Article
Cardiac & Cardiovascular Systems
Gyeoung-Jin Kang, An Xie, Eunji Kim, Samuel C. Dudley Jr
Summary: This study revealed that myocardial ischemia results in the downregulation of KCNA4 gene expression and the upregulation of miR-448 gene expression. miR-448 binds to a specific region of KCNA4 gene, leading to the decreased expression of KCNA4 and the alteration of normal cardiac action potential. These findings provide insights into the mechanism of miR-448 regulation of KCNA4 expression during ischemia.
Review
Environmental Sciences
Zheng-Yong Wen, Chuan-Jie Qin, Yun-Yun Lv, Yan-Ping Li, Yuan-Chao Zou, Sheng-Tao Guo, Qiong Shi
Summary: This article introduces the important roles of potassium channels in biological processes and the research progress in different species, with a focus on the role of TASK1 channel in fishes and its potential applications.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Oncology
Xiaobo Lu, Kainan Li, Jianjun Yang
Summary: The study reveals that KCND2 plays a promoting role in the aggressiveness of lung adenocarcinoma, with its upregulation associated with unfavorable clinical outcomes. Depletion of KCND2 can inhibit the growth and invasion of cancer cells, suggesting it as a potential predictor for patient prognosis and a target for therapy.
Article
Biochemistry & Molecular Biology
Sadaf Firasat, Ali Raza, Abdul Rafay Khan, Aiysha Abid
Summary: The prevalence of three important pharmacogenetic variants of VKORC1, CYP2C9, and CYP3A5 genes among Pakistani populations was investigated. The study found significant differences in the distribution of these variants compared to other populations, highlighting the importance of this research for the development of precision medicine.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Clinical Neurology
Huicong Kang, Lili Lan, Yuchao Jia, Cun Li, Yongkang Fang, Suiqiang Zhu, Heidi Kirsch
Summary: Long QT syndrome (LQTS), especially LQTS type 2 (LQT2), can often be misdiagnosed as refractory epilepsy and treated incorrectly with anti-epileptic drugs (AEDs), increasing the risk of sudden cardiac death. Careful evaluation with electrocardiography and genetic testing is crucial for accurate diagnosis.
Article
Biotechnology & Applied Microbiology
Yuanzhi Peng, Qingqing Zhang, Hao Cheng, Guizhen Yan, Chunli Xing
Summary: The study revealed that Ube2b elevation ameliorated neuropathic pain by regulating Kcna2, potentially offering a novel biomarker for the therapies of neuropathic pain.
Article
Health Care Sciences & Services
Dinara Ivanoshchuk, Elena Shakhtshneider, Svetlana Mikhailova, Alla Ovsyannikova, Oksana Rymar, Emil Valeeva, Pavel Orlov, Mikhail Voevoda
Summary: The greatest difficulties in differential diagnosis of diabetes mellitus lie in young patients due to the various types of diabetes that can occur in this age group. This study used next-generation sequencing technology to identify gene mutations associated with maturity-onset diabetes of the young (MODY). Several known and novel mutations were identified in MODY-associated genes, highlighting the importance of next-generation sequencing in diagnosing rare MODY subtypes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yujie Xu, Dingmao Wang, Guodong Zhao
Summary: This study reveals that KCNE4 and EFEMP2 are highly expressed in colorectal cancer cells. The functional experiments demonstrate that KCNE4 promotes the expression of EFEMP2, which is associated with the malignant phenotypes of colorectal cancer. Therefore, it can be concluded that KCNE4 acts as an oncogene in colorectal cancer via the promotion of EFEMP2 expression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xianyi Zhou, Hairui Lin, Li Wei, Yingyun Tan, Xiaodong Fu
Summary: Severe preeclampsia is a serious obstetric disease with unclear pathogenesis. This study found decreased expression of TRPV1, KATP subtype Kir6.1/SUR2B, and eNOS in severe preeclampsia tissue specimens compared to normal pregnant women. The study also demonstrated lower NO levels and notable damage to the endothelial cell layer in the placental artery of severe preeclampsia patients. In vitro experiments confirmed the potential role of TRPV1-KATP channels in severe preeclampsia. Based on these findings, it is hypothesized that impaired endothelial TRPV1-KATP channels contribute to decreased eNOS/NO pathway activity, suggesting the potential for targeted management of severe preeclampsia through increased NO generation mediated by TRPV1-KATP.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Physiology
Isabelle Bidaud, Alicia D'Souza, Gabriella Forte, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Pietro Mesirca
Summary: Genetic ablation of cardiac I-KACh in mice prevents exercise-induced sinus bradycardia by suppressing training-induced remodeling of inward currents I-f, I-CaT and I-CaL. This finding may offer an alternative to pacemaker implantation for the bradyarrhythmias seen in some veteran athletes.
