Article
Biophysics
Clarinda Costa, Zehua Liu, Sandra Simoes, Alexandra Correia, Antti Rahikkala, Jani Seitsonen, Janne Ruokolainen, Ana Aguiar-Ricardo, Helder A. Santos, M. Luisa Corvo
Summary: The study successfully encapsulated Cu,Zn-Superoxide dismutase (SOD) into liposomes using a glass-capillary microfluidic technique, demonstrating significant therapeutic effects in mouse experiments. SOD@Liposomes exhibit high encapsulation efficiency and enzyme activity, and can effectively inhibit edema through intravenous administration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Larissa D. Coelho, Mirna M. D. Souza, Geovanni D. Cassali, Raphaela A. Silva, Maria J. N. Paiva, Andre L. B. Barros, Eliane M. Teixeira, Josianne N. Silveira, Paulo M. Z. Coelho, Marta M. G. Aguiar, Monica C. Oliveira
Summary: Liposomes containing emetic tartar (ET) were prepared and evaluated for the treatment of leishmaniasis. The encapsulation of ET in liposomes reduced its side effects and showed antileishmanial activity in a mouse model.
Article
Pharmacology & Pharmacy
Kamila Bohne Japiassu, Francois Fay, Alessandro Marengo, Sebastiao A. Mendanha, Catherine Cailleau, Younes Louaguenouni, Qinglin Wang, Stephanie Denis, Nicolas Tsapis, Thais Leite Nascimento, Eliana Martins Lima, Elias Fattal
Summary: In this study, lipid nanoparticulate platforms loaded with dexamethasone were developed and evaluated. The dexamethasone-loaded liposomes, with sizes below 150 nm, were coated with polyethylene glycol, hyaluronic acid, or a mixture of both to cross the pulmonary mucus layer and target alveolar proinflammatory macrophages expressing CD44. In vitro experiments showed that encapsulated dexamethasone in liposomes, especially in HA-bearing ones, improved anti-inflammatory efficacy compared to the free drug. In vivo data demonstrated that dexamethasone-loaded liposomes exhibited improved consistency in efficacy compared to free dexamethasone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Wei Liu, Haowei Lu, Xiaoyong Rao, Xiang Li, Hongdan Lu, Feifei Li, Yan He, Riyue Yu, Rongsheng Zhong, Yao Zhang, Xiaojian Luo, Hongliang Xin
Summary: Inflammation is the main pathological mechanism of cerebral ischemia-reperfusion injury (CIRI), and neutrophils play a role in facilitating drug delivery to the ischemic penumbra through chemotaxis. Puerarin, a neuroprotective isoflavone derivative, is hindered by the blood-brain barrier in treating CIRI. Using neutrophils as carriers can enhance the BBB penetration of puerarin, improving its concentration in the brain parenchyma and enhancing neuroprotection at the ischemic penumbra in response to inflammatory conditions associated with brain injury.
Article
Biochemistry & Molecular Biology
Dinglingge Cao, Huangjuan Li, Yuan Luo, Nianping Feng, Tianyuan Ci
Summary: The study developed a delivery system by loading the photosensitizer ICG into LMWH-modified liposomes to achieve better phototherapeutic efficacy and alleviate the potential risk of tumor metastasis caused by phototherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Miriam Ana Gonzalez-Cela-Casamayor, Jose Javier Lopez-Cano, Irene Bravo-Osuna, Vanessa Andres-Guerrero, Marta Vicario-de-la-Torre, Manuel Guzman-Navarro, Jose Manuel Benitez-del-Castillo, Rocio Herrero-Vanrell, Irene Teresa Molina-Martinez
Summary: Glaucoma, a chronic irreversible neuropathy affecting the retina and optic nerve, is a major cause of blindness worldwide. Elevated intraocular pressure is a modifiable risk factor, and antihypertensive formulations are commonly used for treatment. However, frequent instillation of these formulations can lead to dry eye disease. In this study, liposome formulations loaded with brimonidine or travoprost, enriched with osmoprotective compounds, were developed. These formulations exhibited suitable physicochemical characteristics and encapsulation efficiency for ocular surface administration. They also showed good tolerability and osmoprotective activity in cell cultures. In animal experiments, the liposomal formulations demonstrated faster and longer-lasting reduction of intraocular pressure compared to commercial control products. Overall, the liposomal formulations combined with osmoprotective agents present a promising platform for the treatment of glaucoma and protection of the ocular surface.
