Article
Oncology
Jill Koshiol, Bin Zhu, Renwei Wang, Allan Hildesheim, Yu-Tang Gao, Patricia A. Egner, Jian-Min Yuan, John D. Groopman
Summary: This study found that aflatoxin B1 (AFB1) exposure is associated with an increased risk of developing gallbladder cancer (GBC). Higher levels of AFB1-lysine albumin adducts were associated with a higher risk of GBC, and there was a dose-response relationship. Participants with detectable AFB1-lysine albumin adducts and self-reported gallstones had a greater risk of developing GBC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Minh Thien Nguyen, Nhi Ngoc Yen Huynh, Dai Duc Nguyen, Nguyen Ha Ta, Tai Van Nguyen, Huy Thanh Dang, Ngoan Tran Le
Summary: This case-control study aimed to evaluate the association between vitamin D intake and the risk of gastric cancer. The findings suggest that sufficient vitamin D intake is associated with a lower risk of gastric cancer in the Vietnamese population.
Article
Oncology
Mads Kamper-Jorgensen, Marianne Antonius Jakobsen, Anne Tjonneland, Jane Skjoth-Rasmussen, Gitte Lindved Petersen, Sara Hallum
Summary: Research suggests that pregnancy may reduce the risk of brain cancer in women, with those testing positive for male origin microchimerism having half the risk compared to those testing negative.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
So Young Kim, Dae Myoung Yoo, Mi Jung Kwon, Ji Hee Kim, Joo-Hee Kim, Woo Jin Bang, Sung Kyun Kim, Hyo Geun Choi
Summary: This study investigated the risk of thyroid cancer in patients with gout and found that a prior history of gout was associated with an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
C. Ojeda Sanchez, J. Segu-Tell, D. Gomez-Barroso, E. Pardo Romaguera, J. A. Ortega-Garcia, R. Ramis
Summary: The study found a possible association between lower incidence of childhood leukemia and proximity to urban green spaces, particularly urban parks and wooded areas. This provides a new perspective for future research in this area.
ENVIRONMENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kyoko Kondo, Kanzo Suzuki, Masakazu Washio, Satoko Ohfuji, Satoru Adachi, Sakae Kan, Seiichiro Imai, Kunihiko Yoshimura, Naoyuki Miyashita, Nobumitsu Fujisawa, Akiko Maeda, Wakaba Fukushima, Yoshio Hirota
Summary: A large prospective cohort study in the United States found an inverse association between pneumonia and influenza deaths and coffee intake. In Japan, where the mortality rate of pneumonia in elderly people is high, a hospital-based case control study investigated the association between coffee and green tea intake and pneumonia among the elderly. The study suggested a preventive association between coffee intake over 2 cups per day and pneumonia in the elderly.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Urgena Maharjan, Joonas H. Kauppila
Summary: This study assessed the registry coverage for gastric cancer in FCR and HILMO in Finland. The results showed that gastric cancer was well captured by both registries, but there was a decrease in the proportion of cases reported to FCR over time. The completeness of FCR was estimated at 87% and for HILMO, it was 92.7%. Death due to gastric cancer was most common in those with gastric cancer reported in both registries.
Article
Clinical Neurology
Xinrong Dong, Yeqing Gu, Sabina Rayamajhi, Amrish Thapa, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Huiping Li, Juanjuan Zhang, Jun Dong, Xiaoxi Zheng, Zhixia Cao, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Hong Chang, Yunliang Zheng, Kaijun Niu
Summary: This prospective study suggests that frequent green tea consumption is associated with a decreased risk of depressive symptoms in the general Chinese population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
James A. Chamberlain, Pierre-Antoine Dugue, Julie K. Bassett, Roger L. Milne, Jihoon E. Joo, Ee Ming Wong, Maree T. Brinkman, Geoffrey W. Stuart, Alex Boussioutas, Melissa C. Southey, Graham G. Giles, Hazel Mitchell, Dallas R. English, Allison M. Hodge
Summary: This study aimed to investigate the potential of blood DNA methylation as a biomarker for predicting gastric cancer risk, but the results showed no significant association between blood DNA methylation and gastric cancer risk. Despite this, the importance of early diagnosis in gastric cancer remains, and the search for relevant markers continues.
CANCER PREVENTION RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Sha Lou, Bingru Zhang, Dehua Zhang
Summary: The abuse of pesticides poses major threats to human health, leading to approximately 180,000 deaths worldwide annually. The intention of tea farmers to adopt pro-green control technology is influenced by subjective norms and perceived behavioral control, with attitude having no significant impact.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Nutrition & Dietetics
Abdulmohsen H. Al-Zalabani, Anke Wesselius, Evan Yi-Wen Yu, Piet van den Brandt, Eric J. Grant, Emily White, Guri Skeie, Fredrik Liedberg, Elisabete Weiderpass, Maurice P. Zeegers
Summary: Higher consumption of tea is associated with a reduced risk of bladder cancer, especially among men and smokers. Further studies are needed to clarify the mechanisms of the protective effect of tea and its interaction with smoking and sex.
CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jing Quan, Tingjing Zhang, Yeqing Gu, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Shunming Zhang, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
Summary: A prospective cohort study found that green tea consumption is associated with a reduced risk of hypertension in premenopausal women, despite inconsistent epidemiological evidence.
Article
Endocrinology & Metabolism
Chen Pan, Dawei Deng, Tianfu Wei, Zeming Wu, Biao Zhang, Qihang Yuan, Guogang Liang, Yanfeng Liu, Peiyuan Yin
Summary: Bile acids are potential biomarkers for the early diagnosis of gastric cancer. A diagnostic panel comprising six bile acids or ratios shows high accuracy in diagnosing gastric cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yingshuang Zhu, Yeting Hu, Xiangxing Kong, Qian Xiao, Zhizhong Pan, Zhaoxu Zheng, Ye Wei, Wang Ziqiang, Da Wang, Jiaqi Chen, Kun Chen, Shu Zheng, Meilin Wang, Xifeng Wu, Kefeng Ding
Summary: The National Colorectal Cancer Cohort (NCRCC) study aims to assess risk factors and biomarkers related to colorectal cancer, using data from screening and patient cohorts. The study collects demographic, lifestyle, clinical information, survivorship endpoints, and various biospecimens, with the goal of conducting studies to optimize evidence-based guidelines for colorectal cancer.
Article
Biochemistry & Molecular Biology
Yan Pu, Xu Wen, Zhangjun Jia, Yu Xie, Changxing Luan, Youjia Yu, Feng Chen, Peng Chen, Ding Li, Yan Sun, Jian Zhao, Haiqin Lv
Summary: Gastric cancer ranks second in incidence among all malignancies in China, posing a significant threat to human health. This study identified a significant association between the EFNA1 rs4971066 polymorphism and reduced susceptibility to gastric cancer development through the analysis of tagSNPs in GC related genes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Food Science & Technology
Larissa Naomi Takeda, Lucas Fornari Laurindo, Elen Landgraf Guiguer, Anupam Bishayee, Adriano Cressoni Araujo, Lara Cristina Casadei Ubeda, Ricardo de Alvares Goulart, Sandra Maria Barbalho
Summary: Guava has medicinal properties that can be used in the treatment of various diseases and contribute to reducing the risk of chronic diseases. It also has economic importance for producing countries. The by-products of guava have potential applications in the food and cosmetic industries.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Oncology
Alisha Sachdeva, Dimple Dhawan, Gaurav K. Jain, Muekerrem Betuel Yerer, Taylor E. Collignon, Devesh Tewari, Anupam Bishayee
Summary: Oral cancer is a global cause of death, and traditional treatment methods face challenges of cancer recurrence and adverse reactions to chemotherapy drugs. Natural products play a significant role in drug discovery and have potential effects against various cancers, including oral cancer. The limited bioavailability of natural products is a major obstacle to their therapeutic application. Therefore, comprehensive utilization of various formulation strategies to improve bioavailability is important. This work presents recent advancements in novel strategies for natural product delivery that significantly enhance bioavailability and reduce adverse events in the prevention and treatment of oral cancer.
Review
Chemistry, Medicinal
Suneel Kumar, Stephen O. Mathew, Ravindra Prasad Aharwal, Hardeep Singh Tulli, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang-Seok Ahn, Kassidy Webber, Sardul Singh Sandhu, Anupam Bishayee
Summary: Cancer is a highly significant global health concern, and current treatment options, such as surgery, chemotherapy, radiation therapy, and immune therapy, have limitations and may lead to disease recurrence. Withaferin A, a natural bioactive compound found in the Indian medicinal plant Withania somnifera, has shown promising anticancer activities by modulating the expression and activity of oncogenic proteins. This article comprehensively discusses the biosynthesis, antineoplastic activities, mode-of-action, and clinical potential of withaferin A, as well as its effect on miRNA expression, combinational use with other cytotoxic agents, formulations, and safety profiles.
