Article
Gastroenterology & Hepatology
Xiaobo Yang, Haifeng Xu, Bangyou Zuo, Xu Yang, Jin Bian, Junyu Long, Dongxu Wang, Junwei Zhang, Cong Ning, Yanyu Wang, Ziyu Xun, Yunchao Wang, Xin Lu, Yilei Mao, Xinting Sang, Haitao Zhao
Summary: Combining tyrosine kinase inhibitors (TKIs) and anti-PD-1 antibodies with local regional therapy has shown substantial clinical benefits in converting unresectable hepatocellular carcinoma patients with extrahepatic metastases to resectable. This study of HCC patients with oligometastatic disease utilizing this treatment strategy demonstrated promising outcomes, with a majority of patients surviving without recurrence and a subset achieving a pathological complete response after surgery. Adverse events were common but manageable, with fatigue, elevated aminotransferase levels, and hypertension being the most frequently reported.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Surgery
Yun Le Linn, Yuxin Guo, Ye-Xin Koh, Pierce K. H. Chow, Chung-Yip Chan, Alexander Y. F. Chung, London L. P. J. Ooi, Brian K. P. Goh
Summary: This study retrospectively reviewed 25 patients who underwent metastasectomy for intraabdominal EHM from 2003 to 2016. The findings showed that hepatitis B positivity and high tumor grade were significant preoperative predictors of futile surgery. All 7 patients who had both hepatitis B and high tumor grade experienced early recurrence post-metastasectomy.
WORLD JOURNAL OF SURGERY
(2021)
Review
Oncology
Noriyuki Umakoshi, Yusuke Matsui, Koji Tomita, Mayu Uka, Takahiro Kawabata, Toshihiro Iguchi, Takao Hiraki
Summary: This review summarizes the current evidence on image-guided thermal ablation therapies for extrahepatic metastases from hepatocellular carcinoma (HCC). Local ablative therapies, such as radiofrequency ablation, microwave ablation, and cryoablation, can be used in select patients for curative or palliative intent. The local control rate of thermal ablation therapy is relatively favorable, at approximately 70-90% in various organs.
Article
Oncology
Jianwei Liu, Guokun Zhuang, Shilei Bai, Zhiliang Hu, Yong Xia, Caixia Lu, Jie Wang, Chunyan Wang, Liu Liu, Fengwei Li, Yeye Wu, Feng Shen, Kui Wang
Summary: This study investigated the impact of surgical margin and hepatic resection on prognosis for patients with hepatocellular carcinoma (HCC). The results showed that for patients with MVI-positive HCC, wide margins and anatomical resection were protective factors for prognosis, with wide margins being more important. In clinical practice, ensuring wide margins should be prioritized.
Review
Oncology
Qiao Ke, Lei Wang, Weimin Wu, Xinhui Huang, Ling Li, Jingfeng Liu, Wuhua Guo
Summary: Postoperative adjuvant hepatic artery infusion chemotherapy (HAIC) can improve the long-term prognosis of hepatocellular carcinoma (HCC) patients, especially those with microvascular or macrovascular invasion. Patients would benefit from SR+HAIC regardless of chemotherapy regimens and courses, and further validation is needed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Matteo Serenari, Enrico Prosperi, Marc-Antoine Allard, Michele Paterno, Nicolas Golse, Andrea Laurenzi, Rene Adam, Matteo Ravaioli, Daniel Cherqui, Matteo Cescon
Summary: This study demonstrates that the time interval between hepatic resection (HR) and secondary liver transplantation (SLT) is a key factor in predicting complications after liver transplantation (LT), without affecting hepatocellular carcinoma (HCC)-related death.
Article
Multidisciplinary Sciences
Ji Won Han, Pil Soo Sung, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon
Summary: Elevated diastolic whole blood viscosity (WBV) is associated with distant metastases and poor survival in patients with hepatocellular carcinoma (HCC). High diastolic WBV is an independent risk factor for poor survival and may be predictive of future distant metastases.
