki, Motohiko Kato, Motoki Sasaki, Kentaro Iwata, Teppei Masunaga, Yoko Kubosawa, Yukie Hayashi, Mari Mizutani, Yoshiyuki Kiguchi, Yusaku Takatori, Makoto Mutaguchi, Noriko Matsuura, Atsushi Nakayama, Kaoru Takabayashi, Takanori Kanai, Naohisa Yahagi
Summary: This study evaluated the role of red dichromatic imaging (RDI) in preventing bleeding and hematoma formation during esophageal endoscopic submucosal dissection (ESD). The results showed that RDI reduced the incidence of bleeding and hematoma formation, and improved the visibility of blood vessels.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Multidisciplinary Sciences
Kohei Oka, Naoto Iwai, Takashi Okuda, Toshifumi Tsuji, Hiroaki Sakai, Chie Hattori, Masashi Taniguchi, Tasuku Hara, Toshiyuki Komaki, Junichi Sakagami, Keizo Kagawa, Osamu Dohi, Yoshito Itoh
Summary: This study aimed to evaluate the efficacy of red dichromatic imaging (RDI) in improving the visibility of bleeding during gastric endoscopic submucosal dissection (ESD). The results showed that RDI significantly improved the visibility score and color difference of bleeding spot compared to white light imaging (WLI) during gastric ESD. Further analysis revealed that the submergence of bleeding points was independently associated with the superiority of RDI. Therefore, RDI can effectively enhance the visibility of bleeding during gastric ESD.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Bing Li, Qiang Shi, En-Pan Xu, Li-Qing Yao, Shi-Lun Cai, Zhi-Peng Qi, Di Sun, Dong-Li He, Ayimukedisi Yalikong, Zhen-Tao Lv, Ping-Hong Zhou, Yun-Shi Zhong
Summary: The study established a clinical score model that accurately predicts the success rate of colorectal endoscopic submucosal dissection within 60 minutes, and can be used to evaluate the technical difficulty before the procedure.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Tae-Se Kim, Byung-Hoon Min, Yang Won Min, Hyuk Lee, Poong-Lyul Rhee, Jae J. Kim, Jun Haeng Lee
Summary: This study investigated the clinical features and management strategy of patients with delayed perforation after gastric endoscopic submucosal dissection (ESD). Among 11,531 patients who underwent ESD, delayed perforation occurred in 0.13% of cases and was more common in older patients. Patients with delayed perforation presented with severe abdominal pain and were diagnosed through chest X-rays or CT scans. Non-surgical treatments, including endoscopic closure, might be effective for perforations smaller than 1 cm.
Article
Surgery
Ran Li, Shilun Cai, Di Sun, Qiang Shi, Zhong Ren, Zhipeng Qi, Bing Li, Liqing Yao, Meidong Xu, Pinghong Zhou, Yunshi Zhong
Summary: The study identified hypertension and the use of hot biopsy forceps for wound management as significant risk factors for delayed bleeding following endoscopic submucosal dissection for colorectal neoplasms. Therefore, additional perioperative treatment is recommended in patients with these risk factors to prevent delayed bleeding.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Daisuke Hihara, Hiroyuki Takamaru, Masau Sekiguchi, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Yutaka Saito
Summary: A study on 483 rectal lesions resected using ESD revealed that factors such as cumulative procedure time, lesion location, resection size, invasion depth, and circumferential range are associated with prolonged ESD procedure time. These findings are important for guiding and improving rectal ESD procedures.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Surgery
Yasuhiro Goda, Hideki Kobara, Nobuya Kobayashi, Noriko Nishiyama, Shintaro Fujihara, Naoya Tada, Kazuhiro Kozuka, Takanori Matsui, Taiga Chiyo, Tingting Shi, Koji Fujita, Joji Tani, Tatsuo Yachida, Masashi Takata, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: This study examined the clinical outcomes and long-term characteristics of patients treated with Over-The-Scope Clip (OTSC). The results showed a 100% clinical success rate and a 2.9% complication rate during the observation period. OTSC remains effective in the long-term.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Medicine, General & Internal
Yasuhiro Hamada, Kazushi Deguchi, Kisaki Tachi, Makoto Kita, Wakako Nonaka, Tadayuki Takata, Hideki Kobara, Tetsuo Touge, Katsuya Satoh, Tsutomu Masaki
Summary: A case study of a 63-year-old woman with orofacial dystonia showed cortical ribboning on MRI, a typical presentation of sporadic Creutzfeldt-Jakob disease (sCJD). However, the real-time quaking-induced conversion (RT-QuIC) test, the most sensitive method for early diagnosis of sCJD, initially came out negative. Six months later, when the patient was diagnosed with sCJD, the RT-QuIC test became positive. The cerebral blood flow showed a decrease in the cerebral cortex, consistent with cortical ribboning, but an increase in the basal ganglia, possibly related to orofacial dystonia. The study suggests that cortical ribboning on MRI may be a more reliable biomarker than RT-QuIC in the prodromal phase of sCJD.