Review
Pathology
Amitabha Ray, Melissa J. L. Bonorden, Rajashree Pandit, Katai J. Nkhata, Anupam Bishayee
Summary: About one-fourth of the global population is overweight or obese, increasing the risk of insulin resistance, cardiovascular diseases, and infections. Obesity is connected to the severity of COVID-19 and can lead to metabolic disorders. Diabetes is associated with persistent viral infections and affects vaccine effectiveness. Monitoring inflammatory and energy homeostasis markers is important in preventing obesity-related diseases.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2023)
Correction
Chemistry, Medicinal
Elina Khatoon, Mangala Hegde, Aviral Kumar, Uzini Devi Daimary, Gautam Sethi, Anupam Bishayee, Ajaikumar B. Kunnumakkara
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Jack T. Burcher, Lindsay K. DeLiberto, Andrea M. Allen, Kaitlyn L. Kilpatrick, Anupam Bishayee
Summary: The high incidence of oral cancer and excessive treatment cost highlight the need for new oral cancer prevention and treatment options. The value of natural agents, including plant secondary metabolites, in preventing cancer and providing a wide range of anticancer drugs has been established. This study provides a comprehensive analysis of current preclinical and clinical results on the use of phytochemicals for oral cancer prevention and treatment. Phytochemicals exert their anticancer effects by modulating various signaling pathways and show promising effects in clinical trials. However, concerns about bioavailability may limit their clinical application. Future research should focus on in-depth mechanistic studies, novel formulations of phytochemicals, adjuvant use with conventional treatment, and randomized clinical trials.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Nutrition & Dietetics
Lucas Fornari Laurindo, Sandra Maria Barbalho, Adriano Cressoni Araujo, Elen Landgraf Guiguer, Arijit Mondal, Gabrielle Bachtel, Anupam Bishayee
Summary: The acai palm has been cultivated for thousands of years as a multipurpose dietary plant in Central and South America. The increasing global demand for acai berry is due to its nutritional and healing qualities, which are attributed to various bioactive phenolic compounds. Research has shown that acai possesses antioxidant and anti-inflammatory properties and has beneficial effects on cardiovascular health, gastrointestinal health, liver health, neurological health, kidney health, lipid levels, diabetes, and cancer. Clinical trials have also suggested that acai can protect against metabolic stress induced by various factors. Acai shows promising potential in health promotion, disease prevention, and economic opportunities in the food and cosmetic industries.
Review
Oncology
Dilipkumar Pal, Khushboo Raj, Shyam Sundar Nandi, Surajit Sinha, Abhishek Mishra, Arijit Mondal, Ricardo Lagoa, Jack T. Burcher, Anupam Bishayee
Summary: Histone deacetylases (HDACs) and histone acetyltransferases (HATs) regulate DNA expression by removing or adding acetyl groups to histones, respectively. HDACis have shown promise in treating malignancies by boosting immune response and diminishing tumor immunity. Additional studies are needed to evaluate the efficacy of HDACis, such as anobinostat, vorinostat, and tricostatin A, as therapeutic agents in hematological malignancies.
Review
Biochemistry & Molecular Biology
Maryam Ghanbari-Movahed, Sahar Shafiee, Jack T. Burcher, Ricardo Lagoa, Mohammad Hosein Farzaei, Anupam Bishayee
Summary: It has been found that cancer stem cells exhibit altered metabolism compared to non-CSCs, which plays a crucial role in tumor initiation, progression, immunosuppression, and resistance to conventional therapy. Two natural flavonoids, apigenin and isovitexin, have been shown to enhance the efficacy of conventional chemotherapeutic drugs by sensitizing CSCs. This study aims to critically evaluate the potential of apigenin and isovitexin in targeting CSCs in different cancers as novel therapeutic agents.
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Tara Farhadi, Osman Hesami, Amin Iranpanah, Kassidy Webber, Anupam Bishayee
Summary: The tumor microenvironment (TME) plays a crucial role in cancer development and progression. The use of nanomedicine could be a promising approach to overcome barriers in tumor-targeted therapy. Nanoparticle formulations of natural compounds have shown potential in simultaneously targeting multiple dysregulated factors in TME and reducing tumor resistance mechanisms.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Leila Kooshki, Kassidy Webber, Anupam Bishayee
Summary: Tumor cells use multiple signaling mediators to escape hypoxia and promote angiogenesis and metastasis. HIF-1 plays a critical role in tumor conditions by stimulating target genes and dysregulated pathways in invasion and migration. Targeting the HIF-1 pathway and its cross-talk mediators may be a novel strategy for cancer prevention and treatment.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Food Science & Technology
Taylor E. Collignon, Kassidy Webber, Josh Piasecki, Austin S. W. Rahman, Arijit Mondal, Sandra Maria Barbalho, Anupam Bishayee
Summary: Avocado has shown anticancer properties and contains various phytochemicals that can induce cytotoxicity, reduce tumor size and volume, making it a potential option for cancer prevention and treatment. However, more research is needed before avocado-derived phytochemicals can be developed as cancer preventive agents.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Medicinal
Siddavaram Nagini, Manikandan Palrasu, Anupam Bishayee
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Jose Diogo E. Reis, Paulo Wender P. Gomes, Paulo R. da C. Sa, Sonia das G. S. R. Pamplona, Consuelo Yumiko Y. e Silva, Maria Fatima das G. F. da Silva, Anupam Bishayee, Milton Nascimento da Silva
Summary: This study identified new potential mass spectrometry signatures for phragmalin-type limonoids in Swietenia macrophylla leaves, providing valuable information for future drug development efforts.