FRONTIERS IN PHYSIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Prem Chand, Asna Sulaiman, Salman Kirmani
Summary: Zimmermann-Laband syndrome (ZLS) and Temple-Baraitser syndrome (TMBTS) are phenotypically similar genetic diseases that cause neurodevelopmental problems. Mutations in the KCNH1 gene, primarily the uncommon mutation p.Arg357Trp, have been identified as the cause. This particular mutation leads to pharmacoresistant seizures and autistic behavior in a 2.7-year-old boy. The mutation affects protein modeling and has not been documented in any genetic databases worldwide. In addition, this mutation overlaps with a mutation in the GPHN gene, leading to a complex diagnosis and management due to the coexistence of GPHN-related spectrum disorder and molybdenum cofactor deficiency.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Maengjo Kim, Dan Ye, C. S. John Kim, Wei Zhou, David J. Tester, John R. Giudicessi, Michael J. Ackerman
Summary: This study using iPSC-CM provides further evidence that the common variant p.D85N-KCNE1 in combination with environmental factors such as QT prolonging drugs and female sex leads to arrhythmia.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Haixia Wang, Hongbin Mou, Xiaolan Xu, Changhua Liu, Gang Zhou, Bo Gao
Summary: The study demonstrated that MAPK1 plays a crucial role in sepsis-induced AKI by activating the p38/NF-kappa B pathway, and the long noncoding RNA KCNQ1OT1 may serve as a potential biomarker for the diagnosis and prognosis of AKI patients.
Article
Biotechnology & Applied Microbiology
Juan F. Martin, Paloma Liras
Summary: Recent studies have revealed that the penV gene of Penicillium chrysogenum encodes a TRP ion channel involved in the control of penicillin biosynthesis. This TRP protein may increase the expression of specific genes through calcium signaling cascade and participate in regulatory mechanisms of secondary metabolite biosynthesis in fungi.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
M. Amin, C. Gragnoli
Summary: Polycystic ovarian syndrome (PCOS) is a complex condition affecting women of reproductive age, associated with increased cardiovascular morbidity and mortality. A GW-linkage and linkage disequilibrium study in genetically homogeneous Italian families with PCOS identified several novel risk variants, genes, and pathways potentially involved in the pathogenesis of PCOS.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Psychiatry
Kazutaka Ohi, Takamitsu Shimada, Yuzuru Kataoka, Toshiki Yasuyama, Yasuhiro Kawasaki, Toshiki Shioiri, Paul M. Thompson
BRITISH JOURNAL OF PSYCHIATRY
(2020)
Article
Clinical Neurology
Kazutaka Ohi, Daisuke Nishizawa, Takamitsu Shimada, Yuzuru Kataoka, Junko Hasegawa, Toshiki Shioiri, Yasuhiro Kawasaki, Ryota Hashimoto, Kazutaka Ikeda
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2020)
Letter
Clinical Neurology
Hitoshi Iida, Junichi Iga, Naomi Hasegawa, Yuka Yasuda, Tomoya Yamamoto, Kenichiro Miura, Junya Matsumoto, Atsunobu Murata, Kazuyoshi Ogasawara, Hisashi Yamada, Hikaru Hori, Kayo Ichihashi, Naoki Hashimoto, Kazutaka Ohi, Norio Yasui-Furukori, Takashi Tsuboi, Toshinori Nakamura, Masahide Usami, Ryuji Furihata, Yoshikazu Takaesu, Kunihiro Iwamoto, Nobuhiro Sugiyama, Taishiro Kishimoto, Naohisa Tsujino, Hiroki Yamada, Akitoyo Hishimoto, Kiyotaka Nemoto, Kiyokazu Atake, Hiroyuki Muraoka, Eiichi Katsumoto, Satoru Oishi, Takahiko Inagaki, Fumiaki Ito, Yayoi Imamura, Mikio Kido, Tatsuya Nagasawa, Shusuke Numata, Shinichiro Ochi, Masaaki Iwata, Hidenaga Yamamori, Junichi Fujita, Toshiaki Onitsuka, Satoshi Yamamura, Manabu Makinodan, Michiko Fujimoto, Yoichiro Takayanagi, Kenji Takezawa, Hiroshi Komatsu, Kentaro Fukumoto, Shinichiro Tamai, Hirotaka Yamagata, Chika Kubota, Tadasu Horai, Ken Inada, Koichiro Watanabe, Hiroaki Kawasaki, Ryota Hashimoto
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2020)
Article
Psychiatry
