Article
Immunology
Linlin Xiao, Chi Lin, Yueping Liu, Yajing Wu, Jun Wang
Summary: This article reports a rare case of an ESCC patient whose brain metastatic lesion completely disappeared after receiving ICIs treatment, providing supporting data for the use of ICIs as an option for treating brain metastases in ESCC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yoshihisa Numata, Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Hironori Fujieda, Takuya Nagao, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Keitaro Matsuo, Tsutomu Fujii, Yasuhiro Shimizu
Summary: Metastases to supraclavicular lymph nodes have a significant impact on the prognosis of patients with cervical esophageal cancer. These lymph nodes may be considered extra-regional in this patient population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Xiaoting Chen, Lanlan Huang, Tingting Yang, Jiexuan Xu, Chengyong Zhang, Zhendong Deng, Xiaorong Yang, Naihua Liu, Size Chen, Shaoqiang Lin
Summary: Recent studies have identified pleiotropic roles of METTL3 in tumor progression, but its specific role in esophageal squamous cell carcinoma (ESCC) is still unclear. Higher METTL3 expression in ESCC tissues was associated with poor prognosis, and it was shown to promote migration and invasion of ESCC cells by regulating GLS2. These findings suggest METTL3/GLS2 signaling as a potential therapeutic target for anti-metastatic strategies against ESCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kotaro Sugawara, Daiji Oka, Hiroki Hara, Takako Yoshii, Hiroki Ushijima, Shigehiro Kudo, Takashi Fukuda
Summary: This study aimed to investigate the long-term outcomes and identify prognostic factors in patients with relapsed esophageal carcinoma (EC). The results showed that patients with oligometastasis (OM) had significantly better survival outcomes than those without OM. Surgical treatments provided better survival outcomes than CRT or chemo-/radiotherapy alone. Additionally, cStage III-IV disease, high GPS at the time of recurrence, and non-curative treatments were independently associated with poor survival outcomes.
Article
Oncology
Liqing Qiu, Jing Yue, Lingyu Ding, Zihao Yin, Ke Zhang, Hongfang Zhang
Summary: In this review, the impact of cancer-associated fibroblasts (CAFs) on esophageal squamous cell carcinoma (ESCC) is highlighted, including the induction of chemoresistance, radioresistance, migration, invasion, and immune escape. The origin of CAFs and the influence of ESCC cells on CAF activation are also discussed. Furthermore, the clinical prospects and future trends of CAFs-targeted therapies in ESCC are emphasized. A better understanding of the molecular biology of CAFs may contribute to the development of novel anti-ESCC strategies.
Article
Oncology
Lu Wang, Xiao Xiong, Zhimeng Yao, Jianlin Zhu, Yusheng Lin, Wan Lin, Kai Li, Xiaozheng Xu, Yi Guo, Yuping Chen, Yunlong Pan, Fuyou Zhou, Jun Fan, Yan Chen, Shegan Gao, Sai-Ching Jim Yeung, Hao Zhang
Summary: This study revealed an undocumented function of chimeric RNAs in aggravating cancer stemness and metastasis.
Article
Cell Biology
Peng Li Zhou, Zhengyang Wu, Wenguang Zhang, Miao Xu, Jianzhuang Ren, Qinhui Zhang, Zhanguo Sun, Xinwei Han
Summary: This study identified the oncogenic role of circPDE3B/miR-4766-5p/LAMA1 axis in promoting ESCC cell proliferation, migration, and invasion by acting as a ceRNA to eliminate the inhibitory effect on LAMA1 and inducing epithelial-mesenchymal transition (EMT). This axis may have potential prognostic and therapeutic significance in ESCC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Hongmei Dong, Wan Lin, Liang Du, Zhimeng Yao, Feifei Li, Shuanglong Chen, Yiteng Huang, Hongzheng Ren, Yichen Luo, Songwang Cai, Yexi Chen, Hui Tang, Xiaofu Qiu, Yunlong Pan, Xingxu Huang, Dianzheng Zhang, Shegan Gao, Sai-Ching Jim Yeung, Hao Zhang
Summary: This study demonstrates that protein tyrosine phosphatase receptor-type O (PTPRO) can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO inhibits MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.
Article
Medicine, Research & Experimental
Yun Zhu, Alfred K. Y. Lam, Daisy K. Y. Shum, Di Cui, Jun Zhang, Dong Dong Yan, Bin Li, Wen Wen Xu, Nikki P. Y. Lee, Kin Tak Chan, Simon Law, Sai Wah Tsao, Annie L. M. Cheung
Summary: This study provides evidence that elevated serum SRGN has prognostic significance in patients with ESCC, and sheds light on the molecular mechanism by which elevated circulating SRGN in cancer patients might promote cancer progression. SRGN promotes invasion and metastasis in ESCC through activating ERK pathway and stabilizing c-Myc, and induces the secretion of midkine in an autocrine manner, forming a SRGN/MDK/CD44 complex. Interactions between SRGN, MDK, and matrix metalloproteinase 2 in ESCC are mediated by GAG chains rich in chondroitin sulfate.
