Article
Medicine, Research & Experimental
Benjamin M. Kahn, Alfredo Lucas, Rohan G. Alur, Maximillian D. Wengyn, Gregory W. Schwartz, Jinyang Li, Kathryn Sun, H. Carlo Maurer, Kenneth P. Olive, Robert B. Faryabi, Ben Z. Stanger
Summary: Through studying the tumor vascular environment, the use of the endothelial index (EI) and vascular microenvironment signatures (VMS) can better assess tumor vascular density, which is associated with prognosis in certain cancer types. These findings suggest that these metrics may enable more precise deployment of antiangiogenesis therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Endocrinology & Metabolism
Rick H. G. J. van Lanen, Stan Melchers, Govert Hoogland, Olaf E. M. G. Schijns, Marc A. M. J. van Zandvoort, Roel H. L. Haeren, Kim Rijkers
Summary: The blood-brain barrier is dysfunctional in temporal lobe epilepsy, likely due to microvascular changes. Vascular endothelial growth factor (VEGF) plays a pivotal role in this process.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Yoshiya Asano, Daisuke Okano, Michiya Matsusaki, Tetsuro Watabe, Yasuhiro Yoshimatsu, Mitsuru Akashi, Hiroshi Shimoda
Summary: In this study, an artificial vascular tissue constructed by human adipose tissue-derived stromal cells (hASCs) and HUVECs (ASCVT) showed higher vascular network density and expression of angiogenesis-related factors. Subcutaneous transplantation of ASCVT into nude mice resulted in the formation of functional vessel networks within 4 weeks.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Marion Mesnieres, Anna-Marei Bohm, Nicolas Peredo, Dana Trompet, Roger Valle-Tenney, Manmohan Bajaj, Nikky Corthout, Elena Nefyodova, Ruben Cardoen, Pieter Baatsen, Sebastian Munck, Andras Nagy, Jody J. Haigh, Satish Khurana, Catherine M. Verfaillie, Christa Maes
Summary: The balanced local crosstalk within the skeletal niche is crucial for the successful settlement of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow, with overproduction of VEGF by osteoprogenitor cells impacting stromal-vessel interface and vascular architecture, resulting in impaired HSPC homing and survival. These findings highlight potential targets for improving stem cell therapies, as similar osteo-angiogenic niche changes are induced by irradiation in adult mice.
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Biochemistry & Molecular Biology
Evan Paul Tracy, Michaela Dukes, Gabrielle Rowe, Jason E. Beare, Rajeev Nair, Amanda Jo LeBlanc
Summary: This study aimed to investigate the mechanisms underlying the restorative effects of adipose stromal vascular fraction (SVF) on vasodilation in aging-induced coronary microvascular disease (CMD). The results showed that SVF can attenuate chronic accumulation of reactive oxygen species (ROS) and enhance antioxidant gene and protein expression in coronary arterioles, thus restoring flow- and beta 1-adrenergic receptor (beta 1ADR)-mediated vasodilation. The study also identified a novel mechanism involving the impact of ROS on beta 1ADR trafficking.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Ni Yang, Yucong Zhang, Yi Huang, Jinhua Yan, Zonghao Qian, Han Li, Pengcheng Luo, Zhen Yang, Mandi Luo, Xiuxian Wei, Hao Nie, Lei Ruan, Yi Hao, Shangbang Gao, Kai Zheng, Cuntai Zhang, Le Zhang
Summary: This study explored the effects of serum FGF21 on vascular endothelial cells and found that FGF21 within the physiological concentration range has a beneficial effect on the cells, potentially through the regulation of SIRT1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Medicine, Research & Experimental
Yu-Hang Liu, Lorenz M. Brunner, Johannes Rebling, Maya Ben-Yehuda Greenwald, Sabine Werner, Michael Detmar, Daniel Razansky
Summary: This study used non-invasive imaging technology to observe and monitor the process of skin repair in mice, and found that overexpression of vascular endothelial growth factor A (VEGF-A) can promote vascularization in the skin, which was further validated by detailed histological staining results.
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Reproductive Biology
Kazuki Takasaki, Takayuki Ichinose, Yuko Miyagawa, Shiho Fukui, Kei Hashimoto, Haruka Nishida, Yuko Takahashi, Haruko Hiraike, Koji Saito, Yuko Sasajima, Kazunori Nagasaka
Summary: This study investigated two cases of granulosa cell tumors (GCTs) to find a biomarker for evaluating treatment and predicting recurrence. The findings suggest that serum vascular endothelial growth factor (VEGF) levels can be used as a clinical biomarker for disease progression in GCTs and to determine the efficacy of bevacizumab therapy.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Chao Fang, Lei Dai, Cun Wang, Chuanwen Fan, Yongyang Yu, Lie Yang, Hongxin Deng, Zongguang Zhou
Summary: Research showed that SCG2 expression was associated with the survival of CRC patients, and it exhibited anti-tumor and anti-angiogenesis effects by inhibiting HIF-1 alpha/VEGF activity.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mingli Hsieh, Pei-Ju Huang, Pei-Yu Chou, Shih-Wei Wang, Hsi-Chi Lu, Wei-Wen Su, Yuan-Chiang Chung, Min-Huan Wu
Summary: Research has shown that CAVIII is overexpressed in colorectal cancer tissues and more aggressive cancer cells. It may facilitate the release of VEGF by inhibiting miRNA16-5p. The CAVIII/miR-16-5p signaling pathway appears to function as a metastasis suppressor in CRC.
Review
Chemistry, Medicinal
Yachana Mishra, Aditi Chattaraj, Vijay Mishra, Abhigyan Ranjan, Murtaza M. Tambuwala
Summary: Cancer is a deadly disease characterized by unregulated cell growth that can occur in any part of the body. Detecting ovarian cancer early can help lower the death rate, and aptamers have shown promise as probes for ovarian cancer detection. Compared to other probes, aptamers are more effective in targeting ovarian cancer. Several aptamers have been developed to detect the ovarian tumor marker VEGF, and this review discusses their potential for early-stage ovarian cancer detection and treatment efficacy.