期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 19, 期 7, 页码 984-993出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v19.i7.984
关键词
Curcumin; Resveratrol; (-)-Epigallocatechin gallate; Isothiocyanates; Sulforaphane; Gastroenterological cancers; Molecular target
资金
- Next-Generation BioGreen 21 Program (Plant Molecular Breeding Center) [PJ008187]
- Rural Development Administration
- Leap Research Program [2010-0029233]
- World Class University Program through the National Research Foundation of Korea [R31-2008-00-10056-0]
- Ministry of Education, Science and Technology, South Korea
Cancer is one of the leading causes of death worldwide. Commonly used cancer treatments, including chemotherapy and radiation therapy, often have side effects and a complete cure is sometimes impossible. Therefore, prevention, suppression, and/or delaying the onset of the disease are important. The onset of gastroenterological cancers is closely associated with an individual's lifestyle. Thus, changing lifestyle, specifically the consumption of fruits and vegetables, can help to protect against the development of gastroenterological cancers. In particular, naturally occurring bioactive compounds, including curcumin, resveratrol, isothiocyanates, (-)-epigallocatechin gallate and sulforaphane, are regarded as promising chemopreventive agents. Hence, regular consumption of these natural bioactive compounds found in foods can contribute to prevention, suppression, and/or delay of gastroenterological cancer development. In this review, we will summarize natural phytochemicals possessing potential antioxidant and/or anti-inflammatory and anti-carcinogenic activities, which are exerted by regulating or targeting specific molecules against gastroenterological cancers, including esophageal, gastric and colon cancers. (C) 2013 Baishideng. All rights reserved.
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