Naoki Hashimoto, Norio Yasui-Furukori, Naomi Hasegawa, Shuhei Ishikawa, Shusuke Numata, Hikaru Hori, Hitoshi Iida, Kayo Ichihashi, Ryuji Furihata, Atsunobu Murata, Takashi Tsuboi, Masahiro Takeshima, Yoshitaka Kyou, Hiroshi Komatsu, Chika Kubota, Shinichiro Ochi, Yoshikazu Takaesu, Masahide Usami, Tatsuya Nagasawa, Akitoyo Hishimoto, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Hisashi Yamada, Ken Inada, Koichiro Watanabe, Kazutaka Shimoda, Ryota Hashimoto
Summary: The analysis of discharge prescription data for patients with schizophrenia and MDD revealed differences in prescription patterns for antipsychotics and hypnotics/anxiolytics among patients of different age groups, as well as the common practice of polypharmacy.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Neurosciences
Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki
Summary: This study aimed to compare the roles of genic and regulatory copy number variations (CNVs) in bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD). High-resolution CNV data from 8708 Japanese samples were used to perform the largest cross-disorder analysis of genic and regulatory CNVs in these disorders. The results showed differences in CNV burden, characteristics of CNVs associated with neurodevelopmental disorders, and regulatory CNVs between BD and SCZ/ASD. However, there were also shared molecular mechanisms, particularly in chromatin biology. The study identified specific risk genes for BD that could contribute to understanding the pathogenesis of the disorder.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Hisashi Yamada, Mikuni Motoyama, Naomi Hasegawa, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Norio Yasui-Furukori, Shusuke Numata, Masahiro Takeshima, Nobuhiro Sugiyama, Tatsuya Nagasawa, Chika Kubota, Kiyokazu Atake, Takashi Tsuboi, Kayo Ichihashi, Naoki Hashimoto, Takahiko Inagaki, Yoshikazu Takaesu, Jun-ichi Iga, Hikaru Hori, Toshiaki Onitsuka, Hiroshi Komatsu, Akitoyo Hishimoto, Kentaro Fukumoto, Michiko Fujimoto, Toshinori Nakamura, Kiyotaka Nemoto, Ryuji Furihata, Satoshi Yamamura, Hirotaka Yamagata, Kazuyoshi Ogasawara, Eiichi Katsumoto, Atsunobu Murata, Hitoshi Iida, Shinichiro Ochi, Manabu Makinodan, Mikio Kido, Taishiro Kishimoto, Yuka Yasuda, Masahide Usami, Taro Suwa, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: This study aimed to assess the effectiveness of the EGUIDE project on the clinical behavior of psychiatrists in accordance with clinical practice guidelines. The results showed that the EGUIDE program significantly improved the clinical behaviors of psychiatrists in accordance with guidelines, and these improvements were sustained for at least 2 years.
Article
Psychiatry
Chika Sumiyoshi, Kazutaka Ohi, Haruo Fujino, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Yota Uno, Junichi Takahashi, Kentaro Morita, Asuka Katsuki, Maeri Yamamoto, Yuko Okahisa, Ayumi Sata, Eiichi Katsumoto, Michihiko Koeda, Yoji Hirano, Masahito Nakataki, Junya Matsumoto, Kenichiro Miura, Naoki Hashimoto, Manabu Makinodan, Tsutomu Takahashi, Kiyotaka Nemoto, Toshifumi Kishimoto, Michio Suzuki, Tomiki Sumiyoshi, Ryota Hashimoto
Summary: This study classified individuals with mental disorders based on intellectual abilities and work outcomes, highlighting the effectiveness of transdiagnostic approaches and emphasizing the importance of diagnosis-specific strategies to support functional recovery in people with mental disorders.
Article
Psychology, Clinical
Kazutaka Ohi, Daisuke Nishizawa, Shunsuke Sugiyama, Kentaro Takai, Daisuke Fujikane, Ayumi Kuramitsu, Junko Hasegawa, Midori Soda, Kiyoyuki Kitaichi, Ryota Hashimoto, Kazutaka Ikeda, Toshiki Shioiri
Summary: Individuals with schizophrenia and bipolar disorder commonly experience cognitive impairments. Genetic risk plays a role in the cognitive impairments of schizophrenia. Cognitive performances differ among individuals with different genetic risks.
