Article
Immunology
Laurent Cotte, Laurent Hocqueloux, Maeva Lefebvre, Pierre Pradat, Firouze Bani-Sadr, Thomas Huleux, Isabelle Poizot-Martin, Pascal Pugliese, David Rey, Andre Cabie
Summary: A significant shift in HCV epidemiology was observed in people living with HIV in France from 2012 to 2018, with a decrease in overall HCV prevalence but an increase in new infections among men who have sex with men (MSM), making MSM the primary group for HCV transmission in 2018.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Eveline Hofmann, Bernard Surial, Noemie Boillat-Blanco, Huldrych F. Guenthard, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Franziska Suter-Riniker, Andri Rauch, Gilles Wandeler, Charles Beguelin
Summary: In the Swiss HIV Cohort Study, researchers found that 27% of HIV-suppressed individuals with chronic hepatitis B virus (HBV) infection had HBV replication after two years on tenofovir. However, 77% of them were able to achieve suppression thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were identified as predictors of persistent replication.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Chia-Min Wu, Fu-Hsiung Su, Chih-Hsin Muo, Jou-Chen Huang, Meei-Maan Wu, Chih-Ching Yeh
Summary: This study found that patients with HCV infection treated with PegIFN/RBV therapy had a significantly increased risk of retinopathy, particularly retinal hemorrhage.
Article
Immunology
Boun Kim Tan, Mathieu Chalouni, Dominique Salmon Ceron, Alexandre Cinaud, Laure Esterle, Marc Arthur Loko, Christine Katlama, Isabelle Poizot-Martin, Didier Neau, Julie Chas, Philippe Morlat, Eric Rosenthal, Karine Lacombe, Alissa Naqvi, Karl Barange, Olivier Bouchaud, Anne Gervais, Caroline Lascoux-Combe, Daniel Garipuy, Laurent Alric, Cecile Goujard, Patrick Miailhes, Hugues Aumaitre, Claudine Duvivier, Anne Simon, Jose-Luis Lopez-Zaragoza, David Zucman, Francois Raffi, Estibaliz Lazaro, David Rey, Lionel Piroth, Francois Boue, Camille Gilbert, Firouze Bani-Sadr, Francois Dabis, Philippe Sogni', Linda Wittkop, Franck Boccara
Summary: HIV-HCV coinfected patients have a high incidence of ASCVD events, with traditional cardiovascular risk factors playing a significant role. Controlling cholesterol abnormalities and maintaining undetectable HIV RNA levels are essential in reducing cardiovascular risk.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Cas Isfordink, Anders Boyd, Amanda Mocroft, Katharina Kusejko, Colette Smit, Stephane de Wit, Tabitha Mahungu, Karolin Falconer, Gilles Wandeler, Matthias Cavassini, Marcel Stockle, Janke Schinkel, Andri Rauch, Lars Peters, Marc van der Valk
Summary: The efficacy of direct-acting antivirals (DAAs) to treat hepatitis C virus (HCV) in individuals with human immunodeficiency virus (HIV)/HCV from sub-Saharan Africa (SSA) and Southeastern Asia (SEA) residing in Europe is generally high, indicating that suboptimal DAA efficacy is uncommon in this population.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Mawuena Binka, Zahid Ahmad Butt, Geoffrey McKee, Maryam Darvishian, Darrel Cook, Stanley Wong, Amanda Yu, Maria Alvarez, Hasina Samji, Jason Wong, Mel Krajden, Naveed Zafar Janjua
Summary: This study examined factors associated with HBV and/or HCV and/or HIV infection among different ethnic groups in a large population-based cohort in British Columbia, Canada. It found variations in risk factor distributions among individuals of different ethnic backgrounds, highlighting the need for tailored infection screening approaches for different ethnic groups.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Seyedeh-Kiana Razavi-Amoli, Abbas Alipour
Summary: The prevalence of HCV coinfection is high among Iranian PWH, with significant geographical variations. Screening and treatment for HCV among PWH are necessary to prevent the burden of HCV-related liver damage, cancer, and mortality in the future.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Yadong Wang, Yangyang Hu, Xing Zhang, Yue Luo, Luyuan Ma, Jingjing Lu, Qianfei Liang, Chengjun Xu, Caiyan Zhao, Calvin Q. Pan
Summary: This study investigated the relationship between IP-10 and treatment response in patients with CHC treated with direct-acting antiviral agents. The results showed that IP-10 levels decreased gradually during the treatment and baseline IP-10 level and the decline at 12 weeks were independent predictors of SVR.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Sahar Tabatabavakili, Wesam Aleyadeh, Orlando Cerrocchi, Harry L. A. Janssen, Bettina E. Hansen, Isaac I. Bogoch, Jordan J. Feld
Summary: Sexual transmission of HCV is uncommon in HIV-negative MSM PrEP users, but there are higher rates of other STIs. Routine risk-based HCV surveillance and periodic STI monitoring are recommended for PrEP users.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Alana G. Hudson, Robert A. Bonacci, Anne C. Moorman, McKenna Penley, Suzanne M. Wilson, Jessica L. Hoffman, Erica R. Thomasson, R. Paul McClung, Danae Bixler
