Article
Gastroenterology & Hepatology
Yutaka Suzuki, Toshiyuki Mori, Hirokazu Momose, Ryota Matsuki, Masaharu Kogure, Nobutsugu Abe, Hiroyuki Isayama, Susumu Tazuma, Atsushi Tanaka, Hajime Takikawa, Yoshihiro Sakamoto
Summary: This study aimed to investigate the predictive factors for developing intrahepatic cholangiocarcinoma in hepatolithiasis. The results showed that age, residual stones at the end of treatment, and biliary stricture during follow-up were identified as independent and significant predictive factors. Patients with all three factors had a higher risk of developing intrahepatic cholangiocarcinoma compared to those with fewer factors. The duration between the diagnoses of biliary stricture and intrahepatic cholangiocarcinoma was over 5 years in most cases.
JOURNAL OF GASTROENTEROLOGY
(2022)
Editorial Material
Medicine, General & Internal
Narendra Pandit, Durga Neupane
Summary: The incidence of hepatolithiasis varies, and globalization has had an impact on disease dynamics worldwide. A multi-disciplinary team approach is essential for timely diagnosis, safe and affordable treatment, and good prognosis.
CLINICAL CASE REPORTS
(2023)
Review
Oncology
Yuki Bekki, Dagny Von Ahrens, Hideo Takahashi, Myron Schwartz, Ganesh Gunasekaran
Summary: Understanding the risk factors, patterns, and treatment options for intrahepatic cholangiocarcinoma recurrence is crucial for tailoring postoperative surveillance and selecting treatment strategies. Re-resection may be considered for selected patients at experienced centers, potentially leading to long-term survival. ICC remains a challenging disease, but advances in understanding its genomic landscape are paving the way for personalized treatment options.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jun Seong Hwang, Sung Woo Ko
Summary: Duplication of the extrahepatic bile duct (DCBD) is an extremely rare congenital anomaly with five types, among which Type V is characterized by single drainage of the extrahepatic bile ducts. This case report highlights the importance of recognizing DCBD, as stones in the unrecognized bile duct could have critical consequences for the patient's prognosis. In this case, a patient with DCBD Type Va and remnant choledocholithiasis was successfully treated with ERCP and magnetic resonance cholangiopancreatography.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
HongTian Xia, HangYu Zhang, XianLei Xin, Bin Liang, Tao Yang, Yang Liu, Jing Wang, XiangFei Meng
Summary: This study aimed to analyze the causes of postoperative recurrence of primary intrahepatic bile duct stones and establish appropriate surgical procedures. The results showed that prior cholangiojejunostomy and abnormalities in the structure and function of the common bile duct were associated with recurrence. Surgical procedures including bile duct exploration, partial hepatectomy, hilar ductoplasty, and Roux-en-Y hepaticojejunostomy improved long-term outcomes and reduced recurrence.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Hua Zhao, Benliang Lu
Summary: This study found that serum CA19-9 may be an effective tumor marker in the diagnosis of HL-CCA, with high sensitivity and specificity in the differential diagnosis between hepatolithiasis and HL-CCA. Combined detection of multiple serum tumor markers can improve the detection of HL-CCA.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Jun Li, Jiongjiong Lu, Shaodong Lv, Shujun Sun, Caifeng Liu, Feng Xu, Haiying Sun, Jiamei Yang, Xinjun Wang, Xingyang Zhong, Junhua Lu
Summary: Studying the metabolic phenotypic differences between IBDS and ICC can provide potential mechanisms and therapeutic targets. Long-term monitoring of metabolites and liver function indicators in IBDS patients is important for monitoring IBDS carcinogenesis.
BMC GASTROENTEROLOGY
(2022)
Article
Oncology
Liming Deng, Yi Wang, Jungang Zhao, Yifan Tong, Sina Zhang, Chen Jin, Kaiyu Chen, Wenming Bao, Zhengping Yu, Gang Chen
Summary: ICC patients with sarcopenia and hepatolithiasis have poorer overall survival and recurrence-free survival. The developed nomogram provides a practical tool for more individualized risk assessment for ICC patients undergoing surgical treatment.