PSYCHOLOGICAL MEDICINE
(2023)
Correction
Psychiatry
Klaus Oliver Schubert, Anbupalam Thalamuthu, Azmeraw T. Amare, Joseph Frank, Fabian Streit, Mazda Adl, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Micah Cearns, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R. Clark, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara Konig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nothen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Bernhard T. Baune
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Hiroyuki Muraoka, Fumitoshi Kodaka, Naomi Hasegawa, Norio Yasui-Furukori, Kentaro Fukumoto, Hiroko Kashiwagi, Hiromi Tagata, Hikaru Hori, Kiyokazu Atake, Hitoshi Iida, Kayo Ichihashi, Ryuji Furihata, Takashi Tsuboi, Masahiro Takeshima, Hiroshi Komatsu, Chika Kubota, Shinichiro Ochi, Yoshikazu Takaesu, Masahide Usami, Tatsuya Nagasawa, Manabu Makinodan, Toshinori Nakamura, Mikio Kido, Ikki Ueda, Hirotaka Yamagata, Toshiaki Onitsuka, Takeshi Asami, Akitoyo Hishimoto, Kazuyoshi Ogasawara, Eiichi Katsumoto, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Hisashi Yamada, Koichiro Watanabe, Ken Inada, Katsuji Nishimura, Ryota Hashimoto
Summary: This study investigated the treatment approaches based on the severity of major depressive disorder (MDD) in real-world clinical practice. The findings revealed a decrease in the use of psychotropics with increasing severity of MDD, while a combination of antipsychotics and antidepressants and the implementation rate of modified electroconvulsive therapy (m-ECT) increased. However, the study also highlighted the existence of an evidence-practice gap in the treatment of MDD in Japan.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Genetics & Heredity
Yuka Yasuda, Junya Matsumoto, Kenichiro Miura, Naomi Hasegawa, Ryota Hashimoto
Summary: Autism spectrum disorders (ASDs) are complex genetic disorders that have been increasing in prevalence. Genetic mutations, interactions between genes and the environment, and epigenetic mechanisms all play important roles in the development and diagnosis of ASD.
JOURNAL OF HUMAN GENETICS
(2023)
Article
Clinical Neurology
Itaru Kushima, Branko Aleksic, Hiroki Kimura, Masahiro Nakatochi, Tzuyao Lo, Masashi Ikeda, Makoto Arai, Ryota Hashimoto, Shusuke Numata, Yasunobu Okamura, Taku Obara, Toshiya Inada, Norio Ozaki
Summary: This study found a significant association between 47, XXY and 47, XXX and the risk of schizophrenia. Patients with schizophrenia and 47, XXY may exhibit treatment resistance and manic symptoms.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Letter
Clinical Neurology
Satsuki Ito, Kenichiro Miura, Mirano Miyayama, Junya Matsumoto, Masaki Fukunaga, Keiichiro Ishimaru, Michiko Fujimoto, Yuka Yasuda, Yoshiyuki Watanabe, Ryota Hashimoto
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Clinical Neurology
Takashi Tsuboi, Yoshikazu Takaesu, Naomi Hasegawa, Shinichiro Ochi, Kentaro Fukumoto, Kazutaka Ohi, Hiroyuki Muraoka, Tsuyoshi Okada, Funitoshi Kodaka, Shun Igarashi, Hitoshi Iida, Hiroko Kashiwagi, Hikaru Hori, Kayo Ichihashi, Kazuyoshi Ogasawara, Naoki Hashimoto, Jun-Ichi Iga, Toshinori Nakamura, Masahide Usami, Tatsuya Nagasawa, Mikio Kido, Hiroshi Komatsu, Hirotaka Yamagata, Kiyokazu Atake, Ryuji Furihata, Saya Kikuchi, Tadasu Horai, Masahiro Takeshima, Yoji Hirano, Manabu Makinodan, Junya Matsumoto, Kenichiro Miura, Akitoyo Hishimoto, Shusuke Numata, Hisashi Yamada, Norio Yasui-Furukori, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: The use of electroconvulsive therapy (ECT) may reduce the need for anxiolytic and sleep medication in patients with major depressive disorder (MDD). However, there was no significant difference in anxiolytic and sleep medication use between the ECT and non-ECT groups in patients with schizophrenia (SZ).
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Neurosciences
Zlata Polyakova, Masao Iwase, Ryota Hashimoto, Masatoshi Yoshida
Summary: A pharmacological model of schizophrenia symptoms using a subanesthetic dose of ketamine in marmosets was used to study the effects on eye movement characteristics during free-viewing. Ketamine was found to affect saccadic eye movements in marmosets, reducing the amplitude and scanpath length of saccades while increasing the duration of saccades and fixations. These findings suggest that ketamine affects visual exploration but not the oculomotor aspect of saccades in marmosets.
FRONTIERS IN NEUROSCIENCE
(2022)