Article
Pharmacology & Pharmacy
Xiaomi Li, Jingyan Wang, Xiaoyan Ding, Yawen Xu, Minghua Yu, Hongxiao Wu, Na Deng, Wei Li, Jinglong Chen
Summary: The clinical efficacy of lenvatinib was compared between hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and hepatitis C virus (HCV)-related HCC. The study found that patients with HBV-HCC had higher objective response rate and disease control rate compared to HCV-HCC, but there were no significant differences in progression-free survival and overall survival between the two groups. Multivariate regression analysis identified HBV infection and antiviral time > 5 years as independent favorable factors for progression-free survival. Overall, lenvatinib seemed to be more effective in HBV-related HCC compared to HCV-related HCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jing Miao, Peng Gao, Qian Li, Kaifeng He, Liwen Zhang, Junyan Wang, Lingfei Huang
Summary: Nanoparticle drug delivery systems play a crucial role in anti-hepatitis B virus therapy, promoting the development of related strategies with their superior characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Gastroenterology & Hepatology
Po-Yao Hsu, Yu-Ju Wei, Po-Cheng Liang, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ching- Huang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Ming-Lun Yeh, Chung-Feng Huang, Yi-Wen Chiu, Shang-Jyh Hwang, Wan-Long Chuang, Ming-Lung Yu
Summary: Hemodialysis patients are at increased risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study found that hemodialysis patients with HCV exhibited a higher burden of comorbidities, especially in ischemic heart diseases, respiratory disorders, and mental/behavioral disorders, compared to patients with HBV and those without viral hepatitis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Infectious Diseases
Haruna Hatooka, Yumi Shimomura, Michio Imamura, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Grace Naswa Makokha, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiromi Abe-Chayama, C. Nelson Hayes, Hiroshi Aikata, Shinji Tanaka, Kazuaki Chayama
Summary: The study developed an antibody against preS1 and an ELISA system for measuring serum preS1 levels. PreS1 may serve as a novel tool to predict the need for antiviral therapy in HBeAg-negative HBV-infected patients.
JOURNAL OF INFECTION
(2022)
Article
Biophysics
Suchanat Boonkaew, Abdulhadee Yakoh, Nattaya Chuaypen, Pisit Tangkijvanich, Sirirat Rengpipat, Weena Siangproh, Orawon Chailapakul
Summary: Electrochemical paper-based analytical devices (ePADs) are simple, portable, and low-cost analytical devices for point-of-care testing of clinical biomarkers. A sequential ePAD has been developed for simultaneous detection of hepatitis B surface antigen and hepatitis C core antigen by integrating dual flow behaviors, avoiding the need for complex multi-step reagent manipulation by the user. The proposed ePAD shows high promise as an easy-to-use, portable, and extendable sensor for other multiplex biological assays.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Public, Environmental & Occupational Health
S. Mehmandoost, M. Khezri, G. Mousavian, F. Tavakoli, F. Mehrabi, H. Sharifi, K. Dolan, M. Shokoohi
Summary: This study systematically summarized the prevalence of HIV, HBV, and HCV infections among incarcerated people in Iran. The results showed that the prevalences of these infections are relatively high in this population. Meta-analysis and regression analysis found a decrease in HIV and HCV infections over time.
Editorial Material
Virology
Syeda Kanza Kazmi, Fatima Muhammad Asad Khan, Valentino Natoli, Reem Hunain, Zarmina Islam, Ana Carla dos Santos Costa, Shoaib Ahmad, Mohammad Yasir Essar
Summary: Hepatitis is a significant cause of mortality worldwide, with around 1.34 million deaths annually. Africa is not immune to this issue, with an estimated 100 million individuals infected with Hepatitis B or C. The continent, already fragile, is further burdened by the onset of the COVID-19 pandemic, which could potentially worsen the threat from viral diseases like Hepatitis. Strengthening prevention policies is essential for Africa to build resilience against such threats.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Oncology
Yung-Rung Lai, Ya-Lan Chang, Chiu-Hsiang Lee, Tung-Han Tsai, Kuang-Hua Huang, Chien-Ying Lee
Summary: The study found that patients with HBV and HCV have a higher incidence of NHL, indicating a significant correlation.
Review
Immunology
Wen Hou, Xiaoli Wu
Summary: This study investigates the roles of gamma delta T cells in HBV and HCV infections, discussing the different roles they play in the progression of liver diseases at various stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wanting Shi, Kang Li, Yonghong Zhang
Summary: Viral hepatitis, primarily caused by HBV and HCV, is a global health concern. Delayed diagnosis and treatment can lead to liver damage and the development of cirrhosis. Traditional methods have limitations in detecting viral presence, while the use of nanomaterials has advanced virus detection technologies.
Article
Oncology
Shih-Han Hung, Tzong-Hann Yang, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
Summary: This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection, and suggests a potential association between HBV and HCV infections and the risk of HNC.
