Article
Gastroenterology & Hepatology
Kana Shiraishi, Shinya Furukawa, Sen Yagi, Kenichirou Mori, Tomoyuki Ninomiya, Keitarou Kawasaki, Yuji Mizukami, Seiyuu Suzuki, Masayoshi Uraoka, Naozumi Shibata, Sanae Nakamura, Satoshi Imamine, Hidehiro Murakami, Katsuhisa Ohashi, Masamoto Torisu, Makoto Yano, Aki Hasebe, Harumi Yano, Masato Murakami, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Summary: In patients with ulcerative colitis, serum globulin showed a significant positive association with endoscopic activity and a significant inverse association with mucosal healing, especially in the low C-reactive protein group.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Nathaniel A. Cohen, Maryam Zafer, Namrata Setia, Michael J. Anderson, Atsushi Sakuraba, Sushila Dalal, Joel Pekow, Russell D. Cohen, David T. Rubin, Dejan Micic
Summary: This study found that serum CMV PCR can be used as a non-invasive test for diagnosing CMV colitis in UC patients, and it has excellent negative predictive value and a strong correlation with CMV positivity on histology.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Cristian Hernandez-Rocha, Shadi Nayeri, Williams Turpin, Mike Steel, Krzysztof Borowski, Joanne M. Stempak, James Conner, Mark S. Silverberg
Summary: This study aimed to establish the prognosis, transcriptional and microbial features of histo-endoscopic remission and activity in ulcerative colitis (UC) patients. The results showed that UC patients with histo-endoscopic remission had a lower risk of relapse and their rectosigmoid mucosa transcriptional profile resembled that of healthy controls. Host genes with antimicrobial properties were significantly associated with mucosal microbiota.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biochemistry & Molecular Biology
Keiko Maeda, Masanao Nakamura, Takeshi Yamamura, Tsunaki Sawada, Eri Ishikawa, Akina Oishi, Shuji Ikegami, Naomi Kakushima, Kazuhiro Furukawa, Tadashi Iida, Yasuyuki Mizutani, Takuya Ishikawa, Eizaburo Ohno, Takashi Honda, Masatoshi Ishigami, Hiroki Kawashima
Summary: This study analyzed the usefulness of serum gelsolin as a serological biomarker for clinical and endoscopic activities in ulcerative colitis. The findings indicate that serum gelsolin level correlates with clinical and endoscopic activities in ulcerative colitis, has higher sensitivity and specificity than C-reactive protein, and can detect mucosal healing, suggesting its potential as a biomarker for ulcerative colitis.
Article
Gastroenterology & Hepatology
Heming Yao, Kayvan Najarian, Jonathan Gryak, Shrinivas Bishu, Michael D. Rice, Akbar K. Waljee, H. Jeffrey Wilkins, Ryan W. Stidham
Summary: This study aimed to pilot a fully automated video analysis system for grading endoscopic disease in ulcerative colitis (UC). The results showed promising performance in predicting disease severity in high-resolution videos and clinical trial videos, supporting the potential for artificial intelligence to provide accurate endoscopic disease grading in UC.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Multidisciplinary Sciences
Jiyoung Yoon, Junghwan Lee, Dae Sung Kim, Jin Wook Lee, Seung Wook Hong, Ha Won Hwang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Hwoon-Yong Jung, Suk-Kyun Yang, Jeong-Sik Byeon
Summary: This study investigated the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. It found that most cases occurred in older patients with comorbidities, and the endoscopic features varied with no clear association with clinical outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Emily C. L. Wong, Parambir S. Dulai, Badar Hasan, John K. Marshall, Walter Reinisch, Neeraj Narula
Summary: This study explored the additional value of histo-endoscopic mucosal improvement (HEMI) compared with endoscopic improvement (EI) in predicting outcomes in ulcerative colitis (UC) patients. The findings showed that although HEMI did not demonstrate additional prognostic value in predicting 1-year outcomes over EI, it was associated with lower clinical disease activity in patients at post-induction and at 1 year compared with endoscopic or histological outcomes in isolation.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Medicine, General & Internal
Yafei Qin, Grace Wang, Dejun Kong, Guangming Li, Hongda Wang, Hong Qin, Hao Wang
Summary: CMV reactivation in patients with ulcerative colitis (UC) is significantly associated with disease severity, pancolitis, older age of UC onset, and the use of glucocorticoids, immunosuppressants, and azathioprine. However, infliximab treatment does not increase the risk of CMV reactivation, while 5-aminosalicylic acid is linked to a lower risk. Monitoring for these risk factors is crucial for timely diagnosis and treatment in UC patients.
