Article
Immunology
Jiro Kusakabe, Koichiro Hata, Tetsuya Tajima, Hidetaka Miyauchi, Xiangdong Zhao, Shoichi Kageyama, Tatsuaki Tsuruyama, Etsuro Hatano
Summary: This study found that Properdin inhibition significantly improves hepatic ischemia/reperfusion injury by reducing serum transaminases and histopathological damages, decreasing platelet aggregation and apoptosis, maintaining macrophage population, suppressing HMGB-1 release and infiltration of macrophages and neutrophils, without affecting liver regeneration.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Fatemeh Sabet Sarvestani, Negar Azarpira, Ismail H. Al-Abdullah, Ali-Mohammad Tamaddon
Summary: Ischemia reperfusion injury can lead to tissue damage, especially during organ transplantation. By manipulating miRNAs level, they can be used as a biomarker for early diagnosis of IRI or suggestive to be therapeutic agents in clinical situation in future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Gastroenterology & Hepatology
Jiang Liu, Kwan Man
Summary: Ischemia/reperfusion injury is an inevitable process during liver transplantation, leading to high rates of dysfunction and failure. The mechanism involves microcirculation dysfunction, hypoxia, oxidative stress, and cell death. The immune response also plays a crucial role. Studies on living donor liver transplantation have identified specific mitochondrial and metabolic dysfunction in certain types of graft injury. These findings have paved the way for new biomarkers and potential therapeutics, but further validation and clinical trials are needed. This review emphasizes the importance of the spatiotemporal microenvironment resulting from various factors in liver ischemia/reperfusion injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Asa Noren, Mihai Oltean, Styrbjorn Friman, Antonio Molinaro, Johan Molne, Carina Sihlbom, Gustaf Herlenius, Annika Thorsell
Summary: Acute kidney injury (AKI) is common after liver transplantation (LT) and is related to the later development of chronic kidney disease. This study found that grafts from LT recipients who develop early AKI have distinct proteomic alterations, primarily dominated by an early yet prominent activation of innate immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Giolana Nunes, Estela Regina Ramos Figueira, Joel Avancini Rocha-Filho, Cinthia Lanchotte, Lucas Souto Nacif, Diego Mendes Ferreira, Vitor Carminatti Romano, Emilio Elias Abdo, Luiz Augusto Carneiro D'Albuquerque, Flavio Henrique Ferreira Galvao
Summary: The study found that hypertonic saline solution before hypothermic hepatic ischemia reduced hepatocellular oxidative stress, cytokine concentrations, and promoted better recovery of acid-base disorders secondary to liver ischemia reperfusion. The hypothermic groups displayed less liver damage and improved recovery of blood parameters.
Article
Gastroenterology & Hepatology
Bo Qi, Xiao-Qiang Wang, Shu-Ting Pan, Pei-Ying Li, Ling-Ke Chen, Qiang Xia, Li-Qun Yang, Wei-Feng Yu
Summary: The study found that remote ischemic preconditioning (RIPC) did not have significant protective effects on living liver donors and recipients following pediatric liver transplantation. Limited protective effects were observed in some aspects, but overall, RIPC did not significantly improve the prognosis for transplant recipients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Immunology
Tong Wu, Cheng Zhang, Tianfeng Shao, Jianzhong Chen, Diyu Chen
Summary: Ischemia-reperfusion injury (IRI) is a crucial factor in liver transplantation, and the activation of hepatic macrophages, especially NLRP3 inflammasome, plays a significant role in the progression of IRI. The NLRP3 inflammasome pathway in hepatic macrophages is highly expressed and may lead to liver IRI, making it a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yongliang Hua, Yanan Xu, Xinglong Li, Bing Yin, Shounan Lu, Chaoqun Wang, Shanjia Ke, Baolin Qian, Hongjun Yu, Miaoyu Bai, Yong Ma
Summary: The aim of this study was to investigate the protective mechanisms of ischaemic preconditioning (IPC) against ischaemia-reperfusion (I/R) injury and explore the role of long non-coding RNAs (lncRNAs). The results showed that IPC improved liver damage by reducing liver transaminase levels and pro-inflammatory cytokines. Gene ontology and pathway analyses revealed that the differentially expressed genes (DEGs) were mainly associated with protein folding and metabolism. Additionally, several DEGs were validated using the lncRNA-mRNA weighted coexpression network.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Laurent Reydellet, Audrey Le Saux, Valery Blasco, Cyril Nafati, Karim Harti-Souab, Romain Armand, Ariane Lannelongue, Emilie Gregoire, Jean Hardwigsen, Jacques Albanese, Sophie Chopinet
Summary: Hyperoxia is common during liver transplantation, but no guidelines support its use. Recent studies have shown the potential harm of hyperoxia in similar ischemia-reperfusion models. Hyperoxia after orthotopic liver transplantation can increase lactate levels and worsen patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Wojciech Figiel, Grzegorz Niewinski, Michal Grat, Marek Krawczyk, Jan Stypulkowski, Zbigniew Lewandowski, Maciej Krasnodebski, Waldemar Patkowski, Krzysztof Zieniewicz
Summary: Despite the importance of perioperative hyperoxygenation in preventing postoperative infections, this study found that it should not be used for prophylaxis of infections after liver transplantation due to the lack of efficacy.
