Article
Multidisciplinary Sciences
Song Wang, Meng Qian, Min Wu, Shuo Feng, Kaiguang Zhang
Summary: The objective of this study was to develop a prediction model for Operative Link on Gastric Intestinal Metaplasia (OLGIM) Stage III-IV. By analyzing high-risk gastric cancer patients, a nomogram model consisting of age, gender, PG I, and G-17 was developed, showing excellent performance in calibration curve and clinical impact analysis.
Article
Gastroenterology & Hepatology
Quchuan Zhao, Qing Jia, Tianyu Chi
Summary: In this study, a real-time video monitoring model based on deep learning was developed to assist endoscopists in the real-time diagnosis of chronic atrophic gastritis (CAG) and identification of high-risk gastric cancer patients. The diagnostic evaluation indices of the model were superior to those of endoscopists, and it showed a high consistency with the pathological diagnosis results.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Yongqiang Liang, Yuanhai Yang, Ruiheng Nong, Hao Huang, Xiuyun Chen, Ying Deng, Zhicong Huang, Jingyao Huang, Chunsheng Cheng, Mingzhu Ji, Yinggang Chen, Fulan Hu
Summary: H. pylori eradication significantly improves atrophic gastritis (AG) and intestinal metaplasia (IM) at an early stage. Various factors such as study design, lesion sites, regions, and follow-up time are important in determining this association.
Article
Gastroenterology & Hepatology
Ne Lin, Tao Yu, Wenfang Zheng, Huiyi Hu, Lijuan Xiang, Guoliang Ye, Xingwei Zhong, Bin Ye, Rong Wang, Wanyin Deng, JingJing Li, Xiaoyue Wang, Feng Han, Kun Zhuang, Dekui Zhang, Huanhai Xu, Jin Ding, Xu Zhang, Yuqin Shen, Hai Lin, Zhe Zhang, John J. Kim, Jiquan Liu, Weiling Hu, Huilong Duan, Jianmin Si
Summary: The study successfully developed a diagnostic model using deep convolutional neural network (CNN) that can simultaneously identify AG and GIM, demonstrating high accuracy in recognizing the two conditions.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Pathology
Julia M. Lerch, Rish K. Pai, Ian Brown, Anthony J. Gill, Dhanpat Jain, Bence Kovari, Ryoji Kushima, Kieran Sheahan, Tomas Slavik, Amitabh Srivastava, Gregory Y. Lauwers, Cord Langner
Summary: Subtyping gastric intestinal metaplasia (GIM) on H&E-stained slides shows high interobserver agreement and can be used as a risk stratifying tool with a low rate of misclassification.
Article
Medicine, General & Internal
Bei Pei, Ziang Wen, Qi Yang, Jieyu Wang, Qinglin Cao, Longfei Dai, Xuejun Li
Summary: This study investigated the risk factors and constructed a prediction model for chronic atrophic gastritis (CAG) patients with intestinal metaplasia or dysplasia. Helicobacter pylori infection, pepsinogen I, gastrin-17, and the number of lesions were identified as independent risk factors. The prediction model based on these factors showed excellent predictive value in both training and validation cohorts.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Young Jae Hwang, Yonghoon Choi, Nayoung Kim, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Summary: The study found that both endoscopic and histologic improvements of atrophic gastritis and intestinal metaplasia were observed after H. pylori eradication, with endoscopic improvement taking significantly longer time than histologic improvement.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Taned Chitapanarux, Sarawut Kongkarnka, Komson Wannasai, Patumrat Sripan
Summary: This study determined the prevalence of atrophic gastritis (AG) and intestinal metaplasia (IM) and identified their associated factors. It was found that age and Helicobacter pylori (H. pylori) infection are risk factors for AG and IM, while ingestion of spicy food is a protective factor. Therefore, upper endoscopy and gastric mapping sampling are recommended for patients with chronic dyspepsia older than 50 to reduce the risk of gastric cancer.
CANCER EPIDEMIOLOGY
(2023)
Article
Pathology
Julia M. Lerch, Rish K. Pai, Ian Brown, Anthony J. Gill, Dhanpat Jain, Bence Kovari, Ryoji Kushima, Kieran Sheahan, Tomas Slavik, Amitabh Srivastava, Gregory Y. Lauwers, Cord Langner
Summary: The extent of gastric intestinal metaplasia (GIM) can be effectively determined by international gastrointestinal expert pathologists with high interobserver agreement, with no significant improvement in agreement observed with the use of AB-PAS staining. However, cases with a higher amount of metaplastic epithelium showed lower diagnostic accuracy, indicating the need for further research in these instances.
