Review
Oncology
Katyana Amilca-Seba, Michele Sabbah, Annette K. Larsen, Jerome A. Denis
Summary: The mortality of colorectal cancer is linked to metastatic disease and undetectable micro-metastasis growth. Therapeutic strategies are efficient for locally advanced cancer but struggle to cure metastatic disease due to drug resistance and aggressive phenotype. Osteopontin is emerging as a valuable biomarker in various cancer types, including CRC, and shows potential as a therapeutic target.
Article
Immunology
Tongwu Bie, Xuewen Zhang
Summary: The research revealed significant upregulation of SPP1 in head and neck squamous cell carcinoma tissues and identified it as a prognostic biomarker for HNSCC.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Yu An, Gulimirerouzi Fnu, Changchun Xie, Georg F. F. Weber
Summary: This study conducted a comprehensive analysis of splice variants of Osteopontin and found that they have different expression patterns in various cancer patients, which are related to tumor grade, stage, and patient survival. However, there are still some discrepancies that need further investigation to clarify the diagnostic, prognostic, and potentially predictive potential of Osteopontin splice variants.
Article
Oncology
Weimin Wang, Ke Min, Gaoyang Chen, Hui Zhang, Jianliang Deng, Mengying Lv, Zhihong Cao, Yan Zhou
Summary: This study identified key co-expression module MEyellow related to GC metastasis using WGCNA, and discovered several new biomarkers. FAM30A and TIMD4 could be effective markers for predicting prognosis and therapeutic targets in GC.
Article
Cell Biology
Shiqing Liu, Chengping Hu, Min Li, Jian An, Wolong Zhou, Jia Guo, Yao Xiao
Summary: This study reveals that estrogen receptor beta promotes non-small-cell lung cancer cell invasion through regulating the circ-TMX4/miR-622/CXCR4 signaling pathway. These findings provide a new target for the development of treatment strategies to suppress lung cancer progression.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Jinqi Xue, Xudong Zhu, Xinbo Qiao, Yulun Wang, Jiawen Bu, Xiaoying Zhang, Qingtian Ma, Lu Liang, Lisha Sun, Caigang Liu
Summary: This study evaluated the role of CEMIP in the survival outcome of breast cancer (BC) patients and explored its regulatory mechanism. The results showed that CEMIP expression was higher in BC tissues and was associated with a worse prognosis. CEMIP and its coexpressed genes were found to participate in the progression of BC. Therefore, CEMIP may serve as a potential biomarker for the treatment of BC patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Weihua Jiang, Xiao-Liang Xing, Chenguang Zhang, Lina Yi, Wenting Xu, Jianghua Ou, Ning Zhu
Summary: The study found that the expression of MET and FASN in TNBC patients is closely related to clinical pathological characteristics and prognosis, with positive expression significantly correlated with lymph node metastasis, pathological TNM, and pathological Stage. The combined use of MET and FASN can better predict the survival condition of patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Monu Pandey, Abhirup Mukhopadhyay, Surender K. Sharawat, Sachin Kumar
Summary: SCLC, a smoking-related aggressive cancer, shows universal loss of TP53 and RB1 tumor suppressor genes, with miRNAs playing a key role in regulating cell processes and potential clinical applications in monitoring chemotherapy responses and predicting survival outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Xueling Wang, Haoran Li, Xiaotian Chang, Zibin Tian
Summary: This study evaluated the ability of serum monosaccharides to predict lymph node metastasis and prognosis in colorectal cancer patients. The results showed that high levels of serum mannose and galactose were associated with lymph node metastasis, and mannose performed better than carcinoembryonic antigen in predicting lymph node metastasis. Histologic grade, lymphovascular invasion, CEA, and mannose levels were identified as independent risk factors for lymph node metastasis. Additionally, high serum mannose was associated with poor prognosis in colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhengbao Zhu, Yan He, Mengyao Shi, Daoxia Guo, Kaixin Zhang, Liyun Ren, Yanbo Peng, Pinni Yang, Jing Chen, Yuhan Zang, Aili Wang, Tan Xu, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
Summary: Elevated plasma osteopontin levels at baseline were found to be associated with increased risks of adverse clinical outcomes at 1 year after ischemic stroke in this study.
Article
Oncology
Ningning Li, Liwei Gao, Yuping Ge, Lin Zhao, Chunmei Bai, Yingyi Wang
Summary: This study aimed to investigate the predictive and prognostic values of circulating biomarkers in patients with advanced esophageal and gastric cancers receiving chemotherapy. The results showed that lymphocyte subsets, blood cell counts, and inflammatory parameters were significantly associated with treatment efficacy and patient survival. A combination of these markers can be used to stratify patients into risk groups, which could improve treatment strategies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yun Chen, Jianliang Chen, Dainian Guo, Peixuan Yang, Shuang Chen, Chengkuan Zhao, Chengcheng Xu, Qiuzhen Zhang, Chaoxian Lin, Shilong Zhong, Shuyao Zhang
Summary: This study investigates the effects of tryptophan (TRP) metabolism on the clinical outcomes of esophageal cancer (EC) in a Chinese population cohort. The findings suggest that the TRP metabolic profile is associated with susceptibility, tumor metastasis, and overall survival (OS) in patients with EC. The study provides insights into targeting endogenous TRP metabolism as a potential therapeutic intervention for EC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yuqing Dong, Shuning Zhang, Shuangyuan Zhao, Ming Xuan, Guiquan Zhu, Zhuang Zhang, Weihua Guo
Summary: Increased CCL2 concentration is associated with short-term progress-free survival and predicts patient prognosis. CCL2 may be a preferable biomarker for predicting the prognosis of patients with tongue cancer.
