Review
Biochemistry & Molecular Biology
Mojgan Gharipour, Arya Mani, Mona Amini Baghbahadorani, Camila Kellen de Souza Cardoso, Shayesteh Jahanfar, Nizal Sarrafzadegan, Cesar de Oliveira, Erika Aparecida Silveira
Summary: Epigenetic modifications, influenced by lifestyle and environmental factors, play a significant role in gene expression and cellular function. A healthy lifestyle, including a balanced diet, regular exercise, and stress management, is essential in preventing cardiovascular dysfunction associated with epigenetic changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev
Summary: Epigenetic changes associated with histone modifications are important in the emergence and maintenance of various cancer types. Inhibitors of enzymes involved in these modifications are promising for anticancer drug development. This review explores the main features of common histone modifications and their role in malignant neoplasms, discussing strategies for inhibitor development and analyzing the use of multitarget drugs as the most promising strategy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Chemistry, Medicinal
Dan Zhang, Jifa Zhang, Yuxi Wang, Guan Wang, Pan Tang, Yun Liu, Yiwen Zhang, Liang Ouyang
Summary: Parkinson's disease (PD) is a multifactorial disease caused by a complex interplay between genetic and epigenetic factors. Recent studies have revealed the epigenetic mechanisms involved in PD, such as DNA methylation, histone modifications, and microRNA (miRNA) regulation. Epigenetic regulators could be potential therapeutic targets in neurodegenerative disorders. This review summarizes the mechanisms of epigenetic regulation in PD and discusses the use of inhibitors and activators of these regulators, as well as the neuroprotective effects of small molecule epigenetic modulators. Additionally, the contribution of miRNAs to the underlying mechanisms of PD and miRNA-based therapies are also discussed.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Cell Biology
Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study systematically discusses the different epigenetic modifications and their potential functions in the process of spinal ligament aging.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xiufei Chen, Haiqi Xu, Xiao Shu, Chun-Xiao Song
Summary: The concept of epigenetics was first proposed in 1942. Chemical modifications on histones, DNA, and RNA have been identified as three key components of epigenetic modifications. These modifications play a crucial role in various biological processes and diseases, including cancer. With the advancement of sequencing technologies, scientists are now able to accurately map and quantify different types of epigenetic modifications in histones, DNA, and RNA, providing insights into gene regulation.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Biochemistry & Molecular Biology
S. Pranav Adithya, K. Balagangadharan, N. Selvamurugan
Summary: In bone biology, epigenetics and histone modifications play a crucial role in the commitment and differentiation of mesenchymal stem cells towards osteoblasts. Understanding the importance of histone modifications in osteogenesis can lead to the development of epigenetic-based therapies for genetic bone disorders. This review highlights the significance of epigenetic modifications, including post-translational modifications of histones, in regulating gene expression during osteoblast differentiation and discusses future advancements in the field of epigenetics for orthopaedic therapeutics.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Cell Biology
Liang Kang, Huaqing Zhang, Chongyu Jia, Renjie Zhang, Cailiang Shen
Summary: Intervertebral disc degeneration (IDD) is a common cause of chronic joint-related disability in the elderly, impacting quality of life and causing social and economic burdens. The underlying pathological mechanisms are not fully understood, emphasizing the need for further research.
AGEING RESEARCH REVIEWS
(2023)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Food Science & Technology
Jianmin Wu, Ying Zhao, Xian Wang, Lingchang Kong, Lee J. Johnston, Lin Lu, Xi Ma
Summary: The imbalance of intestinal microecology can lead to impairment of the intestinal mucosa barrier and function, and further damage the functions of distal organs, resulting in systemic diseases.Intestinal microbiota and intestinal mucosa barrier can be shaped and regulated by nutrients and modes of life, which can help mitigate stress.Research shows that dynamic epigenetic modifications of intestinal tissue play a significant role in mediating the interactions between gut microbes and the gut mucosa barrier.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Hui Liu, Huimin Ma, Yang Li, Hua Zhao
Summary: This article reviews the current research status of epigenetic modifications in cervical cancer, including DNA methylation, histone modification, noncoding RNA regulation, and chromatin regulation. The functions and molecular mechanisms of these modifications in the occurrence and progression of cervical cancer are also discussed. This review provides new ideas for early screening, risk assessment, molecular targeted therapy, and prognostic prediction of cervical cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)