Article
Dentistry, Oral Surgery & Medicine
Frederick Gaultier, Anne-laure Ejeil, Sebastien Jungo, Saskia Ingen-Housz-Oro, Francois Le Pelletier de Clatigny, Gogly Bruno, Philippe Pirnay, Fadel Bellakhdar, Sophie-Myriam Dridi
Summary: The study evaluated the diagnostic relevance and tolerance of an original protocol using interdental papilla biopsy for chronic erosive gingivitis, showing that this surgical protocol is simple to perform, well-tolerated, and highly efficient with an excellent contribution level to clinical diagnosis.
Review
Medicine, General & Internal
Ana Maria Sciuca, Mihaela Paula Toader, Carmen Gabriela Stelea, George Alexandru Maftei, Oana Elena Ciurcanu, Ovidiu Mihail Stefanescu, Bianca-Andreea Onofrei, Cristina Popa
Summary: Desquamative gingivitis (DG) is a clinical term used to describe gingival erythema, desquamation, and erosions, with various underlying causes. Accurate diagnosis of the underlying disorder is crucial for appropriate treatment and prognosis. Patients typically seek dental consultation for DG, emphasizing the importance for dentists to be knowledgeable about this condition. Genetic predisposition, metabolic, neuropsychiatric, infectious factors, medication, among others, can lead to an inflammatory immune response in the oral mucosa and DG appearance. Comprehensive medical history, clinical examination, and relevant investigations are necessary for diagnosis. Management includes oral hygiene, regular follow-up, and systemic/topical therapy based on treatment algorithms.
Article
Rheumatology
Yuji Hosono, Brandon Sie, Iago Pinal-Fernandez, Katherine Pak, Christopher A. Mecoli, Maria Casal-Dominguez, Blake M. Warner, Mariana J. Kaplan, Jemima Albayda, Sonye Danoff, Thomas E. Lloyd, Julie J. Paik, Eleni Tiniakou, Rohit Aggarwal, Chester Oddis, Siamak Moghadam-Kia, Carmelo Carmona-Rivera, Jose Cesar Milisenda, Josep Maria Grau-Junyent, Albert Selva-O'Callaghan, Lisa Christopher-Stine, H. Benjamin Larman, Andrew Lee Mammen
Summary: A novel autoantibody Sp4 was discovered in patients with dermatomyositis, and it appears to identify a subgroup of anti-TIF1 gamma-positive dermatomyositis patients with lower cancer risk.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Markus Mueller, Michael E. Gschwandtner, Wolfgang Emminger, Hans Kiener, Sebastian Schnaubelt, Georgiana-Aura Giurgea, Robin Ristl, Thomas Perkmann, Renate Koppensteiner, Oliver Schlager
Summary: The objective of this study was to characterize the associations between individual nailfold capillary aberrations and autoantibodies in children and adults with Raynaud's phenomenon (RP). Nailfold capillaroscopy and laboratory tests were conducted on consecutive RP patients without previously known connective tissue disease. The prevalence of nailfold capillary aberrations and antinuclear antibodies (ANA) was assessed and analyzed separately for children and adults, revealing a less pronounced association between nailfold capillary aberrations and ANA in children. Further studies are needed to validate these observations in children with RP.
Article
Biochemistry & Molecular Biology
Hassan Vahidnezhad, Leila Youssefian, Amir Hossein Saeidian, Lynn M. Boyden, Andrew Touati, Nailah Harvey, Mahtab Naji, Masoud Zabihi, Mohammadreza Barzegar, Soheila Sotoudeh, Lu Liu, Alyson Guy, Ariana Kariminejad, Sirous Zeinali, Keith A. Choate, John A. McGrath, Jouni Uitto
Summary: This study revealed a novel mechanism for epidermolysis bullosa, where a mutation in the USB1 gene leads to splicing abnormalities and loss of protein function, affecting the stable adhesion complexes between the epidermis and dermis.
