Review
Gastroenterology & Hepatology
Mohamed El-Kassas, Abeer Awad
Summary: Chronic hepatitis C virus (HCV) infection is associated with multiple metabolic factors that can impact the course of the illness and the progression of liver and non-liver-related diseases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Endocrinology & Metabolism
Yujin Ding, Guangdi Li, Zhiguang Zhou, Tuo Deng
Summary: Diabetes and hepatitis C are two distinct diseases, but they are closely related, as hepatitis C virus infection may lead to diabetes and influence the occurrence and development of diabetes through multiple mechanisms.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Mosleh Abomughaid, Enoch S. E. Tay, Russell Pickford, Chandra Malladi, Scott A. Read, Jens R. Coorssen, Brian S. Gloss, Jacob George, Mark W. Douglas
Summary: HCV infection increases neutral lipid and phospholipids in cells and induces the expression of PEMT, a key enzyme promoting lipid accumulation and virus replication. The induction of PEMT may explain the genotype-specific differences in hepatic steatosis caused by the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Alessia Ciancio, Davide G. Ribaldone, Anna Dotta, Chiara Giordanino, Marco Sacco, Sharmila Fagoonee, Rinaldo Pellicano, Giorgio M. Saracco
Summary: The study found that clearance of HCV by DAAs led to long-term improvement in glycometabolic control in diabetic patients, but diabetes still had a detrimental effect on the liver in cirrhotic patients.
LIVER INTERNATIONAL
(2021)
Review
Nutrition & Dietetics
Ludovico Abenavoli, Tiziana Larussa, Alessandro Corea, Anna Caterina Procopio, Luigi Boccuto, Marcello Dallio, Alessandro Federico, Francesco Luzza
Summary: NAFLD, characterized by a wide spectrum of liver disorders, is considered a major public health issue globally. Polyphenols, known for their anti-inflammatory and antioxidant properties, are believed to have potential benefits in preventing and treating NAFLD, though limited human clinical trials are available.
Review
Biochemistry & Molecular Biology
Wesal Elgretli, Tianyan Chen, Nadine Kronfli, Giada Sebastiani
Summary: Hepatitis C virus (HCV) infection is the main cause of chronic liver disease and can lead to various hepatic diseases. It is also associated with extrahepatic manifestations such as immune-related disorders and metabolic abnormalities. HCV is dependent on the host's lipid metabolism for successful replication.
Article
Gastroenterology & Hepatology
Jorge Infante-Menendez, Andrea R. Lopez-Pastor, Tamara Gonzalez-Illanes, Paula Gonzalez-Lopez, Raquel Huertas-Larez, Esther Rey, Agueda Gonzalez-Rodriguez, Carmelo Garcia-Monzon, Nikita P. Patil, Melina Vega de Ceniga, Aaron B. Baker, Almudena Gomez-Hernandez, Oscar Escribano
Summary: This study shows that let-7d-5p is up-regulated in NAFLD and may have important roles in the pathophysiology of the disease. The expression of let-7d-5p is correlated with obesity and decreased expression of AKT, IGF1, IGF1R, and INSR. The findings suggest that let-7d-5p could be a potential diagnostic biomarker for NAFLD.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Mi Na Kim, Kyungdo Han, Juhwan Yoo, Seong Gyu Hwang, Sang Hoon Ahn
Summary: This study found that patients with chronic viral hepatitis and concurrent fatty liver have a higher risk of developing hepatocellular carcinoma and mortality, highlighting the importance of managing fatty liver in reducing these risks for patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Songhua Zhang, Aryanna Sousa, Mengqui Lin, Ayako Iwano, Rishubh Jain, Bing Ma, Chang Min Lee, Jin Wook Park, Suchitra Kamle, Rolf Carlson, Ghun Geun Lee, Jack A. Elias, Jack R. Wands
Summary: The recently discovered human glycoprotein Chi3L1 has been found to potentially play a role in inflammation, tissue remodeling, and visceral fat accumulation. Inhibition of the Chi3L1 gene could reduce lipid accumulation and improve insulin signaling in the liver. High-fat diet induced increased Chi3L1 expression in the liver, while anti-Chi3L1 monoclonal antibodies partially restored insulin signaling and decreased hepatic lipid accumulation.