Article
Medicine, Research & Experimental
Zhangliu Jin, Meng Dou, Weihui Peng, Boen Xiao, Jinjin Liu, Wen Meng, Wei Liu
Summary: This study aimed to analyze alterations in gene expression, immune infiltration components, and potential biomarkers in liver ischemia-reperfusion injury (IRI) following liver transplantation (LT). The study identified differentially expressed genes associated with inflammation, apoptosis, cell proliferation, immune disorders, and cellular response, as well as various immune cell types infiltrating the IRI. The study also identified potential biological biomarkers, which may contribute to the diagnosis and prognosis of IRI post-transplant.
Article
Cell Biology
Xiangrong Cui, Hongping Liang, Chonghua Hao, Xuan Jing
Summary: Liraglutide protects cardiomyocytes under hypoxia/reoxygenation conditions by regulating homer1 gene expression, inhibiting intracellular calcium overload, and enhancing cell survival.
Review
Biochemistry & Molecular Biology
Fernando Lucas-Ruiz, Alejandro Penin-Franch, Jose Antonio Pons, Pablo Ramirez, Pablo Pelegrin, Santiago Cuevas, Alberto Baroja-Mazo
Summary: The NLRP3 inflammasome and pyroptosis play important roles in liver transplantation, affecting the progression of liver disease and treatment outcomes. Studying this pathway may lead to new strategies for the future treatment of LT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Surgery
Jeffrey Leung, Jonathan Leong, Kenneth Au Yeung, Bo Zhen Hao, Aled McCluskey, Yusuf Kayani, Brian R. Davidson, Kurinchi S. Gurusamy
Summary: This study systematically evaluated clinical practice guidelines of laparoscopic surgery published in PubMed and Embase, finding that a considerable proportion of guideline statements lack evidence support. Guideline authors tend to overrate the strength of recommendation.
