Article
Medicine, General & Internal
Igor E. Khatkov, Dmitry S. Bordin, Konstantin A. Lesko, Elena A. Dubtsova, Nikolay S. Karnaukhov, Maria A. Kiriukova, Nadezhda V. Makarenko, Alexey S. Dorofeev, Irina V. Savina, Diana A. Salimgereeva, Elena I. Shurygina, Ludmila V. Vinokurova
Summary: This study analyzed the results of 74 patients and found that the unenhanced pancreas density value and contrast enhancement ratio showed significant differences in different fibrosis grades, and were associated with fibrosis, inflammation, and pancreatic duct epithelium metaplasia. However, the serum levels of fibronectin, hyaluronic acid, matrix metalloproteinase-1, and matrix metalloproteinase-9 showed no significant correlation with fibrosis. The unenhanced pancreas density value, normalized contrast enhancement ratio in the venous phase, contrast enhancement ratio, as well as blood levels of fibronectin and hyaluronic acid could be used for non-invasive pancreatic fibrosis diagnosis.
Review
Pharmacology & Pharmacy
Wen-Xiu Cheng, Shao-Bin Wei, Yang Zhou, Yu Shao, Mao-Ya Li
Summary: Adenomyosis is a common benign gynecological disorder that can cause infertility in fertile women. The pathogenesis of adenomyosis is unclear, and new therapeutic approaches are urgently needed. Exosomes, nanoscale vesicles secreted by cells, play a crucial role in the development and progression of adenomyosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Marek Janotka, Petr Ostadal
Summary: The review summarizes the application of biochemical markers including SvO2, lactate, PCO2 gap, and PCO2 gap/Ca-vO2 for hemodynamic assessment of tissue perfusion. Thorough monitoring of tissue perfusion and oxygen supply is essential in critical conditions, leading to improved clinical outcomes.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Public, Environmental & Occupational Health
Shanshan Liu, Qiuyue Li, Xuntao Chu, Minxia Zeng, Mingbin Liu, Xiaomeng He, Heng Zou, Jianghua Zheng, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu, Jin Wang
Summary: The COVID-19 pandemic has prompted the urgent need for rapid diagnosis and isolation measures. A variety of diagnostic tools are currently available, including laboratory analysis and imaging examinations, which can assist scientists and clinicians to develop effective strategies.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Chemistry, Analytical
Noemi Colozza, Sara Tazzioli, Alessandro Sassolini, Lorenzo Agosta, Maria Giuseppina di Monte, Kersti Hermansson, Fabiana Arduini
Summary: Reinforced concrete is widely used in construction and sculptural art, but its degradation poses risks to public safety and cultural heritage. A novel sensor was developed for on-site monitoring of concrete structures, providing an innovative approach for preservation efforts.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra Leszczynska, Christian Stoess, Hana Sung, Davide Povero, Akiko Eguchi, Ariel Feldstein
Summary: Chronic liver diseases can progress to cirrhosis, which poses a significant risk for morbidity and increased mortality rates. Invasive liver biopsy has traditionally been used for diagnosis and staging, but research has focused on non-invasive methods like liquid biopsies. Among these alternative approaches, extracellular vesicles (EVs) have emerged as promising tools for diagnosis and treatment, as they can be isolated and quantified and facilitate cell-to-cell communication.
Review
Medicine, General & Internal
Abdalla Elsayed, Abdulrahman Ismaiel, Anna C. Procopio, Francesco Luzza, Ludovico Abenavoli, Dan L. Dumitrascu
Summary: The diagnosis of nonalcoholic steatohepatitis (NASH) still relies on liver biopsy, but noninvasive biomarkers and scoring systems have shown promise in predicting NASH. These noninvasive methods may play a key role in triaging patients and reducing the financial burden of liver biopsy. Future studies are needed to validate the predictive values of emerging tests and scoring systems, and to find more affordable and reliable noninvasive early diagnostic tools.