CANCER BIOLOGY & THERAPY
(2023)
Article
Oncology
Zheng Li, Nan Liang, Na Wang, Yan Jia, Cui Tian
Summary: This study found that high expression of WDR5 is associated with poor prognosis in brain metastases from NSCLC. Additionally, KPS is also a prognostic factor, with high KPS indicating a more favorable prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Valeria Lucarini, Daniela Nardozi, Valentina Angiolini, Monica Benvenuto, Chiara Focaccetti, Raffaele Carrano, Zein Mersini Besharat, Roberto Bei, Laura Masuelli
Summary: Gastrointestinal(GI) cancers are common and cause a significant number of cancer-related deaths. Metastasis is the primary cause of death from GI cancer, making it important to understand cancer cell migration and develop new therapies. This review summarizes the mechanisms of cancer cell migration and metastasis formation, focusing on the role of tumor microenvironment components. It also discusses the potential of microRNAs as biomarkers for prognosis, monitoring, and diagnosis in GI cancer patients. Additionally, the use of nutraceuticals as a strategy to target microRNAs and pathways involved in GI tumor invasiveness is explored.
Article
Oncology
Lei Shen, Jun Han, Haiyu Wang, Qingyang Meng, Linlin Chen, Yuguo Liu, Ying Feng, Guohao Wu
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Cell Biology
Yuanyuan Yang, Xiaojian Liu, Shuang Li, Yanhao Chen, Yongxu Zhao, Yuda Wei, Yan Qiu, Yan Liu, Zhihua Zhou, Jun Han, Guohao Wu, Qiurong Ding
CELL DEATH & DISEASE
(2020)
Letter
Nutrition & Dietetics
Shanjun Tan, Guohao Wu
CLINICAL NUTRITION
(2020)
Article
Nutrition & Dietetics
Shanjun Tan, Qingyang Meng, Yi Jiang, Qiulin Zhuang, Qiulei Xi, Jiahao Xu, Jinou Zhao, Xiangyu Sui, Guohao Wu
Summary: This study focused on post-discharge patients at nutritional risk following colorectal cancer surgery and found that the use of oral nutritional supplements can reduce skeletal muscle loss, sarcopenia prevalence, and improve chemotherapy tolerance compared to dietary advice alone.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Qingyang Meng, Shanjun Tan, Yi Jiang, Jun Han, Qiulei Xi, Qiulin Zhuang, Guohao Wu
Summary: This study showed that post-discharge oral nutritional supplements (ONS) with dietary advice improved nutritional outcomes, skeletal muscle maintenance, chemotherapy tolerance, and some quality of life variables in patients after surgery for gastric cancer.
CLINICAL NUTRITION
(2021)
Article
Biology
Chang Zhang, Lei Shen, Wei Yuan, Yuguo Liu, Ruochen Guo, Yangjun Luo, Zheng Zhan, Zhiqin Xie, Guohao Wu, Wenwu Wu, Ying Feng
COMMUNICATIONS BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Yick-Liang Lum, John M. Luk, Donald E. Staunton, Dennis K. P. Ng, Wing-Ping Fong
MOLECULAR PHARMACEUTICS
(2020)
Article
Surgery
Shanjun Tan, Feng Zhou, Zhige Zhang, Junjie Wang, Jiahao Xu, Qiulin Zhuang, Qingyang Meng, Qiulei Xi, Yi Jiang, Guohao Wu
Summary: The study found that beta-1 blocker significantly reduces the release of inflammatory mediators and protects intestinal barrier function, thereby reducing systemic and local inflammatory responses after open abdominal surgery.
Letter
Nutrition & Dietetics
Shanjun Tan, Guohao Wu
CLINICAL NUTRITION
(2021)
Review
Endocrinology & Metabolism
Junjie Wang, Shanjun Tan, Guohao Wu
Summary: Sarcopenia is common in cancer patients and has negative impacts. Oral nutritional supplements and physical activity show potential in managing this condition, but more education and training are needed to overcome barriers.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2021)
Article
Nutrition & Dietetics
Jun Han, Lei Shen, Zheng Zhan, Yuguo Liu, Chang Zhang, Ruochen Guo, Yangjun Luo, Zhiqin Xie, Ying Feng, Guohao Wu
Summary: This study identified that MALAT1 is associated with adipose loss in cancer-associated cachexia by regulating adipogenesis through PPAR-gamma, potentially serving as a novel target for diagnosis and treatment of cancer-associated cachexia in the clinic.
NUTRITION & METABOLISM
(2021)
Letter
Nutrition & Dietetics
Shanjun Tan, Guohao Wu
CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Pui-Wah Choi, Tin Lun Liu, Chun Wai Wong, Sze Kei Liu, Yick-Liang Lum, Wai-Kit Ming
Summary: This review focuses on the dysregulation of miRNAs in the pre-stage of cervical cancer. Several dysregulated miRNAs have been identified and found to be associated with the DNA damage response and cell growth response induced by human papillomavirus (HPV) infection. However, discrepancies in sample types, HPV status, expression measurement, and analysis methods have led to non-aligned results across studies. This review provides insight into identifying miRNAs involved in early pathogenic processes and highlights their potential as biomarkers for cervical pre-cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xiangyu Mao, Qingyang Meng, Jun Han, Lei Shen, Xiangyu Sui, Yihua Gu, Guohao Wu
Summary: The research revealed that DRP1 plays a significant role in muscle wasting during cancer-associated cachexia and modulates the atrophy of C2C12 myotubes by regulating DRP1 levels. The alleviated muscle atrophy induced by DRP1 knockdown may be associated with increased ribosomal activity.
TRANSLATIONAL CANCER RESEARCH
(2021)