UPDATES IN SURGERY
(2022)
Article
Computer Science, Interdisciplinary Applications
Ester Bonmati, Yipeng Hu, Alexander Grimwood, Gavin J. Johnson, George Goodchild, Margaret G. Keane, Kurinchi Gurusamy, Brian Davidson, Matthew J. Clarkson, Stephen P. Pereira, Dean C. Barratt
Summary: This research proposes a convolutional neural network model that labels ultrasound images using verbal comments from clinicians. The results show a prediction accuracy of 76% at the image level.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Engineering, Biomedical
Bongjin Koo, Maria R. Robu, Moustafa Allam, Micha Pfeiffer, Stephen Thompson, Kurinchi Gurusamy, Brian Davidson, Stefanie Speidel, David Hawkes, Danail Stoyanov, Matthew J. Clarkson
Summary: This study proposes a novel automatic pipeline for 3D-2D global registration in laparoscopic liver surgery, utilizing a fully convolutional network for semantic contour detection and a contour-based registration algorithm. The method demonstrates excellent generalization and promising results in clinical data, paving the way for more intuitive augmented reality systems for surgeons with potential for incorporation of liver deformation for more accurate registration.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
Article
Surgery
Farid Froghi, Vignesh Gopalan, Zachos Anastasiou, Rahul Koti, Kurinchi Gurusamy, Christine Eastgate, Margaret McNeil, Helder Filipe, Manuel Pinto, Jeshika Singh, Louise Longworth, Susan Mallett, Nick Schofield, Douglas Thorburn, Daniel Martin, Brian R. Davidson
Summary: In this randomized trial of fluid therapy post liver transplant, GDFT was associated with an increased volume of crystalloids administered but did not alter early post-operative pulmonary or renal function when compared with standard care.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Zainab L. Rai, Veronica Ranieri, Daniel H. Palmer, Peter Littler, Pauleh Ghaneh, Kurinchi Gurusamy, Derek Manas, Elena Pizzo, Eftychia Eirini Psarelli, Roopinder Gilmore, Praveen Peddu, David C. Bartlett, Nicola de Liguori Carino, Brian R. Davidson
Summary: This article introduces a study on the treatment of locally advanced pancreatic cancer patients. The aim of the study is to evaluate the feasibility of irreversible electroporation (IRE) therapy compared with chemotherapy, and to collect relevant data to guide subsequent multicenter randomized controlled trials. The trial will recruit 50 patients from seven specialist pancreas centers in the UK and will have a follow-up period of 12 months.
Article
Emergency Medicine
Marco Ceresoli, Michele Pisano, Fikri Abu-Zidan, Niccolo Allievi, Kurinchi Gurusamy, Walt L. Biffl, Giovanni D. Tebala, Fausto Catena, Luca Ansaloni, Massimo Sartelli, Yoram Kluger, Gianluca Baiocchi, Federico Coccolini
Summary: The survey reveals that minimally invasive techniques in emergency surgery are underutilized. Greater emphasis should be placed on the development of laparoscopy training among emergency surgeons.
WORLD JOURNAL OF EMERGENCY SURGERY
(2022)
Review
Psychology, Developmental
Audrey Linden, Lawrence Best, Freya Elise, Danielle Roberts, Aoife Branagan, Yong Boon Ernest Tay, Laura Crane, James Cusack, Brian Davidson, Ian Davidson, Caroline Hearst, William Mandy, Dheeraj Rai, Edward Smith, Kurinchi Gurusamy
Summary: Mental health difficulties are prevalent in autistic individuals, and finding interventions to improve their mental health is a top priority. However, there is currently a lack of high-quality network meta-analysis on the benefits and harms of different interventions. Available evidence suggests that cognitive behavioural therapy may decrease anxiety and depression in autistic individuals, mindfulness therapy may decrease anxiety and depression in autistic adults with previous mental health conditions, and behavioural interventions may provide some benefit for depression in autistic children. Further research is needed to obtain more high-quality evidence. Autistic individuals should have access to mental health interventions available to non-autistic individuals, following person-centred care principles.
Article
Pediatrics
Aoife Branagan, Ivan Yu, Kurinchi Gurusamy, Jan Miletin
Summary: This study conducted a network meta-analysis of different surfactant treatment strategies for respiratory distress syndrome (RDS) and found no clear benefit of surfactant treatment at any threshold of fraction of inspired oxygen (FiO(2)). The use of surfactant at a threshold of 60% FiO(2) may increase the risk of complications. More randomized trials are urgently needed to provide robust evidence for surfactant delivery at different thresholds.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Medicine, General & Internal
Hannah Warren, Thomas Wagner, Michael A. Gorin, Steven Rowe, Beverley Fiona Holman, Deborah Pencharz, Soha El-Sheikh, Ravi Barod, Prasad Patki, Faiz Mumtaz, Axel Bex, Veeru Kasivisvanathan, Caroline M. Moore, Nicholas Campain, Jon Cartledge, Andrew Scarsbrook, Fahim Hassan, Tim S. O'Brien, Grant D. Stewart, Iosif Mendichovszky, Sabina Dizdarevic, Ammar Alanbuki, William H. Wildgoose, Tze Wah, Cecilia Vindrola-Padros, Elena Pizzo, Hakim-Moulay Dehbi, Paula Lorgelly, Kurinchi Gurusamy, Mark Emberton, Maxine G. B. Tran
Summary: The incidence of renal tumours is increasing and anatomic imaging cannot reliably distinguish benign tumours from renal cell carcinoma. Tc-99m-sestamibi SPECT/CT has shown high diagnostic accuracy for benign renal oncocytomas and other oncocytic renal neoplasms of low malignant potential in single-centre studies. The primary aim of MULTI-MIBI is to assess feasibility of a multicentre study of Tc-99m-sestamibi SPECT/CT against a reference standard of histopathology from surgical resection or biopsy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Dowrick, Guofang Xiao, Daniil Nikitichev, Eren Dursun, Neils van Berkel, Moustafa Allam, Bongjin Koo, Joao Ramalhinho, Stephen Thompson, Kurinchi Gurusamy, Ann Blandford, Danail Stoyanov, Brian R. Davidson, Matthew J. Clarkson
Summary: This research aims to find a suitable method for tracked stereo laparoscope calibration within the operating theater. A custom calibration rig was designed and compared with freehand calibration, resulting in significantly reduced errors.