Review
Gastroenterology & Hepatology
Hideki Kobara, Naoya Tada, Shintaro Fujihara, Noriko Nishiyama, Tsutomu Masaki
Summary: This review investigated the clinical efficacy and technical outcomes of endoscopic prophylactic closure for post-ESD defects. The closure group showed significantly lower rates of overall adverse events and delayed bleeding compared to the non-closure group in the stomach, duodenum, and colorectum.
DIGESTIVE ENDOSCOPY
(2023)
Correction
Oncology
Taro Iwatsubo, Toshihisa Takeuchi, Akitoshi Hakoda, Yasuhiro Fujiwara, Yasuaki Nagami, Yuji Naito, Osamu Dohi, Tetsuya Tatsuta, Manabu Sawaya, Xiaoyi Jin, Tomoyuki Koike, Mitsushige Sugimoto, Masaki Murata, Kenta Hamada, Hiroyuki Okada, Hideki Kobara, Taiga Chiyo, Norimasa Yoshida, Naoya Tomatsuri, Tomoki Inaba, Shigenao Ishikawa, Akihito Nagahara, Hiroya Ueyama, Eriko Koizumi, Katsuhiko Iwakiri, Kazuhiro Mizukami, Kazunari Murakami, Takahisa Furuta, Takahiro Suzuki, Naotaka Ogasawara, Kunio Kasugai, Hajime Isomoto, Koichiro Kawaguchi, Kotaro Shibagaki, Hiromi Kataoka, Takaya Shimura, Hidekazu Suzuki, Toshihiro Nishizawa, Kazuhide Higuchi
Article
Gastroenterology & Hepatology
Satoki Shichijo, Nobutsugu Abe, Hirohisa Takeuchi, Ken Ohata, Yohei Minato, Kazutoshi Hashiguchi, Kingo Hirasawa, Shoichi Kayaba, Hirohiko Shinkai, Hideki Kobara, Takeshi Yamashina, Tsukasa Ishida, Hideyuki Chiba, Hiroyuki Ono, Hirohito Mori, Noriya Uedo
Summary: Limited information is available on the efficacy and safety of endoscopic resection (ER) of gastric submucosal tumors (SMTs) in Japanese endoscopic practice where ER for gastric tumors is extremely popular. The study aimed to elucidate the current scenario of ER for gastric SMTs in Japanese endoscopic practice. Results showed an increasing trend in ER performance for gastric SMTs in Japan, with high feasibility and common pathology of gastrointestinal stromal tumors, without recurrence observed during the follow-up period.
DIGESTIVE ENDOSCOPY
(2023)
Article
Peripheral Vascular Disease
Takahiro Ogura, Kento Kitada, Norihiko Morisawa, Yoshihide Fujisawa, Satoshi Kidoguchi, Daisuke Nakano, Hideki Kobara, Tsutomu Masaki, Jens Titze, Akira Nishiyama
Summary: This study investigated the pathogenesis of hypertension in spontaneously hypertensive rats and identified renal concentration ability and skin barrier function for water conservation as potential therapeutic targets for essential hypertension.