Article
Multidisciplinary Sciences
Yi-Jing Sheen, Chih-Cheng Hsu, Pei-Tseng Kung, Li-Ting Chiu, Wen-Chen Tsai
Summary: Chronic hepatitis has an impact on cardiovascular events in patients with type 2 diabetes mellitus, particularly in those with hepatitis C or fatty liver. Glucose variability may also be an independent risk factor for cardiovascular events in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Helena Leal, Joao Cardoso, Patricia Valerio, Marta Quatorze, Vitor Carmona, Janete Cunha-Santos, Luis Pereira de Almeida, Claudia Pereira, Claudia Cavadas, Pedro Gomes
Summary: The protein SIRT2 is found to play a role in the regulation of hepatic lipid metabolism and its activation might be a therapeutic strategy against obesity and its metabolic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ahmed Abdallah Salman, Mohamed Abdalla Salman, Mostafa Said, Mohammad El Sherbiny, Hesham Elkassar, Mohamed Badr Hassan, Ahmed Marwan, Mohamed Abdelkader Morad, Omar Ashoush, Safa Labib, Mohamed H. Aon, Abeer Awad, Mohamed Sayed, Ahmed E. Taha, Ahmed Moustafa, Hossam El-Din Shaaban, Amir Khater, Ahmed Elewa, Adel M. Khalaf, Ahmed A. Mostafa, Mohamed Matter, Ahmed Youssef
Summary: Laparoscopic sleeve gastrectomy (LSG) can reduce pancreatic fat content, improve glucose homeostasis, decrease systemic inflammation, and reduce pancreatic lipase secretion.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Farah Gulzar, Shadab Ahmad, Sushmita Singh, Pawan Kumar, Aditya Sharma, Akhilesh K. Tamrakar
Summary: This study demonstrates that activation of NOD1 in adipocytes can affect lipid metabolism in hepatocytes by promoting lipolysis and inflammatory responses. This effect is associated with enhanced transport of fatty acids and increased triglyceride synthesis rate in hepatocytes. Additionally, NOD1 activation induces inflammatory response and impairs insulin signaling in hepatocytes.
Review
Gastroenterology & Hepatology
Alessandra Mangia, Rosa Cotugno, Giovanna Cocomazzi, Maria Maddalena Squillante, Valeria Piazzolla
Summary: The World Health Organization's goal of eliminating Hepatitis C virus (HCV) by 2030 using direct-acting antiviral treatments has become less attainable post the 2020 pandemic of coronavirus disease 2019. Therefore, a more realistic approach of micro-elimination in population segments where targeted strategies of prevention and treatment are easily attained has been promoted in Europe. Active involvement of stakeholders and community participation are essential components for the success of a micro-elimination project tailored at the geographical level according to HCV epidemiology and individual country's income.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Gastroenterology & Hepatology
Vincent Wai-Sun Wong, Won Young Tak, George Boon Bee Goh, Pin-Nan Cheng, Eric J. Lawitz, Zobair M. Younossi, Raj Vuppalanchi, Ziad Younes, Naim Alkhouri, Lulu Wang, Jialuo Liu, Kathryn Kersey, Robert P. Myers, Stephen A. Harrison, Zachary Goodman, Michael Trauner, Manuel Romero-Gomez, Quentin M. Anstee, Mindie H. Nguyen, Takeshi Okanoue
Summary: This study evaluated the performance of noninvasive tests in diagnosing advanced fibrosis due to NASH in white and Asian patients, and found that these tests performed similarly in both groups. However, the sensitivities of NFS, FIB-4, and ELF were low in white and Asian patients younger than 40 years.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Manuel Romero-Gomez, Rocio Aller, Javier Ampuero, Conrado Fernandez Rodriguez, Salvador Augustin, Raquel Latorre, Jesus Rivera-Esteban, Belen Martinez Urroz, Luisa Gutierrez Garcia Maria, Sonia Alonso Lopez, Agustin Albillos, Marta Hernandez, Isabel Graupera, Salvador Benlloch, Antonio Olveira, Javier Crespo, Jose Luis Calleja
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Gastroenterology & Hepatology
Jiaxu Liang, Javier Ampuero, Javier Castell, Qiong Zhang, Sijia Zhang, Yong Chen, Manuel Romero-Gomez
Summary: Hepatocellular carcinoma (HCC) is a major public health problem worldwide and is closely related to liver fibrosis. Magnetic resonance elastography (MRE) has emerged as a non-invasive technique with excellent diagnostic accuracy for assessing liver fibrosis and tumor stiffness. Recent studies have shown that MRE has several novel clinical applications in HCC management, including predicting HCC development, differentiating between benign/malignant liver lesions and HCC pathological grades, assessing treatment response, and predicting recurrence after treatment. However, some findings are controversial. This review summarizes the novel applications of MRE in HCC patients and discusses their limitations and future advancement.
ANNALS OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Beatriz Mateos-Munoz, Maria Buti, Inmaculada Fernandez Vazquez, Marta Hernandez Conde, Vanesa Bernal-Monterde, Fernando Diaz-Fontenla, Rosa Maria Morillas, Luisa Garcia-Buey, Ester Badia, Mireia Miquel, Alberto Amador-Navarrete, Sergio Rodriguez-Tajes, Lucia Ramos-Merino, Antonio Madejon, Montserrat Garcia-Retortillo, Juan Ignacio Arenas, Joaquin Cabezas, Jesus Manuel Gonzalez Santiago, Conrado Fernandez-Rodriguez, Patricia Cordero, Moises Diago, Antonio Mancebo, Alberto Pardo, Manuel Rodriguez, Elena Hoyas, Jose Javier Moreno, Juan Turnes, Miguel Angel Simon, Cristina Marcos-Fosch, Jose Luis Calleja, Rafael Banares, Sabela Lens, Javier Garcia-Samaniego, Javier Crespo, Manuel Romero-Gomez, Francisco Gea, Enrique Rodriguez de Santiago, Santiago Moreno, Agustin Albillos
Summary: Compared to entecavir, tenofovir hydroxyl fumarate/emtricitabine plays a protective role in the severity of COVID-19 in patients with chronic hepatitis B.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Marta Garzon-Benavides, Angela Ruiz-Carnicer, Veronica Segura, Blanca Fombuena, Francisco Garcia-Fernandez, Salvador Sobrino-Rodriguez, Lourdes Gomez-Izquierdo, Marco Antonio Montes-Cano, Raquel Millan-Dominguez, Maria del Carmen Rico, Carmen Gonzalez-Naranjo, Juan Manuel Bozada-Garcia, Cristobal Coronel-Rodriguez, Beatriz Espin, Jacobo Diaz, Isabel Comino, Federico Arguelles-Arias, Angel Cebolla, Manuel Romero-Gomez, Alfonso Rodriguez-Herrera, Carolina Sousa, Angeles Pizarro-Moreno
Summary: This study analyzed the effects of gluten exposures on coeliac patients following a gluten-free diet for at least 24 months. The results showed that regular monitoring of urinary gluten immunogenic peptides (u-GIP) can accurately detect gluten transgressions and more frequent follow-up visits provide useful data for assessing adherence to the diet and mucosal healing.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Manuel Romero-Gomez, Matthew J. Armstrong, Jesus Funuyet-Salas, Kamal Kant Mangla, Steen Ladelund, Anne-Sophie Sejling, Ichhya Shrestha, Arun J. Sanyal