Article
Gastroenterology & Hepatology
Christine N. Noto, Stella G. Hoft, Kevin A. Bockerstett, Nicholas M. Jackson, Eric L. Ford, Luke S. Vest, Richard J. DiPaolo
Summary: The study identified six unique subsets of IL13-producing immune cells in inflamed stomachs and found that IL13 can directly induce a metaplastic phenotype in gastric epithelial cells. Neutralization of IL13 can reduce the severity of metaplasia during chronic gastritis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Cosmin Grad, Andrei Pop, Emil Gaborean, Simona Grad, Dan Dumitrascu
Summary: The study aimed to assess the diagnostic performance of the serum panel test for atrophic gastritis. Results showed that GastroPanel values did not vary depending on the severity of atrophy, while the ratio PG1/PG2 had lower accuracy in patients with multifocal atrophy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Ombretta Repetto, Valli De Re, Paolo Giuffrida, Marco Vincenzo Lenti, Raffaella Magris, Marino Venerito, Agostino Steffan, Antonio Di Sabatino, Renato Cannizzaro
Summary: This study identified a proteomics signature of AAG, with many differential proteins shared by GC, potentially involved in the progression of AAG to GC.
Article
Plant Sciences
Liping Han, Ting Li, Yingying Wang, Weizi Lai, Hengpu Zhou, Zhuangwei Niu, Jie Su, Guiyuan Lv, Guangji Zhang, Jianli Gao, Jianbo Huang, Zhaohuan Lou
Summary: Weierning tablet (WEN), a traditional Chinese patent medicine, has been widely used for chronic atrophic gastritis (CAG) therapy. This study aimed to investigate the anti-CAG effects and potential mechanisms of WEN. The results showed that WEN could inhibit apoptosis of gastric mucosal cells and block the activation of Hedgehog pathway, thereby improving CAG and reversing intestinal metaplasia of gastric mucosa.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Ning Wei, Mengyue Zhou, Siyu Lei, Ling Yang, Zhihong Duan, Youyu Zhang, Zhiheng Zhong, Yang Liu, Ruihua Shi
Summary: This study conducted a systematic review and meta-analysis on the prediction of severity of gastric intestinal metaplasia (GIM) using endoscopy. The results showed that digital chromoendoscopy is well suited to predicting the severity of localized and overall GIM, with high sensitivity and specificity.
Article
Gastroenterology & Hepatology
Hee Kyong Na, Kee Don Choi, Young Soo Park, Hwa Jung Kim, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: The study aimed to develop an endoscopic scoring system to evaluate gastric atrophy and intestinal metaplasia. The results showed that the endoscopic scoring using NBI-NFM correlated with histologic staging in Korea, a high-risk region for gastric cancer.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Vittoria Matilde Piva, Maria Caterina De Grandis, Irene Sole Zuin, Valentina Angerilli, Floriana Nappo, Rita Alfieri, Selma Ahcene Djaballah, Sabina Murgioni, Francesca Bergamo, Matteo Fassan, Michele Valmasoni, Sara Lonardi
Summary: This review summarizes the current evidence on the use of liquid biopsy in gastroesophageal cancer, focusing on the detection of ctDNA in the postoperative setting and its potential role as a guide for treatment decision.
