Article
Medicine, General & Internal
Silvia Wuerstle, Alexander Hapfelmeier, Siranush Karapetyan, Fabian Studen, Andriana Isaakidou, Tillman Schneider, Roland M. Schmid, Stefan von Delius, Felix Gundling, Rainer Burgkart, Andreas Obermeier, Ulrich Mayr, Marc Ringelhan, Sebastian Rasch, Tobias Lahmer, Fabian Geisler, Paul E. Turner, Benjamin K. Chan, Christoph D. Spinner, Jochen Schneider
Summary: Ascitic fluid infection is a serious complication of liver cirrhosis, and it is crucial to distinguish between spontaneous bacterial peritonitis (SBP) and secondary peritonitis in these patients due to different treatment approaches. This study analyzed 532 SBP episodes and 37 secondary peritonitis episodes to identify key differentiation criteria. Microbiological characteristics, severity of illness, and clinicopathological parameters were identified as the most important predictors to distinguish between SBP and secondary peritonitis. A point-score model with ten discriminatory features was established, and two cut-off scores were defined to divide patients into low-risk and high-risk groups for secondary peritonitis based on a sensitivity of 95% to rule out or rule in SBP episodes. Overall, the discrimination between secondary peritonitis and SBP remains challenging, but the findings of this study may help clinicians with the crucial differentiation.
Article
Emergency Medicine
Brit Long, Michael Gottlieb
Summary: This paper evaluates the current evidence on the diagnosis and management of spontaneous bacterial peritonitis (SBP) for emergency medicine clinicians. SBP is commonly caused by Gram-negative bacteria, but infections from Gram-positive bacteria and multidrug resistant bacteria are increasing. Paracentesis is the preferred diagnostic modality, and ultrasound should be used to optimize the procedure. An ascitic fluid absolute neutrophil count (ANC) ≥ 250 cells/mm3 is diagnostic of SBP. Treatment typically involves a third-generation cephalosporin, but certain patient populations may require broader spectrum antibiotics.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Immunology
Lanlan Yang, Siqi Liu, Qian Zhang, Shengnan Jia, Chen Qiu, Zhenjing Jin
Summary: IL-35 regulates CD8(+) T cells in liver cirrhosis patients, suppressing their cytotoxicity and cytokine secretion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marwin A. Farrugia, Maena Le Corvec, Christophe Renou, Jean-Baptiste J. Nousbaum, Dann J. Ouizeman, Olivier Sire, Olivier Loreal, Hugues Tariel, Jerome Bernard, Thierry Piche, Albert Tran, Hafid Ait-Oufella, Luce Landraud, Philippe Gual, Rodolphe Anty
Summary: This study aimed to evaluate the diagnostic value of a rapid and easy-to-use mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out spontaneous bacterial peritonitis (SBP). The results showed that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP.
Review
Gastroenterology & Hepatology
Pinky Juneja, Dinesh M. Tripathi, Savneet Kaur
Summary: The gut lymphatic system plays a significant role in maintaining gut health, but it is one of the least studied physiological systems. The gut-liver axis is crucial in the pathogenesis of liver diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Roxana-Emanuela Popoiag, Andra-Iulia Suceveanu, Adrian-Paul Suceveanu, Sergiu Micu, Felix Voinea, Laura Mazilu, Lucian Petcu, Eugenia Panaitescu, Georgeta Cozaru, Carmen Fierbinteanu-Braticevici
Summary: This study aimed to analyze the risk factors for spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis, with the neutrophil-to-lymphocyte ratio (NLR) being a predictive factor. Serum white blood cells, total platelet count, total bilirubin, and other factors were also observed to be associated with the occurrence of SBP.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Thomas Deleuran, Hugh Watson, Hendrik Vilstrup, Peter Jepsen
Summary: The study aimed to examine the impact of spontaneous bacterial peritonitis (SBP) on mortality in patients with cirrhosis. The results showed that SBP episodes were associated with a higher short-term mortality rate, but had no lasting effect on long-term mortality.
