期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 18, 期 11, 页码 1257-1261出版社
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v18.i11.1257
关键词
Non-Helicobacter pylori; Bacterial flora; Gastrointestinal diseases; Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
资金
- major projects of infectious disease prevention and control in China, including AIDS and viral hepatitis [2008ZX10004-002, 2009ZX10603]
AIM: To investigate the non-Helicobacter pylori (H. pylon) bacterial flora concurrent with H. pylon infection. METHODS: A total of 103 gastric biopsy specimens from H. pylori positive patients were selected for bacterial culture. All the non-H. pylori bacterial isolates were identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). RESULTS: A total of 201 non-H. pylori bacterial isolates were cultivated from 67 (65.0%) of the 103 gastric samples including 153 isolates identified successfully at species level and 48 at genus level by MALDI-TOF MS. The dominant species were Streptococcus, Neisseria, Rothia and Staphylococcus, which differed from the predominantly acid resistant species reported previously in healthy volunteers. The prevalence of non-H. pylori bacteria was higher in non-ulcer dyspepsia group than in gastric ulcer group (100% vs 42.9%, P < 0.001). Six bacterial species with urease activity (Staphylococcus epidermidis, Staphylococcus warneri, Staphylococcus capitis; Staphylococcus aureus, Brevibacterium spp. and Klebsiella pneumoniae) were also isolated. CONCLUSION: There is a high prevalence of the non-H. pylori bacteria concurrent with H. pylori infection, and the non-H. pylori bacteria may also play important as-yet-undiscovered roles in the pathogenesis of stomach disorders. (C) 2012 Baishideng. All rights reserved.
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