Article
Gastroenterology & Hepatology
Tsukasa Yamawaka, Hiroki Kitamoto, Masanori Nojima, Tomoe Kazama, Kohei Wagatsuma, Keisuke Ishigami, Shuji Yamamoto, Yusuke Honzawa, Minoru Matsuura, Hiroshi Seno, Hiroshi Nakase
Summary: In this study, we analyzed the associations among histopathological tests, antigenemia assays, and mucosal PCR in UC patients with HCMV colitis. The HCMV-DNA copy number in colonic tissues was significantly associated with positive immunohistochemistry and antigenemia results. A cutoff value of 1300 copies/μg of HCMV-DNA was determined to predict positive antigenemia results. Additionally, the HCMV-DNA copy number correlated with the total UCEIS score and bleeding score, indicating its potential use in diagnosing HCMV colitis in UC patients.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Joshua Kwon, Daniela Fluxa, Francis A. Farraye, Paul T. Kroner
Summary: The study found a significant association between IBD and CMV colitis, with a higher occurrence rate in patients with UC. Patients with CD and CMV colitis had increased odds of mortality, shock, and ICU stay, while patients with UC had a higher likelihood of undergoing colectomy. Patients with IBD and CMV colitis also experienced higher odds of acute kidney injury, multiorgan failure, increased hospital costs, and longer hospital stays compared to those without CMV colitis. Prospectively designed studies are needed to further investigate the risk factors and impact of CMV colitis on IBD patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
D. Laharie, J. Y. Mary
Summary: This study aimed to quantify the association between achieving Mayo endoscopic sub-score (MES) of 0 or 1 and long-term disease outcome in patients with acute severe ulcerative colitis (ASUC). The results showed that patients who achieved complete endoscopic healing had better survival and longer time without disease relapse.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Rocio Sedano, Malcolm Hogan, Tran M. Nguyen, Joshua Chang, G. Y. Zou, John K. Macdonald, Niels Vande Casteele, Jurij Hanzel, Eileen Crowley, Robert Battat, Parambir S. Dulai, Siddharth Singh, Geert D'Haens, William Sandborn, Brian G. Feagan, Christopher Ma, Vipul Jairath
Summary: This study provides a summary of placebo rates in induction and maintenance clinical trials of ulcerative colitis, as well as identifying the factors influencing these rates. The results show that placebo rates vary depending on the endpoint assessed, trial purpose, and drug class.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Yu Kamitani, Hiroki Kurumi, Tsutomu Kanda, Yuichiro Ikebuchi, Akira Yoshida, Koichiro Kawaguchi, Kazuo Yashima, Yoshihisa Umekita, Hajime Isomoto
Summary: This study evaluated the correlation between colonic mucus volume and endoscopic and histopathological findings in patients with ulcerative colitis (UC). The study found that reduced mucus volume was correlated with worsening endoscopic and histopathological findings, and the severity of inflammatory findings in UC was correlated with the relative mucus volume, suggesting functional mucosal healing.
Article
Gastroenterology & Hepatology
David Laharie, Arnaud Bourreille, Julien Branche, Matthieu Allez, Yoram Bouhnik, Jerome Filippi, Frank Zerbib, Guillaume Savoye, Lucine Vuitton, Jacques Moreau, Aurelien Amiot, Laurent Beaugerie, Elena Ricart, Olivier Dewit, Antonio Lopez-Sanroman, Mathurin Fumery, Franck Carbonnel, Anthony Buisson, Benoit Coffin, Xavier Roblin, Gert van Assche, Maria Esteve, Martti Farkkila, Javier P. Gisbert, Philippe Marteau, Stephane Nahon, Martine de Vos, Laurent Peyrin-Biroulet, Jean-Yves Mary
Summary: In patients with steroid-refractory ASUC responding to second-line medical therapy, the process of endoscopic remission started with bleeding remission and was not achieved in half the patients at day 98 for vascular pattern. Infliximab provided a higher endoscopic remission rate than cyclosporine at day 98.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Elisabetta Lolli, Elena De Cristofaro, Irene Marafini, Edoardo Troncone, Benedetto Neri, Francesca Zorzi, Livia Biancone, Emma Calabrese, Giovanni Monteleone
Summary: Patients with long-standing and extensive/left-sided colonic inflammatory bowel diseases (IBD) have a higher risk of developing colorectal cancer. Dye-based chromoendoscopy (DCE) is recommended for surveillance and prevention of colon cancer in these patients. This study identified polypoid lesions with specific morphologic features and size greater than 7 mm as frequently dysplastic/neoplastic and, therefore, should be removed.