Article
Biochemistry & Molecular Biology
Xinjiang Cai, Yan Zhao, Yang Yang, Xiuju Wu, Li Zhang, Jocelyn A. Ma, Jaden Ji, Kristina I. Bostrom, Yucheng Yao
Summary: Glycogen synthase kinase-3 beta (GSK3 beta) inhibition or endothelial-specific deletion of GSK3 beta reduces atherosclerotic calcification. The changes in beta-catenin and SMAD1 induced by GSK3 beta inhibition in the aortas of Apoe(-/-) mice are similar to Mgp(-/-) mice. This suggests that GSK3 beta inhibition reduces vascular calcification in atherosclerotic lesions through a similar mechanism to that in Mgp(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Biochemistry & Molecular Biology
Pier Francesca Porceddu, Mariasole Ciampoli, Elisa Romeo, Beatrice Garrone, Lucia Durando, Claudio Milanese, Francesco Paolo Di Giorgio, Angelo Reggiani
Summary: Glycogen-synthase kinase 3 (GSK3) is a kinase involved in the regulation of various cellular processes and its dysregulation has been linked to diseases such as fragile X syndrome (FXS). This study used a potent GSK3 inhibitor in an FXS mouse model and found that behavioral abnormalities were reversed, highlighting the significance of GSK3 as a therapeutic target.
HUMAN MOLECULAR GENETICS
(2022)
Article
Pharmacology & Pharmacy
Timo T. Myohanen, Freke Mertens, Susanna Norrbacka, Hengjing Cui
Summary: The deletion or inhibition of PREP blocks the intracellular effects of lithium on GSK3β and Akt by activating PP2A.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Review
Cell Biology
Ryan T. McCallum, Melissa L. Perreault
Summary: This study discussed the widespread multi-system involvement of GSK-3 in contributing to the neuropathology of MDD, emphasizing the feed-forward mechanistic links between all major neuronal signaling pathways.
Article
Biochemistry & Molecular Biology
Maria-Angeles Cortes-Gomez, Esther Llorens-Alvarez, Jordi Alom, Teodoro del Ser, Jesus Avila, Javier Saez-Valero, Maria-Salud Garcia-Ayllon
Summary: This study demonstrates that P-tau can modulate AChE expression, and suggests that AChE may increase in the initial phases of AD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Immunology
Ricarda Cortes-Vieyra, Octavio Silva-Garcia, Anel Gomez-Garcia, Sergio Gutierrez-Castellanos, Cleto Alvarez-Aguilar, Victor M. Baizabal-Aguirre
Summary: Understanding the regulation of GSK3 beta activity in inflammatory responses caused by pathogenic microorganisms is crucial for controlling the intensity of inflammation. Recent studies have shown that regulating GSK3 beta activity can reduce the detrimental effects of the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Anil Kumar Rana, Supriya Sharma, Rajneesh Kumar, Damanpreet Singh
Summary: Menopause is a natural aging process where decreased sex hormone levels lead to neurobehavioral complications. Hormone replacement therapy is commonly used but has adverse effects. In this study, buckwheat tartary seed extract was investigated and found to rescue memory and behavior in ovariectomized rats. The extract also reversed oxidative stress, neuroinflammation, and altered gene expression, making it a better option for managing neurobehavioral complications associated with menopause.
METABOLIC BRAIN DISEASE
(2023)
Article
Integrative & Complementary Medicine
Hei-Jen Huang, Jie-Ling Chen, Jian-Fu Liao, Yu-Hsin Chen, Min-Wei Chieu, Ya-Yun Ke, Chih-Chieh Hsu, Ying-Chieh Tsai, Hsiu Mei Hsieh-Li
Summary: This study evaluated the beneficial effects of the psychobiotic PS128 in AD mice and found that PS128 effectively prevented damage induced by intracerebroventricular injection of streptozotocin by regulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis. PS128 supplementation is suggested as a potential strategy to prevent and/or delay the progression of AD.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Multidisciplinary Sciences
Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis
Summary: Serine/one-carbon metabolism plays a critical role in cancer cell growth, but the regulatory mechanisms are not well understood. This study reveals that glycogen synthase kinase 3 (GSK3) plays a key role in regulating the expression of serine/one-carbon metabolic enzymes. Inhibition of nuclear GSK3 signaling enhances the efficacy of serine/one-carbon metabolism inhibitors in suppressing cancer cell proliferation.