Summary: This study investigated the effects of semaglutide, a glucagon-like peptide-1 receptor agonist, on health-related quality of life (HRQoL) in patients with non-alcoholic steatohepatitis (NASH). The results showed that treatment with semaglutide significantly improved the physical components of HRQoL in NASH patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Paula Iruzubieta, Ramon Bataller, Maria Teresa Arias-Loste, Marco Arrese, Jose Luis Calleja, Graciela Castro-Narro, Kenneth Cusi, John F. Dillon, Maria Luz Martinez-Chantar, Miguel Mateo, Antonio Perez, Mary E. Rinella, Manuel Romero-Gomez, Joern M. Schattenberg, Shira Zelber-Sagi, Javier Crespo, Jeffrey Lazarus
CLINICS IN LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Monika Lewinska, Martin Lund Karhus, Anne-Marie Gade Ellegaard, Manuel Romero-Gomez, Rocio I. R. Macias, Jesper B. Andersen, Filip Krag Knop
Summary: Scientists developed a blood test-based method for diagnosing bile acid diarrhea (BAD), which showed superior specificity and sensitivity compared with current blood test-based diagnostics.
Article
Gastroenterology & Hepatology
Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Virend Somers, Seung Up Kim, C. Anwar A. Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D. Shapiro, Mohammed Eslam, Philippe Gabriel Steg, Ki-Chul Sung, Anoop Misra, Jian-Jun Li, Carlos Brotons, Yuli Huang, George V. Papatheodoridis, Aijun Sun, Yusuf Yilmaz, Wah Kheong Chan, Hui Huang, Nahum Mendez-Sanchez, Saleh A. Alqahtani, Helena Cortez-Pinto, Gregory Y. H. Lip, Robert J. de Knegt, Ponsiano Ocama, Manuel Romero-Gomez, Marat Fudim, Giada Sebastiani, Jang Won Son, John D. Ryan, Ignatios Ikonomidis, Sombat Treeprasertsuk, Daniele Pastori, Monica Lupsor-Platon, Herbert Tilg, Hasmik Ghazinyan, Jerome Boursier, Masahide Hamaguchi, Mindie H. Nguyen, Jian-Gao Fan, George Boon-Bee Goh, Mamun Al Mahtab, Saeed Hamid, Nilanka Perera, Jacob George, Ming-Hua Zheng
Summary: Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is closely linked to cardiovascular disease (CVD), but the CVD risk is often underestimated. An international panel of experts conducted a Delphi survey to establish the association between MAFLD and CVD risk, and identified potential areas for future research.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Dan Dumitrascu, Igor Bakulin, Annalisa Berzigotti, Marilia Cravo, Laura Gombosova, Milan Lukas, Anna Pietrzak, Jose Maria Remes-Troche, Manuel Romero-Gomez, Mercedes Amieva Balmori, Tiago Curdia Goncalves, Lamine Hamzaoui, Radovan Juricek, Leticia Moreira, Katarzyna Neubauer, Teodora Surdea-Blaga, Igor N. Tikhonov, Jan Trna, Gianluca Ianiro, Francesca Romana Ponziani, Antonio Gasbarrini
Summary: Various environmental factors can lead to gut microbial imbalance and the development of diseases. Hepatic encephalopathy, irritable bowel syndrome, and diverticular disease are all related to dysfunction of the gut-liver-brain axis, but the pathophysiology differs for each condition.