Review
Gastroenterology & Hepatology
Ivana Skrlec, Jasminka Talapko
Summary: The circadian rhythm plays a crucial role in HBV infection and antiviral treatment, and understanding its role can optimize antiviral therapy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Alexis Jose-Abrego, Ingrid Rivera-Iniguez, Luis A. Torres-Reyes, Sonia Roman
Summary: Hepatitis B virus (HBV), a significant cause of chronic liver damage and hepatocellular carcinoma, has different therapeutic options depending on the disease stage. Antivirals are commonly used for chronic patients, while liver transplantation is the best option for end-stage liver disease. However, accessibility and cost issues limit HBV patients' access to treatment, leading to the exploration of alternative approaches like nutritional therapy. This review summarizes the potential antiviral activity of various nutrients against HBV and their mechanisms of action, suggesting promising options such as resveratrol, vitamin E, lactoferrin, selenium, curcumin, and more.
ANNALS OF HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Samina Ejaz, Iqra Abdullah, Waqas Nazir Malik, Shazia Anjum, Muhammad Ashraf, Naveed Akhtar, Aurangzeb Khan, Yasir Hameed, Muhammad Usman, Usman Cheema, Safeena Sidiq
Summary: This study aims to investigate the prevalence and associated risk factors of hepatitis among students and employees in Pakistan and implement measures to make IUB hepatitis free. The study found that hepatitis is more prevalent in men and is associated with sharing of needles and certain behavioral and medical factors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Cristina Sanfilippo, Paola Castrogiovanni, Manlio Vinciguerra, Rosa Imbesi, Martina Ulivieri, Francesco Fazio, Kaj Blennow, Henrik Zetterberg, Michelino Di Rosa
Summary: This study found that high levels of CHI3L1 and CHI3L2 in the brains of AD patients are associated with inflammatory transcriptomic signatures. High CHI3L1 and CHI3L2 expression is associated with inflammatory features, while low expression is associated with neuronal activation. Gene ontology analysis revealed immune response as a main biological process based on the common genes regulated by the two chitinases.
Review
Biochemistry & Molecular Biology
Desislava K. K. Tsoneva, Martin N. N. Ivanov, Nikolay Vladimirov Conev, Rostislav Manev, Dragomir Svetozarov Stoyanov, Manlio Vinciguerra
Summary: Liquid biopsies have emerged as a minimally invasive method for detecting and monitoring cancer, using blood, saliva, and urine to identify cancer-related alterations in nucleosome or histone levels and modifications. Circulating histones and histone complexes have shown promise as biomarkers for cancer detection and management, originating from cell death or immune cell activation. This review provides an overview of circulating histones as a powerful liquid biopsy approach, highlighting their role in hematologic malignancies and solid cancer, as well as strategies for their detection and identification of cancer tissue-of-origin in blood plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Concetta Panebianco, Annacandida Villani, Adele Potenza, Enrica Favaro, Concetta Finocchiaro, Francesco Perri, Valerio Pazienza
Summary: Cancer cachexia is a complex syndrome characterized by weight loss, anorexia, inflammation, and metabolic alterations, which negatively impact cancer patients. Studies have shown a link between gut microbiota and cancer cachexia, suggesting a role for dysbiosis in its pathogenesis. Different manipulation tools of gut microbiota have shown promising improvements in cachexia outcomes, paving the way for future research and clinical interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jan Frohlich, Marco Raffaele, Helena Skalova, Eric Leire, Illar Pata, Pille Pata, Vera Gorbunova, Manlio Vinciguerra
Summary: Non-alcoholic fatty liver disease (NAFLD) is a rapidly rising health concern worldwide. SIRT6 overexpression has been implicated in the amelioration of NAFLD progression, but the underlying molecular mechanisms are not fully understood. This study aimed to clarify how new centenarian-associated SIRT6 genetic variants affect liver metabolism and associated diseases. The results suggest that these variants could prevent NAFLD by altering hepatocyte proteome and lipidome.
