Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Sarah Seberg Diemar, Louise Lylloff, Maria Sode Ronne, Line Tang Mollehave, Malene Heidemann, Betina Heinsbaek Thuesen, Jesper Johannesen, Anders J. Schou, Steffen Husby, Niels Wedderkopp, Christian Molgaard, Niklas Rye Jorgensen
Summary: The study aimed to establish reference intervals for bone turnover markers in children and adolescents, showing that these markers vary with age and sex, with β-CTX and PINP being the most affected by these changes which reflect bone metabolism processes.
Article
Gastroenterology & Hepatology
Asako Murayama, Norie Yamada, Yoshiki Osaki, Masaaki Shiina, Hussein Hassan Aly, Masashi Iwamoto, Senko Tsukuda, Koichi Watashi, Mami Matsuda, Ryosuke Suzuki, Tomohisa Tanaka, Kohji Moriishi, Tetsuro Suzuki, Hironori Nishitsuji, Masaya Sugiyama, Masashi Mizokami, Kunitada Shimotohno, Takaji Wakita, Masamichi Muramatsu, T. Jake Liang, Takanobu Kato
Summary: The study demonstrated that an 11-amino-acid deletion in the preS1 region enhances the infectivity of cell-culture-generated HBV, providing a powerful tool for studying HBV infection and propagation in cell culture as well as developing antiviral strategies against HBV infection.
Article
Medicine, General & Internal
Gianluca Avallone, Carlo Alberto Maronese, Giulia Murgia, Carlo Giovanni Carrera, Luca Mastorino, Gabriele Roccuzzo, Paolo Dapavo, Silvia Alberti-Violetti, Pietro Quaglino, Simone Ribero, Angelo Valerio Marzano
Summary: This study aimed to compare the efficacy of IL-17 and IL-23 inhibitors in treating pustular and erythrodermic psoriasis. The results showed that IL-17 inhibitors had higher effectiveness in treating these conditions, while the efficacy of IL-23 inhibitors remains unknown.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Akinori Higaki, Ahmad U. M. Mahmoud, Pierre Paradis, Ernesto L. Schiffrin
Summary: Hypertension is partially mediated by immune mechanisms, with IL-23 and IL-17 playing important roles. The IL-23/IL-17 axis has not been a major therapeutic target for hypertension treatment, but shows potential for targeting therapy.
CARDIOVASCULAR RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ruth Rodriguez-Montano, Alondra del Carmen Ruiz-Gutierrez, Vianeth Maria del Carmen Martinez-Rodriguez, Juan Ramon Gomez-Sandoval, Juan Manuel Guzman-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velazquez
Summary: This study found that patients with periodontitis have significantly lower levels of IL-17A in plasma, but higher levels of IL-23, IL-17A, and IL-17RA in gingival tissue. Several correlations were also found, suggesting a potential role of the IL-23/IL-17A axis in the progression of periodontitis.
APPLIED SCIENCES-BASEL
(2022)
Review
Ophthalmology
Zhenyu Zhong, Guannan Su, Aize Kijlstra, Peizeng Yang
Summary: Uveitis is a group of diseases characterized by intraocular inflammation, some of which are driven by auto inflammatory or autoimmune responses, and share the activation of the IL-23/IL-17 pathway. Emerging drugs blocking this pathway have been assessed for the treatment of uveitis.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Article
Cell Biology
Nicola L. Stevenson, Dylan J. M. Bergen, Yinhui Lu, M. Esther Prada-Sanchez, Karl E. Kadler, Chrissy L. Hammond, David J. Stephens
Summary: Knockout of the golgin giantin leads to skeletal and craniofacial defects due to changes in glycosylation and extracellular matrix deposition. Our study reveals a conserved role for giantin in collagen biosynthesis and extracellular matrix assembly, as well as a giantin-dependent pathway for intracellular procollagen processing.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shih-Yao Chen, Ting-Chien Tsai, Yuan-Tsung Li, Yun-Chiao Ding, Chung-Teng Wang, Jeng-Long Hsieh, Chao-Liang Wu, Po-Ting Wu, Ai-Li Shiau
Summary: This study demonstrates that IL-23 promotes osteoclastogenesis through transcriptional regulation of miR-223 in murine macrophages and mice with CIA. Furthermore, the study suggests that LSF, a selective inhibitor of STAT4, could be an ideal therapeutic agent for treating rheumatoid arthritis by reducing miR-223-mediated osteoclastogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Laura A. Lucaciu, Maria Ilies, Stefan C. Vesa, Radu Seicean, Shahida Din, Cristina Adela Iuga, Andrada Seicean
Summary: Interleukin (IL)-23 and fecal calprotectin levels were significantly elevated in severe inflammatory bowel disease (IBD), while IL-17 and C-reactive protein were associated with disease severity. IL-23 may serve as a promising novel biomarker for severe Crohn's disease, guiding clinical decision-making on biologic therapy. Identifying the main IL pathway involved in IBD severity could provide valuable insights for personalized treatment approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Dingwu Li, Jianing Chen, Bingru Lin, Yanjun Guo, Jiaqi Pan, Chaohui Yu, Xingyong Wan
Summary: This study aimed to investigate the protective effect of celastrol on liver injury induced by ConA and its potential mechanisms. The results showed that pretreatment with celastrol significantly ameliorated liver injury and inhibited IL-17 signaling, suggesting the potential of celastrol in treating immune-mediated liver diseases.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mohammed El-Gedamy, Zakaria El-khayat, Hassan Abol-Enein, Afaf El-said, Eslam El-Nahrery
Summary: The genetic variant rs1884444 G/T of IL-23R is significantly associated with a reduced risk of bladder urothelial carcinoma (BUC), with the T allele potentially serving as a reliable genetic marker for good prognosis. The G/T variation may regulate BUC risk through modulation of the IL-23/IL-17 pathway.