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2023)
Article
Gastroenterology & Hepatology
Rocio Munoz-Hernandez, Sheila Gato, Antonio Gil-Gomez, Rocio Aller, Angela Rojas, Laura Moran, Javier Gallego, Elena Blazquez-Lopez, Rocio Gallego-Duran, Rocio Montero-Vallejo, Vanessa Garcia-Fernandez, Douglas Maya-Miles, Maria del C. Rico, Francisco J. Cubero, Javier Vaquero, Javier Ampuero, Rafael Banares, Manuel Romero-Gomez
Summary: This study evaluated the circulating AV+ EpCAM+ CD133+ EVs as a potential biomarker for the transition from simple steatosis to steatohepatitis. The results showed that these EVs increased during disease progression in both mouse models and clinical validation. Therefore, EpCAM+ CD133+ EVs hold promise as a non-invasive biomarker for evaluating and managing NAFLD patients.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Ares Villagrasa, Virginia Hernandez-Gea, Ramon Bataller, Alvaro Giraldez, Bogdan Procopet, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibanez-Samaniego, Agustin Albillos, Christophe Bureau, Jonel Trebicka, Elba Llop, Wim Laleman, J. M. Palazon, Jose Castellote, Susana L. Rodrigues, Lise N. Gluud, Carlos Ferreira, Nuria Canete, Manuel Rodriguez, Arnulf L. Ferlitsch, Jose Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'Era, Marco G. Senzolo, Juan Abraldes, Alexander Zipprich, Meritxell Casas, Helena Masnou, Massimo Primignani, Aleksander Krag, Gilberto Silva-Junior, Manuel Romero-Gomez, Marcel A. Tantau, Maria Guardascione, Edilmar Alvarado, Marika Rudler, Rafael Banares, Javier A. Martinez, Marie Robic, Christian L. Jansen, Jose Calleja, Frederik Nevens, Jaime Bosch, Meritxell C. Ventura-Cots, Juan Garcia-Pagan, Joan Genesca
Summary: This study aimed to assess the prevalence of alcohol-related hepatitis (AH) in patients with variceal bleeding and compare the clinical outcomes of AH patients with other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. The results showed that AH patients had more complications and abstinent ALD patients had higher survival rates compared to other groups.
LIVER INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Shiqi Lin, Xingjian Gao, Frauke Degenhardt, Yu Qian, Tianzi Liu, Xavier Farre Ramon, Syed Sibte Hadi, Manuel Romero-Gomez, Javier Fernandez, Agustin Albillos, Maria Buti Ferret, Luis Bujanda, Antonio Julia, Rafael de Cid, Rosanna Asselta, Andre Franke, Fan Liu
Summary: This study conducted a genome-wide epistasis study of COVID-19 severity and identified three significant interactions between different genes. The most significant interaction was found between rs9792388 upstream of PDGFRL and rs3025892 downstream of SNAP25, indicating a possible molecular mechanism by which SARS-CoV-2 affects the nervous system.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Carmen Lara Romero, Jia-Xu Liang, Isabel Fernandez-Lizaranzu, Javier Ampuero Herrojo, Javier Castell, Carmen del Prado Alba, Inmaculada Dominguez Pascual, Manuel Romero-Gomez
Summary: The objective of this study was to evaluate the performance of magnetic resonance elastography (MRE) in staging liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). The results showed that MRE is an effective and non-invasive method for detecting and staging liver fibrosis in NAFLD patients.
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2023)
Article
Gastroenterology & Hepatology
Javier Crespo, Joaquin Cabezas, Antonio Aguilera, Agustin Albillos, Maria Buti, Jose Luis Calleja, Jorge Calvo Montes, Marta Casado Martin, Moises Diago, Conrado M. Fernandez Rodriguez, Inmaculada Fernandez Vazquez, Xavier Forns, Federico Garcia, Javier Garcia-Samaniego, Manuel Hernandez-Guerra de Aguilar, Francisco Jorquera, Jeffrey Lazarus, Sabela Lens, Elisa Martro, Jose Maria Molero Garcia, Maria Jose Pena Lopez, Juan Antonio Pineda, Manuel Rodriguez, Manuel Romero-Gomez, Gloria Sanchez Antolin, Miguel A. Serra Desfilis, Juan Turnes
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2023)