Article
Rheumatology
Sherri Longobardi, Charmaine Lopez-Davis, Bhuwan Khatri, Constantin Georgescu, Cherilyn Pritchett-Frazee, Christina Lawrence, Astrid Rasmussen, Lida Radfar, Robert Hal Scofield, Alan N. Baer, Susan A. Robinson, Erika Darrah, Robert C. Axtell, Gabriel Pardo, Jonathan D. Wren, Kristi A. Koelsch, Joel M. Guthridge, Judith A. James, Christopher J. Lessard, Amy Darise Farris
Summary: This study identified autoantibodies in anti-Ro/SS-A negative primary Sjogren's syndrome (SS), providing a new approach for diagnosing Ro-negative SS.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jean-Baptiste Vulsteke, Rita Derua, Sylvain Dubucquoi, Frederic Coutant, Sebastien Sanges, David Goncalves, Greet Wuyts, Petra De Haes, Daniel Blockmans, Wim A. Wuyts, Kristl G. Claeys, Ellen De Langhe, Nicole Fabien, Xavier Bossuyt
Summary: New and known antisynthetase autoantibodies (ASAs) were discovered and detected through protein immunoprecipitation combined with gel-free liquid chromatography-tandem mass spectrometry (IP-MS). The dominant cognate ARS autoantigen of the newly discovered anti-Ly ASA specificity was identified. Unbiased and targeted IP-MS are promising methods for discovery and detection of autoantibodies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Jennifer E. Hundt, Christian D. Sadik, Nina van Beek, Hauke Busch, Frederic Caux, Matthias Goebeler, Christoph M. Hammers, Karin Hartmann, Takashi Hashimoto, Saleh Ibrahim, Michael Kasperkiewicz, Dedee F. Murrell, Andreas Recke, Christian Rose, Nina Schumacher, Iakov Shimanovich, Cassian Sitaru, Patrick Terheyden, Diamant Thaci, Ralf J. Ludwig, Enno Schmidt
Summary: Dr. Detlef Zillikens, the director and chair of the Department of Dermatology at the University of Lubeck, dedicated his professional life to the research of autoimmune blistering diseases (AIBDs). With his warm, integrative, open-minded, ever-optimistic attitude, he was highly respected and admired by his colleagues, mentees, and friends. He played a significant role in establishing research institutes and centers, bringing researchers and clinicians together, and inspiring research initiatives in the field of AIBDs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Rheumatology
Eduardo Gomez-Banuelos, Andrea Fava, Felipe Andrade
Summary: Autoantibodies play a crucial role in systemic lupus erythematosus (SLE) as they cause tissue damage. They provide information about disease susceptibility, clinical course, outcomes, and the cause of SLE. However, identifying pathogenic autoantibodies in SLE is still challenging. This review summarizes recent advances in the field of autoantibodies in SLE.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Article
Allergy
Jana Koers, Rocco Sciarrillo, Ninotska I. L. Derksen, Esther M. Vletter, Yvonne E. Fillie-Grijpma, Elisabeth Raveling-Eelsing, Nuno A. G. Graca, Thiemo Leijser, Hendri H. Pas, L. Laura van Nijen-Vos, Maaike V. J. Braham, Anne-Marie Buisman, Jan de Jong, Angela I. Schriek, Anne P. Tio-Gillen, Y. K. Onno Teng, Maurice Steenhuis, Francis H. Swaneveld, Steven W. de Taeye, Marit J. van Gils, Jan J. G. M. Verschuuren, Bram Rutgers, Peter Heeringa, Barbara Horvath, Bart C. Jacobs, Karina de Leeuw, Casper F. M. Franssen, Agnes Veyradier, Paul Coppo, Kyra A. Gelderman, D. h S. Marieke van Ham, Cecile A. C. M. van Els, Diane van der Woude, Ruth Huizinga, Maartje G. Huijbers, Taco W. Kuijpers, Rene E. M. Toes, Nicolaas A. Bos, Theo Rispens
Summary: This study investigated the levels of Fab glycosylation on autoantibodies associated with various B cell-mediated autoimmune diseases and found that elevated Fab glycosylation is present in chronic autoimmune diseases. The increased Fab glycosylation was not limited to a specific subclass of IgG and was not caused by chronic antigen-stimulation. These findings suggest that disease-specific autoantibodies in chronic autoimmune diseases are enriched with Fab glycans.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Christina Adamichou, Irini Genitsaridi, Dionysis Nikolopoulos, Myrto Nikoloudaki, Argyro Repa, Alessandra Bortoluzzi, Antonis Fanouriakis, Prodromos Sidiropoulos, Dimitrios T. Boumpas, George K. Bertsias
Summary: A machine learning algorithm was developed to assist in the diagnosis of SLE by analyzing patient data sets, leading to improved diagnostic and treatment outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Rheumatology
Nazariy Koval, Mariana Alves, Rui Placido, Ana G. Almeida, Joao Eurico Fonseca, Joaquim J. Ferreira, Fausto J. Pinto, Daniel Caldeira
Summary: The use of DOACs, particularly rivaroxaban, among patients with APS is associated with a 69% increased risk of thromboembolic events compared to VKA, while the risks of major bleeding, all bleeding events, and mortality are not significantly different. The certainty of these results is very low.