Article
Cell Biology
Zhiyan Ding, Yun Yan, Yu Lian Guo, Chenghai Wang
Summary: This study revealed that the exosomal uc.189 in ESCC targets the EPHA2 of HLECs to promote lymphangiogenesis, potentially serving as a novel marker for diagnosis and treatment of ESCC patients in early stages.
Article
Biochemistry & Molecular Biology
Jianfeng Zhou, Yushang Yang, Hanlu Zhang, Siyuan Luan, Xin Xiao, Xiaokun Li, Pinhao Fang, Qixin Shang, Longqi Chen, Xiaoxi Zeng, Yong Yuan
Summary: In this study, it was found that COL3A1 is significantly upregulated in esophageal squamous cell carcinoma (ESCC) and is associated with poor prognosis. Silencing COL3A1 inhibits tumor cell proliferation and migration, while overexpression of COL3A1 promotes tumor cell proliferation and migration. These findings highlight the important role of COL3A1 in ESCC and provide a new therapeutic target for the disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Linlin Xiao, Yvonne M. Mowery, Brian G. Czito, Yajing Wu, Guangbin Gao, Chang Zhai, Jianing Wang, Jun Wang
Summary: Brain metastases are rare in patients with esophageal squamous cell carcinoma (ESCC). Diagnosis-specific graded prognostic assessment (DS-GPA) score may be a useful prognostic tool for ESCC patients with brain metastases. Receipt of locoregional treatment, including brain surgery and radiotherapy, was associated with improved survival outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Xiaotao Geng, Jie Liu, Huimin Sun, Zhenguo Song, Shaoyong Qin, Yang Li, Yanan Zhang, Furong Hao, Yuanyuan Cai
Summary: This case report presents a rare case of metastatic esophageal squamous cell carcinoma, highlighting the diagnosis and treatment process. The authors hope to provide insights for clinical practice through their experience.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chao Song, Jinhua Peng, Yiping Wei, Jun Shao, Xianglai Chen, Xiaoqiang Zhang, Jianjun Xu
Summary: The study indicated that high expression of USP18 in esophageal squamous cell carcinoma (ESCC) was significantly correlated with malignant phenotype and shorter survival in patients. USP18 promotes ESCC cell metastasis by inducing ZEB1 mediated epithelial-mesenchymal transition (EMT).
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Xiaofeng Duan, Xiaobin Shang, Jie Yue, Zhao Ma, Chuangui Chen, Peng Tang, Hongjing Jiang, Zhentao Yu
Summary: A nomogram was developed to predict lymph node metastasis for patients with early-stage esophageal squamous cell carcinoma, which was validated by an independent cohort. The study confirms the accuracy of the nomogram in predicting the risk of lymph node metastasis for these patients.
Article
Oncology
Terence T. Sio, Pamela J. Atherton, Levi D. Pederson, W. Ken Zhen, Robert W. Mutter, Yolanda I. Garces, Daniel J. Ma, James L. Leenstra, Jean-Claude M. Rwigema, Shaker Dakhil, James D. Bearden, Sonja J. van der Veen, Apar K. Ganti, Steven E. Schild, Robert C. Miller
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Gian Carlo Mattiucci, Alessio G. Morganti, Francesco Cellini, Milly Buwenge, Riccardo Casadei, Andrea Farioli, Sergio Alfieri, Alessandra Arcelli, Federica Bertini, Felipe A. Calvo, Silvia Cammelli, Lorenzo Fuccio, Lucia Giaccherini, Alessandra Guido, Joseph M. Herman, Gabriella Macchia, Bert W. Maidment, Robert C. Miller, Francesco Minni, William F. Regine, Michele Reni, Stefano Partelli, Massimo Falconi, Vincenzo Valentini
TRANSLATIONAL ONCOLOGY
(2019)
Letter
Otorhinolaryngology
Yasmin Lassen-Ramshad, Enis Ozyar, Senem Alanyali, Philip Poortmans, Paul Van Houtte, Schoeb Sohawon, Mustafa Esassolak, Marco Krengli, Salvador Villa, Robert C. Miller, Candan Demiroz, Serap Akyurek, Ninna Aggerholm-Pedersen, Juliette Thariat
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Medicine, General & Internal
Terence T. Sio, Jennifer G. Le-Rademacher, James L. Leenstra, Charles L. Loprinzi, Grant Rine, Amarinthia Curtis, Anurag K. Singh, James A. Martenson, Paul J. Novotny, Angelina D. Tan, Rui Qin, Stephen J. Ko, Paul L. Reiter, Robert C. Miller
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2019)
Article