ANNALS OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sun Woong Kim, Jun Sik Yoon, Junyong Park, Yong Jin Jung, Jae Seung Lee, Jisoo Song, Han Ah Lee, Yeon Seok Seo, Minjong Lee, Jin Myung Park, Dae Hee Choi, Moon Young Kim, Seong Hee Kang, Jin Mo Yang, Do Seon Song, Sung Won Chung, Minseok Albert Kim, Hee Joon Jang, Hyunwoo Oh, Cheol-Hyung Lee, Yun Bin Lee, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee
Summary: Empirical treatment with carbapenem does not reduce in-hospital mortality compared to treatment with TGCs for patients with a first presentation of SBP. However, among critically ill patients with high CLIF-SOFA scores, empirical carbapenem treatment was significantly associated with lower in-hospital mortality than TGCs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Florence Wong, Stephen Chris Pappas, K. Rajender Reddy, Hugo Vargas, Michael P. Curry, Arun Sanyal, Khurram Jamil
Summary: The use of terlipressin in patients with HRS1 and ACLF may increase the incidence of RF, especially in patients with grade 3 ACLF. Patients with hypoxemia are at an increased risk of RF and mortality.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Infectious Diseases
Caterina Zoratti, Rita Moretti, Lisa Rebuzzi, Irma Valeria Albergati, Antonietta Di Somma, Giuliana Decorti, Stefano Di Bella, Lory Saveria Croce, Mauro Giuffre
Summary: This narrative review aims to provide physicians with basic and practical knowledge for efficiently choosing the best antibiotic therapy in patients with liver cirrhosis and ongoing infections.
Article
Gastroenterology & Hepatology
Ngoc Cao Huynh, Thong Duy Vo
Summary: The study validated a new simple scoring system that showed good performance in predicting spontaneous bacterial peritonitis (SBP) in patients with cirrhosis and ascites. This scoring system can rapidly diagnose or exclude SBP without the need for paracentesis.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Backer Abdu, Shalaka Akolkar, Christopher Picking, Judith Boura, Marc Piper
Summary: Studies have shown that delayed paracentesis in patients with SBP is associated with worse outcomes and increased mortality. Research indicates that DP is common in the community setting and is influenced by the ordering physician and the specialty of the physician performing the procedure. Future efforts should focus on interventions to improve this important quality indicator.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Gastroenterology & Hepatology
R. Pimentel, C. Gregorio, P. Figueiredo
Summary: This systematic review concludes that daily norfloxacin is effective in preventing spontaneous bacterial peritonitis in cirrhotic patients, with once weekly ciprofloxacin being a viable alternative. Trimethoprim-sulfamethoxazole and norfloxacin have similar efficacy, but the former has a higher risk of adverse events, whereas rifaximin is more effective in secondary prophylaxis with lower adverse events and mortality rates.
ACTA GASTRO-ENTEROLOGICA BELGICA
(2021)
Review
Gastroenterology & Hepatology
Veeral Ajmera, Beom Kyung Kim, Kun Yang, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Natalie E. Quach, Xin Tu, Xinlian Zhang, Mazen Noureddin, Alina M. Allen, Rohit Loomba
Summary: Liver stiffness assessed by magnetic resonance elastography (MRE) is associated with liver-related events, and the combination of MRE and Fibrosis-4 has excellent negative predictive value for hepatic decompensation.
Review
Biology
Valeria Maccauro, Carlo Airola, Francesco Santopaolo, Antonio Gasbarrini, Francesca Romana Ponziani, Maurizio Pompili
Summary: Liver cirrhosis is a chronic disease that often leads to complications such as variceal bleeding, hepatic encephalopathy, ascites, and jaundice, with increased mortality. Infections, particularly spontaneous bacterial peritonitis (SBP), are common in cirrhotic patients due to impaired immunity and altered intestinal microbiota. SBP is primarily caused by Gram-negative bacteria translocating through the defective intestinal barrier. The first-line treatment is antibiotic therapy, but it may worsen dysbiosis. Future therapies aim to selectively modulate the gut microbiota or reduce intestinal permeability.