Article
Gastroenterology & Hepatology
Floris M. Thunnissen, Daan J. Comes, Carmen S. S. Latenstein, Martijn W. J. Stommel, Cornelis J. H. M. van Laarhoven, Joost P. H. Drenth, Marten A. Lantinga, Femke Atsma, Philip R. de Reuver
Summary: This study defined the ideal outcome for the treatment of uncomplicated gallstone disease through expert meetings and surveys, and found that 64.2% of patients achieved this outcome based on analysis of Dutch patient data.
Review
Health Care Sciences & Services
Danielle Amanda Roberts, Eila Watson, Christopher Macdonald, Yarunnessa Khan, Sarah Prideaux, Alwin Puthiyakunnel Saji, Emilia Postaleniec, Jashan Selvakumar, Mahta Haghighat Ghahfarokhi, Brian Davidson, Kurinchi Gurusamy
Summary: The study aims to compare different interventions for pain and cachexia in people with pancreatic cancer and develop an evidence-based care pathway. Systematic reviews and network meta-analysis will be conducted, and surveys and focus groups involving patients, carers, and healthcare professionals will be performed. The project's completion is expected by April 2024, and the results will be published within 12 months.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Acoustics
Hisham Assi, Rui Cao, Madhura Castelino, Ben Cox, Fiona J. Gilbert, Janek Gro, Kurinchi Gurusamy, Lina Hacker, Aoife M. Ivory, James Joseph, Ferdinand Knieling, Martin J. Leahy, Ledia Lilaj, Srirang Manohar, Igor Meglinski, Carmel Moran, Andrea Murray, Alexander A. Oraevsky, Mark D. Pagel, Manojit Pramanik, Jason Raymond, Mithun Kuniyil Ajith Singh, William C. Vogt, Lihong Wang, Shufan Yang, Sarah E. Bohndiek
Summary: Photoacoustic imaging has a promising potential in clinical trials, but its adoption in healthcare systems for clinical decision making faces barriers such as education, training, and data interpretation. The International Photoacoustic Standardisation Consortium identified these barriers and developed plans to address them.
Article
Computer Science, Artificial Intelligence
Joao Ramalhinho, Soojeong Yoo, Thomas Dowrick, Bongjin Koo, Murali Somasundaram, Kurinchi Gurusamy, David J. Hawkes, Brian Davidson, Ann Blandford, Matthew J. Clarkson
Summary: This paper evaluates the value of augmented reality overlay in laparoscopic surgery. The study finds that compared to a baseline condition, augmented reality can decrease the localization error of surgeons and introduce improvements in usability and user confidence in the surgical task.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Engineering, Biomedical
Thomas Dowrick, Brian Davidson, Kurinchi Gurusamy, Matthew J. Clarkson
Summary: This study demonstrates the use of synthetic data generated with Unity game engine for training a liver segmentation model in image guided surgery. The results show that synthetic data outperforms real data in some cases, although the overall performance is slightly lower compared to models trained on real data only.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)