UPDATES IN SURGERY
(2023)
Letter
Hematology
Alessandro Cellini, Federico Scarmozzino, Alberto Friziero, Valentina Trimarco, Angelo Paolo Dei Tos, Livio Trentin, Marco Pizzi, Andrea Visentin
ANNALS OF HEMATOLOGY
(2023)
Correction
Multidisciplinary Sciences
Claudia Calabrese, Natalie R. Davidson, Deniz Demircioglu, Nuno A. Fonseca, Yao He, Andre Kahles, Kjong-Van Lehmann, Fenglin Liu, Yuichi Shiraishi, Cameron M. Soulette, Lara Urban, Liliana Greger, Siliang Li, Dongbing Liu, Marc D. Perry, Qian Xiang, Fan Zhang, Junjun Zhang, Peter Bailey, Serap Erkek, Katherine A. Hoadley, Yong Hou, Matthew R. Huska, Helena Kilpinen, Jan O. Korbel, Maximillian G. Marin, Julia Markowski, Tannistha Nandi, Qiang Pan-Hammarstrom, Chandra Sekhar Pedamallu, Reiner Siebert, Stefan G. Stark, Hong Su, Patrick Tan, Sebastian M. Waszak, Christina Yung, Shida Zhu, Philip Awadalla, Chad J. Creighton, Matthew Meyerson, B. F. Francis Ouellette, Kui Wu, Huanming Yang, Alvis Brazma, Angela N. Brooks, Jonathan Goeke, Gunnar Raetsch, Roland F. Schwarz, Oliver Stegle, Zemin Zhang
Correction
Multidisciplinary Sciences
Yilong Li, Nicola D. Roberts, Jeremiah A. Wala, Ofer Shapira, Steven E. Schumacher, Kiran Kumar, Ekta Khurana, Sebastian Waszak, Jan O. Korbel, James E. Haber, Marcin Imielinski, Joachim Weischenfeldt, Rameen Beroukhim, Peter J. Campbell
Correction
Multidisciplinary Sciences
Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C. Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J. Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vazquez-Garcia, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, Nilgun Donmez, Dimitri G. Livitz, Marek Cmero, Jonas Demeulemeester, Steven Schumacher, Yu Fan, Xiaotong Yao, Juhee Lee, Matthias Schlesner, Paul C. Boutros, David D. Bowtell, Hongtu Zhu, Gad Getz, Marcin Imielinski, Rameen Beroukhim, S. Cenk Sahinalp, Yuan Ji, Martin Peifer, Florian Markowetz, Ville Mustonen, Ke Yuan, Wenyi Wang, Quaid D. Morris, Paul T. Spellman, David C. Wedge, Peter Van Loo
Correction
Multidisciplinary Sciences
Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A. Wala, Ofer Shapira, Grace Tiao, Henrik Hornshoj, Julian M. Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andres Lanzos, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Pratiti Bandopadhayay, Johanna Bertl, Keith A. Boroevich, John Busanovich, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, David Craft, Priyanka Dhingra, Klev Diamanti, Nuno A. Fonseca, Abel Gonzalez-Perez, Qianyun Guo, Mark P. Hamilton, Nicholas J. Haradhvala, Chen Hong, Keren Isaev, Todd A. Johnson, Malene Juul, Andre Kahles, Abdullah Kahraman, Youngwook Kim, Jan Komorowski, Kiran Kumar, Sushant Kumar, Donghoon Lee, Kjong-Van Lehmann, Yilong Li, Eric Minwei Liu, Lucas Lochovsky, Keunchil Park, Oriol Pich, Nicola D. Roberts, Gordon Saksena, Steven E. Schumacher, Nikos Sidiropoulos, Lina Sieverling, Nasa Sinnott-Armstrong, Chip Stewart, David Tamborero, Jose M. C. Tubio, Husen M. Umer, Liis Uuskuela-Reimand, Claes Wadelius, Lina Wadi, Xiaotong Yao, Cheng-Zhong Zhang, Jing Zhang, James E. Haber, Asger Hobolth, Marcin Imielinski, Manolis Kellis, Michael S. Lawrence, Christian von Mering, Hidewaki Nakagawa, Benjamin J. Raphael, Mark A. Rubin, Chris Sander, Lincoln D. Stein, Joshua M. Stuart, Tatsuhiko Tsunoda, David A. Wheeler, Rory Johnson, Jueri Reimand, Mark Gerstein, Ekta Khurana, Peter J. Campbell, Nuria Lopez-Bigas, Joachim Weischenfeldt, Rameen Beroukhim, Inigo Martincorena, Jakob Skou Pedersen, Gad Getz
Article
Immunology
Laura Quotti Tubi, Elisa Mandato, Sara Canovas Nunes, Arash Arjomand, Fortunato Zaffino, Sabrina Manni, Alessandro Casellato, Paolo Macaccaro, Nicola Vitulo, Sara Zumerle, Odile Filhol, Brigitte Boldyreff, Christian W. Siebel, Antonella Viola, Giorgio Valle, Federica Mainoldi, Stefano Casola, Valeria Cancila, Alessandro Gulino, Claudio Tripodo, Marco Pizzi, Angelo Paolo Dei Tos, Livio Trentin, Gianpietro Semenzato, Francesco Piazza
Summary: The role of CK2 in B-cell development and activation is not well understood. Using a CK2 beta(KO) mouse model, we found that CK2 beta(KO) mice exhibit increased marginal zone (MZ) B cells and reduced follicular B cells, suggesting a role for CK2 in the regulation of BCR and NOTCH2 signaling pathways. Further analysis revealed enhanced activation of the NOTCH2 pathway in CK2 beta(KO) mice, supporting MZ B-cell development. Additionally, CK2 beta(KO) mice showed alterations in immune response and B-cell activation processes. In vitro assays demonstrated impaired signaling downstream of BCR, Toll-like receptor, CD40, and IL-4R in B cells lacking CK2 beta.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Cell Biology
