期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 16, 期 28, 页码 3578-3583出版社
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v16.i28.3578
关键词
Pre-miR-146a; miR-146a; Gastric cancer; Polymorphism; Genotype
资金
- National Natural Science Foundation of China [30873099]
- Natural Science Foundation of Jiangsu Province [BK2006525, 08KJB320004]
- Young Academic Leader of Jiangsu Province
AIM: To investigate the association between pre-miR-146a C/G polymorphism and gastric cancer risk. METHODS: We performed a hospital-based, case-control study using polymerase chain reaction-restriction fragment length Polymorphism method in 608 individuals (304 gastric cancer patients and 304 age and sex matched cancer-free controls). RESULTS: The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups (P = 0.037). Compared with CC genotype carriers, subjects with the variant genotypes (GC + GG) had a 58% increased risk of gastric cancer (adjusted OR = 1.58, 95% CI: 1.11-2.20, P = 0.009). Moreover, a higher gastric cancer risk was especially evident in younger individuals aged 58 years, nonsmokers, and males (adjusted OR = 1.76, 95% CI: 1.08-2.87, P = 0.024; adjusted OR = 1.55, 95% CI: 1.06-2.28, P = 0.025; adjusted OR = 1.53, 95% CI: 1.04-2.27, P = 0.033; respectively). CONCLUSION: Pre-miR-146a C/G polymorphism might be associated with an elevated risk of gastric cancer in Chinese population. (C) 2010 Baishideng. All rights reserved.
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