Article
Chemistry, Medicinal
Xueyang Jiang, Junting Zhou, Yang Wang, Xin Liu, Kaiying Xu, Jian Xu, Feng Feng, Haopeng Sun
Summary: A series of heterobifunctional small molecule PROTACs based on CRBN were designed and synthesized to effectively degrade GSK-3β protein and protect against cell death, showing potential for further investigation in the biological function of GSK-3β protein and its association with diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Psychology, Clinical
Cheng-Ta Li, Jong-Ling Fuh, Bang-Hung Yang, Chen-Ji Hong, Chi-Wei Chang, Pei-Chi Tu, Jia-Shyun Jeng, Mu-Hong Chen, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Hsuan Lee, Wen-Sheng Huang
Summary: This study aimed to investigate the impact of late-life depression on cognitive function and found that late-life MDD patients had abnormal Aβ deposits in the brain, which had a detrimental effect on global cognition. Furthermore, TRD patients had more deposits in specific brain regions. These findings support the theory that late-life depression is a risk factor for AD.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Divya M. Teli, Anuradha K. Gajjar
Summary: Elevated glucose level due to β-cell dysfunction is a key marker of Type-II diabetes. GSK-3, an enzyme involved in glycogen metabolism control, has been explored for its potential as a target for diabetes treatment. This review article examines the structural analysis and molecular modeling of GSK-3, as well as advancements in the development of GSK-3 inhibitors as potential therapeutics for Type II diabetes.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Ryan W. Baranowski, Jessica L. Braun, Briana L. Hockey, Jenalyn L. Yumol, Mia S. Geromella, Colton J. F. Watson, Nigel Kurgan, Holt N. Messner, Kennedy C. Whitley, Adam J. MacNeil, Guillemette Gauquelin-Koch, Fabrice Bertile, William Gittings, Rene Vandenboom, Wendy E. Ward, Val A. Fajardo
Summary: The study examined the effects of 30 days of spaceflight on GSK3 content and serine phosphorylation in murine muscle and bone samples. It was found that spaceflight reduced GSK3 beta content in all missions, but its serine phosphorylation increased in two missions. The reduction in GSK3 beta was associated with the decrease in type IIA fibers, while inhibiting GSK3 before the fiber type shift increased muscle mass and promoted oxidative fiber type.
Article
Biochemistry & Molecular Biology
Laura Vainio, Saija Taponen, Sini M. Kinnunen, Eveliina Halmetoja, Zoltan Szabo, Tarja Alakoski, Johanna Ulvila, Juhani Junttila, Paivi Lakkisto, Johanna Magga, Risto Kerkela
Summary: Phosphorylation of GSK3 beta at S389 enhances cardiomyocyte survival and protects from cardiomyocyte hypertrophy. The GSK3 beta S389A mutation promotes cardiomyocyte growth by activating the mTOR complex 1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychiatry
Rebeca Pelosof, Leonardo A. dos Santos, Luis C. Farhat, Wagner F. Gattaz, Leda Talib, Andre R. Brunoni
Summary: This updated review found an increase in BDNF levels after ECT treatment for depression. However, there was significant heterogeneity and limited sample sizes in the studies, indicating the need for further research to investigate factors driving the variability of effects.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Geriatrics & Gerontology
Breno S. Diniz
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Emma Mastrobattista, Eric J. Lenze, Charles F. Reynolds, Benoit H. Mulsant, Julie Wetherell, Gregory F. Wu, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Breno S. Diniz
Summary: This study assessed the levels of GDF-15 in 393 older adults, including 308 with major depressive disorder (MDD) and 85 non-depressed individuals. The results showed that older adults with MDD had significantly higher levels of GDF-15, which were associated with physical comorbidity burden, cognitive decline, and late-onset depression.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Review
Cell Biology
Erica C. Lorenzo, George A. Kuchel, Chia-Ling Kuo, Terrie E. Moffitt, Breno S. Diniz
Summary: Major depressive disorder (MDD) is associated with an increased risk of age-related adverse outcomes, possibly due to the overlap between biological abnormalities in MDD and biological changes associated with aging. Exploring the intersection between aging and MDD and using geroscience-guided interventions, such as senolytics, could potentially delay or improve MDD by targeting aging.
AGEING RESEARCH REVIEWS
(2023)
Article
Multidisciplinary Sciences
Daniela Martinez, Catharina Lavebratt, Vincent Millischer, Vanessa de Jesus R. de Paula, Thiago Pires, Leandro Michelon, Caroline Camilo, Nubia Esteban, Alexandre Pereira, Martin Schalling, Homero Vallada
Summary: This study reveals that individuals with familial bipolar disorder have shorter leukocyte telomere length, which is associated with disease severity and suicidal ideation.