Article
Medicine, Research & Experimental
Jan Bures, Jaroslav Kvetina, Ilja Tacheci, Michal Pavlik, Martin Kunes, Stanislav Rejchrt, Kamil Kuca, Marcela Kopacova
JOURNAL OF APPLIED BIOMEDICINE
(2015)
Meeting Abstract
Gastroenterology & Hepatology
Tomas Douda, Daniel Jun, Martina Hrabinova, Ilja Tacheci, Jaroslav Kvetina, Michal Pavlik, Stanislav Rejchrt, Martin Kunes, Kamil Kuca, Marcela Kopacova, Jan Bures
Article
Rheumatology
Ilja Tacheci, Petr Bradna, Tomas Douda, Drahomira Bastecka, Marcela Kopacova, Stanislav Rejchrt, Martin Lutonsky, Tomas Soukup, Jan Bures
RHEUMATOLOGY INTERNATIONAL
(2016)
Article
Gastroenterology & Hepatology
Jiri Cyrany, Stanislav Rejchrt, Marcela Kopacova, Jan Bures
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Editorial Material
Gastroenterology & Hepatology
Ilja Tacheci, Jithinraj Edakkanambeth Varayil, Zuzana Zelinkova, Marcela Kopacova, Miroslav Zavoral
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2016)
Article
Gastroenterology & Hepatology
Stanislav Rejchrt, Ilona Koupil, Marcela Kopacova, Miluska Skodova Fendrichova, Bohumil Seifert, Viktor Vorisek, Jana Spirkova, Tomas Douda, Ilja Tacheci, Jan Bures
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2018)
Letter
Gastroenterology & Hepatology
J. Cyrany, T. Vasatko, J. Machac, M. Nova, J. Szanyi, M. Kopacova
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2014)
Article
Gastroenterology & Hepatology
Marcela Kopacova, Ilona Koupil, Bohumil Seifert, Miluska Skodova Fendrichova, Jana Spirkova, Viktor Vorisek, Stanislav Rejchrt, Tomas Douda, Ilja Tacheci, Jan Bures
WORLD JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Multidisciplinary Sciences
Jan Bures, Jaroslav Kvetina, Vera Radochova, Ilja Tacheci, Eva Peterova, David Herman, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Tomas Douda, Vit Sestak, Ladislav Douda, Jana Zdarova Karasova
Review
Gastroenterology & Hepatology
Ilja Tacheci, Marcela Kopacova, Jan Bures
Summary: Peutz-Jeghers syndrome is a rare genetic disease with increased risk of various cancers, requiring regular monitoring to reduce complications.
CURRENT OPINION IN GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova
Summary: The gastrointestinal side effects of donepezil are common in patients, occurring in 20-30% of cases. Experimental studies in pigs showed that intestinal injury and prolonged transit time led to higher plasma concentrations of donepezil, highlighting the importance of dose adjustment in patients with underlying gastrointestinal diseases. Additionally, donepezil had a negative impact on gastric myoelectric activity, especially when combined with intestinal injury, which may explain the dyspepsia associated with the medication in humans.
Meeting Abstract
Gastroenterology & Hepatology
Tomas Douda, Jaroslav Pejchal, Darina Kohoutova, Jaroslav Kvetina, Vera Radochova, Ales Tichy, Stanislav Rejchrt, Marcela Kopacova, Jan Bures
Article
Pharmacology & Pharmacy
Jaroslav Kvetina, Ilja Tacheci, Milan Nobilis, Marcela Kopacova, Martin Kunes, Jan Bures
CURRENT PHARMACEUTICAL DESIGN
(2017)
Article
Physiology
J. Kvetina, I. Tacheci, M. Pavlik, M. Kopacova, S. Rejchrt, T. Douda, M. Kunes, J. Bures
PHYSIOLOGICAL RESEARCH
(2015)
Article
Endocrinology & Metabolism
Jan Bures, Daniel Jun, Martina Hrabinova, Ilja Tacheci, Jaroslav Kvetina, Michal Pavlik, Stanislav Rejchrt, Tomas Douda, Martin Kunes, Kamil Kuca, Marcela Kopacova
NEUROENDOCRINOLOGY LETTERS
(2015)