Article
Medicine, General & Internal
Hamzah Adwan, Lars Hammann, Thomas J. Vogl
Summary: This study evaluated the efficacy and safety of microwave ablation (MWA) as a treatment for recurrent hepatocellular carcinoma (HCC) after initial surgical resection. The results showed that MWA treatment is effective and safe for recurrent HCC lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Eun Ko, Min Woo Lee, Soohyun Ahn, Hyunchul Rhim, Tae Wook Kang, Kyoung Doo Song, Jong Man Kim, Gyu-Seong Choi, Dong Ik Cha, Ji Hye Min, Dong Hyun Sinn, Moon Seok Choi, Hyo Keun Lim
Summary: This study compared the therapeutic outcomes of laparoscopic hepatic resection (LHR) and laparoscopic radiofrequency ablation (LRFA) for single subcapsular hepatocellular carcinoma (HCC) measuring 1-3 cm. The results showed no significant difference in therapeutic outcomes between the two methods.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fei Wu, Haitao Sun, Changwu Zhou, Peng Huang, Yuyao Xiao, Chun Yang, Mengsu Zeng
Summary: This study evaluated whether radiological similarity and clinicopathological factors determine the prognosis in bifocal hepatocellular carcinoma (bHCC) stratified by the Milan criteria. The study found that the radiological similarity of bHCC lesions is associated with long-term prognosis, in addition to other factors.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shintaro Yamazaki, Tadatoshi Takayama, Masaru Aoki, Nao Yoshida, Tokio Higaki
Summary: High dorsal resection (HDR) is a systematic resection technique for hepatocellular carcinoma (HCC) arising in the caudate lobe, which requires high operative skill and knowledge of liver anatomy. The procedure has a low severe morbidity rate and no operative mortality, with a median overall survival of 49.7 months.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Moheieldin M. Abouzied, Nayef Alhinti, Ahmad AlMuhaideb, Abdulaziz S. Al Sugair, Mohammed Al Qahtani
Summary: HCC survival has improved due to better primary tumor control and development of newer treatment modalities, with imaging techniques playing a crucial role in diagnosis and therapy assessment. Molecular imaging tools such as radiolabeled deoxyglucose and fluorocholine have shown promising value as complementary tools to conventional imaging, guiding treatment planning for patients.
NUCLEAR MEDICINE COMMUNICATIONS
(2021)
Review
Oncology
Flavio Milana, Michela Anna Polidoro, Simone Famularo, Ana Lleo, Renzo Boldorini, Matteo Donadon, Guido Torzilli
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and both liver resection and liver transplantation are considered potentially curative options. The management of HCC recurrence is still not well defined, but surgery remains a curative option for selected patients. This study aimed to summarize the patterns and histopathological characteristics of HCC recurrence, their prognostic value, and the main surgical strategies for dealing with HCC relapse.
Article
Surgery
J-H Zhong, B-C Xing, W-G Zhang, A. W-H Chan, C. C. N. Chong, M. Serenari, N. Peng, T. Huang, S-D Lu, Z-Y Liang, R-R Huo, Y-Y Wang, M. Cescon, T-Q Liu, L. Li, F-X Wu, L. Ma, M. Ravaioli, J. Neri, A. Cucchetti, P. J. Johnson, L-Q Li, B-D Xiang
Summary: This study investigated the safety and efficacy of repeat hepatic resection (rHR) and radiofrequency ablation (RFA) for recurrent hepatocellular carcinoma (HCC). The results showed that rHR was associated with longer recurrence-free survival compared with RFA, while RFA had lower morbidity and shorter hospital stay.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Daniel Hoffman, Amy Shui, Ryan Gill, Shareef Syed, Neil Mehta
Summary: AFP >= 1000 ng/mL, multinodularity, and vascular invasion were found to be independent risk factors for HCC recurrence. The researchers developed the RESTORE index to predict HCC recurrence risk, which can stratify the risk into different levels based on patient's scores.