Article
Behavioral Sciences
Thamires Naela Cardoso Magalhaes, Raphael Fernandes Casseb, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Siva, Mateus Henrique Nogueira, Camila Vieira Ligo Teixeira, Ana Flavia Mac Knight Carletti, Thiago Junqueira Ribeiro de Rezende, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthazar
Summary: The causes of neurodegenerative processes in Alzheimer's disease are not fully understood. Recent studies have shown that damage in white matter may be more severe and widespread than cortical atrophy in the brain, appearing even before gray matter damage. Amyloid-beta and tau proteins in AD can directly affect white matter and spread across brain networks. This study aimed to evaluate whole-brain white matter integrity using diffusion tensor imaging in mild AD and amnestic mild cognitive impairment (aMCI) due to AD. Widespread white matter alterations were found, with correlations between tau proteins and tracts linked to the mesial temporal lobe. However, hippocampal volume better explained the variation in diffusion tensor imaging measures compared to CSF proteins.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Jessica Gong, Katie Harris, Darren M. Lipnicki, Erico Castro-Costa, Maria Fernanda Lima-Costa, Breno S. Diniz, Shifu Xiao, Richard B. Lipton, Mindy J. Katz, Cuiling Wang, Pierre-Marie Preux, Maelenn Guerchet, Antoine Gbessemehlan, Karen Ritchie, Marie-Laure Ancelin, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Mary H. Kosmidis, Antonio Guaita, Elena Rolandi, Annalisa Davin, Oye Gureje, Stella Trompet, Jacobijn Gussekloo, Steffi Riedel-Heller, Alexander Pabst, Susanne Rohr, Suzana Shahar, Devinder Kaur Ajit Singh, Nurul Fatin Malek Rivan, Martin van Boxtel, Sebastian Kohler, Mary Ganguli, Chung-Chou Chang, Erin Jacobsen, Mary Haan, Ding Ding, Qianhua Zhao, Zhenxu Xiao, Kenji Narazaki, Tao Chen, Sanmei Chen, Tze Pin Ng, Xinyi Gwee, Katya Numbers, Karen A. Mather, Marcia Scazufca, Antonio Lobo, Concepcion De-la-Camara, Elena Lobo, Perminder S. Sachdev, Henry Brodaty, Maree L. Hackett, Sanne A. E. Peters, Mark Woodward
Summary: This meta-analysis of data from 21 cohorts across six continents found that women have a higher risk of developing dementia than men, especially in low- and lower-middle-income economies. Longer education and former alcohol use are stronger risk factors for dementia in men than in women, while other risk factors have similar effects in both genders.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Clinical
Ethan Shuster, Amy E. E. Miles, Lindsay K. K. Heyland, Navona Calarco, Jerrold Jeyachandra, Salim Mansour, Aristotle N. N. Voineskos, David C. C. Steffens, Yuliya S. S. Nikolova, Breno S. S. Diniz
Summary: In this cross-sectional study, we found that depression and frailty have a joint effect on brain structure, with significant microstructural changes in white matter tracts in the depression-frailty group. These findings suggest a potential common neuroinflammatory burden underlying the co-occurrence of depression and frailty in older adults.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Alana C. Costa, Larissa B. Rica, Martinus van de Bilt, Flavia S. Zandonadi, Wagner F. Gattaz, Leda L. Talib, Alessandra Sussulini
Summary: In this study, lipidomic profiles of drug-naive patients with schizophrenia (SZ) and bipolar disorder (BD) were compared to healthy controls. Significant alterations in lipid metabolism pathways, especially glycerophospholipids, sphingolipids, and glycerolipids, were observed between SZ and BD patients. These findings provide a basis for differential diagnosis and may contribute to effective treatment and improved quality of life for patients with psychotic disorders.
Article
Psychiatry
Rodolfo Furlan Damiano, Julia Cunha Loureiro, Marcos Vasconcelos Pais, Rodrigo Furtado Pereira, Marina de Menezes Corradi, Talita Di Santi, Gustavo Antonio Marcolongo Bezerra, Marcia Radanovic, Leda Leme Talib, Orestes Vicente Forlenza
Summary: This study re-evaluated older adults who were previously enrolled in a trial for lithium treatment for amnestic mild cognitive impairment. The results showed that those who received lithium treatment had better cognitive function and language abilities.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Johanna Seitz-Holland, Benoit H. Mulsant, Charles F. Reynolds, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Eric J. Lenze, Breno S. Diniz
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Alana Costa, Marcos Pais, Julia Loureiro, Florindo Stella, Marcia Radanovic, Wagner Gattaz, Orestes Forlenza, Leda Talib
Summary: The study aimed to determine the viability of using a decision-tree method to analyze CSF biomarkers of AD as a support for clinical diagnosis. The results showed that automated analyses of AD biomarkers provide valuable information in differentiating MCI and AD from controls.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neuroimaging
Navona Calarco, Clifford M. Cassidy, Ben Selby, Colin Hawco, Aristotle N. Voineskos, Breno S. Diniz, Yuliya S. Nikolova
Summary: Late-life depression may be a risk factor for age-dependent cognitive deterioration, potentially due to degeneration in the norepinephrine system in the locus coeruleus. Using neuromelanin-sensitive MRI and cognitive assessments, a strong association between integrity and cognition was found.
NEUROIMAGE-CLINICAL
(2022)
Meeting Abstract
Neurosciences
Erica Vieira, John Nolan, Thomas Maslanik, Ana Paula Mendes Silva, Etienne Sibille, Tarek Rajji, Breno Diniz
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Navona Calarco, Clifford Cassidy, Ben Selby, Colin Hawco, Aristotle Voineskos, Breno Diniz, Yuliya Nikolova
BIOLOGICAL PSYCHIATRY
(2022)