Review
Biochemistry & Molecular Biology
Sara Gomes, Ana Catarina Rodrigues, Valerio Pazienza, Ana Preto
Summary: Finding new therapeutic approaches to colorectal cancer is crucial due to its high prevalence. Current standard therapies have limitations in terms of side effects and resistance. Microbiota-derived short-chain fatty acids have shown antitumorigenic properties and can modulate the tumor microenvironment. Manipulating the gut microbiota to increase the production of these fatty acids may be an important strategy in colorectal cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Cristina Sanfilippo, Paola Castrogiovanni, Manlio Vinciguerra, Rosa Imbesi, Martina Ulivieri, Francesco Fazio, Antonio Cantarella, Giuseppe Nunnari, Michelino Di Rosa
Summary: Neurological complications of AIDS, such as HIV-associated neurocognitive disorder (HAND), are influenced by OAS3 gene expression and inflammation.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Review
Behavioral Sciences
A. M. Tartaglione, V. Pazienza, G. Calamandrei, L. Ricceri
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and repetitive behaviors. The microbiota-gut-brain axis has been recognized as a potential therapeutic target for ASD. This article provides an overview of microbiota changes in ASD murine models and discusses therapeutic approaches targeting the microbiota and neurobehavioral profiles. Despite variations in microbiota composition among different ASD murine models, studying these models under standardized conditions can still yield valuable insights into the effects of manipulating gut microbiota on behavioral abnormalities and the underlying neurobiological mechanisms related to the gut-brain axis.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Medicine, General & Internal
Claudio Carmine Guida, Maria Nardella, Leonardo Fiorentino, Tiziana Latiano, Francesco Napolitano, Gaetano Ferrara, Annalisa Crisetti, Gianluigi Mazzoccoli, Francesco Aucella, Filippo Aucella
Summary: Patients with acute hepatic porphyria are at a high risk of developing primary liver cancer, particularly hepatocellular carcinoma and cholangiocarcinoma, due to the active nature of the disease, although the exact mechanism of carcinogenesis is still unknown. This case report presents the clinical case of a 72-year-old woman who developed intrahepatic cholangiocarcinoma approximately 29 years after being diagnosed with acute intermittent porphyria. The tumor was histologically diagnosed as adenocarcinoma originating from the biliary-pancreatic ducts, and was discovered during the evaluation of a pathological femur fracture.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Laura Manna, Eleonora Rizzi, Eleonora Bafile, Andrea Cappelleri, Massimiliano Ruscica, Chiara Macchi, Michele Podaliri Vulpiani, Romolo Salini, Emanuela Rossi, Concetta Panebianco, Francesco Perri, Valerio Pazienza, Federica Federici
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that have a significant impact on patients' quality of life. This study aimed to evaluate the effects of oral administration of Lentilactobacillus kefiri SGL 13 and Andrographis paniculata on DSS-treated mice.
FRONTIERS IN NUTRITION
(2023)
Article
Biotechnology & Applied Microbiology
Valentina Melocchi, Roberto Cuttano, Emanuele Murgo, Gianluigi Mazzoccoli, Fabrizio Bianchi
Summary: The progression and resistance of cancer can be attributed to the heterogeneity of tumor cells caused by their plasticity. The development programs related to the epithelial-to-mesenchymal transition and acquisition of stem cell properties play essential roles in this process. Through computational analysis, we identified time-specific molecular states in colorectal cancer and lung adenocarcinoma, which are associated with different patterns of gene expression. This temporal classification allows for a better understanding of cancer phenotype switching and its impact on patient prognosis.
CANCER GENE THERAPY
(2023)
Editorial Material
Genetics & Heredity
Desislava K. Tsoneva, Manlio Vinciguerra
Article
Genetics & Heredity
Niccolo Liorni, Alessandro Napoli, Stefano Castellana, Sebastiano Giallongo, Daniela Rehakova, Oriana Lo Re, Irena Koutna, Tommaso Mazza, Manlio Vinciguerra
Summary: This study used a combination of CUT&Tag and RNA-Seq data to analyze the differences between macroH2A1.1 and macroH2A1.2 during iPSCs reprogramming. The results demonstrated that macroH2A1.1 had wider genome occupancy and specifically activated ectoderm/neural processes during reprogramming.
Article
Multidisciplinary Sciences
Riccardo Turchi, Francesca Sciarretta, Veronica Ceci, Marta Tiberi, Matteo Audano, Silvia Pedretti, Concetta Panebianco, Veronica Nesci, Valerio Pazienza, Alberto Ferri, Simone Carotti, Valerio Chiurchiu, Nico Mitro, Daniele Lettieri-Barbato, Katia Aquilano
Summary: Friedreich's ataxia (FA) is a neurodegenerative disease caused by a mutation in the FXN gene, leading to deficiency of mitochondrial frataxin. This study investigated the role of visceral white adipose tissue (vWAT) in FA-related metabolic complications. The findings suggest that vWAT abnormalities contribute to metabolic issues in FA, and a butyrate-enriched diet may be a safe and promising adjunct for FA management.
Review
Gastroenterology & Hepatology
Desislava K. Tsoneva, Martin N. Ivanov, Manlio Vinciguerra
Summary: Liver diseases are a global burden and their prevalence is expected to increase in the coming years. Current blood markers for liver dysfunction have limited accuracy, while liver biopsy poses risks due to its invasive nature. Liquid biopsy, which detects disease-associated particles in biological fluids, has shown promise in the diagnosis, prognosis, and monitoring of liver diseases. Histones, core components of nucleosomes, can be detected in circulation and offer stable biomarkers for liver diseases. This article provides an overview of the research on histone-mediated liquid biopsy methods for liver diseases, focusing on common detection methods.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Giuseppe Mainas, Pasquale Santamaria, Mark Ide, Valter Longo, Manlio Vinciguerra, Jose Nart, Luigi Nibali
Summary: This review aimed to evaluate the potential benefits of caloric restriction (CR) on periodontal disease progression and treatment response. Through electronic and manual searches, it was found that CR may have the potential to reduce the hyper-inflammatory state and disease progression in periodontal patients. However, the results should be interpreted with caution as more robust research is needed.
CLINICAL ORAL INVESTIGATIONS
(2023)