Summary: Among 65 cases of HIV outbreak among persons who inject drugs (PWID) in West Virginia (2019-2021), 94% were diagnosed with hepatitis C a median of 46 months before HIV diagnosis. Diagnosis of hepatitis C among PWID should lead to improved access to prevention and treatment services.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Liyu Chen, Lingyao Du, Shuang Kang, Fanghua Ma, Changmin Li, Min He, Lang Bai, Hong Tang
Summary: In Liangshan, China, people living with HIV have a high prevalence of HCV coinfection. A 24-week regimen of SOF+RBV can achieve good efficacy and is well-tolerated in this population. This treatment has the potential to be generalized in regions with limited resources.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Penglei Jiang, Hongyu Jia, Xinyue Qian, Tian Tang, Yingli Han, Zhaoru Zhang, Lingli Jiang, Zebin Yu, Lin Zheng, Guodong Yu, Huan Cai, Shanyan Zhang, Xiaoli Zhang, Jueqing Gu, Chanyuan Ye, Lisha Yang, Yingfeng Lu, Heng Liu, Xiaoqing Lu, Ciliang Jin, Yue Ren, Miaomiao Lu, Lingling Xu, Jiong Yu, Xi Jin, Yida Yang, Pengxu Qian
Summary: This study used single-cell RNA sequencing to investigate the transcriptomic landscape of peripheral immune cells in CHB patients before and after PegIFN-alpha therapy. The study identified specific cell subsets associated with CHB and found that PegIFN-alpha treatment could decrease hyperactivated monocytes, increase long-lived naive/memory T cells, and enhance effector T cell cytotoxicity. Furthermore, the treatment altered the transcriptional profiles of immune cells and enhanced innate antiviral response.
Article
Public, Environmental & Occupational Health
Alia Alassad, Mhd Jawad Al Rahwanji, Amal Yousfan, Sally Al Moualem, Arwa Farhat, Lama A. Youssef
Summary: The seroprevalence of HBV, HCV, and HIV has decreased in Syria over an 18-year period, possibly due to the implementation of the HBV vaccine, a strong national health system, conservative sociocultural values, and isolation.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Virology
Mengqi Luo, Lingyan Zhang, Chou Yang, Bin Zhou, Jinlin Hou, De-Ke Jiang
Summary: This study found that single-nucleotide polymorphism CXCL13_rs76084459 is significantly associated with response to PegIFNa therapy in patients with chronic hepatitis B. Furthermore, a polygenic score composed of 6 SNPs including CXCL13_rs76084459 has a better predictive value for PegIFNa treatment response.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Kai Zhang, Xinyuan Lai, Ji Song, Lingyuan He, Luwei Wang, Guomin Ou, Xing Tian, Lei Wang, Juan Deng, Jiajia Zhang, Chuanyun Li, Hui Zhuang, Tong Li, Kuanhui Xiang
Summary: The coinfection of hepatitis B virus (HBV) and hepatitis C virus (HCV) can lead to severe liver disease, but a robust HBV/HCV coinfection cell culture model has been established to investigate their interaction. This model supports infection and replication of both HBV and HCV, allowing for a better understanding of their molecular details and outcomes.
ANTIVIRAL RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Loretta Jophlin, Ashwani K. Singal
Summary: Patients with alcohol-associated liver disease may develop severe forms of acute-on-chronic liver failure, increasing the risk of short-term mortality. Suspecting alcoholic hepatitis is important when diagnosing acute-on-chronic liver failure in patients with alcohol-associated liver disease. This review explores the necessity and feasibility of liver biopsy in diagnosing alcoholic hepatitis and predicting its prognosis in decompensated patients with alcohol-associated liver disease and acute-on-chronic liver failure.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
D. Morales-Arraez, M. Ventura-Cots, J. Altamirano, J. G. Abraldes, M. Cruz-Lemini, M. R. Thursz, S. R. Atkinson, S. K. Sarin, W. Kim, R. Chavez-Araujo, M. F. Higuera-de La Tijera, A. K. Singal, V. H. Shah, P. S. Kamath, A. Duarte-Rojo, E. A. Charles, V. Vargas, M. Jager, P. E. Rautou, D. Rincon, F. Zamarripa, J. C. Restrepo-Gutierrez, A. Torre, M. R. Lucey, J. P. Arab, P. Mathurin, A. Louvet, G. Garcia-Tsao, J. A. Gonzalez, E. C. Verna, R. S. Brown, J. Argemi, C. Fernandez-Carillo, A. Clemente, E. Alvarado-Tapias, E. Forrest, M. Allison, R. Bataller
Summary: This study assessed the accuracy of different scoring systems to predict short-term mortality in alcohol-associated hepatitis (AH) and found that the MELD score had the best performance in predicting short-term mortality.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Camille A. Kezer, Seth M. Buryska, Joseph C. Ahn, William S. Harmsen, Winston Dunn, Ashwani K. Singal, Juan P. Arab, Luis A. Diaz, Jorge Arnold, Patrick S. Kamath, Vijay H. Shah, Douglas A. Simonetto
Summary: This study developed a new scoring system for predicting 30-day mortality in patients with alcohol-associated hepatitis. The scoring system, named Mortality Index for Alcohol-Associated Hepatitis (MIAAH), showed promising accuracy and performance characteristics in identifying high-risk patients.