Andrea Remo, Federica Grillo, Alessandro Vanoli, Paola Parente, Luca Mastracci, Valentina Angerilli, Emanuele Damiano Urso, Francesca Bergamo, Matteo Fassan
Article
Pathology
Federica Miglietta, Valentina Carraro, Ottavia Amato, Gaia Griguolo, Michele Bottosso, Giada Munari, Giovanni Zarrilli, Marcello Lo Mele, Caterina Barbieri, Angelo Paolo Dei Tos, Valentina Guarneri, Maria Vittoria Dieci, Matteo Fassan
Summary: This study aims to track the dynamics of the PI3K/PTEN/mTOR pathway in HR+/HER2- breast cancer patients receiving neoadjuvant chemotherapy. The results show that this pathway is highly dynamic and may play a crucial role in shaping the molecular landscape of breast cancer with residual disease after chemotherapy.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Pathology
Valentina Angerilli, Paola Parente, Michela Campora, Clara Ugolini, Serena Battista, Paola Cassoni, Alessandro Gambella, Francesco Cavallin, Giuseppe De Lisi, Alessandro Vanoli, Federica Grillo, Luca Mastracci, Matteo Fassan
Summary: In this study, the clinicopathological and molecular features of HER2-low gastric/gastro-oesophageal junction cancers were investigated. It was found that HER2-low expression was more common in biopsy specimens and varied among different institutions. If further research confirms the effectiveness of novel anti-HER2 agents in HER2-low gastro-oesophageal cancers, the interpretation of HER2 status may need to be revised.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Oncology
Alessandro Cellini, Federico Scarmozzino, Francesco Angotzi, Edoardo Ruggeri, Angelo Paolo Dei Tos, Livio Trentin, Marco Pizzi, Andrea Visentin
Summary: Immune evasion through overexpression of PD-L1 and PD-L2 proteins and the role of the microenvironment are key factors in classical Hodgkin Lymphoma. This review discusses the strategies used by cHL to create an immunosuppressive microenvironment and achieve optimal immune evasion, as well as the success and resistance mechanisms of checkpoint inhibitors in cHL immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Oncology
Damanti Carlotta Caterina, Ferrone Lavinia, Gaffo Enrico, Garbin Anna, Tosato Anna, Contarini Giorgia, Gallingani Ilaria, Angioni Roberta, Molon Barbara, Borile Giulia, Carraro Elisa, Pillon Marta, Scarmozzino Federico, Dei Tos Angelo Paolo, Pizzi Marco, Ciscato Francesco, Rasola Andrea, Biffi Alessandra, Bortoluzzi Stefania, Lovisa Federica, Mussolin Lara
CANCER COMMUNICATIONS
(2023)
Article
Oncology
Ottavia De Simoni, Luca Dal Santo, Marco Scarpa, Giada Munari, Ylenia Camilla Spolverato, Antonio Scapinello, Sara Lonardi, Caterina Solda, Francesca Bergamo, Alberto Fantin, Romeo Bardini, Pierluigi Pilati, Matteo Fassan, Mario Gruppo
Summary: The aim of this study is to determine the potential significant tumor microenvironment (TME) immune markers of long-term survival in pancreatic ductal adenocarcinoma (PDAC) patients. Immunohistochemical staining was performed to characterize the TME using tissue microarray. The results showed that high density of CD8+ lymphocytes and low density of FOXP3+ and iNOS+ tumor-associated macrophages (TAMs) are predictors of good prognosis in PDAC patients.
Article
Pathology
Remo Alessandris, Federico Moroso, Mauro Michelotto, Matteo Fassan, Valentina Angerilli, Linda Callegari, Mirto Foletto
Summary: The use of preoperative upper gastrointestinal endoscopy and postoperative histopathological examination in bariatric surgery is still controversial. Based on the clinical experience of the authors, both preoperative endoscopic assessment and postoperative histopathological examination of the specimen are recommended to provide optimal treatment for these patients.
Review
Pathology
Valentina Angerilli, Matteo Fassan, Paola Parente, Irene Gullo, Michela Campora, Chiara Rossi, Maria Luisa Sacramento, Gianmaria Pennelli, Alessandro Vanoli, Federica Grillo, Luca Mastracci
Summary: PD-L1 is an established immunohistochemical biomarker for predicting the response to immunotherapy. However, it still has limitations due to changing cut-off values and scoring systems, as well as variability between observers and laboratories. This review focuses on the staining patterns and challenges in evaluating PD-L1 in gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma.