Article
Multidisciplinary Sciences
Nicholas J. Tustison, Philip A. Cook, Andrew J. Holbrook, Hans J. Johnson, John Muschelli, Gabriel A. Devenyi, Jeffrey T. Duda, Sandhitsu R. Das, Nicholas C. Cullen, Daniel L. Gillen, Michael A. Yassa, James R. Stone, James C. Gee, Brian B. Avants
Summary: ANTsX is an ecosystem of multiple open-source software libraries consisting of top-performing algorithms for processing and analyzing biological and medical imaging data. It provides statistical, visualization, and deep learning capabilities, along with popular network architectures and trained models for specific applications, improving computational efficiency and accuracy.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Harald Hampel, Aya Elhage, Min Cho, Liana G. Apostolova, James A. R. Nicoll, Alireza Atri
Summary: Excess accumulation and aggregation of toxic amyloid-beta species in the brain is a major characteristic of Alzheimer's disease. This review comprehensively summarizes the radiological features, clinical challenges, pathophysiology, and risk factors associated with amyloid-related imaging abnormalities (ARIA) in relation to anti-amyloid monoclonal antibody treatment.
Article
Acoustics
Samuel John, Scott Hester, Maryam Basij, Avijit Paul, Marvin Xavierselvan, Mohammad Mehrmohammadi, Srivalleesha Mallidi
Summary: Photoacoustic (PA) imaging has gained popularity in the past decade due to its successful application in both preclinical and clinical settings. It has notable features such as non-ionizing, cost-effective, easily deployable, and high resolution for assessing tissue characteristics and therapeutic efficacy. PA imaging can be integrated with ultrasound systems to co-register and cross-reference various imaging features. This review discusses the applications of PA imaging with endogenous contrast in clinically relevant areas.
Review
Medicine, General & Internal
Shakuntala Mahilkar, Sachee Agrawal, Sakshi Chaudhary, Swapneil Parikh, Subash C. Sonkar, Dileep Kumar Verma, Vidushi Chitalia, Divya Mehta, Bidhan Chandra Koner, Neetu Vijay, Jayanthi Shastri, Sujatha Sunil
Summary: The emerging variants and mutations of SARS-CoV-2 have significant impacts on the spread, disease presentation, and management of COVID-19, as well as the understanding of virus-host interactions.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Quoc Dat Pham, Sofi Nojd, Martin Edman, Katarina Lindell, Daniel Topgaard, Marie Wahlgren
Summary: Mucoadhesion is a common method employed in drug delivery to prolong the contact of drugs with absorption sites and improve drug absorption. By studying the molecular interactions between different polymers and mucin, researchers can gain insights into the mechanisms of how different polymers affect mucin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Noureddin Osseiran, Elias M. Neeman, Pascal Drean, Manuel Goubet, Therese R. Huet
Summary: The gas-phase non-covalent interactions in the endo-fenchol-H2S and fenchone-H2S complexes have been revealed using rotational spectroscopy in a supersonic jet expansion and quantum chemical calculations. In endo-fenchol, the hydrogen bond HSH...OH together with dispersive interactions stabilizes the system. In fenchone, the weak interaction HSH...O=C allows an internal dynamic of H2S.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pinar Helin Ergen, Susan Shorter, Vasilis Ntziachristos, Saak Victor Ovsepian
Summary: The highly specific and potent biological toxins that target various ion channels and receptors have attracted significant interest for delivering therapeutics to specific cell types and subcellular compartments. By fusing with reporter proteins or labeling with fluorophores and nanocomposites, animal toxins and their detoxified variants offer opportunities for visualizing molecular processes and functions in preclinical models and clinical studies. This article presents state-of-the-art optical probes derived from neurotoxins that target ion channels and discusses their applications in basic and translational biomedical research. It describes the design and production of these probes, reviews their advantages and limitations, and outlines prospects for future improvements.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Computer Science, Information Systems
Francisco Erivaldo Fernandes Jr, Gary G. Yen
Summary: Deep Convolutional Neural Networks (DCNNs) have the potential to revolutionize medical imaging diagnostics, but due to data scarcity and unbalanced classes in medical data, researchers often turn to Generative Adversarial Networks (GANs) to synthesize more data. In this study, an algorithm for pruning GANs based on Evolution Strategy (ES) and Multi-Criteria Decision Making (MCDM) is proposed to find a model with the best trade-off between computational complexity and synthesis performance.
INFORMATION SCIENCES
(2021)
Article
Medicine, General & Internal
Clara Wollenhaupt, Thomas Sudhop, Werner Knoess
Summary: The EU's IVDR introduces companion diagnostics (CDx) as a new legal term, aimed at identifying patient subgroups most likely to benefit from a treatment. A systematic search in a clinical trials database identified 3643 trials conducted between 2004 and 2022, analyzing the use of biomarker testing in patient stratification, with PD-L1 and HER2 being the most frequently tested biomarkers. The findings also suggest overlap with non-European authorities implementing the CDx concept, indicating potential CDx candidates under the IVDR.
Article
Chemistry, Multidisciplinary
Alessandra Gianoncelli, Valentina Bonanni, Gianluca Gariani, Francesco Guzzi, Lorella Pascolo, Roberto Borghes, Fulvio Bille, George Kourousias
Summary: Progress in nanotechnology requires high sensitivity and resolution material probing techniques, with soft X-ray microscopy being one of the most powerful tools in medicine and the life sciences for studying complex biological processes at micrometric and sub-micrometric length scales. The TwinMic soft X-ray microscopy end-station at the Elettra synchrotron demonstrates capabilities in medical and biological imaging, along with novel uses and developments.
APPLIED SCIENCES-BASEL
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Guy Cloutier, Francois Destrempes, Francois Yu, An Tang
Summary: Quantitative ultrasound (QUS) is a technique that quantifies interactions between ultrasound and biological tissues, extracting fundamental physical properties of tissues for tissue characterization and imaging. Clinical applications are limited but promising, with potential for liver fibrosis, steatosis grading, and breast cancer characterization.
INSIGHTS INTO IMAGING
(2021)
Article
Medicine, Research & Experimental
Md Rashidur Rahman, Md Amjad Hossain, Md Mozibullah, Fateh Al Mujib, Afrina Afrose, Md Shahed-Al-Mahmud, Md Aminul Islam Apu
Summary: The global spread of the COVID-19 pandemic has posed challenges in the quick and cost-effective detection of SARS-CoV-2. While RT-qPCR is currently widely used, CRISPR-based detection methods offer promising alternatives with potential advantages in terms of time, cost, and effectiveness.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ana Penades-Blasco, Sonia Gines-Cardenas, Amadeo Ten-Esteve, Pilar Bello Arques, Juan M. Soriano Llobera, David Vivas Consuelo, Luis Marti-Bonmati
Summary: The purpose of this study was to design and describe a management and control tool for efficiently managing the imaging process within clinical trials in order to improve the quality of care for patients. A unit was created and a customized software package was used to organize the participation of the Medical Imaging Department in clinical trials. The results showed that the department successfully participated and monitored a significant number of clinical trials, leading to improved coordination and collaboration with other departments and principal investigators.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Andre Shamsabadi, Tabasom Haghighi, Sara Carvalho, Leah C. C. Frenette, Molly M. M. Stevens
Summary: Nanozymes are nanosized materials that have catalytic properties similar to biological enzymes, making them promising candidates for clinical sensing devices. They can amplify signals in nanosensor-based platforms and improve sensor detection limits. Recent developments have led to highly effective nanozymes that can detect clinically relevant biomarkers, but there are hurdles to overcome before they can be used in clinical diagnostics. This overview discusses the current understanding of nanozymes for disease diagnostics and biosensing applications, and the challenges that need to be addressed for their translation into clinical tests.
ADVANCED MATERIALS
(2023)
Article
Education, Scientific Disciplines
David M. Irby, Bridget C. O'Brien, Terese Stenfors, Per J. Palmgren
Summary: Learning environments are crucial in shaping the experiences of learners and practitioners, making them a significant component of program evaluation. Educators face challenges in deciding whether to use existing instruments or design new ones to measure clinical learning environments. Tools for assessing clinical learning environments vary in their characteristics, constructs, and coverage of different domains, prompting educators to consider key questions such as defining the learning environment and choosing the most appropriate theoretical lens.
Article
Ophthalmology
Andrea Govetto, Jean-Pierre Hubschman, David Sarraf, Marta S. Figueroa, Ferdinando Bottoni, Roberto Dell'Omo, Christine A. Curcio, Patrizio Seidenari, Giulia Delledonne, Robert Gunzenhauser, Mariantonia Ferrara, Adrian Au, Gianni Virgili, Antonio Scialdone, Rodolfo Repetto, Mario R. Romano
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Andrea Govetto, David Sarraf, Jean-Pierre Hubschman, Ramin Tadayoni, Aude Couturier, Ismael Chehaibou, Adrian Au, Christelle Grondin, Gianni Virgili, Mario R. Romano
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Review
Ophthalmology
Matthew J. Gerber, Moritz Pettenkofer, Jean-Pierre Hubschman
Article
Multidisciplinary Sciences
Mahiul M. K. Muqit, Jean Pierre Hubschman, Serge Picaud, Douglas B. McCreery, Jan C. van Meurs, Ralf Hornig, Guillaume Buc, Martin Deterre, Celine Nouvel-Jaillard, Elodie Bouillet, Claire-Maelle Fovet, Philippe Hantraye, Jose Sahel, Joseph N. Martel, Yannick Le Mer
Article
Oncology
Rita Abi-Raad, Manju L. Prasad, Syed Gilani, James Garritano, Deborah Barlow, Guoping Cai, Adebowale J. Adeniran
Summary: At least 40% of p16 expression in tumor clusters may be appropriate threshold for p16 positivity in cytology CB specimens. HPV by PCR on needle rinse can serve as a substitute for p16 expression in surgical specimens, with 88% sensitivity and 100% specificity.
CANCER CYTOPATHOLOGY
(2021)
Article
Critical Care Medicine
Urs Weber, Qiang Zhang, Derek Ou, James Garritano, Jennifer Johnson, Nathanial Anderson, Andrea K. Knies, Belinda Nhundu, Cynthia Bautista, Kevin B. Huang, Ana-Maria Vranceanu, Jonathan Rosand, David Y. Hwang
Summary: The study aimed to identify factors associated with dissatisfaction with shared decision-making support among families of neuro-critically ill patients. Results showed that families who were dissatisfied with decision-making support participated in fewer formal family meetings in the neuro-ICU. Future studies should consider broad inclusion criteria and promoting frequency of family meetings as a core strategy to improve family satisfaction with neurocritical care decision-making support.
NEUROCRITICAL CARE
(2021)
Article
Medical Laboratory Technology
Lina Irshaid, Jonathan Bleiberg, Ethan Weinberger, James Garritano, Rory M. Shallis, Jonathan Patsenker, Ofir Lindenbaum, Yuval Kluger, Samuel G. Katz, Mina L. Xu
Summary: This study aimed to investigate the accuracy and reproducibility of a trained convolutional neural network in identifying large cell transformation (LCT) in bone marrow biopsy. The results showed that certain morphologic criteria were significantly correlated with LCT, and the machine learning tools demonstrated better reproducibility and predictive ability compared to pathologists' estimates, providing a new method for the diagnosis of LCT in bone marrow biopsy.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Ophthalmology
Anibal Francone, Andrea Govetto, Lisa Yun, Juliet Essilfie, Kouros Nouri-Mahdavi, David Sarraf, Jean-Pierre Hubschman
Summary: Eyes with retinal vein occlusion and concurrent glaucoma have a higher prevalence of microcystoid macular abnormalities and poorer visual acuity compared to eyes without glaucoma. Additionally, the number of anti-VEGF injections is significantly higher in eyes with glaucoma.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Pathology
Peter Podany, Rita Abi-Raad, Andrea Barbieri, James Garritano, Manju L. Prasad, Guoping Cai, Adebowale J. Adeniran, Syed M. Gilani
Summary: This study retrospectively examined the cytologic features of anaplastic thyroid carcinoma (ATC) cases, identifying key differences with differentiated thyroid carcinoma. The study found that ATC cases commonly exhibit moderate to high cellularity, epithelioid cytomorphology, nuclear enlargement, nuclear membrane irregularities, and other features. Significant differences were observed in nuclear pleomorphism, coarse/clumped chromatin, macronucleoli, apoptosis, and necrosis between ATC and the control group.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Oncology
Syed M. Gilani, Rita Abi-Raad, James Garritano, Guoping Cai, Manju L. Prasad, Adebowale J. Adeniran
Summary: This study found that the overall risk of malignancy associated with RAS mutations in thyroid fine-needle aspiration was intermediate (29%), with isolated HRAS mutations potentially having a higher risk (27%). Among cases with a cytologic diagnosis of category IV, RAS mutations had a higher risk compared to category III cases.