Review
Medicine, General & Internal
Abdalla Elsayed, Abdulrahman Ismaiel, Anna C. Procopio, Francesco Luzza, Ludovico Abenavoli, Dan L. Dumitrascu
Summary: This review summarizes the current knowledge about noninvasive diagnostic biomarkers and scores for NASH. Noninvasive biomarkers are unable to replace liver biopsy and histological assessment, but they may play a key role in triaging patients for liver biopsy.
Article
Pediatrics
Antonella Mosca, Luca Della Volpe, Anna Alisi, Silvio Veraldi, Paola Francalanci, Giuseppe Maggiore
Summary: The study showed that Hepamet and APRI perform better than NFS and FIB-4 in identifying fibrosis in NAFLD patients. However, their positive predictive values are not high enough to be considered diagnostic, indicating the need for further research on new markers for fibrosis.
FRONTIERS IN PEDIATRICS
(2022)
Review
Medicine, General & Internal
Agnes Rita Martonosi, Alexandra Soos, Zoltan Rumbus, Peter Hegyi, Vera Izsak, Piroska Pazmany, Marcell Imrei, Szilard Vancsa, Zsolt Szakacs, Andrea Parniczky
Summary: This study ranked different non-invasive diagnostic methods for cystic fibrosis-related liver disease (CFLD) and found that the New criteria had the best diagnostic performance. Transient elastography was identified as a simple, affordable, and effective tool for detecting CFLD, outperforming other imaging, biochemical, and fibrosis tests. Further validation studies are needed to confirm these findings.
FRONTIERS IN MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Alison Schulz, Justin Loloi, Luis Pina Martina, Alexander Sankin
Summary: Bladder cancer is a challenging disease with high recurrence rates, leading to invasive surveillance methods. Non-invasive urinary tests have gained attention for early detection and to reduce unnecessary procedures; however, there is a need for improved sensitivity and specificity. Recent advancements in technology and research offer novel detection systems and biomarkers that show promise in clinical practice.
ONCOTARGETS AND THERAPY
(2022)
Review
Gastroenterology & Hepatology
Nehna Abdul Majeed, Asif A. Hitawala, Theo Heller, Christopher Koh
Summary: Hepatitis D viral infection in humans relies on hepatitis B for replication and transmission. Significant progress has been made in understanding the virus's life cycle, pathogenesis, diagnostics, and treatment. Diagnostic assays for hepatitis D have evolved, and monitoring its global impact is crucial. Non-invasive fibrosis markers are being explored for clinical monitoring. This review discusses virology, diagnostics, and non-invasive markers for fibrosis detection and monitoring in hepatitis D patients.
LIVER INTERNATIONAL
(2023)
Article
Food Science & Technology
Ajda Moskric, Katarina Mole, Janez Presern
Summary: The entomological origin of honey can affect its price, with honey from native or non-domesticated species being more valued. DNA-based techniques are used to determine the source of honey.
Review
Biochemistry & Molecular Biology
Caecilia H. C. Sukowati, Loraine Kay D. Cabral, Claudio Tiribelli, Devis Pascut
Summary: This review discusses how long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) could potentially be used as diagnostic tools for Hepatocellular Carcinoma (HCC) by analyzing their differential expression in HCC patients compared to non-HCC patients. These non-coding RNAs (ncRNAs) show high stability in the blood and are being explored as possible diagnostic biomarkers for HCC, with further research also delving into their pathophysiological mechanisms in liver carcinogenesis.
Article
Nutrition & Dietetics
Sjoerd C. J. Nagelkerke, Laura G. Draijer, Marc A. Benninga, Bart G. P. Koot, Merit M. Tabbers
Summary: In a cohort of pediatric patients suffering from chronic intestinal failure, non-invasive tests such as TE measurement, APRI, and ELF score show a substantial proportion of subjects with liver fibrosis. The diagnostic value of these tests and their role in the management of pediatric intestinal failure need further investigation in larger cohorts with liver biopsy as reference standard.
CLINICAL NUTRITION
(2021)