Review
Immunology
Xinhua Yu, Jacqueline Wax, Gabriela Riemekasten, Frank Petersen
Summary: A comprehensive overview of the emerging topic of functional autoantibodies is provided, including their definition, mechanisms of action, potential triggers of production, and their contribution to autoimmune and non-autoimmune disorders. The relevance of functional autoantibodies in pathogenic conditions and homeostasis regulation is highlighted.
AUTOIMMUNITY REVIEWS
(2023)
Article
Virology
Jerzy Swierkot, Marta Madej, Magdalena Szmyrka, Lucyna Korman, Renata Sokolik, Iga Andrasiak, Ewa Morgiel, Agata Sebastian
Summary: This study evaluated the prevalence of autoimmune antibodies before and after SARS-CoV-2 mRNA vaccination in healthcare professionals. The findings showed no significant increase in the prevalence of certain antibodies or autoimmune diseases after vaccination. However, there was an association between the severity of vaccine adverse events and ANA titre.
Article
Rheumatology
Christopher P. Denton, Shiwen Xu, Fenge Zhang, Rory H. Maclean, Kristina E. N. Clark, Signe Borchert, Rizwan Hussain, Joerg Klingelhofer, Jonas Hallen, Voon H. Ong
Summary: This study investigated the role of S100A4 in fibroblast activation in systemic sclerosis (SSc). The results showed that S100A4 concentration was higher in SSc patients compared to healthy controls, and was associated with interstitial lung disease and scleroderma renal crisis. In vitro experiments demonstrated that S100A4 promoted the expression of profibrotic genes in SSc fibroblasts, while a neutralizing antibody against S100A4 reduced this expression. These findings provide evidence for the profibrotic role of S100A4 in SSc and suggest its potential as a therapeutic target.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Stefano Fedele, Stephen Porter
Letter
Dentistry, Oral Surgery & Medicine
Daniel Cohen Goldemberg, Andreia Cristina de Melo, Livia Cristina de Melo Pino, Heliton Spindola Antunes, Jair Carneiro Leao, Stephen Porter
Article
Dermatology
Maryam Aghighi, Bruce R. Smoller
Summary: Hailey-Hailey disease is a hereditary skin condition characterized by blisters and erosions, with decreased expression of Galectin-3 potentially playing a role in the pathogenesis of the disease.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Article
Dermatology
Chau M. Bui, Sumire Kitahara, Wonwoo Shon, Tatsiana Pukhalskaya, Bruce R. Smoller
Summary: PRAME is not expressed in cutaneous T-cell lymphomas (CTCLs), suggesting that the pathogenesis of CTCL is not mediated by PRAME. Further study is required to identify biomarkers that might aid in the diagnosis and prognostication of CTCLs.
Article
Dermatology
Hatice B. Zengin, Bahadir Yildiz, Tatsiana Pukhalskaya, Bruce R. Smoller
Summary: Our study failed to reveal possible TFE3 gene fusion by IHC staining in benign, atypical, and malignant chondroid syringomas. Although the negative staining in MCS suggests a genetic heterogeneity in this entity, further studies with larger case groups are needed for a more definitive conclusion.
