Review
Immunology
Zhaosong Meng, Tianle Yang, Dayong Liu
Summary: The oral mucosa is a protective barrier against pathogens, and inflammatory oral mucosal disorders are associated with type-2 epithelial-mesenchymal transition (EMT). This review comprehensively evaluates type-2 EMT in chronically inflammatory oral mucosal disorders, aiming to provide a foundation for future research and potential treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Pelin Balcik-Ercin, Laure Cayrefourcq, Rama Soundararajan, Sendurai A. Mani, Catherine Alix-Panabieres
Summary: Metastasis is a complex and not fully understood process in cancer, where circulating tumor cells (CTCs) play a crucial role. CTCs possess a unique ability to transition between epithelial and mesenchymal states, known as epithelial-to-mesenchymal plasticity (EMP), which aids in their metastatic potential. This study focuses on the EMP phenotype of colon CTC lines, showing that these cells have minimal mesenchymal features but exhibit an increase in mesenchymal-epithelial transition (MET) markers, suggesting a quick reversion to the epithelial state for successful metastasis.
Review
Pharmacology & Pharmacy
Paula I. Escalante, Luis A. Quinones, Hector R. Contreras
Summary: The FOLFOX scheme is commonly used for metastatic colorectal cancer patients, but chemoresistance is a major challenge. EMT and overexpression of multiple genes may contribute to drug resistance.
Article
Cell Biology
Xinyue Yu, Qian Wang, Baocai Liu, Ning Zhang, Guanghui Cheng
Summary: Vitamin D3 demonstrates antitumor effects on colorectal cancer cells and sensitizes them to ionizing radiation by regulating apoptosis, autophagy, and epithelial-mesenchymal transition (EMT). Proteomics analysis reveals that VD3 can modulate cell migration and cadherin expression to enhance radiosensitivity. Additionally, VD3 can partially block the JAK/STAT3 signaling pathway to increase sensitivity to radiation, providing a novel insight for improving therapeutic efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Katrien De Clercq, Joris Vriens
Summary: EMT is a tightly regulated process essential for normal development but can also lead to fibrosis and cancer progression. Calcium is a key player in translating molecular messages during EMT, and calcium-permeable ion channels play a significant role in influencing cellular phenotype. TRP channels, as cellular sensors, are important proteins involved in decoding physical and chemical stimuli, making them ideal candidates to study in the context of phenotypic transitions like EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Cristina Lungulescu, Valentina Ghimpau, Dan Ionut Gheonea, Daniel Sur, Cristian Virgil Lungulescu
Summary: This systematic review investigates the expression and function of neuropilin-2 (NRP-2) in colorectal cancer. The majority of studies suggest that NRP-2 is highly expressed in colorectal cancer cells compared to normal colonic mucosa. The presence of NRP-2 is associated with epithelial-mesenchymal transition and metastatic progression in cancer.
Review
Cell Biology
Guya D. Marconi, Luigia Fonticoli, Thangavelu Soundara Rajan, Sante D. Pierdomenico, Oriana Trubiani, Jacopo Pizzicannella, Francesca Diomede
Summary: The epithelial-mesenchymal transition (EMT) is a crucial event in cell development, playing key roles in wound healing and organ fibrosis. EMT is classified into three types: type-1 EMT, type-2 EMT, and type-3 EMT, each with specific functions in embryogenesis, wound healing, and cancer progression respectively.
Article
Pharmacology & Pharmacy
Zhiyao Xu, Zhuha Zhou, Jing Zhang, Feichao Xuan, Mengjing Fan, Difan Zhou, Zhenyu Liuyang, Ximei Ma, Yiyang Hong, Yihong Wang, Sherven Sharma, Qinghua Dong, Guanyu Wang
Summary: The study showed that the polycomb protein BMI-1 plays a crucial role in colorectal cancer liver metastasis, and knocking down BMI-1 can reduce liver metastasis, suggesting it as a potential therapeutic target.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Fengting Liu, Xiaofang Ma, Xiyun Bian, Chunyan Zhang, Xiaozhi Liu, Qiang Liu
Summary: This study aimed to uncover the epigenetic regulation mechanism of the LINC00586/LSD1/ASXL1 axis in colorectal cancer (CRC). The results revealed that LINC00586 overexpression was associated with CRC patient survival, and silencing LINC00586 could inhibit the viability and migration of CRC cells, thereby limiting CRC metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patricia F. de Souza Oliveira, Alessandra V. S. Faria, Stefano P. Clerici, Erica M. Akagi, Hernandes F. Carvalho, Giselle Z. Justo, Nelson Duran, Carmen Ferreira-Halder
Summary: This study evaluates the ability of violacein to interfere with cancer hallmarks and demonstrates its inhibitory effects on cell migration and signaling pathways in colorectal cancer cells and spheroids. These findings further reinforce the potential of violacein as an antitumor agent.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Cell Biology
Dulce C. Macias-Ceja, M. Teresa Mendoza-Ballesteros, Maria Ortega-Albiach, M. Dolores Barrachina, Dolores Ortiz-Masia
Summary: Chronic inflammation in inflammatory bowel disease (IBD) can lead to tissue damage and remodeling, ultimately resulting in fibrosis. Epithelial cells play a key role in fibrosis by promoting fibroblast activation and extracellular matrix deposition. Additionally, epithelial cells can undergo epithelial-mesenchymal transition and directly contribute to fibroblast activation and extracellular matrix deposition. Understanding these complex interactions may provide new therapeutic targets for preventing or treating fibrosis in IBD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sara Lovisa
Summary: EMT, a process crucial in wound healing, fibrosis, and cancer, has gained significant attention from researchers since its discovery in the seventies. Despite advances in understanding its functional role, targeting EMT in fibrotic diseases remains a challenge at an early stage of development.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Multidisciplinary Sciences
Ruina Li, Hui Xu, Xiaoling Gao
Summary: Epithelial-mesenchymal transition (EMT) is involved in the progression and metastasis of colorectal cancer (CRC), and dysregulation of non-coding RNA (ncRNA) is linked to EMT. CeRNA dysregulation-induced EMT, involving lncRNA, miRNA, and mRNA interactions, has attracted attention in CRC. Understanding the role of ceRNA networks and key transcription factors in EMT, as well as miRNAs and lncRNAs targeting genes for EMT promotion, is critical for exploring therapeutic targets in CRC.
Article
Medicine, Research & Experimental
Omer Faruk Hatipoglu, Eyyup Uctepe, Gabriel Opoku, Hidenori Wake, Kentaro Ikemura, Takashi Ohtsuki, Junko Inagaki, Mehmet Gunduz, Esra Gunduz, Shogo Watanabe, Takashi Nishinaka, Hideo Takahashi, Satoshi Hirohata
Summary: The study demonstrated that knocking down osteopontin (OPN) using small interfering RNA (siRNA) effectively reduced fibrotic areas in a mouse model of pulmonary fibrosis. OPN siRNA treatment also led to a decrease in inflammatory cell count in bronchoalveolar lavage fluid. Furthermore, both in vitro and in vivo experiments showed that OPN downregulation effectively reduced pulmonary fibrosis and epithelial-mesenchymal transition.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Nima Zafari, Mahla Velayati, Mohammadreza Nassiri, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan
Summary: Preventing the metastasis of colorectal cancer is crucial for improving the survival rate of patients, and targeting the epithelial-to-mesenchymal transition (EMT) process has shown promising results.
CURRENT PHARMACEUTICAL DESIGN
(2022)