Oncology
Alessio G. Morganti, Francesco Cellini, Milly Buwenge, Alessandra Arcelli, Sergio Alfieri, Felipe A. Calvo, Riccardo Casadei, Savino Cilla, Francesco Deodato, Giancarmine Di Gioia, Mariacristina Di Marco, Lorenzo Fuccio, Federica Bertini, Alessandra Guido, Joseph M. Herman, Gabriella Macchia, Bert W. Maidment, Robert C. Miller, Francesco Minni, Paolo Passoni, Chiara Valentini, Alessia Re, William F. Regine, Michele Reni, Massimo Falconi, Vincenzo Valentini, Gian Carlo Mattiucci
Editorial Material
Oncology
Nathan Y. Yu, Terence T. Sio, Pranshu Mohindra, William F. Regine, Robert C. Miller, Anita Mahajan, Sameer R. Keole
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Daniel J. Ma, Katharine A. Price, Eric J. Moore, Samir H. Patel, Michael L. Hinni, Joaquin J. Garcia, Darlene E. Graner, Nathan R. Foster, Brenda Ginos, Michelle Neben-Wittich, Yolanda I. Garces, Ashish V. Chintakuntlawar, Daniel L. Price, Kerry D. Olsen, Kathryn M. Van Abel, Jan L. Kasperbauer, Jeffrey R. Janus, Mark Waddle, Robert Miller, Satomi Shiraishi, Robert L. Foote
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Mark R. Waddle, William C. Stross, Laura A. Vallow, James M. Naessens, Launia White, Sarah Meier, Aaron C. Spaulding, Steven J. Buskirk, Daniel M. Trifiletti, Sameer R. Keole, Daniel J. Ma, Gopal K. Bajaj, Nadia N. Laack, Robert C. Miller
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Clinical Neurology
William C. Stross, Timothy D. Malouff, Mark R. Waddle, Robert C. Miller, Jennifer Peterson, Daniel M. Trifiletti
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Oncology
Avani Dholakia Rao, Kai Sun, Mingyao Zhu, Sina Mossahebi, Pouya Sabouri, Thomas Houser, Jenna Jatczak, Mark Zakhary, William F. Regine, Robert C. Miller, Soren Bentzen, Mark Mishra
Summary: This study evaluated the impact of maximum MU weighting per spot restrictions on pencil beam scanning proton therapy plan quality, and found that within the evaluated thresholds, these restrictions did not degrade overall plan quality metrics and did not increase treatment delivery time. Further studies are needed to evaluate spot weighting manipulation on clinical outcomes and toxicity mitigation.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Christine Joyce, Faustin Laurentiu Roman, Brett Miller, John Jeffries, Robert C. Miller
Summary: Modern image guided radiation therapy relies on information technology, making it vulnerable to cyberattacks. In the past decade, cyberattacks have interrupted radiation therapy for thousands of patients, and the evolving threats pose challenges in protecting patients.
ADVANCES IN RADIATION ONCOLOGY
(2021)
Article
Oncology
Nancy Anabaraonye, Chiaojung Jillian Tsai, Hina Saeed, Fumiko Chino, Ekaete Ekpo, Sudeep Ahuja, Oscar Garcia, Robert C. Miller
Summary: During the early months of the COVID-19 pandemic, there was a decrease in the participation of nonsenior female researchers in article publishing, particularly in scientific manuscripts.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Article
Oncology
Gamze Ugurluer, Enis Ozyar, Funda Corapcioglu, Robert C. Miller
Summary: Psychosocial care is crucial for pediatric cancer patients and their families. The strain on family communication, structure, and finances can lead to negative psychological outcomes. The Russian invasion of Ukraine has exacerbated these problems for Ukrainian pediatric cancer patients who had left their country for medical treatment. Their concerns include emotional stress, difficulties obtaining medical records, financial expenses, and uncertainty about their future. Although the psychosocial distress related to the war may subside in the near future, the patients and their families will continue to face challenges related to displacement and financial burdens.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Editorial Material
Oncology
Robert C. Miller
ADVANCES IN RADIATION ONCOLOGY
(2019)
Article
Oncology
Dawit Tegbaru, Lisa Braverman, Anthony L. Zietman, Sue S. Yom, W. Robert Lee, Robert C. Miller, Isabel L. Jackson, Todd McNutt, Andre Dekker
ADVANCES IN RADIATION ONCOLOGY
(2019)