Biographical-Item
Dentistry, Oral Surgery & Medicine
Stephen R. Porter, Alexander Crighton
Article
Oncology
Alessio Gambino, Adriana Cafaro, Roberto Broccoletti, Luca Turotti, Dora Karimi, Giorgia El Haddad, Colin Hopper, Stephen R. Porter, Luigi Chiusa, Paolo G. Arduino
Summary: Ulcers in the oral mucosa can be caused by various factors and are difficult to diagnose. Optical coherence tomography has been suggested as a potential method for diagnosing and distinguishing between traumatic and malignant ulcers.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Dermatology
Hatice B. Zengin, Bahadir Yildiz, Tatsiana Pukhalskaya, Bruce R. Smoller
Summary: Melanocytic nevi in lymph nodes pose a diagnostic challenge and can be mistaken for metastases. The use of PRAME immunohistochemical stain can help differentiate between the two. FLI-1 immunohistochemical expression has shown variable sensitivity in malignant melanoma, while melanocytic nevi are reported to be negative. In this study, we examined lymph nodes with metastatic melanoma and benign deposits, and found that FLI-1/Melan-A dual staining is equally sensitive and specific as PRAME in distinguishing between the two. Larger studies are needed to confirm these significant results.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Dermatology
Hatice B. Zengin, Chau M. Bui, Kristin Rybski, Tatsiana Pukhalskaya, Bahadir Yildiz, Bruce R. Smoller
Summary: A recent study investigated the expression of TRPS1 in various sweat gland tumors, revealing a high expression in both malignant and benign tumors. However, there was differential staining among different types of sweat gland tumors, suggesting potential differences in cellular origin or differentiation.
Article
Dermatology
Chau M. M. Bui, Tatsiana Pukhalskaya, Bruce R. R. Smoller, Hatice Betul Zengin, Saleh Heneidi, Eric Vail, Elias Makhoul, Bonnie Balzer
Summary: This study presents a series of eight cases of digital papillary adenocarcinoma (DPA) with two distinct clinical presentations, morphologies, immunophenotypes, and molecular features. Four cases showed painless, slow-growing nodules with glandular structures, while the other four cases showed painful, rapidly growing masses with solid, tightly packed papillary architecture.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Dermatology
Buket Bagci, Cansu Karakas, Harsimran Kaur, Bruce R. Smoller
Summary: Granuloma annulare (GA) is a benign inflammatory disease with different histologic patterns, while malignancy-associated granuloma annulare (MGA) is rarely associated with cancer. This study aimed to compare the clinical and histopathological differences between GA and MGA. It was found that MGA is more common in older individuals and affects the extremities, with chronic lymphocytic leukemia being the most common associated malignancy. The histopathological pattern of interstitial was more commonly seen in MGA, while necrobiotic pattern was more common in GA.
Article
Dermatology
Kristin J. Rybski, Hatice B. Zengin, Bruce R. Smoller
Summary: This study evaluates the immunohistochemical expression of TRPS1 in cutaneous neoplasms with follicular differentiation, including trichoblastoma, trichoepithelioma, and basal cell carcinoma. The study found that TRPS1 showed intermediate-to-high positivity in trichoblastoma and trichoepithelioma, while it was negative or sporadically positive in basal cell carcinoma.
Review
Dentistry, Oral Surgery & Medicine
S. R. Porter, A. Ukwas
Summary: Cachexia is a common feature in patients with advanced malignancy of the head and neck, driven by various mechanisms induced by the tumor itself, leading to reduced nutritional intake, increased metabolism, and loss of adipose and skeletal tissue.
Article
Dentistry, Oral Surgery & Medicine
Waleed Alamoudi, Richeal Ni Riordain, Stefano Fedele, Stephen Porter
Summary: This study aims to evaluate the content and quality of audiovisual online information about OED. The findings show that most of the materials are scientific in nature, with poor quality and lacking essential patient information. However, these materials could still be useful for patient education with improvements needed.
Article
Dentistry, Oral Surgery & Medicine
Abdullah Alsoghier, Richeal Ni Riordain, Stefano Fedele, Stephen Porter
Summary: This study aimed to assess the information needs of patients with chronic oral diseases and the agreement between clinicians and patients on important topics. The results showed that there were unmet needs regarding dysplasia, and clinicians were not able to fully predict patients' priorities.