Article
Pediatrics
Valentina Talarico, Giuseppe Mazza, Mario Rubino, Giovanna Monti, Laura Giancotti, Adriana Bua, Ali M. Mohamed, Roberto Miniero
Summary: This study confirms the presence of cross-sensitization between cow's milk and camel's milk, with higher wheal diameters and IgE titers in the CM SPT+ group. Predictors for selecting patients with negative CM SPT and lower risk of allergic reactions include small wheals and low IgE titers towards cow's milk antigens.
MINERVA PEDIATRICS
(2021)
Article
Allergy
Christopher M. Warren, Avni Agrawal, Divya Gandhi, Ruchi S. Gupta
Summary: This study comprehensively characterizes the burden of cow's milk allergy in the US population, including prevalence, severity, healthcare utilization, psychosocial impact, and other associated factors. The data indicate a high population-level burden of cow's milk allergy in the US, particularly among those who cannot tolerate baked forms of milk.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Review
Nutrition & Dietetics
Laurien Ulfman, Angela Tsuang, Aline B. Sprikkelman, Anne Goh, R. J. Joost van Neerven
Summary: The incidence of food allergies has increased worldwide in the past 20 years. Early introduction of allergenic foods has been shown to reduce the risk of allergies, but less is known about the introduction of cow's milk. Recent studies suggest that early introduction of cow's-milk-based formulas with intact milk proteins can reduce the risk of cow's milk allergy, while very early introduction followed by discontinuation may increase the risk.
Article
Gastroenterology & Hepatology
Jesus Gonzalez-Cervera, Angel Arias, Pilar Navarro, Rocio Juarez-Tosina, Maria Cobo-Palacios, Jose M. Olalla, Teresa Angueira-Lapena, Alfredo J. Lucendo
Summary: The study evaluated the tolerance of sterilised milk in EoE patients and its impact on quality of life. The results showed that the majority of patients could tolerate sterilised milk in both the short-term and long-term, but it may cause EoE recurrence in some patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pediatrics
Rohan Malik, Sanjeevani Kaul
Summary: Cow's milk allergy is an immunological reaction to milk protein, commonly occurring in infants under 1 year of age. The disease can be IgE or non-IgE mediated, with symptoms involving multiple organ systems. The gold standard for diagnosis is a double-blind placebo-controlled oral challenge. Treatment involves eliminating the allergen and using specialized formula.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Food Science & Technology
Sabine Geiselhart, Aleksandra Podzhilkova, Karin Hoffmann-Sommergruber
Summary: Cow's milk is an essential part of our diet but can also trigger immune-mediated diseases. Allergens in cow's milk have been identified, but processing methods can impact their immunogenicity.
Article
Nutrition & Dietetics
Frank E. E. van Boven, Nicolette J. T. Arends, Aline B. B. Sprikkelman, Joyce A. M. Emons, Astrid I. I. Hendriks, Marloes van Splunter, Marco W. J. Schreurs, Severina Terlouw, Roy Gerth van Wijk, Harry J. J. Wichers, Huub F. J. Savelkoul, R. J. Joost van Neerven, Kasper A. Hettinga, Nicolette W. W. de Jong
Summary: Accelerating tolerance induction to cow's milk can reduce the burden of cow's milk allergy. This study aimed to investigate the tolerance induction of a novel heated cow milk protein in children with cow's milk allergy. Results showed that 73% of children in the treatment group had a negative food challenge test, compared to 57% in the control group.
Article
Allergy
Karen M. Switkowski, Emily Oken, Sheryl L. Rifas-Shiman, Carlos A. Camargo, Diane R. Gold, Joanne E. Sordillo, Jenifer R. Lightdale
Summary: This study examined the timing of cow's milk protein introduction and its relationship with adverse reactions in children. The results showed that early and consistent exposure to cow's milk can protect children from adverse reactions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Pediatrics
Khaled Saad, Anas Elgenidy, Mostafa Atef, Mostafa K. Abdelsattar, Mahmoud Al-Ashwah, Emad M. Hammad, Faisal-Alkhateeb Ahmed, Amir Aboelgheet, Mohamed Shawky Elfarargy, Ahmad M. Ali, Amira H. El-Ashry, Hamad Ghaleb Dailah, Amira Elhoufey, Samaher F. Taha
Summary: This study assessed the ability of Cow's Milk-related Symptom Score (CoMiss) in screening cow's milk protein allergy (CMPA). The results showed that CoMiss may be a promising symptom score in CMPA awareness and a useful tool in monitoring the response to a cow's milk-free diet.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Julie Lemale, Jean-Luc Decline, Catherine Dive-Pouletty, Chantal Touboul, Nadege Pichon, Christophe Dupont
Summary: The study observed the effects of a whey-based extensively hydrolyzed formula on symptoms related to cow's milk protein allergy. The results showed a decrease in the number of symptoms and a reduction in CMPA-related symptoms, particularly daily crying and regurgitation.
Article
Nutrition & Dietetics
Michael J. Wilsey, Jared Florio, Jesse Beacker, Luke Lamos, Jessica V. Baran, Lea Oliveros, Panida Sriaroon, Jerry M. Brown, Jon A. Vanderhoof
Summary: Although evidence on the short-term efficacy of extensively hydrolyzed formula for managing cow's milk protein allergy (CMPA) is lacking, this study found statistically significant improvements in symptom severity for infants diagnosed with CMPA and managed with extensively hydrolyzed formula. The study, the largest prospective analysis conducted in the United States, suggests that extensively hydrolyzed formula is associated with noticeable clinical symptom relief by the next follow-up visit. Further randomized control trials are needed to validate these findings.
Article
Allergy
Rosie Vincent, Stephanie J. MacNeill, Tom Marrs, Joanna Craven, Kirsty Logan, Carsten Flohr, Gideon Lack, Suzana Radulovic, Michael R. Perkin, Matthew J. Ridd
Summary: Non-IgE-mediated Cow's Milk Allergy (CMA) in infants is very common, and guidelines may contribute to milk allergy overdiagnosis by labeling normal infant symptoms as potential signs of milk allergy.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Review
Nutrition & Dietetics
Katerina Bajerova, Silvia Salvatore, Christophe Dupont, Philippe Eigenmann, Mikael Kuitunen, Rosan Meyer, Carmen Ribes-Koninckx, Raanan Shamir, Hania Szajewska, Yvan Vandenplas
Summary: This review summarizes the current evidence on the Cow's Milk-related Symptom Score (CoMiSS), which is a clinical tool used to assess symptoms possibly related to cow's milk intake. It found that CoMiSS can be used to predict the response to a cow's milk-free diet in infants and diagnose cow's milk allergy in children.
Review
Allergy
Elissa M. Abrams, Scott H. Sicherer
Summary: Early and ongoing cow's milk ingestion may play a role in the prevention of cow's milk allergy, but further research is needed to determine the mechanism of action and the specific populations in which it is most effective.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2021)
Article
Pediatrics
Brock A. Williams, Stephanie C. Erdle, Kelsey M. Cochrane, Kirstin Wingate, Kyla J. Hildebrand
Summary: Cow's milk allergy is a common food allergy in early childhood, affecting 2-5% of children worldwide. While most children eventually develop tolerance, selecting an appropriate alternative milk is crucial for their growth and development. The increasing variety of alternative milk products adds complexity for families and clinicians. This article aims to provide guidance to Canadian healthcare professionals on recommending the most suitable and nutritionally optimal alternatives for individuals with cow's milk allergy.
PAEDIATRICS & CHILD HEALTH
(2023)