MAYO CLINIC PROCEEDINGS
(2022)
Editorial Material
Gastroenterology & Hepatology
Gustavo Ayares, Juan Pablo Arab, Ashwani K. Singal
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yousaf B. Hadi, Raja S. Khan, Dhairya A. Lakhani, Ali Y. Khan, Rida U. Jannat, Adnan Aman Khan, Syeda Fatima Naqvi, George Obeng, Justin T. Kupec, Ashwani K. Singal
Summary: This study aimed to investigate the effect of shorter antibiotic duration on patient outcomes in patients with cirrhosis and upper gastrointestinal bleeding. A retrospective study of 980 cirrhosis patients found that a short course of antibiotics (around 3 days) for prophylaxis is safe and sufficient in the absence of active infection.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Pradeep Yarra, Winston Dunn, Zobair Younossi, Yong-Fang Kuo, Ashwani K. Singal
Summary: This study found that previous RYGB in patients with AC is associated with increased likelihood of concomitant AH, hepatic encephalopathy, and infection, but similar in-hospital mortality.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Letter
Gastroenterology & Hepatology
Mohamed A. Elfeki, Ashwani K. Singal
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Nipun Verma, Ashwani K. Singal
Summary: This article is linked to the papers by Singal et al. To read these papers, visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Ashwani K. K. Singal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Anand V. Kulkarni, Ashwani K. Singal
DIGESTIVE AND LIVER DISEASE
(2023)
Editorial Material
Gastroenterology & Hepatology
Chencheng Xie, Ashwani K. Singal
HEPATOLOGY INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Malia Holbeck, Hannah Statz DeVries, Ashwani K. Singal
Summary: Alcohol-associated liver disease (ALD) is a common liver disease and a reason for liver transplantation (LT). Patients with ALD often have alcohol use disorder (AUD) and psychiatric comorbidities. Early identification of ALD and treatment of AUD can prevent progression to advanced stages of the disease. However, there are barriers to screening and treatment for AUD in ALD patients. This review discusses the multidisciplinary care model for managing the dual pathology of ALD and AUD, with a focus on the roles of hepatologists, psychiatrists, addiction counselors, and social workers.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ashwani K. Singal, Yong-Fang Kuo
Summary: This study compared the waitlist and post-transplant outcomes of liver transplantation alone (LTA) and simultaneous liver kidney (SLK) listings. It found that SLK patients had lower mortality on the waitlist and higher survival rates after transplantation. Therefore, the kidney function of patients should be taken into consideration when choosing the transplantation method.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Ayooluwatomiwa Deborah Adekunle, Adeyinka Adejumo, Ashwani K. K. Singal
Summary: Alcohol-associated liver disease (ALD) is a complex and rapidly increasing disease without approved therapeutic targets. Challenges in study designs and clinical trials need to be overcome to drive drug development in this field. ALD management should focus on achieving and maintaining alcohol abstinence, while early liver transplantation protocols and noninvasive biomarkers require improvement. Integrated multidisciplinary care models are urgently needed to improve long-term outcomes for ALD patients with alcohol use disorder and liver disease.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Ashwani K. Singal, Lorenzo Leggio, Andrea DiMartini
Summary: Alcohol-associated liver disease (ALD) is a leading cause for liver transplantation (LT) globally, particularly during the COVID-19 pandemic and among young individuals. Alcohol use disorder (AUD) is prevalent in the majority of ALD patients, and early liver transplantation (eLT) has emerged as a potential treatment for selected patients with alcohol-associated hepatitis. However, the challenge lies in addressing AUD treatment, which requires an integrated multidisciplinary care approach.
LIVER TRANSPLANTATION
(2023)