HYPERTENSION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Hironobu Suto, Minoru Oshima, Yasuhisa Ando, Hiroyuki Matsukawa, Shigeo Takahashi, Toru Shibata, Hideki Kamada, Hideki Kobara, Tsutomu Masaki, Kensuke Kumamoto, Yasuyuki Suzuki, Keiichi Okano
Summary: The benefit of preoperative treatment followed by pancreatic resection in older patients with PDAC remains unclear. This study showed that preoperative treatment followed by curative resection could be safely performed in older patients, with similar outcomes as younger patients. Although older patients had a higher frequency of postoperative complications, the prognosis was similar.
Article
Gastroenterology & Hepatology
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Kazuhiro Kozuka, Takanori Matsui, Taiga Chiyo, Nobuya Kobayashi, Tatsuo Yachida, Shintaro Fujihara, Tsutomu Masaki
Summary: This study examined the feasibility of endoscopic ligation with O-ring closure (E-LOC) for closing defects after rectal endoscopic submucosal dissection (ESD). The results showed that E-LOC was successful in achieving complete closure of rectal defects and may decrease the incidence of delayed bleeding.
Editorial Material
Gastroenterology & Hepatology
Takehiro Iwasaki, Kunihisa Uchita, Nobuya Kobayashi, Koji Kojima, Noriko Nishiyama, Hiromichi Yamai, Hideki Kobara
Article
Gastroenterology & Hepatology
Kazuhiro Kozuka, Hideki Kobara, Takanori Matsui, Akihiko Fujisawa, Miwa Tatsuta, Mitsuyoshi Kobayashi, Mitsugu Yasuda, Kaho Nakatani, Naoya Tada, Taiga Chiyo, Nobuya Kobayashi, Tatsuo Yachida, Noriko Nishiyama, Shintaro Fujihara, Akihiro Kondo, Keiichi Okano, Akihito Tsuji, Tsutomu Masaki
Summary: This study established a new duodenal examination protocol called the Seven Pictures Rule (7PR), and investigated its feasibility and ability to detect neoplasms. The results showed that the completion rate of 7PR was 81.1%, and the overall detection rates of neoplasms, adenomas, and carcinomas were 0.84%, 0.71%, and 0.06% respectively. Most neoplasms were detected contralateral to the ampulla (69.2%), and the fewest were found in the transverse duodenum (0%). The completion rates for standard and ultrathin endoscopes were 84.4% and 65.6% respectively.
DIGESTIVE ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Nobuya Kobayashi, Hideki Kobara, Noriko Nishiyama, Kazuhiro Kozuka, Naoya Tada, Akihiro Kondo, Tsutomu Masaki
Article
Medicine, General & Internal
Manabu Yamada, Tsuyoshi Takeda, Takashi Sasaki, Takeshi Okamoto, Tsuyoshi Hamada, Takahiro Ishitsuka, Hiroki Nakagawa, Takafumi Mie, Takaaki Furukawa, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Hideki Kobara, Tsutomu Masaki, Naoki Sasahira
Summary: This study evaluates the efficacy and safety of intraductal self-expandable metal stent (SEMS) placement in patients with unresectable distal malignant biliary obstruction. The results show that there is no significant difference in the recurrence rate, recurrence time, adverse events, and reintervention rates between SEMS placements above and across the papilla. Intraductal SEMS placement is not associated with a prolonged time to recurrence in this study.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Tsutomu Masaki, Noriya Uedo
Summary: This systematic review evaluated the current status and limitations of endoscopic full-thickness resection (EFTR) for gastric subepithelial tumors (SETs). The study demonstrated acceptable outcomes of EFTR and closure for gastric SETs, indicating that EFTR is a promising forthcoming procedure.
Correction
Gastroenterology & Hepatology
Noriko Nishiyama, Shintaro Fujihara, Naoya Tada, Kaho Nakatani, Asahiro Morishita, Takayoshi Kishino, Hideki Kobara
Article
Oncology
Yoshimi Yamana, Shintaro Fujihara, Hideki Kobara, Kyoko Oura, Eri Samukawa, Taiga Chiyo, Megumi Okamura, Hiroki Yamana, Tomoko Tadokoro, Koji Fujita, Asahiro Morishita, Hisakazu Iwama, Tsutomu Masaki
Summary: Telmisartan inhibits the proliferation of PDAC cells by inducing cell cycle arrest and alters miRNA expression.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)