期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 14, 期 39, 页码 5962-5968出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.14.5962
关键词
MYC; Gastric adenocarcinoma; Gastric preneoplastic lesions; Gastric carcinogenesis; Helicobacter pylori
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, DQC, MACS and RRB)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, MFL)
MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. In the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinorna carcinogenesis, including its association with Helicobacterpylori (Hpylorl) and clinical applications. (c) 2008 The WIG Press. All rights reserved.
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