CANCER CYTOPATHOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
James Garritano, Yuval Kluger, Vladimir Rokhlin, Kirill Serkh
Summary: In this paper, an efficient algorithm for evaluating the azimuthal Fourier components of the Green's function for the Helmholtz equation in cylindrical coordinates is developed. The algorithm is essential for solving electromagnetic scattering problems and is not affected by the proximity of the source and target, the magnitude or complexity of the wavenumber. Furthermore, the algorithm can be easily parallelized.
JOURNAL OF COMPUTATIONAL PHYSICS
(2022)
Article
Pathology
Peter Podany, Karleen Meiklejohn, James Garritano, Elizabeth H. Holt, Andrea Barbieri, Manju Prasad, Syed M. Gilani
Summary: This study evaluated the applicability of the two-tier grading system for MTC in a cohort of MTC cases and found that tumor grade and necrosis are significantly associated with overall survival. Comparing cases with and without nodal disease, nodal disease is more strongly associated with nuclear pleomorphism, tumor fibrosis, vascular invasion, and distant metastasis.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2023)
Letter
Ophthalmology
Clemence Bonnet, Ismael Chehaibou, Colin A. McCannel, Tara A. McCannel, Pradeep S. Prasad, Allan E. Kreiger, Steven D. Schwartz, Anthony Aldave, Jean-Pierre Hubschman
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Cameron Pole, Ismael Chehaibou, Andrea Govetto, Sean Garrity, Steven D. Schwartz, Jean-Pierre Hubschman
Summary: Risk factors for CME include complex retinal detachment repairs requiring multiple surgeries, and pseudophakic or aphakic lens status. Although this cCME was associated with poor therapeutic response, corticosteroids were the most effective studied treatments.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2021)
Article
Ophthalmology
Elizabeth J. Rossin, Irena Tsui, Sui Chien Wong, Kirk K. Hou, Supalert Prakhunhungsit, Michael P. Blair, Michael J. Shapiro, Lisa Leishman, Aaron Nagiel, Jacob A. Lifton, Polly Quiram, Alexander L. Ringeisen, Robert H. Henderson, Natalia Arruti, Dominic M. Buzzacco, Shunji Kusaka, Philip J. Ferrone, Peter J. Belin, Emmanuel Chang, Jean-Pierre Hubschman, Timothy G. Murray, Ella H. Leung, Wei-Chi Wu, Karl R. Olsen, C. Armitage Harper, Safa Rahmani, Jessica Goldstein, Thomas Lee, Eric Nudleman, Linda A. Cernichiaro-Espinosa, Jay Chhablani, Audina M. Berrocal, Yoshihiro Yonekawa
Summary: This study reviewed the clinical characteristics, surgical outcomes, and management recommendations in patients with traumatic RRD resulting from self-injurious behavior. It found that surgical success rates were low, SB usage could improve outcomes, and anatomic reattachment correlated with better visual acuity.
OPHTHALMOLOGY RETINA
(2021)