Article
Medicine, General & Internal
Carlos King Ho Wong, David Tak Wai Lui, Xi Xiong, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Ching Lung Cheung, Chi Ho Lee, Yu Cho Woo, Ivan Chi Ho Au, Matthew Shing Hin Chung, Franco Wing Tak Cheng, Kathryn Choon Beng Tan, Ian Chi Kei Wong
Summary: The study found no evidence of an increased risk of incident hyperthyroidism or hypothyroidism following vaccination with BNT162b2 and CoronaVac COVID-19 vaccines.
Article
Medicine, General & Internal
Maria Pina Dore, Giuseppe Fanciulli, Alessandra Manca, Giovanni Mario Pes
Summary: This study investigated the relationship between thyroid diseases (TDs) and Helicobacter pylori infection. The results showed that long-lasting H. pylori infection was significantly associated with autoimmune thyroid diseases (AITD), but not with non-autoimmune TD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Mengyu Zhang, Wen Jiang, Ganghua Lu, Ru Wang, Zhongwei Lv, Dan Li
Summary: Hyperthyroidism is a condition characterized by excessive production of thyroid hormones, with Graves' disease being the most common cause. Disease models have been established, and novel treatments for Graves' disease and Graves' orbitopathy have been discovered. Potential therapeutic targets have also been identified in mouse models of Graves' orbitopathy. Human placental mesenchymal stem cells, fucoxanthin, and icariin may provide alternative therapies in addition to existing drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mustafa Genco Erdem, Ozge Unlu, Fatma Ates, Denizhan Karis, Mehmet Demirci
Summary: The study found that the oral microbiota of male patients with treated and untreated hyperthyroidism differ, while the treatment method has no impact on the oral microbiota. By conducting extensive multicenter studies to identify the core oral microbiota and long-term monitoring of hyperthyroidism, important data for understanding the pathogenesis of the disease may be obtained.
Article
Endocrinology & Metabolism
Xiao Jiang, Xinyu Zhao, Xiaotong Gu, Tao Luo, Pengqian Li, Chuchu Wan, Haixia Liu
Summary: Hashimoto's thyroiditis, an autoimmune disease, is associated with an increased risk of hypothyroidism. Metabolomics was applied to analyze 21 metabolites in Hashimoto's thyroiditis, revealing the impact of phospholipids and different metabolic pathways in the pathogenesis of the disease. The study suggests the potential of SM, LPC, and PC as biomarkers for identifying patients with Hashimoto's thyroiditis in different clinical stages.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Jiaojiao Yuan, Shuo Qi, Xufan Zhang, Hezheng Lai, Xinyi Li, Xiaoheng Chen, Zhe Li, Simiao Yao, Zhiguo Ding
Summary: This study aimed to investigate the local symptoms of Hashimoto's thyroiditis (HT) and their prevalence. The common local symptoms in HT patients include neck pain, voice changes, throat discomfort, shortness of breath, dysphagia, and goiter-related symptoms. These symptoms should be identified in the clinic and included in the early diagnosis and management of HT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jakob Skov, Jan Calissendorff, Daniel Eriksson, Patrik Magnusson, Olle Kampe, Sophie Bensing, Ralf Kuja-Halkola
Summary: Hashimoto's thyroiditis (HT) and Graves' disease (GD) have a modest genetic relationship, with genetic factors playing a more significant role in men's susceptibility to HT compared to women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Filippo Biscarini, Giulia Masetti, Ilaria Muller, Hedda Luise Verhasselt, Danila Covelli, Giuseppe Colucci, Lei Zhang, Mohd Shazli Draman, Onyebuchi Okosieme, Pete Taylor, Chantal Daumerie, Maria-Cristina Burlacu, Michele Marino, Daniel George Ezra, Petros Perros, Sue Plummer, Anja Eckstein, Mario Salvi, Julian R. Marchesi, Marian Ludgate
Summary: This study compared the fecal microbiota in patients with hyperthyroidism caused by Graves disease (GD) and varying severity of Graves orbitopathy (GO) with healthy controls. The results showed an increase in Actinobacteria and a decrease in Bacteroidetes in GD/GO patients compared to controls. A higher Firmicutes to Bacteroidetes ratio was observed in GD/GO. Longitudinal analysis revealed a correlation between the presence of certain bacteria (Clostridiales) at diagnosis and the persistence of thyroid antibodies even after antithyroid drug treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Beata Pyrzak, Malgorzata Ruminska, Ewelina Witkowska-Sedek, Anna Kucharska
Summary: Maternal Graves' disease can cause various thyroid dysfunctions in newborns, including hyperthyroidism and hypothyroidism. This study found that transient hyperthyroidism was the most common thyroid dysfunction in newborns with neonatal hyperthyroidism, but central hypothyroidism can also occur.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Martin Andersson, Soren Mattsson
Summary: Radioactive iodine is commonly used for the treatment of thyroid diseases, with EANM and ICRP developing pre-therapeutic procedures and biokinetic models. Combining the EANM method and ICRP model provides more accurate patient-specific dosimetry estimates and absorbed dose estimates including most organs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Haitao Zheng, Jie Xu, Yongli Chu, Wenzhou Jiang, Wenjie Yao, Shaowen Mo, Xicheng Song, Jin Zhou
Summary: This study reveals that abnormal interactions between immune cells in patients with Hashimoto's thyroiditis (HT) and Graves' disease (GD) activate relevant immune pathways, exacerbating the immune response and potentially leading to the targeting of thyroid tissue and disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Linghuan Wang, Binqi Li, He Zhao, Peixin Wu, Qingzhen Wu, Kang Chen, Yiming Mu
Summary: This systematic review and meta-analysis evaluated the incidence, evaluation, and management of interferon and endocrine side effects. The study found a higher incidence of hypothyroidism and hyperthyroidism in patients treated with interferon, particularly in combination with ribavirin.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikola Ralchev Ralchev, Aleksandar Mishel Markovski, Inna Angelova Yankova, Iliyan Konstantinov Manoylov, Irini Atanas Doytchinova, Nikolina Mihaylova Mihaylova, Alexander Dimitrov Shinkov, Andrey Ivanov Tchorbanov
Summary: This study aims to selectively suppress anti-thyroglobulin IgG antibody-producing B lymphocytes in Hashimoto's thyroiditis patients using a chimeric protein molecule. The results show that this treatment method can reduce B-cell autoreactivity and promote apoptosis in targeted cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Wen Jiang, Ganghua Lu, Dingwei Gao, Zhongwei Lv, Dan Li
Summary: Emerging studies have provided initial understanding of the thyroid-gut axis, but more research is needed to elucidate the specific relationships and mechanisms between gut microbiota and thyroid.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Ivani Novato Silva, Lara Vieira Marcal, Dulciene Maria Magalhaes Queiroz
Summary: Helicobacter pylori (H. pylori) infection is associated with autoimmune thyroid disease (ATD) in children, and the prevalence of infection in this study cohort was 19.44%. While there were no differences in thyroid hormone levels and antithyroid antibodies, the infection may lead to impairment in the thyroid hormonal balance.
FRONTIERS IN PEDIATRICS
(2022)