Article
Endocrinology & Metabolism
Liang-Jie Tang, Hong-Lei Ma, Mohammed Eslam, Grace Lai-Hung Wong, Pei-Wu Zhu, Sui-Dan Chen, Diana Julie Leeming, Morten Karsdal, Gang Li, Ou-Yang Huang, Howard Ho-Wai Leung, Yu-Jie Zhou, Qian Feng, Pei Jiang, Li-Mei Gao, Christopher D. Byrne, Giovanni Targher, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng
Summary: This study evaluated the performance of new biomarkers and algorithms for diagnosing advanced fibrosis in an Asian population. The results showed that the ADAPT score had good accuracy and sensitivity in diagnosing advanced fibrosis, and it outperformed other non-invasive fibrosis biomarkers. The ADAPT score also had good diagnostic performance in subgroup analyses.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Medicine, Research & Experimental
Waleed A. Mohamed, Rania M. Salama, Mona F. Schaalan
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Medicine, Research & Experimental
Neven M. Sarhan, Mohamed H. Shahin, Nihal M. El Rouby, Lamia M. El-Wakeel, Mohamed H. Solayman, Taimour Langaee, Hazem Khorshid, Mona F. Schaalan, Nagwa A. Sabri, Larisa H. Cavallari
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2020)
Article
Neurosciences
Rania M. Salama, Ghada A. Abdel-Latif, Samah S. Abbas, Hekmat M. El Magdoub, Mona F. Schaalan
Article
Pharmacology & Pharmacy
Rania M. Salama, Azza H. Abd Elwahab, Mona M. Abd-Elgalil, Noura F. Elmongy, Mona F. Schaalan
Article
Food Science & Technology
L. H. Khedr, Rania M. Rahmo, Doaa Boshra Farag, Mona F. Schaalan, Hekmat M. El Magdoub
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Immunology
Mona Schaalan, Waleed Mohamed, Shimaa Fathy
MICROBIAL PATHOGENESIS
(2020)
Article
Multidisciplinary Sciences
Ghada A. Abdel-Latif, Azza H. Abd Elwahab, Rehab A. Hasan, Noura F. ElMongy, Maggie M. Ramzy, Manal L. Louka, Mona F. Schaalan
SCIENTIFIC REPORTS
(2020)
Article
Pharmacology & Pharmacy
Hekmat M. El Magdoub, Mona F. Schaalan, Rania M. Rahmo, Doaa B. Farag, Lobna H. Khedr
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ismail El Shaffei, Ghada A. Abdel-Latif, Doaa B. Farag, Mona Schaalan, Rania M. Salama
Summary: CIS-induced liver injury can be alleviated by modulating miRNA-34a expression and the SIRT1/PGC-1 alpha signaling cascade, while betanin can improve liver toxicity induced by CIS through this pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Virology
Mona Schaalan, Ahmed E. Abou Warda, Samir M. Osman, Shaimaa Fathy, Rania M. Sarhan, Marian S. Boshra, Neven Sarhan, Sayed Gaber, Ahmed Mahmoud Abdelhaleem Ali
Summary: This study aimed to explore the factors influencing the incidence of COVID-19 infection in the Egyptian population. The results showed that patients with hypertension and diabetes had higher infection rates, with higher risk for females, individuals over the age of 50, and those who were obese. Additionally, individuals over the age of 50, without education, and consuming meat and eggs had a higher risk of blood clotting.
Article
Medicine, General & Internal
Neven Sarhan, Ahmed E. Abou Warda, Rania M. Sarhan, Marian S. Boshra, Gomaa Mostafa-Hedeab, Bashayer F. ALruwaili, Haytham Soliman Ghareeb Ibrahim, Mona F. Schaalan, Shaimaa Fathy
Summary: This study investigated the effect of high-dose vitamin D on moderate-to-severe COVID-19 patients and found that it significantly reduced hospital stay, the need for oxygen support and mechanical ventilation, and improved clinical outcomes compared to low-dose vitamin D.
MEDICINA-LITHUANIA
(2022)
Article
Multidisciplinary Sciences
Momen Mohamed M. Ahmed, Mohamed Abdel-Basset Abdo, Waleed Abo El-Wafa Mohamed
Summary: The paper assesses the seismic performance of buildings with vertical irregularities, finding that these buildings are more vulnerable to early damages and have lower seismic capacities. It is suggested that additional precautions and adjustments in seismic force calculation may be necessary for structures with vertical geometric irregularities.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Medicine, General & Internal
Amal Ahmed Mohamed, Abdellah Abosrie Ali Omar, Rehab R. El-Awady, Sally Mohamed Aboelsayed Hassan, Waleed Mohamed, Soliman Eitah, Rehab Ahmed, Amir Khater, Omnia Mohamed Saad Tantawi, Ahmed Abdelhafeez Mohamed
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Waleed Seif Eldin Mohamed Mostafa, Mohammed Hassan Saiem Al-Dahr, Dalia Abdel Hamid Omran, Zeinab Fathy Abdullah, Suzan Hamdy Elmasry, Mohamed Nabil Ibrahim
CLINICAL AND MOLECULAR HEPATOLOGY
(2020)