Article
Pharmacology & Pharmacy
Ming Wu, Hongrui Ping, Kun Wang, Hui Ding, Meng Zhang, Ziqiong Yang, Qian Du
Summary: Oral delivery of anti-inflammatory drugs is a promising strategy for treating ulcerative colitis, but achieving specific drug delivery to colon tissues and target cells is challenging. In this study, macrophages-targeted liposome-loaded pectin-chitosan hydrogels were developed for effective UC treatment through oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Sipan Li, Yongan Wang, Siting Wang, Jianjun Xie, Tingming Fu, Shaoguang Li
Summary: We developed a hydrogel with berberine hydrochloride liposomes to disrupt bacterial biofilms and accelerate wound healing. In mouse experiments, the hydrogel effectively reduced the number of biofilms, decreased inflammation, and promoted re-epithelialization and vascular regeneration in wound tissue. This study provides a new perspective for tackling drug resistance and fighting wound infections.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Abigail R. Bland, Fergus M. Payne, John C. Ashton, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: During cardiac reperfusion after myocardial infarction, the heart faces ischaemia reperfusion injury (IRI) which leads to myocardial dysfunction and cell death. Research has identified potential targeted therapies focusing on mitochondria, such as opening of the mitochondrial permeability transition pore, activation of mitoK(ATP) channels, and inhibition of GSK3 beta phosphorylation, to reduce the severity of myocardial IRI. Additionally, statins have shown direct cardioprotective effects on specific mitochondrial components, indicating their potential as a preconditioning agent.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Zhicheng Wang, Weikang Bian, Yufeng Yan, Dai-Min Zhang
Summary: ATP-sensitive potassium channels (K-ATP channels) play important roles in cellular excitability and metabolism. Activation of K-ATP channels can repolarize the membrane potential and reduce the occurrence of arrhythmias. Under severe and prolonged anoxia, K-ATP channels open to decrease cellular excitability and prevent action potential generation. Small active molecules can enhance the opening of K-ATP channels, leading to membrane repolarization and decreased malignant arrhythmias. Mutations in K-ATP channels worsen the regulatory roles in mutation-related diseases. However, efficient treatments for patients with K-ATP channel mutations are still lacking.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bernard R. Chaitman, Karen P. Alexander, Derek D. Cyr, Jeffrey S. Berger, Harmony R. Reynolds, Sripal Bangalore, William E. Boden, Renato D. Lopes, Marcin Demkow, Gian Piero Perna, Robert K. Riezebos, Edward O. McFalls, Subhash Banerjee, Akshay Bagai, Gilbert Gosselin, Sean M. O'Brien, Frank W. Rockhold, David D. Waters, Kristian A. Thygesen, Gregg W. Stone, Harvey D. White, David J. Maron, Judith S. Hochman
Summary: The ISCHEMIA trial showed that an initial invasive strategy did not reduce cardiovascular events or all-cause mortality in patients with stable ischemic heart disease. Procedural MI rates were higher with the invasive strategy compared to conservative strategy, with the use of the secondary MI definition.
Review
Pharmacology & Pharmacy
Mahfoozur Rahman, Waleed H. Almalki, Majed Alrobaian, Jawed Iqbal, Saad Alghamdi, Khalid S. Alharbi, Nabil K. Alruwaili, Abdul Hafeez, Adil Shaharyar, Tanuja Singh, Mohammad Waris, Vikas Kumar, Sarwar Beg
Summary: Natural actives have shown great potential in inhibiting HCC through different molecular pathways, along with the advantages of bioactive-loaded nanocarriers. Thorough assessment of the safety and efficacy evaluation of these nanocarriers is needed for the delivery of targeted natural active ingredients in HCC treatment.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Nanoscience & Nanotechnology
Xiangxiang Zhang, Huaen Chen, Yang Zhang, Qijing Huang, Jianjia Feng, Haoyu Xing, Xiaguo Fu, Xiufang Yan, Yingying Zhang, Qin Xu, Jianming Liang
Summary: The study developed a nano drug delivery system by combining HNK-loaded liposomes with HA-DOPE modification, which demonstrated effective antitumor abilities in both in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Wenqiang Qian, Daozhou Liu, Ying Han, Miao Liu, Bao Liu, Qifeng Ji, Bangle Zhang, Qibing Mei, Siyuan Zhou, Ying Cheng
Summary: Simultaneous inhibition of ferroptosis and apoptosis of cardiomyocytes can be a promising strategy to treat myocardial ischemia-reperfusion injury (MI/RI). Taking advantage of the highly expressed transferrin receptor in ischemic myocardium, cyclosporin A (CsA) was wrapped with apoferritin (ApoFn) to actively target and inhibit both ferroptosis and apoptosis in MI/RI mice, resulting in the restoration of cardiac function.
ACTA BIOMATERIALIA
(2023)
Article
Plant Sciences
Sihan Hu, Lan Jiang, Qi Yan, Chenyang Zhou, Xiaochuan Guo, Tong Chen, Siting Ma, Yimiao Luo, Caiyu Hu, Fumin Yang, Lishan Yuan, Xiao Ma, Jinhao Zeng
Summary: Baicalin exhibits positive effects on myocardial ischemia diseases, achieved by regulating key pathological indicators and various signaling pathways. In animal models of myocardial ischemia, reperfusion injury, and myocardial infarction, baicalin can reduce myocardial infarction size, improve cardiac pathological condition, and enhance heart function indicators.