Article
Gastroenterology & Hepatology
Hao Shen, Shichao Zhang, Yong Xia, Can Chen, Lei Huo, Linhe Gan, Jun Li, Kui Wang, Timothy M. Pawlik, Wan Yee Lau, Mengchao Wu, Feng Shen
Summary: This study identified risk factors for the development of intrahepatic cholangiocarcinoma (ICC) in patients with hepatolithiasis after partial hepatectomy (PH) and developed a nomogram to predict ICC risk. Independent risk factors included duration of symptoms, metabolic syndrome, neutrophil-to-lymphocyte ratio, hepatic atrophy, segmental intensity differences, persistent biliary strictures, and residual stone disease. The constructed nomogram showed good predictive ability for ICC after PH for hepatolithiasis.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Seung Jae Lee, In Seok Choi, Ju Ik Moon, Yong Woo Choi
Summary: Single-stage laparoscopic CBD exploration (LCBDE) combined with laparoscopic cholecystectomy (LC) is a safe and effective treatment option for patients with concomitant gallbladder stones and common bile duct stones compared to endoscopic stone extraction (ESE) combined with LC. LCBDE should be considered for patients at high risk of ESE failure, and careful follow-up is recommended for patients at high risk of recurrence of CBD stones, especially within 24 months after surgical or endoscopic treatment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Immunology
Xiao-Jun Guo, Jia-Cheng Lu, Hai-Ying Zeng, Rong Zhou, Qi-Man Sun, Guo-Huan Yang, Yan-Zi Pei, Xian-Long Meng, Ying-Hao Shen, Peng-Fei Zhang, Jia-Bin Cai, Pei-Xin Huang, Ai-Wu Ke, Ying-Hong Shi, Jian Zhou, Jia Fan, Yi Chen, Liu-Xiao Yang, Guo-Ming Shi, Xiao-Yong Huang
Summary: The study found that in ICC tumors, CTLA-4(+) lymphocyte density was elevated compared to peritumoral hepatic tissues, and patients with high CTLA-4(+) tumor-infiltrating lymphocytes (TILs(CTLA-4 High)) had lower overall survival rates and higher cumulative recurrence rates. High FOXP3(+) TILs (TILs(FOXP3 High)) were associated with poorer prognoses, and the density of CTLA-4(+) TILs was positively correlated with FOXP3(+) TILs. High PD-L1 expression in tumors (Tumor(PD-L1 High)) and/or TILs(CTLA-4 High) were also linked to worse outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Qi Li, Chen Chen, Jingbo Su, Yinghe Qiu, Hong Wu, Tianqiang Song, Xianhai Mao, Yu He, Zhangjun Cheng, Jingdong Li, Wenlong Zhai, Dong Zhang, Zhimin Geng, Zhaohui Tang
Summary: This study aimed to evaluate the prognosis and adjuvant chemotherapy in intrahepatic cholangiocarcinoma patients with different etiology after radical resection. The study found that different etiology is a prognostic factor for overall survival and relapse-free survival in ICC patients, and etiology is also an independent risk factor for overall survival. The study also showed that adjuvant chemotherapy can improve the prognosis of patients with hepatolithiasis.
Review
Surgery
Ali Ramouz, Sadeq Ali-Hasan-Al-Saegh, Saeed Shafiei, Sanam Fakour, Elias Khajeh, Ali Majlesara, Ali Adeliansedehi, Pascal Probst, Christoph Springfeld, De-Hua Chang, Christian Rupp, Carlos Carvalho, Mohammad Golriz, Katrin Hoffmann, Arianeb Mehrabi
Summary: Repeat liver resection is a suitable strategy for the treatment of recurrent intrahepatic cholangiocarcinoma, improving short- and long-term outcomes compared to non-surgical approaches.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Cell Biology
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
Summary: The prevalence of bile duct adenomas in the background liver was significantly higher in small duct iCCA compared to other primary liver carcinomas, suggesting they may be precursor lesions. Alterations in ARID1A, p53, and PBRM1 genes may be involved in the carcinogenesis of small duct iCCA.
Article
Gastroenterology & Hepatology
Fabian Bartsch, Johannes Eberhard, Felix Rueckert, Moritz Schmelzle, Nadja Lehwald-Tywuschik, Stefan Fichtner-Feigl, Jochen Gaedcke, Karl J. Oldhafer, Felix Oldhafer, Markus Diener, Arianeb Mehrabi, Utz Settmacher, Thomas Becker, Tobias Keck, Helmut Friess, Benjamin Struecker, Sabine Opitz, Johannes Lemke, Andreas Schnitzbauer, Hauke Lang
Summary: Repeated resection of intrahepatic cholangiocarcinoma (ICC) shows acceptable morbidity and mortality rates, with improved long-term survival outcomes. Factors such as preoperative CA19-9 levels, R status of initial liver resection, and time to recurrence play significant roles in determining the feasibility of repeated resection. Structured follow-up post-ICC resection is crucial for early identification and management of recurrent cases.
LIVER INTERNATIONAL
(2021)