Article
Pharmacology & Pharmacy
Yoshihisa Yamamoto, Mizuho Kajita, Yutaro Hirose, Naoki Shimada, Toshiro Fukami, Tatsuo Koide
Summary: This study evaluated the pharmaceutical properties of levofloxacin (LV) in the form of orally disintegrating tablets (LVODT) using low frequency (LF) Raman spectroscopy. The results showed that LVODT and LV tablets (LVT) contained the active pharmaceutical ingredient (API) in different crystalline forms or environments. Microscopic LF Raman spectroscopy also detected thin layers containing titanium dioxide and a polymer that masked the bitterness of the API on the outer edges of the granules. This study highlights the new applications of LF Raman spectroscopy in pharmaceutical science.
Article
Gastroenterology & Hepatology
Evan S. Dellon, Alfredo J. Lucendo, Christoph Schlag, Alain M. Schoepfer, Gary W. Falk, Gina Eagle, James Nezamis, Gail M. Comer, Karol Knoop, Ikuo Hirano
Summary: This study demonstrates that APT-1011 (fluticasone propionate oral disintegrating tablet) is an effective and well-tolerated treatment for eosinophilic esophagitis (EoE). Different doses of APT-1011 showed superior histologic and endoscopic responses, as well as a reduction in dysphagia frequency, compared to placebo. The once daily 3 mg dose at bedtime showed the most favorable risk-benefit profile.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dilawar Khan, Daniel Kirby, Simon Bryson, Maryam Shah, Afzal Rahman Mohammed
Summary: Due to anatomical and physiological differences between pediatric subsets, it is well established that children respond differently to drugs compared to adults. Orally disintegrating mini-tablets have been considered an age-appropriate formulation option for pediatric use due to their dose flexibility and superior stability.
Article
Pharmacology & Pharmacy
Yoshinori Onuki, Daisuke Sugiura, Shungo Kumada, Ryosuke Kobayashi, Taichi Nakamura, Toru Kogawa, Hideki Sakai, Kotaro Okada
Summary: This study investigated the impact of thickening solutions on drug dissolution from orally disintegrating tablets (ODTs) and found that the disintegrants contained in ODTs play a crucial role in reducing drug dissolution when treated with a thickening solution. Additionally, the swelling behavior and mechanical strength of the ODTs were also affected by the thickening solution.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Kai Bin Liew, Kok Khiang Peh
Summary: The study investigated the effect of different polymers and wheat starch on the properties of lyophilized ODT, finding that increasing concentrations of HPMC and Carbopol 934P led to higher tablet hardness and longer disintegration time. Eudragit (R) EPO was unable to form tablets with sufficient hardness. Wheat starch acted as a binder to strengthen tablet hardness and prolong disintegration time, with the optimal formulation being a combination of HPMC and wheat starch at a ratio of 2:1.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Alicia Potter DeFalco, Rachel Lazim, Nathan E. Cope
Summary: Rimegepant orally disintegrating tablet is an effective option for treating migraines, providing rapid pain relief and symptom improvement, with potential adverse effects. It offers a promising therapeutic option for patients who cannot tolerate or have contraindications to other treatments.
ANNALS OF PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Mahmoud Teaima, Sandra Hababeh, Mai Khanfar, Fares Alanazi, Doaa Alshora, Mohammed El-Nabrawi
Summary: This study aimed to improve the solubility and dissolution rate of Pioglitazone Hydrochloride (PGZ) by designing orally disintegrating tablets with self-nanoemulsifying properties (T-SNEDDS). The optimized formulation showed enhanced dissolution profiles and improved pharmacokinetics and pharmacodynamics compared to the pure drug and commercial tablet.
Article
Multidisciplinary Sciences
Chernet Tafere, Zewdu Yilma, Solomon Abrha, Adane Yehualaw
Summary: The study successfully formulated co-trimoxazole orally disintegrating tablets (ODTs) to overcome swallowing difficulties and improve patient compliance. Central composite design was effectively used to optimize friability, disintegration time (DT), and wetting time (WT). Optimization was achieved through numerical and graphical methods, resulting in significantly rapid disintegration, minimal friability, and enhanced dissolution profiles for CTX ODTs.
Article
Chemistry, Medicinal
Busra Kandilli, Afife Busra Ugur Kaplan, Meltem Cetin, Numan Taspinar, Sidika Genc, Yesim Yeni, Muhammed Sait Ertugrul, Ismail Cagri Aydin, Ahmet Hacimuftuoglu
Summary: This study successfully prepared orally disintegrating tablet formulations containing the combination of levetiracetam and carbamazepine for the treatment of epilepsy. The formulations were characterized and evaluated for their antiepileptic effects in rats, showing promising results that suggest the potential benefits of using this combination in epilepsy treatment.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Shohei Nakamura, Tomomi Fukai, Takatoshi Sakamoto
Summary: The study focused on the benefits of cellulose nanofiber (CNF) in orally disintegrating (OD) tablet manufacturing, finding that adding CNF enhanced tablet hardness and disintegration time. Optimal tablet physical properties were achieved with a CNF concentration of 10-20% and a compression force of 12-13 kN.
Article
Pharmacology & Pharmacy
Emma A. Kean, Oluwatoyin A. Adeleke
Summary: Non-compliance, dosing inaccuracy, choking risk, flavor, and instability are some of the challenges associated with pediatric oral dosage forms. Orally disintegrating drug carriers are gaining interest for their ability to rapidly disintegrate in the buccal cavity without water. This review provides an updated report on various types of orodispersible delivery systems, their characteristics, manufacturing processes, and applications in the pediatric population.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Food Science & Technology
Chao Yuan, Haojie Sha, Bo Cui
Summary: Orally disintegrating film (ODF) has gained increasing attention recently. It can rapidly dissolve in saliva without the need for chewing and water intake, allowing the active ingredients to be directly absorbed by the oral mucosa, thereby improving their bioavailability. The combination of 3D printing technology and ODF allows for customized ODF production, catering to the specific needs of consumers. Future research should focus on the preparation of ODF using 3D printing technology to meet the demand for personalized nutritional supplementation.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Chemistry, Applied
Haojie Sha, Chao Yuan, Bo Cui, Meng Zhao, Jialin Wang
Summary: The study found that incorporating beta-Cyclodextrin in the preparation process of orally disintegrating films can improve the mechanical properties and surface hydrophilicity of the films, as well as promote the uniform dispersion of pre-gelatinized cassava starch, forming a more complete network structure.
FOOD HYDROCOLLOIDS
(2022)
Article
Pharmacology & Pharmacy
Jiaqi Zhang, Yu Yao, Wei Sun, Liling Tang, Xiaodong Li, Huaqing Lin
Summary: This study aims to reduce the weight of sildenafil orally disintegrating tablets (ODTs) and optimize their formulation through modeling methods. The models established using the back-propagation neural network (BPNN) and the non-dominated sorting genetic algorithm II (NSGA-II) successfully predicted the hardness and disintegration time of ODTs. The bioequivalence trial confirmed the effectiveness of the optimized formulation, which resulted in a bioequivalent formulation with better medication experience.
Article
Integrative & Complementary Medicine
Liang Fang, Ying Xu, Xuefei Tong, Xue Wu, Xiaomeng Zhou
Summary: This study investigated the efficacy of risperidone orally disintegrating tablets combined with oxazepam in treating schizophrenia. The results showed that this combination therapy significantly relieved symptoms, improved quality of life and daily living activities, and reduced the incidence of adverse reactions.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
